|
US20100111856A1
(en)
|
2004-09-23 |
2010-05-06 |
Herman Gill |
Zirconium-radiolabeled, cysteine engineered antibody conjugates
|
|
US8865875B2
(en)
|
2007-08-22 |
2014-10-21 |
Medarex, L.L.C. |
Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions
|
|
NZ584514A
(en)
|
2007-10-19 |
2012-07-27 |
Genentech Inc |
Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates
|
|
JP6192294B2
(ja)
|
2009-07-15 |
2017-09-06 |
エーアイエムエム セラピューティクス ベー.フェー. |
グラム陽性菌特異的結合化合物
|
|
CN102770456B
(zh)
|
2009-12-04 |
2018-04-06 |
弗·哈夫曼-拉罗切有限公司 |
多特异性抗体、抗体类似物、组合物和方法
|
|
WO2011075185A1
(en)
|
2009-12-18 |
2011-06-23 |
Oligasis |
Targeted drug phosphorylcholine polymer conjugates
|
|
US20110159588A1
(en)
*
|
2009-12-30 |
2011-06-30 |
Kui Lin |
Methods for Modulating a PDGF-AA Mediated Biological Response
|
|
WO2011118739A1
(ja)
|
2010-03-26 |
2011-09-29 |
協和発酵キリン株式会社 |
新規修飾部位導入抗体および抗体フラグメント
|
|
SI2528625T1
(sl)
|
2010-04-15 |
2013-11-29 |
Spirogen Sarl |
Pirolobenzodiazepini in njihovi konjugati
|
|
CA2799540A1
(en)
|
2010-06-08 |
2011-12-15 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
|
US20120121615A1
(en)
|
2010-11-17 |
2012-05-17 |
Flygare John A |
Alaninyl maytansinol antibody conjugates
|
|
US8815226B2
(en)
|
2011-06-10 |
2014-08-26 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
WO2012171020A1
(en)
|
2011-06-10 |
2012-12-13 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
UY34317A
(es)
|
2011-09-12 |
2013-02-28 |
Genzyme Corp |
Anticuerpo antireceptor de célula T (alfa)/ß
|
|
BR112014009050B1
(pt)
|
2011-10-14 |
2022-06-21 |
Medimmune Limited |
Conjugado anticorpo-fármaco de pirrolbenzodiazepinas, composição farmacêutica que compreende o mesmo, bem como compostos de pirrolbenzodiazepinas
|
|
WO2013093122A2
(en)
*
|
2011-12-23 |
2013-06-27 |
Phenoquest Ag |
Antibodies for the treatment and diagnosis of affective and anxiety disorders
|
|
AU2013222935B2
(en)
*
|
2012-02-24 |
2016-03-10 |
Alteogen Inc. |
Modified antibody in which motif comprising cysteine residue is bound, modified antibody-drug conjugate comprising the modified antibody, and production method for same
|
|
JP6325463B2
(ja)
*
|
2012-03-16 |
2018-05-16 |
コヴァジェン アクチェン ゲゼルシャフト |
抗腫瘍活性を有する新規結合分子
|
|
EP2638916A1
(en)
*
|
2012-03-16 |
2013-09-18 |
Covagen AG |
Novel binding molecules with antitumoral activity
|
|
WO2013177481A1
(en)
|
2012-05-25 |
2013-11-28 |
Immunogen, Inc. |
Benzodiazepines and conjugates thereof
|
|
EP2859017B1
(en)
|
2012-06-08 |
2019-02-20 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
WO2014004639A1
(en)
*
|
2012-06-26 |
2014-01-03 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
|
KR102006997B1
(ko)
*
|
2012-07-03 |
2019-08-02 |
한국생명공학연구원 |
IgG Fc 위치선택적 결합 펩티드 및 이를 포함하는 하이브리드 분자
|
|
EP2890402B1
(en)
|
2012-08-31 |
2019-04-17 |
Sutro Biopharma, Inc. |
Modified amino acids comprising an azido group
|
|
US9790268B2
(en)
|
2012-09-12 |
2017-10-17 |
Genzyme Corporation |
Fc containing polypeptides with altered glycosylation and reduced effector function
|
|
EP2906249B1
(en)
|
2012-10-12 |
2018-06-27 |
MedImmune Limited |
Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
|
|
EP2906297B1
(en)
|
2012-10-12 |
2017-12-06 |
ADC Therapeutics SA |
Pyrrolobenzodiazepine-antibody conjugates
|
|
RS57694B1
(sr)
|
2012-10-12 |
2018-11-30 |
Adc Therapeutics Sa |
Pirolobenzodiazepin - anti-psma konjugati antitela
|
|
HRP20190366T1
(hr)
|
2012-10-12 |
2019-04-19 |
Medimmune Limited |
Pirolobenzodiazepini i njihovi konjugati
|
|
EP2906296B1
(en)
|
2012-10-12 |
2018-03-21 |
ADC Therapeutics SA |
Pyrrolobenzodiazepine-antibody conjugates
|
|
JP6392765B2
(ja)
|
2012-10-12 |
2018-09-19 |
エイディーシー・セラピューティクス・エス・アーAdc Therapeutics Sa |
ピロロベンゾジアゼピン−抗体結合体
|
|
MX338711B
(es)
|
2012-10-12 |
2016-04-28 |
Medimmune Ltd |
Pirrolobenzodiazepinas y conjugados de las mismas.
