ATE412184T1 - Verfahren zur analyse einer mehrzahl von proben verschiedenen ursprungs auf einen analyten - Google Patents

Verfahren zur analyse einer mehrzahl von proben verschiedenen ursprungs auf einen analyten

Info

Publication number
ATE412184T1
ATE412184T1 AT00955625T AT00955625T ATE412184T1 AT E412184 T1 ATE412184 T1 AT E412184T1 AT 00955625 T AT00955625 T AT 00955625T AT 00955625 T AT00955625 T AT 00955625T AT E412184 T1 ATE412184 T1 AT E412184T1
Authority
AT
Austria
Prior art keywords
particles
fluorescent
analyte
analyzing
samples
Prior art date
Application number
AT00955625T
Other languages
English (en)
Inventor
Mark Chandler
Don Chandler
Original Assignee
Luminex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luminex Corp filed Critical Luminex Corp
Application granted granted Critical
Publication of ATE412184T1 publication Critical patent/ATE412184T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/823—Immunogenic carrier or carrier per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/707—Integrated with dissimilar structures on a common substrate having different types of nanoscale structures or devices on a common substrate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/92—Detection of biochemical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/109163—Inorganic standards or controls
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Luminescent Compositions (AREA)
AT00955625T 1999-08-17 2000-08-17 Verfahren zur analyse einer mehrzahl von proben verschiedenen ursprungs auf einen analyten ATE412184T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14922599P 1999-08-17 1999-08-17

Publications (1)

Publication Number Publication Date
ATE412184T1 true ATE412184T1 (de) 2008-11-15

Family

ID=22529308

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00955625T ATE412184T1 (de) 1999-08-17 2000-08-17 Verfahren zur analyse einer mehrzahl von proben verschiedenen ursprungs auf einen analyten

Country Status (6)

Country Link
US (3) US6649414B1 (de)
EP (1) EP1204869B1 (de)
AT (1) ATE412184T1 (de)
AU (1) AU6779700A (de)
DE (1) DE60040603D1 (de)
WO (1) WO2001013120A1 (de)

