JP2011508220A5 - - Google Patents
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- JP2011508220A5 JP2011508220A5 JP2010539848A JP2010539848A JP2011508220A5 JP 2011508220 A5 JP2011508220 A5 JP 2011508220A5 JP 2010539848 A JP2010539848 A JP 2010539848A JP 2010539848 A JP2010539848 A JP 2010539848A JP 2011508220 A5 JP2011508220 A5 JP 2011508220A5
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- particles
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- 239000002245 particle Substances 0.000 claims 82
- 239000012530 fluid Substances 0.000 claims 13
- 210000001736 Capillaries Anatomy 0.000 claims 7
- 239000011860 particles by size Substances 0.000 claims 4
- 210000001772 Blood Platelets Anatomy 0.000 claims 2
- 210000003743 Erythrocytes Anatomy 0.000 claims 2
- 210000003324 RBC Anatomy 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 238000007689 inspection Methods 0.000 claims 2
- 229910052747 lanthanoid Inorganic materials 0.000 claims 2
- 150000002602 lanthanoids Chemical class 0.000 claims 2
- 230000032258 transport Effects 0.000 claims 2
- 210000004027 cells Anatomy 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 230000003287 optical Effects 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
Claims (69)
- 粒子をその中に含む流体を流動させるためのキャピラリと、
流動停止デバイスと、
該粒子を音響的に操作するための音響信号生成トランスデューサであって、粒子位置合わせは、流動構成および停止構成において維持される、トランスデューサと、
を備える、装置。 - 前記粒子を分析するための分析器をさらに備える、請求項1に記載の装置。
- 粒子選別器をさらに備える、請求項1に記載の装置。
- 粒子分別器をさらに備える、請求項1に記載の装置。
- フローサイトメータをさらに備える、請求項1に記載の装置。
- 撮像器をさらに備える、請求項1に記載の装置。
- 前記流動停止デバイスは、ポンプを備える、請求項1に記載の装置。
- 前記流動停止デバイスは、1つ以上の弁を備える、請求項1に記載の装置。
- 粒子をその中に含む流体を流動させるためのキャピラリと、
逆流デバイスと、
該粒子を音響的に操作するための音響信号生成トランスデューサであって、粒子位置合わせは、流動構成および逆流構成において維持される、トランスデューサと、
を備える、装置。 - 前記粒子を分析するための分析器をさらに備える、請求項9に記載の装置。
- 選別器をさらに備える、請求項9に記載の装置。
- 分別器をさらに備える、請求項9に記載の装置。
- フローサイトメータをさらに備える、請求項9に記載の装置。
- 撮像器をさらに備える、請求項9に記載の装置。
- 前記逆流デバイスは、ポンプを備える、請求項9に記載の装置。
- 前記逆流デバイスは、1つ以上の弁を備える、請求項9に記載の装置。
- 粒子をその中に含む流体を流動させるためのキャピラリと、
該粒子を音響的に配向するための音響信号生成トランスデューサと、
粒子分析器と
を備える、装置。 - 前記装置は、フローサイトメータを備える、請求項17に記載の装置。
- 粒子選別器をさらに備える、請求項17に記載の装置。
- 前記選別器は、分析前にサイズに基づいて前記粒子を分離する、請求項19に記載の装置。
- 前記音響信号生成トランスデューサは、流動軸を中心に、極性方向に前記粒子を整列させる、請求項17に記載の装置。
- 前記音響信号生成トランスデューサは、流動方向に前記粒子を整列させる、請求項17に記載の装置。
- 粒子分別器を備える、請求項17に記載の装置。
- 前記粒子は、赤血球または血小板である、請求項17に記載の装置。
- 前記粒子は、精子である、請求項17に記載の装置。
- 撮像器をさらに備える、請求項17に記載の装置。
- 粒子をその中に含む流体を流動させるためのキャピラリと、