|
|
ES2680153T3
(es)
|
2012-10-12 |
2018-09-04 |
Adc Therapeutics Sa |
Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas
|
|
HRP20182129T1
(hr)
|
2012-10-12 |
2019-02-08 |
Adc Therapeutics Sa |
Konjugati protutijelo - pirolobenzodiazepin
|
|
CN110627797A
(zh)
|
2012-12-21 |
2019-12-31 |
麦迪穆有限责任公司 |
用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物
|
|
CN105189507A
(zh)
|
2012-12-21 |
2015-12-23 |
斯皮罗根有限公司 |
吡咯并苯并二氮杂卓及其结合物
|
|
JP6118914B2
(ja)
*
|
2012-12-28 |
2017-04-19 |
ターベダ セラピューティクス インコーポレイテッドTarveda Therapeutics,Inc. |
放出制御型の固体ポリマーナノ粒子
|
|
CN103933575B
(zh)
|
2013-01-23 |
2017-09-29 |
上海新理念生物医药科技有限公司 |
一种三齿型连接子及其应用
|
|
EP2953976B1
(en)
|
2013-02-08 |
2021-03-24 |
Novartis Ag |
Specific sites for modifying antibodies to make immunoconjugates
|
|
ES2731681T3
(es)
|
2013-02-22 |
2019-11-18 |
Abbvie Stemcentrx Llc |
Conjugados de anticuerpo anti-DLL3 y PBD y usos de los mismos
|
|
US9701753B2
(en)
|
2013-03-11 |
2017-07-11 |
Genzyme Corporation |
Hyperglycosylated binding polypeptides
|
|
AU2014229529B2
(en)
|
2013-03-13 |
2018-02-15 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
MX362970B
(es)
|
2013-03-13 |
2019-02-28 |
Medimmune Ltd |
Pirrolobenzodiazepinas y conjugados de las mismas.
|
|
TWI680766B
(zh)
|
2013-03-13 |
2020-01-01 |
英商梅迪繆思有限公司 |
吡咯并苯并二氮呯及其共軛物
|
|
MX368259B
(es)
*
|
2013-04-16 |
2019-09-25 |
Genentech Inc |
Variantes de pertuzumab y su evaluacion.
|
|
MX369022B
(es)
|
2013-05-31 |
2019-10-25 |
Genentech Inc |
Anticuerpos anti-ácido teicoico de la pared celular y conjugados.
|
|
US9803002B2
(en)
|
2013-05-31 |
2017-10-31 |
Genentench, Inc. |
Anti-wall teichoic antibodies and conjugates
|
|
RU2687044C2
(ru)
|
2013-05-31 |
2019-05-06 |
Дженентек, Инк. |
Антитела против стеночной тейхоевой кислоты и их конъюгаты
|
|
EP3018143B1
(en)
|
2013-07-03 |
2019-05-29 |
Seoul National University R&DB Foundation |
Chicken antibody transformed into cysteine and site-specific conjugation using same
|
|
WO2015006555A2
(en)
|
2013-07-10 |
2015-01-15 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
BR112016002829A2
(pt)
|
2013-08-12 |
2017-09-19 |
Genentech Inc |
Composto e processo para preparar o composto de conjugado anticorpo-¿droga, composição farmacêutica, método de tratamento do câncer, kit para o tratamento do câncer, intermediário ligante¿-droga, porção e composto de porção droga de dímero cbi
|
|
SG11201601424PA
(en)
|
2013-08-28 |
2016-03-30 |
Stemcentrx Inc |
Site-specific antibody conjugation methods and compositions
|
|
WO2015035342A2
(en)
|
2013-09-08 |
2015-03-12 |
Oligasis Llc |
Factor viii zwitterionic polymer conjugates
|
|
GB201317981D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
ES2754397T3
(es)
|
2013-10-11 |
2020-04-17 |
Asana Biosciences Llc |
Conjugados de proteína-polímero-fármaco
|
|
EP3054983B1
(en)
|
2013-10-11 |
2019-03-20 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
GB201317982D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
