JP2011501661A5 - - Google Patents

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JP2011501661A5
JP2011501661A5 JP2010528141A JP2010528141A JP2011501661A5 JP 2011501661 A5 JP2011501661 A5 JP 2011501661A5 JP 2010528141 A JP2010528141 A JP 2010528141A JP 2010528141 A JP2010528141 A JP 2010528141A JP 2011501661 A5 JP2011501661 A5 JP 2011501661A5
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acid
oil
weight percent
eicosapentaenoic
host cell
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JP2010528141A
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JP5711968B2 (ja
JP2011501661A (ja
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Priority claimed from PCT/US2008/078642 external-priority patent/WO2009046231A1/en
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JP2010528141A 2007-10-03 2008-10-03 高エイコサペンタエン酸を生成するためのヤロウィア・リポリティカ（ＹａｒｒｏｗｉａＬｉｐｏｌｙｔｉｃａ）の最適化株 Expired - Fee Related JP5711968B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97717407P 2007-10-03 2007-10-03
US97717707P 2007-10-03 2007-10-03
US60/977,174 2007-10-03
US60/977,177 2007-10-03
PCT/US2008/078642 WO2009046231A1 (en) 2007-10-03 2008-10-03 Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production

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JP2011501661A JP2011501661A (ja) 2011-01-13
JP2011501661A5 true JP2011501661A5 (https=) 2011-11-17
JP5711968B2 JP5711968B2 (ja) 2015-05-07

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JP2010528141A Expired - Fee Related JP5711968B2 (ja) 2007-10-03 2008-10-03 高エイコサペンタエン酸を生成するためのヤロウィア・リポリティカ（ＹａｒｒｏｗｉａＬｉｐｏｌｙｔｉｃａ）の最適化株

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US (5) US20090117253A1 (https=)
EP (1) EP2195415A1 (https=)
JP (1) JP5711968B2 (https=)
CN (1) CN101970638B (https=)
CA (1) CA2701094A1 (https=)
WO (1) WO2009046231A1 (https=)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8313911B2 (en) * 2003-05-07 2012-11-20 E I Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US7794701B2 (en) * 2007-04-16 2010-09-14 E.I. Du Pont De Nemours And Company Δ-9 elongases and their use in making polyunsaturated fatty acids
US8957280B2 (en) * 2007-05-03 2015-02-17 E. I. Du Pont De Nemours And Company Delta-5 desaturases and their use in making polyunsaturated fatty acids
US20090004715A1 (en) 2007-06-01 2009-01-01 Solazyme, Inc. Glycerol Feedstock Utilization for Oil-Based Fuel Manufacturing
WO2010025374A2 (en) 2008-08-29 2010-03-04 E. I. Du Pont De Nemours And Company Manipulation of snf1 protein kinase activity for altered oil content in oleaginous organisms
AU2009293160B2 (en) * 2008-09-19 2013-11-21 E. I. Du Pont De Nemours And Company Mutant delta5 desaturases and their use in making polyunsaturated fatty acids
CN102257126B (zh) 2008-12-18 2014-07-09 纳幕尔杜邦公司 减少发酵过程中的丙二酸副产物
US8207363B2 (en) 2009-03-19 2012-06-26 Martek Biosciences Corporation Thraustochytrids, fatty acid compositions, and methods of making and uses thereof
