JP2011503103A - タンパク質輸送の調節方法 - Google Patents

タンパク質輸送の調節方法 Download PDF

Info

Publication number
JP2011503103A
JP2011503103A JP2010533304A JP2010533304A JP2011503103A JP 2011503103 A JP2011503103 A JP 2011503103A JP 2010533304 A JP2010533304 A JP 2010533304A JP 2010533304 A JP2010533304 A JP 2010533304A JP 2011503103 A JP2011503103 A JP 2011503103A
Authority
JP
Japan
Prior art keywords
disease
coor
alkyl
compound
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2010533304A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011503103A5 (https=
Inventor
クリスティーヌ エレン ブラワ
マイケル デビト
ダニエル エルボーム
Original Assignee
フォールドアールエックス ファーマシューティカルズ インコーポレーティッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by フォールドアールエックス ファーマシューティカルズ インコーポレーティッド filed Critical フォールドアールエックス ファーマシューティカルズ インコーポレーティッド
Publication of JP2011503103A publication Critical patent/JP2011503103A/ja
Publication of JP2011503103A5 publication Critical patent/JP2011503103A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2010533304A 2007-11-07 2008-11-07 タンパク質輸送の調節方法 Withdrawn JP2011503103A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98628207P 2007-11-07 2007-11-07
PCT/US2008/082909 WO2009062118A2 (en) 2007-11-07 2008-11-07 Modulation of protein trafficking

Publications (2)

Publication Number Publication Date
JP2011503103A true JP2011503103A (ja) 2011-01-27
JP2011503103A5 JP2011503103A5 (https=) 2013-01-17

Family

ID=40521617

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010533304A Withdrawn JP2011503103A (ja) 2007-11-07 2008-11-07 タンパク質輸送の調節方法

Country Status (10)

Country Link
US (1) US20100331297A1 (https=)
EP (1) EP2217239A2 (https=)
JP (1) JP2011503103A (https=)
CN (1) CN101917999A (https=)
AU (1) AU2008323694A1 (https=)
BR (1) BRPI0820342A2 (https=)
CA (1) CA2705303A1 (https=)
EA (1) EA201070572A1 (https=)
WO (1) WO2009062118A2 (https=)
ZA (1) ZA201003725B (https=)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014515758A (ja) * 2011-04-25 2014-07-03 アッシャー・サード・イニシアティブ・インコーポレイテッド ピラゾロピリダジンおよび網膜変性疾患およびアッシャー症候群に伴う聴覚損失を治療するための方法
JP2014520872A (ja) * 2011-07-21 2014-08-25 ラボラトリオス・デル・デエレ・エステベ・エセ・ア ピラゾロ[3,4−d]ピリミジン化合物、その製造およびシグマリガンドとしての使用
JP2014520863A (ja) * 2011-07-13 2014-08-25 ファーマサイクリックス,インク. Bruton型チロシンキナーゼの阻害剤
JP2014193925A (ja) * 2008-10-16 2014-10-09 Regents Of The Univ Of California 融合環ヘテロアリールキナーゼ阻害剤
JP2015535256A (ja) * 2012-10-25 2015-12-10 アッシャー・サード・イニシアティブ・インコーポレイテッド ピラゾロピリダジンならびに網膜変性疾患およびアッシャー症候群に伴う聴力損失を処置するための方法
JP2015535257A (ja) * 2012-10-25 2015-12-10 アッシャー・サード・イニシアティブ・インコーポレイテッド ピラゾロピリダジンならびに網膜変性疾患およびアッシャー症候群に伴う聴力損失を処置するための方法
US9371332B2 (en) 2012-10-25 2016-06-21 Usher Iii Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with Usher syndrome
WO2016208595A1 (ja) * 2015-06-22 2016-12-29 小野薬品工業株式会社 Brk阻害化合物
JP2017515836A (ja) * 2014-05-14 2017-06-15 ファイザー・インク ピラゾロピリジンおよびピラゾロピリミジン
JP2018529743A (ja) * 2015-10-09 2018-10-11 アッヴィ・エス・ア・エール・エル N−スルホニル化ピラゾロ[3,4−b]ピリジン−6−カルボキサミドおよび使用法
JP2019501142A (ja) * 2015-11-30 2019-01-17 ミッション セラピューティクス リミティド Usp30の阻害剤としての1−シアノピロリジン誘導体
JP2019504898A (ja) * 2016-02-12 2019-02-21 ファーマクシス リミテッド リジルオキシダーゼのハロアリルアミンインドールおよびアザインドール誘導体阻害剤およびその使用
JP2019521992A (ja) * 2016-06-16 2019-08-08 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズShanghai Institute Of Materia Medica, Chinese Academy Of Sciences Fgfr阻害活性を有する新規な化合物およびその製造と使用
JP2020510668A (ja) * 2016-11-18 2020-04-09 システィック ファイブロシス ファンデーション セラピューティクス インコーポレイテッドCystic Fibrosis Foundation Therapeutics Inc. Cftr増強物質としてのピロロピリミジン
JP2021506918A (ja) * 2017-12-21 2021-02-22 ガルデルマ・リサーチ・アンド・デヴェロップメント 新規mTOR阻害剤化合物
WO2025121320A1 (ja) * 2023-12-04 2025-06-12 国立大学法人山口大学 多発性嚢胞腎の予防又は治療剤