WO2015052535A1
(en)
|
2013-10-11 |
2015-04-16 |
Spirogen Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
|
WO2015052534A1
(en)
|
2013-10-11 |
2015-04-16 |
Spirogen Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
|
KR102087850B1
(ko)
|
2013-10-11 |
2020-03-12 |
메르사나 테라퓨틱스, 인코포레이티드 |
단백질-고분자-약물 접합체
|
|
EP3082876B1
(en)
|
2013-12-16 |
2018-01-17 |
Genentech, Inc. |
1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
|
|
JP6671292B2
(ja)
|
2013-12-16 |
2020-03-25 |
ジェネンテック, インコーポレイテッド |
ペプチド模倣化合物及びその抗体−薬物コンジュゲート
|
|
WO2015095227A2
(en)
|
2013-12-16 |
2015-06-25 |
Genentech, Inc. |
Peptidomimetic compounds and antibody-drug conjugates thereof
|
|
CA2939941A1
(en)
|
2014-02-21 |
2015-08-27 |
Abbvie Stemcentrx Llc |
Anti-dll3 antibodies and drug conjugates for use in melanoma
|
|
CN104672330A
(zh)
*
|
2014-03-11 |
2015-06-03 |
南京任诺药业有限公司 |
用于构建放射性同位素偶联标记的ADC药物的改造抗体IgG1-CH-N267C
|
|
CN104788566A
(zh)
*
|
2014-03-11 |
2015-07-22 |
南京任诺药业有限公司 |
用于构建放射性同位素偶联标记的ADC药物的改造抗体IgG1-CH-V280C
|
|
WO2015143091A1
(en)
|
2014-03-19 |
2015-09-24 |
Genzyme Corporation |
Site-specific glycoengineering of targeting moieties
|
|
US10285955B2
(en)
|
2014-04-10 |
2019-05-14 |
Af Chemicals, Llc |
Affinity medicant conjugate
|
|
US11135182B2
(en)
|
2014-04-10 |
2021-10-05 |
Af Chemicals, Llc |
Affinity medicant conjugates
|
|
WO2015157578A2
(en)
|
2014-04-10 |
2015-10-15 |
Af Chemicals, Llc |
Affinity medicant conjugates
|
|
GB201406767D0
(en)
|
2014-04-15 |
2014-05-28 |
Cancer Rec Tech Ltd |
Humanized anti-Tn-MUC1 antibodies anf their conjugates
|
|
DK3134438T3
(da)
|
2014-04-25 |
2020-12-07 |
Pf Medicament |
IGF-1R-antistof og anvendelse heraf som adresseringsvehikel til behandling af cancer
|
|
HRP20190888T8
(hr)
|
2014-04-25 |
2019-10-04 |
Pierre Fabre Médicament |
Konjugat antitijela za igf-1r i lijeka i njegova upotreba u liječenju karcinoma
|
|
HUE047952T2
(hu)
|
2014-04-25 |
2020-05-28 |
Pf Medicament |
Ellenanyag-drog konjugátum és alkalmazása rák kezelésében történõ alkalmazásra
|
|
US10273208B2
(en)
*
|
2014-05-23 |
2019-04-30 |
Northwestern University |
Screening methods for the binding affinity of chemical entities to biological molecules and NEDD4-1 inhibitors identified by the screening methods
|
|
US9840553B2
(en)
|
2014-06-28 |
2017-12-12 |
Kodiak Sciences Inc. |
Dual PDGF/VEGF antagonists
|
|
EP3193940A1
(en)
|
2014-09-10 |
2017-07-26 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
SG11201701128YA
(en)
|
2014-09-12 |
2017-03-30 |
Genentech Inc |
Cysteine engineered antibodies and conjugates
|
|
WO2016040825A1
(en)
|
2014-09-12 |
2016-03-17 |
Genentech, Inc. |
Anthracycline disulfide intermediates, antibody-drug conjugates and methods
|
|
GB201416112D0
(en)
|
2014-09-12 |
2014-10-29 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
MX2017003472A
(es)
|
2014-09-17 |
2017-10-31 |
Genentech Inc |
Inmunoconjugados que comprenden anticuerpos anti-her2.