CN102459627B (zh) 2009-06-16 2015-07-29 纳幕尔杜邦公司 通过酰基-辅酶A溶血磷脂酰基转移酶的表达对长链ω-3和ω-6多不饱和脂肪酸的生物合成的改善
US8637298B2 (en) * 2009-06-16 2014-01-28 E I Du Pont De Nemours And Company Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production
DK2475679T3 (da) * 2009-06-16 2016-05-09 Du Pont Forbedrede, optimerede stammer af yarrowia lipolytica til fremstilling af højkoncentreret eicosapentaensyre
EP2442666B1 (en) * 2009-06-16 2015-04-08 E. I. du Pont de Nemours and Company High eicosapentaenoic acid oils from improved optimized strains of yarrowia lipolytica
WO2011087981A2 (en) 2010-01-15 2011-07-21 E. I. Du Pont De Nemours And Company Clinical benefits of eicosapentaenoic acid in humans
WO2011090493A1 (en) 2010-01-19 2011-07-28 Martek Biosciences Corporation Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof
WO2011133610A1 (en) 2010-04-22 2011-10-27 E. I. Du Pont De Nemours And Company Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass
US8592188B2 (en) * 2010-05-28 2013-11-26 Solazyme, Inc. Tailored oils produced from recombinant heterotrophic microorganisms
US8769868B2 (en) 2010-06-09 2014-07-08 Photonz Corporation Limited Compositions comprising eicosapentaenoic acid suitable for high purification
WO2012021686A1 (en) 2010-08-11 2012-02-16 E. I. Du Pont De Nemours And Company Improved aquaculture meat products
US20120040076A1 (en) 2010-08-11 2012-02-16 E. I. Du Pont De Nemours And Company Aquaculture feed compositions
TW201207116A (en) 2010-08-13 2012-02-16 Univ Fu Jen Catholic A method for producing oil by Cystofilobasidium spp.
EP2609203B1 (en) * 2010-08-26 2018-06-20 E. I. du Pont de Nemours and Company Recombinant microbial host cells for high eicosapentaenoic acid production
AU2011293167B2 (en) * 2010-08-26 2016-12-08 E. I. Du Pont De Nemours And Company Mutant delta-9 elongases and their use in making polyunsaturated fatty acids
CA2808002A1 (en) * 2010-08-26 2012-03-01 E. I. Du Pont De Nemours And Company Mutant hpgg motif and hdash motif delta-5 desaturases and their use in making polyunsaturated fatty acids
EP2635663B1 (en) 2010-11-03 2019-05-08 Corbion Biotech, Inc. Microbial oils with lowered pour points, dielectric fluids produced therefrom, and related methods
JP2014505472A (ja) 2010-12-30 2014-03-06 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 油性酵母中のｙａｐ１転写因子活性を増大させることにより増加した含油率
JP2014503216A (ja) 2010-12-30 2014-02-13 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー スクロース利用のための、ヤロウィア・リポリティカ（Ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）におけるサッカロミセス・セレビシア（Ｓａｃｃｈａｒｏｍｙｃｅｓｃｅｒｅｖｉｓｉａｅ）ＳＵＣ２遺伝子の使用
KR101964965B1 (ko) 2011-02-02 2019-04-03 테라비아 홀딩스 인코포레이티드 재조합 유지성 미생물로부터 생산된 맞춤 오일
US20130040340A1 (en) 2011-02-07 2013-02-14 E. I. Du Pont De Nemours And Company Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms
US8999663B2 (en) 2011-02-11 2015-04-07 E L Du Pont De Nemours And Company Method for obtaining a lipid-containing composition from microbial biomass