該キャピラリ内における半径方向音響場において非軸対称の粒子を音響的に配向する半径方向音響信号生成トランスデューサと、
該粒子を検査点を通して輸送するための輸送デバイスと、
粒子分析器と
を備える、装置。 - 前記半径方向音響信号生成トランスデューサは、前記キャピラリにおいて前記粒子を整列させる、請求項27に記載の装置。
- 前記半径方向音響信号生成トランスデューサは、前記キャピラリにおいて前記粒子を濃縮する、請求項27に記載の装置。
- 前記半径方向音響信号生成トランスデューサは、前記粒子を整列させる音響場を生成する、請求項27に記載の装置。
- 前記粒子を整列させる流体力学的シースを備える、請求項27に記載の装置。
- 撮像器をさらに備える、請求項27に記載の装置。
- 1つ以上の粒子を音響的に操作するための方法であって、
1つ以上の粒子を含む流体を流動させることと、
音響放射圧を該流体に向けることであって、該音響放射圧は、1つ以上の粒子の位置合わせを流動構成および停止構成において音響的に維持することと、
該流体を停止させることと、
該粒子のうちの少なくとも1つをレビューすることと
を含む、方法。 - 前記レビューすることは、前記粒子のうちの少なくとも1つを分析することを含む、請求項33に記載の方法。
- 前記レビューすることは、前記粒子のうちの少なくとも1つを選別することを含む、請求項33に記載の方法。
- 前記流体をフローサイトメータを通して流動させることをさらに含む、請求項33に記載の方法。
- 1つ以上の粒子を音響的に操作するための方法であって、
1つ以上の粒子を含む流体を流動させることと、
音響放射圧を該流体に向けることであって、該音響放射圧は、1つ以上の粒子の位置合わせを流動構成および逆流構成において音響的に維持することと、
該流体の流動の方向を逆にすることと、
該流動において逆行された該粒子のうちの少なくとも1つをレビューすることと
を含む、方法。 - 前記レビューすることは、前記粒子のうちの少なくとも1つを分析することを含む、請求項37に記載の方法。
- 前記レビューすることは、前記粒子のうちの少なくとも1つを選別することを含む、請求項37に記載の方法。
- 前記流体をフローサイトメータを通して流動させることを含む、請求項37に記載の方法。
- 粒子分析器のフロー流において粒子を音響的に配向するための方法であって、
粒子をフロー流によって流動させることと、
音響放射圧を該粒子に向けることと、
該粒子分析器の該フロー流において該粒子を音響的に配向することと
を含む、方法。 - 前記粒子分析器は、フローサイトメータである、請求項41に記載の方法。
- 前記音響放射圧は、非対称的である、請求項41に記載の方法。
- 前記粒子は、非対称的である、請求項41に記載の方法。
- 前記粒子の所定の配向を選択することをさらに含む、請求項41に記載の方法。
- 前記配向は、光学的散乱平面内にある、請求項45に記載の方法。
- 粒子非対称性に基づいて異なる種類の粒子を区別することをさらに含む、請求項41に記載の方法。
- 粒子集団の繰り返し可能な配向をもたらすことをさらに含む、請求項41に記載の方法。
- 前記粒子を選別することをさらに含む、請求項41に記載の方法。
- 前記選別することは、サイズに基づく粒子の事前分析インライン分離を含む、請求項49に記載の方法。
- 流動軸を中心に、極性方向に前記粒子を整列させることを含む、請求項41に記載の方法。
- 流動方向に前記粒子を整列させることを含む、請求項41に記載の方法。
- 前記粒子を分別することをさらに含む、請求項41に記載の方法。
- 前記粒子は、赤血球または血小板である、請求項41に記載の方法。
- 前記粒子は、精子である、請求項41に記載の方法。
- 粒子分析器において粒子を分析するための方法であって、
1つ以上の粒子をフロー流において流動させることと、
半径方向音響放射圧を該フロー流に向けることと、
非対称粒子を該フロー流において音響的に配向することと、
各粒子を検査点を通して輸送することと、
該粒子の各々を分析することと
を含む、方法。 - 前記粒子を前記フロー流において整列させることをさらに含む、請求項56に記載の方法。
- 前記整列させることは、音響場による、請求項57に記載の方法。
- 前記整列させることは、流体力学的収束による、請求項57に記載の方法。
- 前記粒子を前記フロー流において濃縮することをさらに含む、請求項56に記載の方法。
- フロー流において1つ以上の粒子を分析する方法であって、
ランタニドにより粒子を標識することと、
該粒子をフロー流において流動させることと、
該フロー流の方向に沿って該粒子を整列させるために、半径方向音響放射圧を該フロー流に向けることであって、該半径方向音響放射圧は、流体の流動、停止、逆流の間、粒子位置合わせを維持する、ことと、
該ランタニドにより標識された該粒子の少なくとも一部分を分析することと
を含む、方法。 - 前記フロー流を停止させることをさらに含む、請求項61に記載の方法。
- 前記フロー流を逆行させることをさらに含む、請求項61に記載の方法。
- サイズにより粒子を分離するための方法であって、
粒子をフロー流において流動させることと、
半径方向音響放射圧を該フロー流に適用することと、
半径方向音響放射圧を適用することによって、サイズにより該粒子を音響的に分離することであって、小さい方の粒子は該放射圧によって実質的に影響を受けない、ことと
を含む、方法。 - 前記分離された粒子のうちの大きい方の粒子をフローサイトメータに輸送することをさらに含む、請求項64に記載の方法。