|
|
CN107073136A
(zh)
|
2014-09-17 |
2017-08-18 |
健泰科生物技术公司 |
吡咯并苯并二氮杂卓及其抗体二硫化物偶联物
|
|
CA3205824A1
(en)
|
2014-10-09 |
2016-04-14 |
Genzyme Corporation |
Glycoengineered antibody drug conjugates
|
|
KR20210013299A
(ko)
|
2014-10-17 |
2021-02-03 |
코디악 사이언시스 인코포레이티드 |
부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트
|
|
CN107148285B
(zh)
|
2014-11-25 |
2022-01-04 |
Adc治疗股份有限公司 |
吡咯并苯并二氮杂䓬-抗体缀合物
|
|
RU2017118792A
(ru)
|
2014-12-03 |
2019-01-09 |
Дженентек, Инк. |
Конъюгаты антитела к staphylococcus aureus с рифамицином и их применение
|
|
AU2015358532C1
(en)
|
2014-12-03 |
2020-10-29 |
Genentech, Inc. |
Quaternary amine compounds and antibody-drug conjugates thereof
|
|
HK1243931A1
(zh)
|
2014-12-03 |
2018-07-27 |
F. Hoffmann-La Roche Ag |
抗金黄色葡萄球菌抗体利福霉素缀合物及其用途
|
|
CA2982205A1
(en)
|
2015-04-10 |
2016-10-13 |
David W. Andrews |
Methods and compositions for treating cancers and enhancing therapeutic immunity by selectively reducing immunomodulatory m2 monocytes
|
|
GB201506389D0
(en)
|
2015-04-15 |
2015-05-27 |
Berkel Patricius H C Van And Howard Philip W |
Site-specific antibody-drug conjugates
|
|
GB201506411D0
(en)
|
2015-04-15 |
2015-05-27 |
Bergenbio As |
Humanized anti-axl antibodies
|
|
GB201506402D0
(en)
|
2015-04-15 |
2015-05-27 |
Berkel Patricius H C Van And Howard Philip W |
Site-specific antibody-drug conjugates
|
|
GB201514928D0
(en)
|
2015-08-21 |
2015-10-07 |
King S College London |
PDD compounds
|
|
US10821191B2
(en)
*
|
2015-09-22 |
2020-11-03 |
Byondis B.V. |
SYD985 treatment of T-DM1 refractory cancer patients
|
|
EP3365025B1
(en)
|
2015-10-20 |
2020-07-15 |
Genentech, Inc. |
Calicheamicin-antibody-drug conjugates and methods of use
|
|
KR20180105634A
(ko)
|
2015-10-26 |
2018-09-28 |
피에르 파브르 메디카먼트 |
Igf-1r을 발현하는 암의 치료를 위한 조성물
|
|
US9669106B2
(en)
|
2015-10-26 |
2017-06-06 |
Pierre Fabre Medicament |
Conjugate of monomethyl auristatin F and trastuzumab and its use for the treatment of cancer
|
|
EP3368092B9
(en)
|
2015-10-29 |
2020-07-29 |
Novartis AG |
Antibody conjugates comprising toll-like receptor agonist
|
|
AU2016359235B2
(en)
|
2015-11-25 |
2022-09-15 |
Ligachem Biosciences Inc. |
Antibody-drug conjugates comprising branched linkers and methods related thereto
|
|
TWI727380B
(zh)
|
2015-11-30 |
2021-05-11 |
美商輝瑞股份有限公司 |
位點專一性her2抗體藥物共軛體
|
|
UA124622C2
(uk)
*
|
2015-12-18 |
2021-10-20 |
ЕЙСАЙ Ар ЕНД Ді МЕНЕДЖМЕНТ КО., ЛТД. |
Кон'юговані імуноглобуліни з c-кінцевим лізином
|
|
KR20250057128A
(ko)
|
2015-12-30 |
2025-04-28 |
코디악 사이언시스 인코포레이티드 |
항체 및 이의 접합체
|
|
GB201601431D0
(en)
|
2016-01-26 |
2016-03-09 |
Medimmune Ltd |
Pyrrolobenzodiazepines
|
|
WO2017132615A1
(en)
|
2016-01-27 |
2017-08-03 |
Sutro Biopharma, Inc. |
Anti-cd74 antibody conjugates, compositions comprising anti-cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates
|
|
GB201602356D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
GB201602359D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
PE20231050A1
(es)
*
|
2016-03-02 |
2023-07-11 |
Eisai Randd Man Co Ltd |
Conjugados de anticuerpo y farmaco basados en eribulina y metodos para su uso
|
|
KR102204805B1
(ko)
|
2016-03-04 |
2021-01-20 |
제넨테크, 인크. |
항체-리파마이신 접합체의 제조 방법
|
|
CN108700598A
(zh)
|
2016-03-25 |
2018-10-23 |
豪夫迈·罗氏有限公司 |
多路总抗体和抗体缀合的药物量化测定法
|
|
GB201607478D0
(en)
|
2016-04-29 |
2016-06-15 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
CN118436801A
(zh)
|
2016-05-20 |
2024-08-06 |
豪夫迈·罗氏有限公司 |
Protac抗体缀合物及其使用方法
|
|
EP3465221B1
(en)
|
2016-05-27 |
2020-07-22 |
H. Hoffnabb-La Roche Ag |
Bioanalytical method for the characterization of site-specific antibody-drug conjugates