US8765425B2 (en) 2011-03-23 2014-07-01 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
US8759044B2 (en) 2011-03-23 2014-06-24 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
EP2691518A1 (en) 2011-03-31 2014-02-05 E.I. Du Pont De Nemours And Company Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast
EP2694665A1 (en) 2011-04-01 2014-02-12 E. I. Du Pont de Nemours and Company Yarrowia esterase/lipase promoter regions for gene expression in yeast
US20120247066A1 (en) 2011-04-01 2012-10-04 Ice House America, Llc Ice bagging apparatus and methods
US8735094B2 (en) 2011-04-05 2014-05-27 E I Du Pont De Nemours And Company Yarrowia n-alkane-hydroxylating cytochrome P450 promoter regions for gene expression in yeast
EP2702148A1 (en) 2011-04-07 2014-03-05 E.I. Du Pont De Nemours And Company Yarrowia peroxisomal 2,4-dienoyl-coa reductase promoter regions for gene expression in yeast
CA2833400A1 (en) 2011-05-26 2012-11-29 E.I. Dupont De Nemours And Company Expression of caleosin in recombinant oleaginous microorganisms to increase oil content therein
US8544772B2 (en) * 2011-05-27 2013-10-01 Ginn Mineral Technology, Inc. Method for the recovery of minerals
US20140323569A1 (en) * 2011-07-21 2014-10-30 Krishna Raman Microbial oils enriched in polyunsaturated fatty acids
CN104011217B (zh) * 2011-07-21 2018-09-04 帝斯曼知识产权资产管理有限公司 生产二十碳五烯酸的微生物、脂肪酸组合物及其制作方法与用途
HK1198515A1 (en) * 2011-07-21 2015-05-15 Dsm Ip Assets B.V. Fatty acid compositions
CN103031349B (zh) * 2011-09-29 2014-07-09 私立辅仁大学 利用Cystofilobasidium属的酵母菌产生油脂的方法和系统
US8945908B2 (en) 2012-04-18 2015-02-03 Solazyme, Inc. Tailored oils
US9416382B2 (en) 2012-06-19 2016-08-16 E I Du Pont De Nemours And Company Production of polyunsaturated fatty acids by coexpression of acyl-CoA:lysophosphatidylcholine acyltransferases and phospholipid:diacylglycerol acyltransferases
CN102787128A (zh) * 2012-08-28 2012-11-21 江南大学 一种用于多不饱和脂肪酸生物合成的脱饱和酶Δ9 Des
EP2935591B1 (en) 2012-12-21 2017-07-05 E. I. du Pont de Nemours and Company Down-regulation of a polynucleotide encoding a sou2 sorbitol utilization protein to modify lipid production in microbial cells
CA2893409A1 (en) 2012-12-21 2014-06-26 E. I. Du Pont De Nemours And Company Recombinant microbial cells that produce at least 28% eicosapentaenoic acid as dry cell weight
US9629820B2 (en) 2012-12-24 2017-04-25 Qualitas Health, Ltd. Eicosapentaenoic acid (EPA) formulations
MX372724B (es) 2012-12-24 2020-06-19 Qualitas Health Inc Formulaciones de acido eicosapentaenoico (epa).
US10123986B2 (en) 2012-12-24 2018-11-13 Qualitas Health, Ltd. Eicosapentaenoic acid (EPA) formulations
CA2911158A1 (en) 2013-05-03 2014-11-06 Board Of Regents, The University Of Texas System Compositions and methods for fungal lipid production
MX369685B (es) 2013-10-04 2019-11-19 Terravia Holdings Inc Aceites adaptables.