Families Citing this family (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE254965T1 (de) * 1995-04-25 2003-12-15 Discovery Partners Internation Fernprogrammierbare matrizen mit speichern und verwendungen davon
EP1023464B1 (de) * 1997-10-14 2017-07-26 Luminex Corporation Fluoreszierend gefärbte präzisionspartikel sowie verfahren zu deren herstellung und verwendung
DE60040603D1 (de) * 1999-08-17 2008-12-04 Luminex Corp Verfahren zur analyse einer mehrzahl von proben verschiedenen ursprungs auf einen analyten
US7083951B2 (en) * 2001-02-14 2006-08-01 The Regents Of The University Of California Flow cytometric detection method for DNA samples
US8148171B2 (en) 2001-10-09 2012-04-03 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US20050164261A1 (en) * 2001-10-09 2005-07-28 Chandler Don J. Multiplexed analysis of clinical specimens apparatus and methods
ATE371442T1 (de) * 2001-10-12 2007-09-15 Elan Pharma Int Ltd Zusammensetzungen mit einer kombination aus eigenschaften sofortiger freisetzung und kontrollierter freisetzung
CA2478985A1 (en) 2002-03-13 2003-09-25 Syngenta Participations Ag Nucleic acid detection method
CA2483053A1 (en) 2002-04-30 2004-10-19 Merck & Co., Inc. Human papillomavirus multiplexed assay
US7291460B2 (en) 2002-05-31 2007-11-06 Verenium Corporation Multiplexed systems for nucleic acid sequencing
US7326573B2 (en) 2003-01-10 2008-02-05 Beckman Coulter, Inc. Assay procedures and apparatus
FR2855613B1 (fr) * 2003-05-26 2005-08-19 Biocytex Procede de detection et de quantification multiplex d'analytes dans un echantillon a l'aide de microspheres
US7927796B2 (en) * 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
EP1692512B1 (de) * 2003-12-09 2012-09-05 bioMérieux, Inc. Verfahren zum nachweis bakterieller krankheitserreger
CN101187621B (zh) * 2004-01-14 2012-02-15 卢米尼克斯股份有限公司 用于动态范围扩展的方法和系统
US7229778B2 (en) * 2004-02-26 2007-06-12 The Procter & Gamble Company Methods for determining the relative benefits and/or evaluating quantitative changes of products on epithelial tissue
US7465543B1 (en) 2004-05-21 2008-12-16 The United States Of America, As Represented By The Secretary Of Agriculture Multiplex DNA identification of clinical yeasts using flow cytometry
WO2005123959A2 (en) * 2004-06-10 2005-12-29 Perkinelmer Las, Inc. Multiplexing assays for analyte detection
US7635563B2 (en) * 2004-06-30 2009-12-22 Massachusetts Institute Of Technology High throughput methods relating to microRNA expression analysis
US7807468B2 (en) * 2004-07-21 2010-10-05 Bates Lynn S Methods of marking and testing pharmaceutical products
US7964407B2 (en) * 2004-07-21 2011-06-21 Bates Lynn S Methods of marking products using natural materials having genetically controlled micromorphological structures as markers
US7340957B2 (en) 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
US20060024815A1 (en) * 2004-07-30 2006-02-02 Allman Steve L High sensitivity array-based detection system
US20060045814A1 (en) * 2004-09-01 2006-03-02 Zhang Yu-Zhong Microplates containing microsphere fluorescence standards, microsphere standards, and methods for their use
CN103951595B (zh) 2004-10-12 2015-10-14 卢米尼克斯股份有限公司 形成染色的微球体和染色的微球体群的方法
JP4988578B2 (ja) * 2004-10-12 2012-08-01 ルミネックス コーポレーション ミクロスフェアの表面特性を変化させるための方法
EP1825267A4 (de) * 2004-11-29 2008-07-09 Perkinelmer Life & Analytical Sciences Mutliplex-assay auf partikelbasis zur glycosylierungsidentifizierung
CA2495138C (en) * 2005-01-20 2012-10-23 Alison Jane Basile Multiplexed analysis for determining a serodiagnosis of viral infection
JP4543170B2 (ja) * 2005-01-28 2010-09-15 国立大学法人 東京大学 標識製造方法
EP1861710A4 (de) * 2005-03-03 2008-07-23 Univ North Dakota Mit zielinduzierten fluoreszierenden verbindungen beschichtete oberflächen zur detektion von zielelementen
US8247018B2 (en) * 2005-06-20 2012-08-21 Authentiform Technologies, Llc Methods for quality control
US7874489B2 (en) * 2005-06-20 2011-01-25 Authentiform Technologies, Llc Product authentication
EP1907988B1 (de) * 2005-06-20 2013-11-06 AuthentiForm Technologies, L.L.C. Systeme und verfahren zur produktauthentifikation
NO20053373D0 (no) * 2005-07-11 2005-07-11 Rikshospitalet Radiumhospitale Multicolored Particles.
CA2984772C (en) 2005-09-21 2018-04-03 Luminex Corporation Methods and systems for image data processing
GB2432419A (en) 2005-11-16 2007-05-23 Agency Science Tech & Res Influenza A virus detection method
WO2007075910A2 (en) * 2005-12-23 2007-07-05 Perkinelmer Las, Inc. Methods and compositions for detecting enzymatic activity
US7932037B2 (en) 2007-12-05 2011-04-26 Perkinelmer Health Sciences, Inc. DNA assays using amplicon probes on encoded particles