|
|
WO2017214024A1
(en)
|
2016-06-06 |
2017-12-14 |
Genentech, Inc. |
Silvestrol antibody-drug conjugates and methods of use
|
|
WO2018027204A1
(en)
|
2016-08-05 |
2018-02-08 |
Genentech, Inc. |
Multivalent and multiepitopic anitibodies having agonistic activity and methods of use
|
|
JP7050770B2
(ja)
|
2016-10-05 |
2022-04-08 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
抗体薬物コンジュゲートの調製方法
|
|
CN117398475A
(zh)
*
|
2016-10-08 |
2024-01-16 |
四川百利药业有限责任公司 |
半胱氨酸改造的抗体-毒素偶联物及其制备方法
|
|
GB201617466D0
(en)
|
2016-10-14 |
2016-11-30 |
Medimmune Ltd |
Pyrrolobenzodiazepine conjugates
|
|
RS61795B1
(sr)
|
2017-02-08 |
2021-06-30 |
Adc Therapeutics Sa |
Konjugati pirolobenzodiazepin antitela
|
|
HUE056289T2
(hu)
|
2017-02-08 |
2022-02-28 |
Adc Therapeutics Sa |
Pirrolobenzodiazepin-antitest konjugátumok
|
|
GB201702031D0
(en)
|
2017-02-08 |
2017-03-22 |
Medlmmune Ltd |
Pyrrolobenzodiazepine-antibody conjugates
|
|
CA3058360A1
(en)
|
2017-03-29 |
2018-10-04 |
Legochem Biosciences, Inc. |
Pyrrolobenzodiazepine dimer prodrug and ligand-linker conjugate compound of the same
|
|
CA3059938A1
(en)
|
2017-04-14 |
2018-10-18 |
Kodiak Sciences Inc. |
Complement factor d antagonist antibodies and conjugates thereof
|
|
CN110582505B
(zh)
|
2017-04-18 |
2021-04-02 |
免疫医疗有限公司 |
吡咯并苯并二氮杂*缀合物
|
|
WO2018193102A1
(en)
|
2017-04-20 |
2018-10-25 |
Adc Therapeutics Sa |
Combination therapy with an anti-axl antibody-drug conjugate
|
|
CA3064804A1
(en)
|
2017-06-14 |
2018-12-20 |
Adc Therapeutics Sa |
Dosage regimes for the administration of an anti-cd19 adc
|
|
KR102270107B1
(ko)
|
2017-08-18 |
2021-06-30 |
메디뮨 리미티드 |
피롤로벤조디아제핀 컨쥬게이트
|
|
GB201803342D0
(en)
|
2018-03-01 |
2018-04-18 |
Medimmune Ltd |
Methods
|
|
EP3758737A4
(en)
|
2018-03-02 |
2022-10-12 |
Kodiak Sciences Inc. |
IL-6 ANTIBODIES AND FUSION CONSTRUCTS AND CONJUGATES THEREOF
|
|
GB201806022D0
(en)
|
2018-04-12 |
2018-05-30 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
CN112601555A
(zh)
|
2018-05-09 |
2021-04-02 |
乐高化学生物科学股份有限公司 |
与抗cd19抗体药物结合物相关的组合物和方法
|
|
MA52772A
(fr)
|
2018-05-24 |
2021-04-14 |
Janssen Biotech Inc |
Anticorps anti-tmeff2 monospécifiques et multispécifiques et leurs utilisations
|
|
GB201814281D0
(en)
|
2018-09-03 |
2018-10-17 |
Femtogenix Ltd |
Cytotoxic agents
|
|
WO2020081493A1
(en)
|
2018-10-16 |
2020-04-23 |
Molecular Templates, Inc. |
Pd-l1 binding proteins
|
|
KR20210081349A
(ko)
|
2018-10-19 |
2021-07-01 |
메드임뮨 리미티드 |
피롤로벤조디아제핀 컨쥬게이트
|
|
WO2020079229A1
(en)
|
2018-10-19 |
2020-04-23 |
Medimmune Limited |
Pyrrolobenzodiazepine conjugates
|
|
JP2022513198A
(ja)
|
2018-12-10 |
2022-02-07 |
ジェネンテック, インコーポレイテッド |
Fc含有タンパク質への部位特異的コンジュゲーションのための光架橋性ペプチド
|
|
EP3667323B1
(en)
|
2018-12-11 |
2024-11-13 |
AF Chemical LLC |
Methods, compositions and devices for treating cancer with illudofulvenes
|
|
GB201901197D0
(en)
|
2019-01-29 |
2019-03-20 |
Femtogenix Ltd |
G-A Crosslinking cytotoxic agents
|
|
US11478553B2
(en)
|
2019-02-15 |
2022-10-25 |
Wuxi Biologies Ireland Limited |
Process for preparing antibody-drug conjugates with improved homogeneity
|
|
US12109273B2
(en)
|
2019-02-15 |
2024-10-08 |
Wuxi Xdc Singapore Private Limited |
Process for preparing antibody-drug conjugates with improved homogeneity
|
|
KR102503143B1
(ko)
*
|
2019-03-06 |
2023-02-24 |
주식회사 레고켐 바이오사이언스 |
인간 dlk1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도
|
|
CN113631560B
(zh)
|
2019-03-15 |
2025-02-18 |
麦迪穆有限责任公司 |
氮杂环丁烷并苯并二氮杂䓬二聚体和用于治疗癌症的包含它们的缀合物
|
|
MX2021011812A
(es)
|
2019-03-29 |
2021-10-22 |
Medimmune Ltd |
Compuestos y conjugados de estos.
