JP2011508775A - Bh4応答性状態を治療するためのプテリン類似体 - Google Patents

Bh4応答性状態を治療するためのプテリン類似体 Download PDF

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JP2011508775A
JP2011508775A JP2010541450A JP2010541450A JP2011508775A JP 2011508775 A JP2011508775 A JP 2011508775A JP 2010541450 A JP2010541450 A JP 2010541450A JP 2010541450 A JP2010541450 A JP 2010541450A JP 2011508775 A JP2011508775 A JP 2011508775A
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acid
alkenylene
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disease
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JP2011508775A5 (enExample
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ディー.カッキス エミル
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ビオマリン プハルマセウトイカル インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
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    • A61P25/24Antidepressants
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    • A61P27/00Drugs for disorders of the senses
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    • A61P3/06Antihyperlipidemics
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    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
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    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
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    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/12Antihypertensives
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Diabetes (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
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  • Obesity (AREA)
  • Urology & Nephrology (AREA)
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  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
JP2010541450A 2008-01-03 2008-07-07 Bh4応答性状態を治療するためのプテリン類似体 Ceased JP2011508775A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1873508P 2008-01-03 2008-01-03
US1975308P 2008-01-08 2008-01-08
PCT/US2008/069319 WO2009088530A1 (en) 2008-01-03 2008-07-07 Pterin analog for treating bh4 responsive condition

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JP2011508775A true JP2011508775A (ja) 2011-03-17
JP2011508775A5 JP2011508775A5 (enExample) 2011-08-25

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JP2010541450A Ceased JP2011508775A (ja) 2008-01-03 2008-07-07 Bh4応答性状態を治療するためのプテリン類似体

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US (2) US7601717B2 (enExample)
EP (1) EP2224927B1 (enExample)
JP (1) JP2011508775A (enExample)
CN (1) CN101969953B (enExample)
AU (1) AU2008347005B2 (enExample)
BR (1) BRPI0821970A2 (enExample)
CA (1) CA2711160A1 (enExample)
ES (1) ES2524026T3 (enExample)
MX (1) MX2010006025A (enExample)
RU (1) RU2470642C2 (enExample)
WO (1) WO2009088530A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010515747A (ja) * 2007-01-12 2010-05-13 ビオマリン プハルマセウトイカル インコーポレイテッド テトラヒドロビオプテリンプロドラッグ
JP5066756B2 (ja) * 2010-04-22 2012-11-07 学校法人日本大学 脳機能障害予防・改善用の薬剤及び飲食物
JP2016504286A (ja) * 2012-11-14 2016-02-12 バイアル−ポルテラ アンド シーエー,エス.エー. 肺動脈高血圧症及び肺障害の治療に使用するための1,3‐ジヒドロイミダゾール‐2‐チオン誘導体
JP2018500361A (ja) * 2014-12-30 2018-01-11 ダウ アグロサイエンシィズ エルエルシー 殺真菌剤としてのピコリンアミドの使用
JP2020068734A (ja) * 2018-11-01 2020-05-07 国立大学法人東京工業大学 Sprをコードするポリヌクレオチドを含む組換えベクター、及びそれを含む組成物
JP2020517663A (ja) * 2017-04-21 2020-06-18 スティーブン・ホフマン 網膜症を治療するための組成物及び方法

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US20130338176A1 (en) * 2010-10-29 2013-12-19 The Trustees Of Columbia University In The City Of New York Methods of preventing and treating hyperlipidemia or atherosclerosis
US10047386B2 (en) * 2011-10-11 2018-08-14 The Regents Of The University Of California Biomarker for abdominal aortic aneurysm
DK2806877T3 (da) 2012-01-23 2019-11-04 Sage Therapeutics Inc Neuroaktive steroidformuleringer omfattende et kompleks af allopregnanolon og sulfobutylether beta-cyclodekstrin
CA2882708A1 (en) 2012-08-21 2014-02-27 Sage Therapeutics, Inc. Methods of treating epilepsy or status epilepticus
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
WO2017156103A1 (en) 2016-03-08 2017-09-14 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
WO2019067782A1 (en) * 2017-09-28 2019-04-04 University Of Massachusetts COMBINED TREATMENT OF NEUROPSYCHIATRIC DISORDERS
WO2019175332A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity
WO2019175328A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4pathwayactivationandusethereoffortreatingcancer
CN112394178B (zh) * 2020-11-16 2022-08-05 首都医科大学附属北京朝阳医院 莫西沙星相关肝损伤的生物标志物、试剂盒及应用

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JPS59112987A (ja) * 1982-12-20 1984-06-29 Kanegafuchi Chem Ind Co Ltd 1′,2′―ジアシル―(6r,s)―5,6,7,8―テトラヒドロ―l―ビオプテリンおよびその製法
US20060194808A1 (en) * 2005-01-14 2006-08-31 Chronorx Llc, An Alaska Limited Liability Company Clinical applications of tetrahydrobiopterin, lipoic acid and their salts and methods of preparing tetrahydrobiopterin bis-lipoate

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010515747A (ja) * 2007-01-12 2010-05-13 ビオマリン プハルマセウトイカル インコーポレイテッド テトラヒドロビオプテリンプロドラッグ
JP5066756B2 (ja) * 2010-04-22 2012-11-07 学校法人日本大学 脳機能障害予防・改善用の薬剤及び飲食物
JP2016504286A (ja) * 2012-11-14 2016-02-12 バイアル−ポルテラ アンド シーエー,エス.エー. 肺動脈高血圧症及び肺障害の治療に使用するための1,3‐ジヒドロイミダゾール‐2‐チオン誘導体
US10308640B2 (en) 2012-11-14 2019-06-04 Bial-Portela & Ca, S.A. 1,3-dihydroimidazole-2-thione derivatives for use in the treatment of pulmonary arterial hypertension and lung injury
JP2018500361A (ja) * 2014-12-30 2018-01-11 ダウ アグロサイエンシィズ エルエルシー 殺真菌剤としてのピコリンアミドの使用
JP2020517663A (ja) * 2017-04-21 2020-06-18 スティーブン・ホフマン 網膜症を治療するための組成物及び方法
JP7171611B2 (ja) 2017-04-21 2022-11-15 スティーブン・ホフマン 網膜症を治療するための組成物及び方法
JP2020068734A (ja) * 2018-11-01 2020-05-07 国立大学法人東京工業大学 Sprをコードするポリヌクレオチドを含む組換えベクター、及びそれを含む組成物
JP2023041849A (ja) * 2018-11-01 2023-03-24 宏 一瀬 Sprをコードするポリヌクレオチドを含む組換えベクター、及びそれを含む組成物

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US8324210B2 (en) 2012-12-04
RU2470642C2 (ru) 2012-12-27
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EP2224927B1 (en) 2014-08-20
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US7601717B2 (en) 2009-10-13
BRPI0821970A2 (pt) 2015-06-23
RU2010132278A (ru) 2012-02-10
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