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9512125B2 (en) 2004-11-19 2016-12-06 The Regents Of The University Of California Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
DE102009004245A1 (de) * 2009-01-09 2010-07-15 Bayer Schering Pharma Aktiengesellschaft Neue anellierte, Heteroatom-verbrückte Pyrazol- und Imidazol-Derivate und ihre Verwendung
CN104945420A (zh) 2009-06-29 2015-09-30 因塞特公司 作为pi3k抑制剂的嘧啶酮类
US8980899B2 (en) 2009-10-16 2015-03-17 The Regents Of The University Of California Methods of inhibiting Ire1
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
SG181857A1 (en) 2009-12-23 2012-07-30 Takeda Pharmaceutical Fused heteroaromatic pyrrolidinones as syk inhibitors
JP2013516420A (ja) 2009-12-30 2013-05-13 アークル インコーポレイテッド 置換されたピロロ−アミノピリミジン化合物
MX2012008643A (es) * 2010-01-27 2013-02-26 Vertex Pharma Inhibidores de cinasas de pirazolopiridinas.
MX336731B (es) 2010-01-28 2016-01-28 Harvard College Composiciones y metodos para potenciar la actividad de proteasoma.
CA2794153C (en) 2010-03-25 2018-01-02 Glaxosmithkline Llc Substituted indoline derivatives as perk inhibitors
AR081823A1 (es) 2010-04-14 2012-10-24 Incyte Corp DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
US8642606B2 (en) * 2010-09-29 2014-02-04 Plexxikon Inc. ZAP-70 active compounds
EP2655374B1 (en) 2010-12-20 2019-10-23 Incyte Holdings Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
US9295673B2 (en) 2011-02-23 2016-03-29 Intellikine Llc Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
DK2707101T3 (da) 2011-05-12 2019-05-13 Proteostasis Therapeutics Inc Proteostaseregulatorer
JP6026525B2 (ja) 2011-06-22 2016-11-16 武田薬品工業株式会社 置換6−アザ−イソインドリン−1−オン誘導体
MX370814B (es) 2011-09-02 2020-01-08 Univ California Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
KR102507287B1 (ko) 2011-09-02 2023-03-07 인사이트 홀딩스 코포레이션 Pi3k 억제제로서 헤테로시클릴아민
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
MX2015003874A (es) 2012-09-26 2015-12-16 Univ California Modulacion de ire1.
ITMI20122065A1 (it) 2012-12-03 2014-06-04 Univ Padova Uso dei correttori del cftr nel trattamento delle patologie del muscolo striato
US9849135B2 (en) 2013-01-25 2017-12-26 President And Fellows Of Harvard College USP14 inhibitors for treating or preventing viral infections
CU24275B1 (es) 2013-02-22 2017-10-05 Pfizer Derivados de cicloalquilo pirrolo [2,3-d] pirimidina-4-il amino útiles como inhibidores de quinasas janus relacionadas y composiciones farmacéuticas que contienen tales compuestos
WO2015073528A1 (en) 2013-11-12 2015-05-21 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds
WO2015171527A1 (en) * 2014-05-05 2015-11-12 Global Blood Therapeutics, Inc. Pyrazolopyridine pyrazolopyrimidine and related compounds
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
EP3180344B1 (en) 2014-08-12 2019-09-18 Pfizer Inc Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase
