JP2011501737A5 - - Google Patents
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- JP2011501737A5 JP2011501737A5 JP2010527260A JP2010527260A JP2011501737A5 JP 2011501737 A5 JP2011501737 A5 JP 2011501737A5 JP 2010527260 A JP2010527260 A JP 2010527260A JP 2010527260 A JP2010527260 A JP 2010527260A JP 2011501737 A5 JP2011501737 A5 JP 2011501737A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- antibody
- region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 53
- 239000003112 inhibitor Substances 0.000 claims 8
- 239000011159 matrix material Substances 0.000 claims 7
- 235000001014 amino acid Nutrition 0.000 claims 5
- 241000712461 unidentified influenza virus Species 0.000 claims 5
- 229940123424 Neuraminidase inhibitor Drugs 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 4
- 239000003443 antiviral agent Substances 0.000 claims 4
- 229940126181 ion channel inhibitor Drugs 0.000 claims 4
- 239000002911 sialidase inhibitor Substances 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 3
- 208000037797 influenza A Diseases 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 2
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical group C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 claims 2
- 229960003805 amantadine Drugs 0.000 claims 2
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- VSZGPKBBMSAYNT-RRFJBIMHSA-N oseltamivir Chemical compound CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 claims 2
- 229960002194 oseltamivir phosphate Drugs 0.000 claims 2
- 229960000888 rimantadine Drugs 0.000 claims 2
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 229960001028 zanamivir Drugs 0.000 claims 2
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical group CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 claims 2
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98735307P | 2007-11-12 | 2007-11-12 | |
| US98735507P | 2007-11-12 | 2007-11-12 | |
| US60/987,353 | 2007-11-12 | ||
| US60/987,355 | 2007-11-12 | ||
| US5384008P | 2008-05-16 | 2008-05-16 | |
| US61/053,840 | 2008-05-16 | ||
| US9520808P | 2008-09-08 | 2008-09-08 | |
| US61/095,208 | 2008-09-08 | ||
| PCT/US2008/083265 WO2009064805A1 (en) | 2007-11-12 | 2008-11-12 | Compositions and methods for the therapy and diagnosis of influenza |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011105659A Division JP5623332B2 (ja) | 2007-11-12 | 2011-05-10 | インフルエンザの治療および診断のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011501737A JP2011501737A (ja) | 2011-01-13 |
| JP2011501737A5 true JP2011501737A5 (enExample) | 2011-06-30 |
| JP4932940B2 JP4932940B2 (ja) | 2012-05-16 |
Family
ID=40404221
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527260A Expired - Fee Related JP4932940B2 (ja) | 2007-11-12 | 2008-11-12 | インフルエンザの治療および診断のための組成物および方法 |
| JP2011105659A Expired - Fee Related JP5623332B2 (ja) | 2007-11-12 | 2011-05-10 | インフルエンザの治療および診断のための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011105659A Expired - Fee Related JP5623332B2 (ja) | 2007-11-12 | 2011-05-10 | インフルエンザの治療および診断のための組成物および方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US8057796B2 (enExample) |
| EP (1) | EP2220116B1 (enExample) |
| JP (2) | JP4932940B2 (enExample) |
| KR (1) | KR20100097691A (enExample) |
| CN (2) | CN102089324B (enExample) |
| AU (1) | AU2008321016B2 (enExample) |
| CA (1) | CA2705555A1 (enExample) |
| DK (1) | DK2220116T3 (enExample) |
| ES (1) | ES2395784T3 (enExample) |
| HK (1) | HK1202558A1 (enExample) |
| IL (1) | IL205705A (enExample) |
| MX (1) | MX2010005244A (enExample) |
| NZ (1) | NZ585500A (enExample) |
| PT (1) | PT2220116E (enExample) |
| WO (1) | WO2009064805A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102089324B (zh) | 2007-11-12 | 2014-04-16 | 特罗科隆科学有限公司 | 用于对流行性感冒进行治疗以及诊断的组合物以及方法 |
| US20110033476A1 (en) * | 2007-11-12 | 2011-02-10 | Theraclone Sciences Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| US8658180B2 (en) | 2008-08-15 | 2014-02-25 | Mark A. Miller | Vaccines against influenza virus |
| CA2743306A1 (en) * | 2008-11-12 | 2010-05-20 | Theraclone Sciences, Inc. | Human m2e peptide immunogens |
| EP2432803A2 (en) | 2009-05-20 | 2012-03-28 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| EP2464383A4 (en) * | 2009-08-14 | 2013-02-13 | Theraclone Sciences Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF FLU |
| NZ604040A (en) | 2010-06-03 | 2015-02-27 | Pharmacyclics Inc | The use of inhibitors of bruton’s tyrosine kinase (btk) |
| AU2011289275A1 (en) * | 2010-08-12 | 2013-02-21 | Theraclone Sciences, Inc. | Anti-hemagglutinin antibody compositions and methods of use thereof |
| ES2630012T3 (es) | 2010-12-02 | 2017-08-17 | Oncolytics Biotech Inc. | Formulaciones virales liofilizadas |
| EA201390810A1 (ru) | 2010-12-02 | 2013-09-30 | Онколитикс Байотек Инк. | Жидкие вирусные составы |