|
|
CN120192414A
(zh)
|
2019-04-03 |
2025-06-24 |
建新公司 |
具有降低的断裂的抗αβTCR结合多肽
|
|
GB201908128D0
(en)
|
2019-06-07 |
2019-07-24 |
Adc Therapeutics Sa |
Pyrrolobenzodiazepine-antibody conjugates
|
|
US20200390899A1
(en)
|
2019-06-13 |
2020-12-17 |
Bolt Biotherapeutics, Inc. |
Aminobenzazepine compounds, immunoconjugates, and uses thereof
|
|
US20220313835A1
(en)
|
2019-09-03 |
2022-10-06 |
Bolt Biotherapeutics, Inc. |
Aminoquinoline compounds, immunoconjugates, and uses thereof
|
|
WO2021055816A1
(en)
|
2019-09-18 |
2021-03-25 |
Molecular Templates, Inc. |
Pd-l1 binding molecules comprising shiga toxin a subunit scaffolds
|
|
US20220347310A1
(en)
|
2019-09-30 |
2022-11-03 |
Bolt Biotherapeutics, Inc. |
Amide-linked, aminobenzazepine immunoconjugates, and uses thereof
|
|
CA3157509A1
(en)
|
2019-10-10 |
2021-04-15 |
Kodiak Sciences Inc. |
Methods of treating an eye disorder
|
|
TWI857167B
(zh)
|
2019-10-25 |
2024-10-01 |
美商博特生物治療公司 |
噻吩并氮呯免疫結合物及其用途
|
|
WO2021080608A1
(en)
|
2019-10-25 |
2021-04-29 |
Medimmune, Llc |
Branched moiety for use in conjugates
|
|
US11591295B2
(en)
|
2019-11-25 |
2023-02-28 |
Af Chemicals Llc |
Affinity illudofulvene conjugates
|
|
EP4093439A1
(en)
|
2020-01-22 |
2022-11-30 |
MedImmune Limited |
Compounds and conjugates thereof
|
|
TW202140076A
(zh)
|
2020-01-22 |
2021-11-01 |
英商梅迪繆思有限公司 |
化合物及其軛合物
|
|
US20230293716A1
(en)
|
2020-05-08 |
2023-09-21 |
Bolt Biotherapeutics, Inc. |
Elastase-substrate, peptide linker immunoconjugates, and uses thereof
|
|
GB2597532A
(en)
|
2020-07-28 |
2022-02-02 |
Femtogenix Ltd |
Cytotoxic compounds
|
|
GB202011993D0
(en)
|
2020-07-31 |
2020-09-16 |
Adc Therapeutics Sa |
ANTI-IL 13Ra2 antibodies
|
|
IL300316A
(en)
|
2020-08-13 |
2023-04-01 |
Bolt Biotherapeutics Inc |
Immune conjugates of pyrazolozapines and their uses
|
|
EP4208259A2
(en)
|
2020-09-04 |
2023-07-12 |
NovaRock Biotherapeutics, Ltd. |
Nectin-4 antibodies and uses thereof
|
|
BR112023004415A2
(pt)
|
2020-09-11 |
2023-05-09 |
Medimmune Ltd |
Moléculas terapêuticas de ligação a b7-h4
|
|
CA3200168A1
(en)
|
2020-12-11 |
2022-06-16 |
Shelley Erin ACKERMAN |
Anti-pd-l1 immunoconjugates, and uses thereof
|
|
CN116897054A
(zh)
|
2020-12-11 |
2023-10-17 |
博尔特生物治疗药物有限公司 |
抗her2免疫缀合物及其用途
|
|
US20220195066A1
(en)
|
2020-12-11 |
2022-06-23 |
Bolt Biotherapeutics, Inc. |
Anti-cea immunoconjugates, and uses thereof
|
|
CN116635084A
(zh)
|
2020-12-11 |
2023-08-22 |
博尔特生物治疗药物有限公司 |
抗cea免疫缀合物和其用途
|
|
CA3200056A1
(en)
|
2020-12-11 |
2022-06-16 |
Shelley Erin ACKERMAN |
Anti-her2 immunoconjugates, and uses thereof
|
|
EP4046996A1
(en)
|
2021-02-19 |
2022-08-24 |
Universität Bielefeld |
Cryptophycin compounds and conjugates thereof
|
|
WO2022197945A1
(en)
|
2021-03-17 |
2022-09-22 |
Molecular Templates, Inc. |
Pd-l1 binding proteins comprising shiga toxin a subunit scaffolds and cd8+ t cell antigens
|
|