CN104530151A (zh) * 2015-01-15 2015-04-22 佛山市赛维斯医药科技有限公司 一种含硝基苯s-葡萄糖苷结构的化合物及其用途
CN104530153A (zh) * 2015-01-15 2015-04-22 佛山市赛维斯医药科技有限公司 一类苯基s-葡萄糖苷衍生物、其制备方法和在医药上的用途
SI3831833T1 (sl) 2015-02-27 2023-03-31 Incyte Holdings Corporation Postopki za pripravo inhibitorja PI3K
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
AR105392A1 (es) * 2015-07-20 2017-09-27 Genzyme Corp Inhibidores del receptor del factor estimulador de colonias 1 (csf-1r)
LV15201B (lv) 2015-08-31 2017-07-20 Latvijas Organiskās Sintēzes Institūts Ibrutiniba izejvielas iegūšanas paņēmiens
CN105198887B (zh) * 2015-09-23 2017-07-28 上海泰坦科技股份有限公司 具有生物活性吡唑并[3,4‑d]嘧啶类试剂的合成工艺
BR112018007176A2 (pt) * 2015-10-09 2018-10-16 AbbVie S.à.r.l. combinações de potenciador-corretor úteis no tratamento da fibrose cística
US9630968B1 (en) 2015-12-23 2017-04-25 Arqule, Inc. Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof
CA3013666C (en) * 2016-02-15 2023-12-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of stiripentol and their derivatives for decreasing urinary oxalate concentration in an individual
WO2017161344A1 (en) * 2016-03-17 2017-09-21 The Regants Of The University Of California Compositions and methods for treating parasitic diseases
TW201811795A (zh) 2016-08-24 2018-04-01 美商亞闊股份有限公司 胺基-吡咯并嘧啶酮化合物及其用途
IL248028B (en) * 2016-09-25 2022-02-01 Univ Bar Ilan Wasp-protecting small molecules, compositions, methods and uses thereof in the treatment of wiskott-aldrich syndrome and x-linked thrombocytopenia
RU2748833C2 (ru) 2016-11-28 2021-05-31 Цзянсу Хэнжуй Медсин Ко., Лтд. Производное пиразоло-гетероарила, способ его получения и медицинское применение
SG10201911076QA (en) * 2016-12-16 2020-01-30 Cystic Fibrosis Found Bycyclic heteroaryl derivatives as cftr potentiators
TW201837040A (zh) * 2017-03-15 2018-10-16 美商微拉製藥公司 Cdpk1抑制劑及與其相關之組合物及方法
US11518761B2 (en) 2017-08-17 2022-12-06 Vyera Pharmaceuticals, LLC CDPK1 inhibitors, compositions, and methods related thereto
FR3075795A1 (fr) 2017-12-21 2019-06-28 Galderma Research & Development Nouveaux composes inhibiteurs de mtor
WO2019143991A1 (en) * 2018-01-18 2019-07-25 Array Biopharma Inc. SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS
CN110526918B (zh) * 2018-05-25 2021-09-03 江苏恒瑞医药股份有限公司 一种吡唑并杂芳基类衍生物的晶型及制备方法
CN110526917B (zh) * 2018-05-25 2021-09-03 江苏恒瑞医药股份有限公司 一种吡唑并杂芳基类衍生物的可药用盐、晶型及其制备方法
CN111819178B (zh) * 2018-05-25 2022-04-12 江苏恒瑞医药股份有限公司 一种吡唑并杂芳基类衍生物盐酸盐的晶型及制备方法
CA3101323A1 (en) 2018-06-01 2019-12-05 Incyte Corporation Dosing regimen for the treatment of pi3k related disorders
WO2019233994A1 (en) 2018-06-04 2019-12-12 Exscientia Ltd Pyrazolopyrimidine compounds as adenosine receptor antagonists
JP2022500422A (ja) * 2018-09-18 2022-01-04 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 骨格筋調節のためのsrc阻害剤化合物、それらの方法及び使用
MA53672A (fr) * 2018-09-19 2021-07-28 Vyera Pharmaceuticals Llc Inhibiteurs de cdpk1, compositions et procédés associés