US20100009373A1 (en) * 2005-12-23 2010-01-14 Perkinelmer Health Sciences, Inc. Methods and compositions relating to multiplex genomic gain and loss assays
EP1969337A4 (de) * 2005-12-23 2010-01-27 Perkinelmer Las Inc Multiplex-testverfahren unter verwendung magnetischer und nichtmagnetischer partikel
US20090104613A1 (en) * 2005-12-23 2009-04-23 Perkinelmer Las, Inc. Methods and compositions relating to multiplexed genomic gain and loss assays
EP1969142B1 (de) * 2005-12-23 2018-02-14 PerkinElmer LAS, Inc. Vergleichende genomische hybridisierung auf codierten multiplex-partikeln
US8309025B1 (en) 2006-01-26 2012-11-13 Luminex Corporation Methods and systems for determining composition and completion of an experiment
EP1987361A4 (de) * 2006-01-30 2009-03-04 Invitrogen Corp Zusammensetzungen und verfahren zur erkennung und quantifizierung toxischer substanzen in krankheitsstadien
US8124943B1 (en) 2006-04-06 2012-02-28 Lugade Ananda G Methods and systems for altering fluorescent intensities of a plurality of particles
US8841134B2 (en) * 2006-04-10 2014-09-23 Bruker Biospin Corporation Fluorescence resonance energy transfer detection with nanoparticles for in vitro and in vivo applications
WO2007127988A2 (en) * 2006-04-28 2007-11-08 Perkinelmer Las, Inc. Detecting phospho-transfer activity
WO2007130403A2 (en) * 2006-05-02 2007-11-15 University Of Pittsburgh-Of The Commonwealth System Of Higher Education REGULATION OF ApoB BY Hspl 10 PROTEINS AND RELATED COMPOSITIONS AND METHODS
CN101484806A (zh) 2006-05-17 2009-07-15 协乐民公司 一种对组织进行自动分析的方法
WO2007143615A2 (en) 2006-06-02 2007-12-13 Luminex Corporation Systems and methods for performing measurements of one or more analytes comprising using magnetic particles and applying a magnetic field
US8296088B2 (en) 2006-06-02 2012-10-23 Luminex Corporation Systems and methods for performing measurements of one or more materials
US20080131875A1 (en) * 2006-06-07 2008-06-05 Third Wave Technologies, Inc. Multiplex assays
US7764361B2 (en) * 2006-07-27 2010-07-27 Northwestern University Systems and methods to analyze multiplexed bead-based assays using backscattered light
US7501290B2 (en) * 2006-09-13 2009-03-10 Hanley Brian P Intraplexing method for improving precision of suspended microarray assays
SG143090A1 (en) * 2006-11-27 2008-06-27 Agency Science Tech & Res Influenza b virus detection method and kit therefor
US8288110B2 (en) * 2006-12-04 2012-10-16 Perkinelmer Health Sciences, Inc. Biomarkers for detecting cancer
US8003312B2 (en) * 2007-02-16 2011-08-23 The Board Of Trustees Of The Leland Stanford Junior University Multiplex cellular assays using detectable cell barcodes
DE102007010109A1 (de) * 2007-02-28 2008-09-04 Henkel Ag & Co. Kgaa Wirkstoffträgersysteme
WO2008122051A1 (en) 2007-04-02 2008-10-09 Acoustic Cytometry Systems, Inc. Methods and devices for enhanced analysis of field focused cells and particles
US20080279874A1 (en) * 2007-05-07 2008-11-13 Wyeth Compositions and methods for modulation of plk1 kinase activity
EP2148885A4 (de) * 2007-05-31 2010-12-15 Monsanto Technology Llc Sojabohnenpolymorphismen und verfahren zu ihrer genotypisierung
JP4360652B2 (ja) 2007-06-08 2009-11-11 古河電気工業株式会社 イムノクロマト法試薬用標識シリカナノ粒子、イムノクロマト法試薬、それを用いたイムノクロマト法用テストストリップ、及びイムノクロマト法用蛍光検出システム
CN101796197B (zh) 2007-06-08 2014-02-12 比奥根艾迪克Ma公司 预测抗tnf响应性或无响应性的生物标志物
US7947465B2 (en) * 2007-08-20 2011-05-24 Bio-Rad Laboratories, Inc. Simultaneous assay for determining drugs
US20090053832A1 (en) * 2007-08-20 2009-02-26 Link William F Simultaneous assay for determining drugs
GB0719373D0 (en) * 2007-10-04 2007-11-14 Univ Cranfield Optical multisensor
EP3136103B1 (de) * 2007-10-05 2018-08-29 Affymetrix, Inc. Stark gebündelte assays
US8266951B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, Llc Particle analysis in an acoustic cytometer
WO2009086525A2 (en) * 2007-12-27 2009-07-09 Luminex Corporation Luminescent reporter modality for analyzing an assay
US20100279272A1 (en) * 2008-02-13 2010-11-04 Michael Craig Burrell Multiplexed analysis methods using sers-active nanoparticles
CA2718276A1 (en) 2008-03-13 2009-09-17 Perkinelmer Las, Inc. Enzymatic substrates for multiple detection systems
WO2009120755A1 (en) * 2008-03-25 2009-10-01 University Of Medicine And Dentistry Of New Jersey Multiplex screening for pathogenic hypertrophic cardiomyopathy mutations
CN101981450A (zh) * 2008-03-26 2011-02-23 默克专利有限公司 底物偶联珠的长期储存方法
EP2350651B1 (de) 2008-11-10 2015-01-14 Luminex Corporation Verfahren zur herstellung makroporöser kügelchen