WO2022197877A1
(en)
|
2021-03-19 |
2022-09-22 |
Genentech, Inc. |
Methods and compositions for time delayed bio-orthogonal release of cytotoxic agents
|
|
CN117940168A
(zh)
|
2021-03-26 |
2024-04-26 |
博尔特生物治疗药物有限公司 |
2-氨基-4-甲酰胺-苯并氮杂䓬免疫缀合物及其用途
|
|
CN117769439A
(zh)
|
2021-03-26 |
2024-03-26 |
博尔特生物治疗药物有限公司 |
2-氨基-4-甲酰胺-苯并氮杂卓免疫缀合物及其用途
|
|
GB202105187D0
(en)
|
2021-04-12 |
2021-05-26 |
Medimmune Ltd |
Pyrrolobenzodiazepine conjugates
|
|
EP4323399A4
(en)
|
2021-04-14 |
2025-04-09 |
Kodiak Sciences Inc. |
Methods of treating an eye disorder
|
|
JP2024539993A
(ja)
|
2021-10-29 |
2024-10-31 |
ボルト バイオセラピューティクス、インコーポレーテッド |
システイン変異抗体を含むtlrアゴニスト免疫複合体、及びその使用
|
|
US12065496B2
(en)
|
2021-11-10 |
2024-08-20 |
Astrazeneca Ab |
Antibody molecules and conjugates
|
|
WO2023088963A1
(en)
|
2021-11-19 |
2023-05-25 |
Adc Therapeutics Sa |
Anti-il-13ralpha2 conjugates
|
|
WO2023088966A1
(en)
|
2021-11-19 |
2023-05-25 |
Adc Therapeutics Sa |
Anti-psma conjugates
|
|
CN114214341B
(zh)
*
|
2021-12-30 |
2023-12-26 |
山西大学 |
番茄SlSERAT1;1基因或其片段在植物发育过程中的应用
|
|
TW202348252A
(zh)
|
2022-02-16 |
2023-12-16 |
英商梅迪繆思有限公司 |
用治療性結合分子治療癌症的組合療法
|
|
EP4230222A1
(en)
|
2022-02-17 |
2023-08-23 |
Oxsonics Limited |
Combination therapy with an anti-axl antibody-pbd conjugate and nanocups
|
|
JP2025507736A
(ja)
|
2022-02-28 |
2025-03-21 |
アーデーセー セラピューティクス ソシエテ アノニム |
投薬レジメン
|
|
EP4489859A1
(en)
|
2022-03-09 |
2025-01-15 |
Astrazeneca AB |
Binding molecules against fr alpha
|
|
KR20240162086A
(ko)
|
2022-03-11 |
2024-11-14 |
아스트라제네카 아베 |
항-FRα 항체-약물 접합체 치료법에 대한 점수 산정 방법
|
|
AU2023260131A1
(en)
*
|
2022-04-29 |
2024-09-12 |
Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. |
Antibody-drug conjugate, pharmaceutical composition thereof and use thereof
|
|
CA3259492A1
(en)
|
2022-06-27 |
2024-01-04 |
Astrazeneca Ab |
COMBINATIONS INVOLVING EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER
|
|
WO2024052685A1
(en)
|
2022-09-09 |
2024-03-14 |
MyricX Pharma Limited |
Cytotoxic imidazo[1,2-a]pyridine compounds and their use in therapy
|
|
KR20250099224A
(ko)
|
2022-11-01 |
2025-07-01 |
하이델베르크 파마 리서치 게엠베하 |
항-gucy2c 항체 및 이의 용도
|
|
AU2023393382A1
(en)
|
2022-12-14 |
2025-06-19 |
Pheon Therapeutics Ltd |
Cytotoxic compounds
|
|
WO2024137619A1
(en)
|
2022-12-20 |
2024-06-27 |
Bolt Biotherapeutics, Inc. |
Anti-claudin, bis-benzimid azole sting agonist immunoconjugates, and uses thereof
|
|
WO2024138128A2
(en)
|
2022-12-23 |
2024-06-27 |
Genentech, Inc. |
Cereblon degrader conjugates, and uses thereof
|
|
EP4410314A1
(en)
|
2023-02-02 |
2024-08-07 |
ADC Therapeutics SA |
Combination therapy comprising anti-cd22 antibody-drug conjugate and irak1 inhibitor
|
|
WO2024173384A1
(en)
|
2023-02-14 |
2024-08-22 |
Bolt Biotherapeutics, Inc. |
Aza-benzazepine immunoconjugates, and uses thereof
|
|
CN120936382A
(zh)
|
2023-02-16 |
2025-11-11 |
阿斯利康(瑞典)有限公司 |
采用治疗性结合分子治疗癌症的组合疗法