CN103749744A (zh) * 2014-02-24 2014-04-30 四川省三台县通宇食品有限公司 一种富含氨基酸食用菌油的制备方法
US9969990B2 (en) 2014-07-10 2018-05-15 Corbion Biotech, Inc. Ketoacyl ACP synthase genes and uses thereof
US10513711B2 (en) 2014-08-13 2019-12-24 Dupont Us Holding, Llc Genetic targeting in non-conventional yeast using an RNA-guided endonuclease
IL241841B (en) * 2014-09-30 2019-09-26 Univ Free State Production of proteins for human and animal health using yarrowia lipolytica
EP3224381B1 (en) * 2014-11-25 2019-09-04 The Brigham and Women's Hospital, Inc. Method of identifying a person having a predisposition to or afflicted with a cardiometabolic disease
WO2016085876A1 (en) 2014-11-25 2016-06-02 The Broad Institute Inc. Clonal haematopoiesis
WO2016144569A1 (en) 2015-03-10 2016-09-15 Elc Management Llc Methods and compositions for treating skin to resolve inflammation and screening for actives that stimulate pro-resolution pathways
CN104805027B (zh) * 2015-05-27 2018-04-27 天津大学 一种重组耶氏解脂酵母菌株及其构建方法和应用
JP6898915B2 (ja) 2015-07-22 2021-07-07 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ 生物を用いる長鎖ジカルボン酸の高レベルの生産
GB201602410D0 (en) 2016-02-10 2016-03-23 Tate & Lyle Ingredients Methods for improving the gastrointestinal tolerance of food and beverage products comprising sweet, low-digestible carbohydrates
WO2017055169A1 (en) 2015-10-01 2017-04-06 Dsm Ip Assets B.V. Supplement material for use in pet food
EP4144844B1 (en) 2015-10-12 2025-09-10 DuPont US Holding, LLC Protected dna templates for gene modification and increased homologous recombination in cells and methods of use
CN106190872B (zh) * 2016-09-23 2019-10-25 厦门大学 发酵罐底物流加生产二十二碳六烯酸的方法
WO2018109163A1 (en) 2016-12-16 2018-06-21 Danmarks Tekniske Universitet Methods for producing fatty alcohols and derivatives thereof in yeast
HUE060726T2 (hu) 2016-12-16 2023-04-28 Univ Danmarks Tekniske Telítetlen zsíralkoholok és telítetlen zsír-acil-acetátok elõállítása élesztõben
EP3348647A1 (en) 2017-01-13 2018-07-18 Institut National De La Recherche Agronomique Mutant yeast strain capable of producing medium chain fatty acids
CN108728477B (zh) * 2017-04-24 2022-02-22 华东理工大学 一种高效的转座突变系统及构建方法
CN107502601B (zh) * 2017-06-13 2020-04-21 天津科技大学 一种胰蛋白酶抗性改良的脂肪酶突变体及其基因和应用
WO2019143660A1 (en) * 2018-01-16 2019-07-25 Trustees Of Boston University Clonal hematopoiesis and cytokine targets
WO2019209241A1 (en) 2018-04-23 2019-10-31 Dupont Nutrition Biosciences Aps Increasing export of 2' fucosyllactose from microbial cells through the expression of a heterologous nucleic acid
CN119498443A (zh) 2019-01-03 2025-02-25 柯碧恩生物技术公司 制造裂解细胞悬浮液的方法
CN110499259B (zh) * 2019-07-22 2021-07-27 浙江工业大学 一种解酯耶氏酵母yw100-1及其应用
US11572546B2 (en) 2019-07-29 2023-02-07 Ginkgo Bioworks, Inc. Methods and compositions involving promoters derived from Yarrowia lipolytica
WO2022235655A1 (en) 2021-05-04 2022-11-10 Nutrition & Biosciences USA 4, Inc. Compositions comprising insoluble alpha-glucan
EP4334364A1 (en) 2021-05-04 2024-03-13 Nutrition & Biosciences USA 4, Inc. Compositions comprising oxidized insoluble alpha-glucan
EP4463519A1 (en) 2022-01-12 2024-11-20 Nutrition & Biosciences USA 4, Inc. Coating compositions comprising rubber and insoluble alpha-glucan
KR20240167661A (ko) 2022-03-21 2024-11-27 뉴트리션 앤드 바이오사이언시스 유에스에이 4, 인크. 불용성 알파-글루칸을 포함하는 조성물
PE20251752A1 (es) * 2022-12-02 2025-07-09 Mara Renewables Corp Composiciones de aceite con perfiles lipidicos modificados y metodos para su produccion
CN116121093B (zh) * 2022-12-12 2025-11-07 浙江大学杭州国际科创中心 一种用于表达细胞色素p450的工程酵母菌株及其应用
WO2025207802A1 (en) 2024-03-27 2025-10-02 Nutrition & Biosciences USA 4, Inc. Recombinant microbial strains comprising reduced beta-oxidation phenotypes and methods thereof
CN118703533B (zh) * 2024-08-01 2025-11-21 湖南农业大学 OsGAT3基因在调控水稻Cd、Cu或Mn含量及株高中的应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3783396T2 (de) 1986-07-08 1993-07-29 Suntory Ltd Verfahren zur herstellung von bishomo-gamma-linolensaeure und eicosapentaensaeure.