| CN102172348B (zh) * | 2011-02-12 | 2013-02-20 | 北京博康宁生物医药科技有限公司 | 固体的磷酸奥司他韦药物组合物 |
| CA2827301A1 (en) * | 2011-02-14 | 2012-08-23 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| WO2012122484A1 (en) * | 2011-03-09 | 2012-09-13 | Roberto Polakiewicz | Methods and reagents for creating monoclonal antibodies |
| AU2012229188A1 (en) * | 2011-03-15 | 2013-09-26 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| ES2822199T3 (es) * | 2011-04-29 | 2021-04-29 | Oncolytics Biotech Inc | Métodos de purificación de virus usando cromatografía por permeación en gel |
| US9284533B2 (en) | 2011-06-24 | 2016-03-15 | Flugen, Inc. | Influenza virus mutants and uses therefor |
| WO2014012165A1 (en) | 2012-07-19 | 2014-01-23 | Alethia Biotherapeutics Inc. | Anti-siglec-15 antibodies |
| KR20150032340A (ko) | 2012-07-24 | 2015-03-25 | 파마시클릭스, 인코포레이티드 | 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이 |
| EA201590822A1 (ru) | 2012-11-02 | 2016-01-29 | Фармасайкликс, Инк. | Адъювантная терапия ингибитором киназы семейства tec |
| JP2016519688A (ja) * | 2013-04-22 | 2016-07-07 | セラクローン サイエンシーズ， インコーポレイテッド | インフルエンザの治療および診断のための組成物および方法 |
| JP6182027B2 (ja) * | 2013-09-10 | 2017-08-16 | デンカ生研株式会社 | Ｂ型インフルエンザウイルスの測定方法 |
| JP6262969B2 (ja) | 2013-09-10 | 2018-01-17 | デンカ生研株式会社 | Ａ型インフルエンザウイルスの測定方法 |
| JP2017509336A (ja) | 2014-03-20 | 2017-04-06 | ファーマサイクリックス エルエルシー | ホスホリパーゼｃガンマ２及び耐性に関連した変異 |
| JP6545981B2 (ja) | 2015-03-12 | 2019-07-17 | アルパッド株式会社 | 半導体発光装置 |
| CN108135994B (zh) | 2015-05-13 | 2022-01-25 | 宾夕法尼亚州大学信托人 | Aav-介导的抗-流感抗体的表达及其使用方法 |
| US11827906B2 (en) | 2017-02-28 | 2023-11-28 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (AAV) clade f vector and uses therefor |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| SG11201907611WA (en) | 2017-02-28 | 2019-09-27 | Univ Pennsylvania | Influenza vaccines based on aav vectors |
| WO2021201677A1 (en) | 2020-04-01 | 2021-10-07 | Kiadis Pharma Intellectual Property B.V. | Compositions and methods targeting influenza |
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| CA2585104A1 (en) * | 2004-12-06 | 2006-06-15 | Kirin Beer Kabushiki Kaisha | Human monoclonal antibodies to influenza m2 protein and methods of making and using same |
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| EP2041175A4 (en) * | 2006-06-23 | 2011-03-16 | Augmenta Biolog Llc | TARGETED IMMUNOJUGATE |
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| CN102089324B (zh) | 2007-11-12 | 2014-04-16 | 特罗科隆科学有限公司 | 用于对流行性感冒进行治疗以及诊断的组合物以及方法 |
| AU2009324251A1 (en) | 2008-12-04 | 2010-06-10 | Elatos Gmbh | Fully human influenza M2 specific antibodies |
| EP2464383A4 (en) * | 2009-08-14 | 2013-02-13 | Theraclone Sciences Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF FLU |
| CA2827301A1 (en) * | 2011-02-14 | 2012-08-23 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| JP2016519688A (ja) * | 2013-04-22 | 2016-07-07 | セラクローン サイエンシーズ， インコーポレイテッド | インフルエンザの治療および診断のための組成物および方法 |
-
2008
- 2008-11-12 CN CN200880123932.8A patent/CN102089324B/zh not_active Expired - Fee Related
- 2008-11-12 WO PCT/US2008/083265 patent/WO2009064805A1/en not_active Ceased
- 2008-11-12 JP JP2010527260A patent/JP4932940B2/ja not_active Expired - Fee Related
- 2008-11-12 US US12/269,781 patent/US8057796B2/en not_active Expired - Fee Related
- 2008-11-12 CN CN201410103093.0A patent/CN104059143A/zh active Pending
- 2008-11-12 MX MX2010005244A patent/MX2010005244A/es active IP Right Grant
- 2008-11-12 PT PT88501127T patent/PT2220116E/pt unknown
- 2008-11-12 AU AU2008321016A patent/AU2008321016B2/en not_active Ceased
- 2008-11-12 ES ES08850112T patent/ES2395784T3/es active Active
- 2008-11-12 DK DK08850112.7T patent/DK2220116T3/da active
- 2008-11-12 EP EP08850112A patent/EP2220116B1/en not_active Not-in-force
- 2008-11-12 KR KR1020107012975A patent/KR20100097691A/ko not_active Ceased
- 2008-11-12 NZ NZ585500A patent/NZ585500A/en not_active IP Right Cessation
- 2008-11-12 CA CA2705555A patent/CA2705555A1/en not_active Abandoned
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2010
- 2010-03-17 US US12/726,297 patent/US8114402B2/en not_active Expired - Fee Related
- 2010-05-12 IL IL205705A patent/IL205705A/en active IP Right Grant
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2011
- 2011-05-10 JP JP2011105659A patent/JP5623332B2/ja not_active Expired - Fee Related
- 2011-08-23 US US13/215,841 patent/US8460671B2/en not_active Expired - Fee Related
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2013
- 2013-06-10 US US13/914,380 patent/US20140135480A1/en not_active Abandoned
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2015
- 2015-03-23 HK HK15102928.6A patent/HK1202558A1/xx unknown
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