|
|
WO2024186626A1
(en)
|
2023-03-03 |
2024-09-12 |
Bolt Biotherapeutics, Inc. |
Aza-bicyclic sting agonist immunoconjugates, and uses thereof
|
|
AU2024237541A1
(en)
|
2023-03-13 |
2025-08-28 |
Heidelberg Pharma Research Gmbh |
Subcutaneously administered antibody-drug conjugates for use in cancer treatment
|
|
TW202506194A
(zh)
|
2023-04-28 |
2025-02-16 |
英商梅迪繆思有限公司 |
用於治療癌症的b7-h4治療性結合分子
|
|
WO2025083064A1
(en)
|
2023-10-17 |
2025-04-24 |
Adc Therapeutics Sa |
Anti-asct2 conjugates
|
|
WO2025083061A1
(en)
|
2023-10-17 |
2025-04-24 |
Adc Therapeutics Sa |
Anti-napi2b conjugates
|
|
WO2025083067A1
(en)
|
2023-10-17 |
2025-04-24 |
Adc Therapeutics Sa |
Anti-claudin-6 conjugates
|
|
EP4548936A1
(en)
*
|
2023-10-30 |
2025-05-07 |
BioNTech SE |
Antibody-drug conjugates having a tailor-made drug-to-antibody ratio
|
|
WO2025109097A2
(en)
|
2023-11-24 |
2025-05-30 |
Heidelberg Pharma Research Gmbh |
Novel nicotinamide phosphoribosyltransferase inhibitors and uses thereof
|
|
EP4566631A1
(en)
|
2023-12-06 |
2025-06-11 |
Heidelberg Pharma Research GmbH |
New antibody drug conjugate as well as methods of production and uses thereof
|
|
US20250186604A1
(en)
|
2023-12-06 |
2025-06-12 |
Adc Therapeutics Sa |
Anti-psma antibody conjugates
|
|
WO2025134068A1
(en)
|
2023-12-22 |
2025-06-26 |
Ac Immune Sa |
Antibody drug conjugates targeting proteinopathies, and uses thereof
|
|
GB202403391D0
(en)
|
2024-03-08 |
2024-04-24 |
Myricx Pharma Ltd |
Novel compounds and their use in therapy
|
|
GB202405758D0
(en)
|
2024-04-24 |
2024-06-05 |
King S College London |
Compounds
|
|
GB202407700D0
(en)
|
2024-05-30 |
2024-07-17 |
Francis Crick Institute Ltd |
F-actin binding agents
|
|
WO2026006688A2
(en)
|
2024-06-28 |
2026-01-02 |
Firefly Bio, Inc. |
Degrader antibody conjugates and uses thereof
|
|
WO2026006689A2
(en)
|
2024-06-28 |
2026-01-02 |
Firefly Bio, Inc. |
Bcl-xl degrader antibody conjugates and uses thereof
|
|
US20260078179A1
(en)
|
2024-07-18 |
2026-03-19 |
Novarock Biotherapeutics, Ltd. |
Cdh17 antibodies and uses thereof
|
|
WO2026050214A1
(en)
|
2024-08-27 |
2026-03-05 |
Bolt Biotherapeutics, Inc. |
Anti-claudin, tlr agonist immunoconjugates and uses thereof
|
|
WO2026055185A1
(en)
|
2024-09-04 |
2026-03-12 |
Bolt Biotherapeutics, Inc. |
Sting agonist immunoconjugates and uses thereof
|
|
EP4706676A1
(en)
*
|
2024-09-10 |
2026-03-11 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Cysteine-engineered antigen-binding domains
|
|
EP4706675A1
(en)
*
|
2024-09-10 |
2026-03-11 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Cysteine-engineered chimeric antigen receptor
|
|
WO2026057740A1
(en)
|
2024-09-12 |
2026-03-19 |
Astrazeneca Ab |
Treatment of cancer with therapeutic binding molecules
|
|
WO2026078620A1
(en)
|
2024-10-11 |
2026-04-16 |
Medimmune Llc |
Cd22 antibody and drug conjugates and uses thereof
|