US7879625B1 (en) 2008-12-03 2011-02-01 The United States Of America As Represented By The Secretary Of The Navy Preparation of SERS substrates on silica-coated magnetic microspheres
CN101864288B (zh) * 2009-04-14 2013-11-13 博阳生物科技（上海）有限公司 游离三碘甲腺原氨酸检测微粒、其制备及应用
US8343775B2 (en) * 2009-05-06 2013-01-01 Hanley Brian P Method and device for affinity differential intraplexing
EP2290102A1 (de) 2009-07-08 2011-03-02 Administración General De La Communidad Autónoma De Euskadi Verfahren zur Diagnose von multipler Sklerose basierend auf dem MikroRNA-Expressionsprofil
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
US20110046009A1 (en) * 2009-08-24 2011-02-24 Perkinelmer Health Sciences, Inc. Methods for detecting dna methylation using encoded particles
US20110097723A1 (en) * 2009-09-19 2011-04-28 Qun Liu Methods and reagents for analyte detection
AU2010298000A1 (en) * 2009-09-25 2012-04-05 Signature Genomics Laboratories Llc Multiplex (+/-) stranded arrays and assays for detecting chromosomal abnormalities associated with cancer and other diseases
GB2475226A (en) 2009-11-03 2011-05-18 Genetic Analysis As Universal Prokaryote 16S ribosome PCR primer pair
US8927271B1 (en) 2010-01-21 2015-01-06 Jack T. Johansen Compositions and methods for detecting target analytes
US10273544B2 (en) 2010-02-11 2019-04-30 Dana-Farber Cancer Institute, Inc. Methods for predicting likelihood of responding to treatment
HUE027972T2 (en) 2010-02-25 2016-11-28 Advanced Liquid Logic Inc A method for generating nucleic acid libraries
US9428547B2 (en) * 2010-04-21 2016-08-30 Dna Electronics, Inc. Compositions for isolating a target analyte from a heterogeneous sample
US9476812B2 (en) * 2010-04-21 2016-10-25 Dna Electronics, Inc. Methods for isolating a target analyte from a heterogeneous sample
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
US8841104B2 (en) * 2010-04-21 2014-09-23 Nanomr, Inc. Methods for isolating a target analyte from a heterogeneous sample
US8767069B2 (en) 2010-06-30 2014-07-01 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device using light distribution
US8274656B2 (en) 2010-06-30 2012-09-25 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device
US9163287B2 (en) 2010-10-26 2015-10-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention Rapid salmonella serotyping assay
US9115408B2 (en) 2010-10-26 2015-08-25 The United States Of America As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention Rapid Salmonella serotyping assay
JP5937780B2 (ja) * 2010-11-11 2016-06-22 ソニー株式会社 蛍光スペクトル補正方法及び蛍光スペクトル測定装置
US20130293246A1 (en) 2010-11-17 2013-11-07 Advanced Liquid Logic Inc. Capacitance Detection in a Droplet Actuator
GB201021397D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Diagnosis of Crohn's disease
GB201021399D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Oligonucleotide probe set and methods of microbiota profiling
GB201102693D0 (en) 2011-02-16 2011-03-30 Genetic Analysis As Method for identifying neonates at risk for necrotizing enterocolitis
US9448173B2 (en) 2011-03-08 2016-09-20 The Board Of Trustees Of The University Of Illinois Dye-conjugated dendrimers
US10018631B2 (en) 2011-03-17 2018-07-10 Cernostics, Inc. Systems and compositions for diagnosing Barrett's esophagus and methods of using the same
US20140174926A1 (en) 2011-05-02 2014-06-26 Advanced Liquid Logic, Inc. Molecular diagnostics platform
CA2833897C (en) 2011-05-09 2020-05-19 Advanced Liquid Logic, Inc. Microfluidic feedback using impedance detection
WO2012154794A2 (en) 2011-05-10 2012-11-15 Advanced Liquid Logic, Inc. Enzyme concentration and assays
EP2546358A1 (de) 2011-07-15 2013-01-16 Laboratorios Del. Dr. Esteve, S.A. Verfahren und Reagenzien zur effizienten Steuerung des HIV-Fortschritts
JP5873183B2 (ja) 2011-10-18 2016-03-01 ルミネックス コーポレーション 画像データ処理方法及びシステム
WO2013078216A1 (en) 2011-11-21 2013-05-30 Advanced Liquid Logic Inc Glucose-6-phosphate dehydrogenase assays
JP6215223B2 (ja) * 2011-12-09 2017-10-18 アンスティテュ・パストゥール マルチプレックス免疫スクリーニングアッセイ
EP2812704A4 (de) 2012-02-07 2016-03-23 Intuitive Biosciences Inc Mycobakteriumstuberkulose-spezifische peptide zur erkennung einer infektion oder immunisierung nichtmenschlicher primaten
ES2434853B1 (es) 2012-06-12 2014-09-30 Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii Marcador molecular de potencia terapéutica de células madre mesenquimales humanas y sus usos
EP2861969B1 (de) 2012-06-15 2022-08-03 Luminex Corporation Verfahren zur bildnormalisierung anhand eines gaussschen restes von anpassungsauswahlkriterien
WO2014031902A2 (en) 2012-08-23 2014-02-27 The Regents Of The University Of California Spectrally encoded microbeads and methods and devices for making and using same