KR102706457B1 (ko) * 2018-12-06 2024-09-11 한국화학연구원 Pde9a 저해 활성을 가지는 화합물 및 이들의 의약 용도
AU2020204717B2 (en) * 2019-01-03 2025-01-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for increasing transcription factor EB polypeptide levels
IL299695A (en) 2020-07-09 2023-03-01 Usher Iii Initiative Inc Treatment of cancer, inflammatory diseases and autoimmune diseases
UY39482A (es) 2020-10-23 2022-05-31 Ildong Pharmaceutical Co Ltd Compuestos moduladores del cftr, composiciones y usos de estos
WO2022133480A1 (en) * 2020-12-18 2022-06-23 Ikena Oncology, Inc. Aryl hydrocarbon receptor (ahr) agonists and uses thereof
JP2024500919A (ja) 2020-12-23 2024-01-10 ジェンザイム・コーポレーション 重水素化コロニー刺激因子-1受容体(csf-1r)阻害剤
EP4301348A1 (en) * 2021-03-03 2024-01-10 Instytut Biologii doswiadczalnej imienia Marcelego Nenckiego Polskiej Akademii Nauk Inhibitor of protein kinase d for use in prevention or treatment of hyperlipidemia
CN116514845B (zh) * 2022-01-22 2026-03-10 轩竹生物科技股份有限公司 Usp1抑制剂及其用途
ES3038124T3 (en) * 2023-05-09 2025-10-09 Molecular Horizon S R L Phenylpyrazole insecticide compounds and compositions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342501B1 (en) * 1994-02-25 2002-01-29 The Regents Of The University Of Michigan Pyrrolo[2,3-d] pyrimidines as antiviral agents
CA2450777C (en) * 2001-08-10 2013-04-09 Novartis Ag Use of c-src inhibitors alone or in combination with sti571 for the treatment of leukaemia
WO2003082341A1 (en) * 2002-03-22 2003-10-09 Cellular Genomics, Inc. AN IMPROVED FORMULATION OF CERTAIN PYRAZOLO[3,4-d] PYRIMIDINES AS KINASE MODULATORS
UA80171C2 (en) * 2002-12-19 2007-08-27 Pfizer Prod Inc Pyrrolopyrimidine derivatives
EP1631268A2 (en) * 2003-05-21 2006-03-08 Board Of Regents The University Of Texas System Inhibition of protein kinase c-mu (pkd) as a treatment for cardiac hypertrophy and heart failure
US7429596B2 (en) * 2003-06-20 2008-09-30 The Regents Of The University Of California 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof
WO2005112936A1 (en) * 2004-05-14 2005-12-01 The Regents Of The University Of Michigan Compositions and methods relating to protein kinase inhibitors
US20060094682A1 (en) * 2004-10-29 2006-05-04 Odyssey Thera, Inc. Kinase inhibitors for the treatment of diabetes and obesity
US9512125B2 (en) * 2004-11-19 2016-12-06 The Regents Of The University Of California Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
US20090270431A1 (en) * 2005-10-19 2009-10-29 The University Of Georgia Research Foundation Cyclopentenol Nucleoside Compounds Intermediates for their Synthesis and Methods of Treating Viral Infections
CA2647543A1 (en) * 2006-03-29 2007-11-08 Foldrx Pharmaceuticals, Inc. Inhibition of alpha-synuclein toxicity
US20100160339A1 (en) * 2007-05-21 2010-06-24 Mayo Foundation For Medical Education And Research Treating pancreatitis