- 前記大きい方の粒子を分析することをさらに含む、請求項65に記載の方法。
- 前記輸送することは、前記大きい方の粒子を前記フロー流の中心軸に輸送する、請求項65に記載の方法。
- 前記粒子をインライン分離することをさらに含む、請求項64に記載の方法。
- サイズにより粒子を分離するための方法であって、
粒子をフロー流において流動させることと、
半径方向音響放射圧を該フロー流に適用することと、
半径方向音響放射圧を適用することによって、サイズにより該粒子を音響的に分離し、大きい方の粒子をフローサイトメータ内に輸送することであって、小さい方の粒子は細胞残屑を含む、ことと
を含む、方法。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US842207P | 2007-12-19 | 2007-12-19 | |
US12/283,461 US8266950B2 (en) | 2007-12-19 | 2008-09-11 | Particle analysis in an acoustic cytometer |
US12/283,491 US8266951B2 (en) | 2007-12-19 | 2008-09-11 | Particle analysis in an acoustic cytometer |
PCT/US2008/087579 WO2009086043A2 (en) | 2007-12-19 | 2008-12-19 | Particle analysis in an acoustic cytometer |
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JP2013035328A Division JP6163320B2 (ja) | 2007-12-19 | 2013-02-26 | 音響サイトメータにおける粒子分析 |
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JP2011508220A JP2011508220A (ja) | 2011-03-10 |
JP2011508220A5 true JP2011508220A5 (ja) | 2012-02-02 |
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JP2010539848A Pending JP2011508220A (ja) | 2007-12-19 | 2008-12-19 | 音響サイトメータにおける粒子分析 |
JP2013035328A Active JP6163320B2 (ja) | 2007-12-19 | 2013-02-26 | 音響サイトメータにおける粒子分析 |
JP2013208104A Pending JP2014029344A (ja) | 2007-12-19 | 2013-10-03 | 音響サイトメータにおける粒子分析 |
JP2015117340A Active JP6423315B2 (ja) | 2007-12-19 | 2015-06-10 | 音響サイトメータにおける粒子分析 |
JP2017072063A Pending JP2017134083A (ja) | 2007-12-19 | 2017-03-31 | 音響サイトメータにおける粒子分析 |
Family Applications After (4)
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JP2013035328A Active JP6163320B2 (ja) | 2007-12-19 | 2013-02-26 | 音響サイトメータにおける粒子分析 |
JP2013208104A Pending JP2014029344A (ja) | 2007-12-19 | 2013-10-03 | 音響サイトメータにおける粒子分析 |
JP2015117340A Active JP6423315B2 (ja) | 2007-12-19 | 2015-06-10 | 音響サイトメータにおける粒子分析 |
JP2017072063A Pending JP2017134083A (ja) | 2007-12-19 | 2017-03-31 | 音響サイトメータにおける粒子分析 |
Country Status (12)
Country | Link |
---|---|
US (7) | US8266951B2 (ja) |
EP (1) | EP2232212B1 (ja) |
JP (5) | JP2011508220A (ja) |
KR (2) | KR101817410B1 (ja) |
CN (2) | CN104614302B (ja) |
AU (1) | AU2008343033B2 (ja) |
BR (1) | BRPI0821646A8 (ja) |
CA (1) | CA2709765C (ja) |
EA (1) | EA022506B1 (ja) |
IL (1) | IL206331A (ja) |
WO (1) | WO2009086043A2 (ja) |
ZA (1) | ZA201004306B (ja) |
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