EP2915098A4 (de) 2012-10-30 2016-07-06 Certirx Corp Produkt-, bild- oder dokumentenauthentifizierung und -verifizierung und objektidentifikation
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
US9551704B2 (en) 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
US9995742B2 (en) 2012-12-19 2018-06-12 Dnae Group Holdings Limited Sample entry
US9804069B2 (en) 2012-12-19 2017-10-31 Dnae Group Holdings Limited Methods for degrading nucleic acid
US9599610B2 (en) 2012-12-19 2017-03-21 Dnae Group Holdings Limited Target capture system
WO2014134280A1 (en) 2013-02-28 2014-09-04 The Terasaki Family Foundation Methods, compositions and kits to recycle internally dyed particles
US9428792B2 (en) 2013-03-14 2016-08-30 Certirx Corporation Nucleic acid-based authentication and identification codes
US10436778B2 (en) * 2013-03-15 2019-10-08 Plexbio Co., Ltd. Methods and systems for multiplex assays
EP4414372A3 (de) 2013-03-15 2024-10-02 Perkinelmer Health Sciences Inc. Verbindungen und verfahren im zusammenhang mit dem testen lysosomaler speicherkrankheiten
ES2523016B1 (es) 2013-05-20 2015-09-09 3P Biopharmaceuticals Vectores alfavirales y líneas celulares para la producción de proteínas recombinantes
WO2015023747A1 (en) 2013-08-13 2015-02-19 Advanced Liquid Logic, Inc. Methods of improving accuracy and precision of droplet metering using an on-actuator reservoir as the fluid input
WO2015031849A1 (en) 2013-08-30 2015-03-05 Illumina, Inc. Manipulation of droplets on hydrophilic or variegated-hydrophilic surfaces
JP6237194B2 (ja) * 2013-12-18 2017-11-29 コニカミノルタ株式会社 染色方法
CN106459967A (zh) 2014-04-29 2017-02-22 Illumina公司 使用模板转换和标签化的多重单细胞基因表达分析
CN107112105A (zh) 2014-10-23 2017-08-29 康宁股份有限公司 聚合物包封的磁性纳米颗粒
CN104569443B (zh) * 2014-12-22 2016-05-11 合肥天一生物技术研究所 一种Rh血型检测卡
US10576471B2 (en) 2015-03-20 2020-03-03 Illumina, Inc. Fluidics cartridge for use in the vertical or substantially vertical position
EP3277836B1 (de) 2015-04-02 2019-02-27 HMNC Value GmbH Behandlungsverfahren unter verwendung von genetischen prädiktoren einer reaktion auf eine behandlung mit ssr-125543
EP3277835B1 (de) 2015-04-02 2019-01-09 HMNC Value GmbH Genetische prädiktoren der reaktion auf eine behandlung mit crhr1-antagonisten
TWI737614B (zh) 2015-06-11 2021-09-01 博錸生技股份有限公司 已編碼微載體及其製造方法以及用以進行多工分析之包含該等已編碼微載體之套件
EP3341494B1 (de) 2015-08-28 2024-08-07 Illumina, Inc. Analyse von nukleinsäuresequenzen aus einzelnen zellen
CN113640512A (zh) * 2015-10-05 2021-11-12 北卡罗来纳-查佩尔山大学 用于多路测定的解码方法及相关流体设备、试剂盒和固体支持物
CN105738182A (zh) * 2016-02-25 2016-07-06 河南中医学院 一种用于植物显微结构观察的荧光染色方法
CA3016221C (en) 2016-04-07 2021-09-28 Illumina, Inc. Methods and systems for construction of normalized nucleic acid libraries
JP7062002B2 (ja) 2016-09-16 2022-05-02 プレックスバイオ カンパニー， リミテッド マルチプレックスアッセイの方法及びシステム
WO2018085375A1 (en) 2016-11-01 2018-05-11 Ohio State Innovation Foundation Methods for the iodination of biomolecules
CN106771168A (zh) * 2016-12-30 2017-05-31 武汉纽康度生物科技股份有限公司 荧光免疫层析检测卡及其制备方法和应用
EP3658916A4 (de) * 2017-07-24 2021-04-28 WWHS Biotech, Inc Teststreifen zur kurzwellen-nahinfrarot-immunofluoreszenz-chromatographischen detektion und verwendung davon
US20210063387A1 (en) * 2017-08-26 2021-03-04 Aj Innuscreen Gmbh Means and method for detecting analytes by means of macroscopic granulate particles
WO2019046288A1 (en) 2017-08-31 2019-03-07 Massachusetts Institute Of Technology MULTIPLEX COMPOSITIONS AND ASSAYS FOR CHARACTERIZING ACTIVE PROTEASE AND THEIR INHIBITORS
CN112041459B (zh) 2018-01-29 2024-09-10 圣祖德儿童研究医院 核酸扩增方法
CN108531550A (zh) * 2018-02-01 2018-09-14 武汉尚码生物科技有限公司 一种微粒载体的标记和鉴别方法及其应用
BR112022019541A2 (pt) 2020-03-30 2022-11-16 Illumina Inc Métodos e composições para preparação de bibliotecas de ácido nucleico
US20230194528A1 (en) 2020-04-14 2023-06-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for detecting the presence of coronavirus-specific antibodies in a subject
WO2022020234A2 (en) * 2020-07-20 2022-01-27 Bio-Rad Laboratories, Inc. Immunoassay for sars-cov-2 neutralizing antibodies and materials therefor
WO2022043415A1 (en) 2020-08-27 2022-03-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for detecting the presence of pemphigus-specific autoantibodies in a sample
US20230383342A1 (en) * 2022-05-31 2023-11-30 Illumina Cambridge Limited Compositions and methods for nucleic acid sequencing
US20240044769A1 (en) * 2022-08-02 2024-02-08 Becton, Dickinson And Company Methods for determining particle positional information in a flow cytometer core stream and systems for same