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014193925A (ja) * 2008-10-16 2014-10-09 Regents Of The Univ Of California 融合環ヘテロアリールキナーゼ阻害剤
US10307422B2 (en) 2011-04-25 2019-06-04 Usher Iii Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
JP2014515758A (ja) * 2011-04-25 2014-07-03 アッシャー・サード・イニシアティブ・インコーポレイテッド ピラゾロピリダジンおよび網膜変性疾患およびアッシャー症候群に伴う聴覚損失を治療するための方法
US9549910B2 (en) 2011-04-25 2017-01-24 Usher Iii Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
US9925187B2 (en) 2011-04-25 2018-03-27 Usher Iii Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
JP2014520863A (ja) * 2011-07-13 2014-08-25 ファーマサイクリックス,インク. Bruton型チロシンキナーゼの阻害剤
JP2014520872A (ja) * 2011-07-21 2014-08-25 ラボラトリオス・デル・デエレ・エステベ・エセ・ア ピラゾロ[3,4−d]ピリミジン化合物、その製造およびシグマリガンドとしての使用
JP2015535256A (ja) * 2012-10-25 2015-12-10 アッシャー・サード・イニシアティブ・インコーポレイテッド ピラゾロピリダジンならびに網膜変性疾患およびアッシャー症候群に伴う聴力損失を処置するための方法
JP2015535257A (ja) * 2012-10-25 2015-12-10 アッシャー・サード・イニシアティブ・インコーポレイテッド ピラゾロピリダジンならびに網膜変性疾患およびアッシャー症候群に伴う聴力損失を処置するための方法
US9371332B2 (en) 2012-10-25 2016-06-21 Usher Iii Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with Usher syndrome
US9783545B2 (en) 2012-10-25 2017-10-10 Usher Iii Initiative, Inc. Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome
JP2017515836A (ja) * 2014-05-14 2017-06-15 ファイザー・インク ピラゾロピリジンおよびピラゾロピリミジン
RU2719477C2 (ru) * 2015-06-22 2020-04-17 Оно Фармасьютикал Ко., Лтд. Соединение, ингибирующее brk
WO2016208595A1 (ja) * 2015-06-22 2016-12-29 小野薬品工業株式会社 Brk阻害化合物
US11512087B2 (en) 2015-06-22 2022-11-29 Ono Pharmaceutical Co., Ltd. BRK inhibitory compound
US10377759B2 (en) 2015-06-22 2019-08-13 Ono Pharmaceutical Co., Ltd. Brk inhibitory compound
JPWO2016208595A1 (ja) * 2015-06-22 2018-04-05 小野薬品工業株式会社 Brk阻害化合物
JP2018529743A (ja) * 2015-10-09 2018-10-11 アッヴィ・エス・ア・エール・エル N−スルホニル化ピラゾロ[3,4−b]ピリジン−6−カルボキサミドおよび使用法
JP2019501142A (ja) * 2015-11-30 2019-01-17 ミッション セラピューティクス リミティド Usp30の阻害剤としての1−シアノピロリジン誘導体
JP2019504899A (ja) * 2016-02-12 2019-02-21 ファーマクシス リミテッド リジルオキシダーゼのインドールおよびアザインドールハロアリルアミン誘導体阻害剤およびその使用
JP2019504898A (ja) * 2016-02-12 2019-02-21 ファーマクシス リミテッド リジルオキシダーゼのハロアリルアミンインドールおよびアザインドール誘導体阻害剤およびその使用
JP2019521992A (ja) * 2016-06-16 2019-08-08 上海 インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズShanghai Institute Of Materia Medica, Chinese Academy Of Sciences Fgfr阻害活性を有する新規な化合物およびその製造と使用
JP2022024023A (ja) * 2016-11-18 2022-02-08 システィック・ファイブロシス・ファンデーション Cftr増強物質としてのピロロピリミジン
JP2020510668A (ja) * 2016-11-18 2020-04-09 システィック ファイブロシス ファンデーション セラピューティクス インコーポレイテッドCystic Fibrosis Foundation Therapeutics Inc. Cftr増強物質としてのピロロピリミジン
JP7360434B2 (ja) 2016-11-18 2023-10-12 システィック・ファイブロシス・ファンデーション Cftr増強物質としてのピロロピリミジン
JP2023182694A (ja) * 2016-11-18 2023-12-26 システィック・ファイブロシス・ファンデーション Cftr増強物質としてのピロロピリミジン
JP7592814B2 (ja) 2016-11-18 2024-12-02 システィック・ファイブロシス・ファンデーション Cftr増強物質としてのピロロピリミジン
JP2021506918A (ja) * 2017-12-21 2021-02-22 ガルデルマ・リサーチ・アンド・デヴェロップメント 新規mTOR阻害剤化合物
JP7307072B2 (ja) 2017-12-21 2023-07-11 ガルデルマ・リサーチ・アンド・デヴェロップメント 新規mTOR阻害剤化合物
WO2025121320A1 (ja) * 2023-12-04 2025-06-12 国立大学法人山口大学 多発性嚢胞腎の予防又は治療剤