US5246841A (en) 1986-12-26 1993-09-21 Sagami Chemical Research Center Microbial process for production of eicosapentaenoic acid
US5244921A (en) 1990-03-21 1993-09-14 Martek Corporation Eicosapentaenoic acids and methods for their production
US5246842A (en) 1991-10-30 1993-09-21 The United States Of America As Represented By The Secretary Of Agriculture Production of eicosapentaenoic acid from filamentous fungi utilizing lactose as a primary carbon source
CN1109543C (zh) 1996-10-11 2003-05-28 斯卡里斯塔有限公司 包括二十碳五烯酸和/或十八碳四烯酸的药物制剂
US5968809A (en) 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US6825017B1 (en) 1998-12-07 2004-11-30 Washington State University Research Foundation Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
DE60027376T2 (de) * 1999-09-30 2007-02-01 Loders Croklaan B.V. Zusammensetzungen, enthaltend Pinolensäure sowie deren Verwendung zur Gesundheitserhaltung
EP1279400A1 (en) * 2001-07-25 2003-01-29 Target Hit sa Modifying the fatty acid composition of cell membranes of organs and tissues
US7410663B2 (en) 2002-08-07 2008-08-12 Kao Corporation Oil or fat composition
EP1544281B1 (en) * 2002-08-07 2016-10-05 Kao Corporation Fat composition
BR0317609B1 (pt) 2002-12-20 2013-10-08 Textura laminada com tufos
US7238482B2 (en) 2003-05-07 2007-07-03 E. I. Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US8313911B2 (en) * 2003-05-07 2012-11-20 E I Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US7214491B2 (en) * 2003-05-07 2007-05-08 E. I. Du Pont De Nemours And Company Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts
US7125672B2 (en) 2003-05-07 2006-10-24 E. I. Du Pont De Nemours And Company Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
US7267976B2 (en) 2003-07-02 2007-09-11 E.I. Du Pont De Nemours And Company Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts
US7504259B2 (en) * 2003-11-12 2009-03-17 E. I. Du Pont De Nemours And Company Δ12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast
US7550651B2 (en) 2004-06-25 2009-06-23 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
US7465564B2 (en) 2004-08-10 2008-12-16 E.I. Du Pont De Nemours And Company Production of γ-linolenic acid in oleaginous yeast
US7550286B2 (en) * 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
WO2006124598A2 (en) * 2005-05-12 2006-11-23 Martek Biosciences Corporation Biomass hydrolysate and uses and production thereof
FR2888976B1 (fr) 2005-07-25 2007-10-12 Oberthur Card Syst Sa Entite electronique avec moyens de communication par contact et a distance
DK1951866T3 (da) * 2005-11-23 2014-10-27 Du Pont Delta-9-elongaser og anvendelse heraf til fremstilling af flerumættede fedtsyrer
US20070225370A1 (en) 2006-03-21 2007-09-27 Joar Opheim Nutritional Compositions and Methods
US7943823B2 (en) 2006-04-28 2011-05-17 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
US7709239B2 (en) 2006-12-07 2010-05-04 E.I. Du Pont De Nemours And Company Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids
ES2559312T3 (es) 2007-04-03 2016-02-11 E. I. Du Pont De Nemours And Company Multienzimas y su uso en la fabricación de ácidos grasos poliinsaturados
US7790156B2 (en) * 2007-04-10 2010-09-07 E. I. Du Pont De Nemours And Company Δ-8 desaturases and their use in making polyunsaturated fatty acids

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