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2045431B (en) * 1979-02-26 1983-04-20 Technicon Instr Immunoassay utilising two particulate reagents
US5093234A (en) * 1984-12-24 1992-03-03 Caribbean Microparticles Corporation Method of aligning, compensating, and calibrating a flow cytometer for analysis of samples, and microbead standards kit therefor
US5073498A (en) * 1984-12-24 1991-12-17 Caribbean Microparticles Corporation Fluorescent alignment microbeads with broad excitation and emission spectra and its use
US4774189A (en) * 1984-12-24 1988-09-27 Flow Cytometry Standards Corp. Fluorescent calibration microbeads simulating stained cells
US5194300A (en) * 1987-07-15 1993-03-16 Cheung Sau W Methods of making fluorescent microspheres
US4987539A (en) 1987-08-05 1991-01-22 Stanford University Apparatus and method for multidimensional characterization of objects in real time
US5326692B1 (en) * 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
ATE171543T1 (de) * 1991-07-16 1998-10-15 Transmed Biotech Inc Verfahren und zusammensetzungen für die gleichzeitige analyse einer vielzahl von analyten
US5409813A (en) * 1993-09-30 1995-04-25 Systemix, Inc. Method for mammalian cell separation from a mixture of cell populations
US5736330A (en) * 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
ATE496288T1 (de) * 1995-10-11 2011-02-15 Luminex Corp Gleichzeitige mehrfachanalyse klinischer proben
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
AU1141597A (en) * 1995-11-30 1997-06-19 Wlodek Mandecki Electronically-solid-phase assay biomolecules
US5641634A (en) * 1995-11-30 1997-06-24 Mandecki; Wlodek Electronically-indexed solid-phase assay for biomolecules
US5747349A (en) * 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
US5872015A (en) 1996-05-10 1999-02-16 Board Of Trustees Of The University Of Illinois Molecular diversity screening method
US5786219A (en) * 1996-10-28 1998-07-28 Molecular Probes, Inc. Microspheres with fluorescent spherical zones
GB9714023D0 (en) * 1997-07-02 1997-09-10 Hexagen Technology Ltd Paired mutations
AU9472998A (en) * 1997-09-04 1999-03-22 Science Research Laboratory, Inc. Cell separation using electric fields
EP1023464B1 (de) * 1997-10-14 2017-07-26 Luminex Corporation Fluoreszierend gefärbte präzisionspartikel sowie verfahren zu deren herstellung und verwendung
ATE239801T1 (de) * 1998-01-22 2003-05-15 Luminex Corp Mikropartikel mit multiplen fluoreszenz-signalen
US6642062B2 (en) * 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
DE60040603D1 (de) * 1999-08-17 2008-12-04 Luminex Corp Verfahren zur analyse einer mehrzahl von proben verschiedenen ursprungs auf einen analyten