Also Published As

Publication number Publication date
CA2705303A1 (en) 2009-05-14
EP2217239A2 (en) 2010-08-18
BRPI0820342A2 (pt) 2015-05-26
ZA201003725B (en) 2011-03-30
AU2008323694A1 (en) 2009-05-14
US20100331297A1 (en) 2010-12-30
WO2009062118A3 (en) 2009-12-30
EA201070572A1 (ru) 2010-12-30
WO2009062118A2 (en) 2009-05-14
CN101917999A (zh) 2010-12-15

Similar Documents

Publication Publication Date Title
JP2011503103A (ja) タンパク質輸送の調節方法
US20100273776A1 (en) Inhibition of alpha-synuclein toxicity
US20190060311A1 (en) Compositions and methods for treatment of vitiligo
ES2275628T3 (es) Uso de un agonista/antagonista de estrogenos para el tratamiento de disfucion sexual femenina.
US8476260B2 (en) Antitumor agent
US8802844B2 (en) Isothiazolopyridinones useful for the treatment of (inter alia) cystic fibrosis
US20230142913A1 (en) Tricyclic heteroarenes, pharmaceutical compositions containing the same, and methods of using the same
JP5001843B2 (ja) α−シヌクレイン毒性を阻害する化合物、組成物および方法
KR100196368B1 (ko) 아폽토시스 조정제
CN1426310A (zh) 促进排便的药物组合物
US10980812B2 (en) 3-(4-((4-(morpholinomethyl-benzyl)oxy)-1 -oxoisoindolin-2-yl)piperidine-2,6-dione for the treatment of systemic lupus erythematosus
TW200811142A (en) Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by VLA-4
JP2009525966A (ja) タンパク質輸送を調節するための化合物および方法
TW200413374A (en) Novel adenine derivative and its use
JP2018531289A6 (ja) セラストロールの類似体
JP2018531289A (ja) セラストロールの類似体
JP2002541258A (ja) インターリューキン−12シグナルを阻害するための治療用化合物及びその使用方法
EP3878446A1 (en) Hsd11b1 inhibitors for use in immunotherapy and uses thereof
KR20030027865A (ko) 성장 호르몬 분비촉진제를 포함하는 약학 조성물 및 키트
CN115215807A (zh) Olig2活性的抑制
CN101410384A (zh) 调节蛋白质运输的化合物和方法
US20240325382A1 (en) Compositions and methods for treating anemia associated with a ribosomal disorder
CN115151257B (zh) 用于治疗与dux4表达相关的疾病的新颖化合物
US20230348464A1 (en) Novel vdac1 inhibitors
JP2022526287A (ja) ロスコビチン類似体および希少胆道疾患を治療するためのその使用

Legal Events

Date Code Title Description
RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20110906

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20110912

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111101

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20111101

A072 Dismissal of procedure [no reply to invitation to correct request for examination]

Free format text: JAPANESE INTERMEDIATE CODE: A073

Effective date: 20130311

A300 Application deemed to be withdrawn because no request for examination was validly filed

Free format text: JAPANESE INTERMEDIATE CODE: A300

Effective date: 20130402