Also Published As

Publication number Publication date
DE60040603D1 (de) 2008-12-04
AU6779700A (en) 2001-03-13
US7141431B2 (en) 2006-11-28
EP1204869B1 (de) 2008-10-22
WO2001013120A1 (en) 2001-02-22
EP1204869A1 (de) 2002-05-15
US6916661B2 (en) 2005-07-12
US20050277197A1 (en) 2005-12-15
US6649414B1 (en) 2003-11-18
US20040087032A1 (en) 2004-05-06

Similar Documents

Publication Publication Date Title
ATE412184T1 (de) Verfahren zur analyse einer mehrzahl von proben verschiedenen ursprungs auf einen analyten
ATE239801T1 (de) Mikropartikel mit multiplen fluoreszenz-signalen
ATE516492T1 (de) Vorrichtung und verfahren zur multianalytbestimmung
WO2005017184A3 (en) Method for the enumeration of micronucleated erythrocyte populations while distinguishing platelets and/or platelet-associated aggregates
US20050089924A1 (en) Biosensors and methods for their use
ATE265889T1 (de) Vorrichtung und verfahren zur tropfenmikrochemie
DE19940810A1 (de) Verfahren und Meßeinrichtung zur Bestimmung einer Vielzahl von Analyten in einer Probe
EP1329514A3 (de) Verfahren und Vorrichtung zum Nachweis von Mikroorganismen und zur Bestimmung ihres physiologischen Statuses
DE602005014835D1 (de) Methode, Apparat, Reagenzkit und Reagenz zur Unterscheidung von Erythrozyten in biologischen Proben
Meltzer et al. A lab-on-chip for biothreat detection using single-molecule DNA mapping
ATE133257T1 (de) Ermittlung und quantifizierung mehrerer analyten unter verwendung von markierungstechniken
DE602004021185D1 (de) Auf bio-barcodes beruhender nachweis von zielanalyten
WO2004011607A3 (en) Reagent and method for determination of a substance using an immunoaggregator
ATE339687T1 (de) Immunologische verfahren, vorrichtungen und reagenzien
EP4375669A3 (de) Direkter nachweis von einzelmolekülen auf mikropartikeln
WO2007041734A2 (de) Vorrichtung zur analyse von flüssigen proben
DE10023423B4 (de) Direkter Nachweis von Einzelmolekülen
ATE371857T1 (de) Verfahren zur identifikation von fluoreszierenden,lumineszierenden und/oder absorbierenden substanzen auf und/oder in probenträgern
WO2004079343A3 (en) Sample preparation for colorimetric and fluorescent assays as implemented on optical analysis discs
EP1406088A3 (de) Reagenzsatz und Verfahren zum Nachweis von Malariaparasiten, wobei eine Hämolyse in zwei Schritten mittels Tensiden durchgeführt wird
ATE556029T1 (de) Verfahren und mikrovorrichtung zur identifizierung und/oder quantifizierung eines analyten in einer biologischen probe
DE602004029255D1 (de) Verfahren zum nachweis von aneuploidie unter verwendung eines multiplex-mikropartikelnachweises
WO2002002225A2 (de) Einzelmolekül-sequenzierungsverfahren
CN101501222A (zh) 通过使用可磁化物体或磁性物体作为标记物监测酶促过程
Palacios et al. Assessing the stochastic intermittency of single quantum dot luminescence for robust quantification of biomolecules

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties