JP2011501661A5 - - Google Patents
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- JP2011501661A5 JP2011501661A5 JP2010528141A JP2010528141A JP2011501661A5 JP 2011501661 A5 JP2011501661 A5 JP 2011501661A5 JP 2010528141 A JP2010528141 A JP 2010528141A JP 2010528141 A JP2010528141 A JP 2010528141A JP 2011501661 A5 JP2011501661 A5 JP 2011501661A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- oil
- weight percent
- eicosapentaenoic
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 9
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 9
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 9
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 9
- 230000000813 microbial effect Effects 0.000 claims 8
- 241001465754 Metazoa Species 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims 5
- 229930195729 fatty acid Natural products 0.000 claims 5
- 239000000194 fatty acid Substances 0.000 claims 5
- 150000004665 fatty acids Chemical class 0.000 claims 5
- 235000013305 food Nutrition 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 4
- 241000235013 Yarrowia Species 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 claims 2
- 239000002028 Biomass Substances 0.000 claims 2
- 235000021294 Docosapentaenoic acid Nutrition 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 2
- 244000144974 aquaculture Species 0.000 claims 2
- 238000009360 aquaculture Methods 0.000 claims 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 108010022240 delta-8 fatty acid desaturase Proteins 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 2
- 235000020778 linoleic acid Nutrition 0.000 claims 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 2
- 239000000047 product Substances 0.000 claims 2
- XSXIVVZCUAHUJO-AVQMFFATSA-N (11e,14e)-icosa-11,14-dienoic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-AVQMFFATSA-N 0.000 claims 1
- BBWMTEYXFFWPIF-CJBMEHDJSA-N (2e,4e,6e)-icosa-2,4,6-trienoic acid Chemical compound CCCCCCCCCCCCC\C=C\C=C\C=C\C(O)=O BBWMTEYXFFWPIF-CJBMEHDJSA-N 0.000 claims 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 235000021297 Eicosadienoic acid Nutrition 0.000 claims 1
- OPGOLNDOMSBSCW-CLNHMMGSSA-N Fursultiamine hydrochloride Chemical compound Cl.C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N OPGOLNDOMSBSCW-CLNHMMGSSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- 241000490645 Yarrowia sp. Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 1
- 235000021342 arachidonic acid Nutrition 0.000 claims 1
- 229940114079 arachidonic acid Drugs 0.000 claims 1
- BIRYUMUXPVBNBH-UHFFFAOYSA-N docosa-1,3,5,7-tetraene Chemical compound CCCCCCCCCCCCCCC=CC=CC=CC=C BIRYUMUXPVBNBH-UHFFFAOYSA-N 0.000 claims 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 1
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 1
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims 1
- 235000013376 functional food Nutrition 0.000 claims 1
- 229940098330 gamma linoleic acid Drugs 0.000 claims 1
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 claims 1
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 claims 1
- 235000020664 gamma-linolenic acid Nutrition 0.000 claims 1
- 229960002733 gamolenic acid Drugs 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 229960004488 linolenic acid Drugs 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97717407P | 2007-10-03 | 2007-10-03 | |
| US97717707P | 2007-10-03 | 2007-10-03 | |
| US60/977,174 | 2007-10-03 | ||
| US60/977,177 | 2007-10-03 | ||
| PCT/US2008/078642 WO2009046231A1 (en) | 2007-10-03 | 2008-10-03 | Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011501661A JP2011501661A (ja) | 2011-01-13 |
| JP2011501661A5 true JP2011501661A5 (enExample) | 2011-11-17 |
| JP5711968B2 JP5711968B2 (ja) | 2015-05-07 |
Family
ID=40084411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010528141A Expired - Fee Related JP5711968B2 (ja) | 2007-10-03 | 2008-10-03 | 高エイコサペンタエン酸を生成するためのヤロウィア・リポリティカ（ＹａｒｒｏｗｉａＬｉｐｏｌｙｔｉｃａ）の最適化株 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US8323935B2 (enExample) |
| EP (1) | EP2195415A1 (enExample) |
| JP (1) | JP5711968B2 (enExample) |
| CN (1) | CN101970638B (enExample) |
| CA (1) | CA2701094A1 (enExample) |
| WO (1) | WO2009046231A1 (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8313911B2 (en) * | 2003-05-07 | 2012-11-20 | E I Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
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| US7943365B2 (en) * | 2007-05-03 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Δ-5 desaturases and their use in making polyunsaturated fatty acids |
| JP2010528627A (ja) | 2007-06-01 | 2010-08-26 | ソラザイム、インク | 微生物による油の生産 |
| EP2324120B1 (en) | 2008-08-29 | 2016-01-27 | E. I. du Pont de Nemours and Company | Manipulation of snf1 protein kinase activity for altered oil content in oleaginous organisms |
| DK2324119T3 (en) * | 2008-09-19 | 2016-07-18 | Du Pont | Mutant DELTA5 Desaturases AND USE THEREOF FOR THE PRODUCTION OF polyunsaturated fatty acids |
| CA2744716C (en) | 2008-12-18 | 2017-05-23 | E.I. Du Pont De Nemours And Company | Reducing byproduction of malonates in a fermentation process |
| US8207363B2 (en) * | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| CN102803289B (zh) * | 2009-06-16 | 2015-07-22 | 纳幕尔杜邦公司 | 用于高水平生产二十碳五烯酸的改善的优化的解脂耶氏酵母菌株 |
| US8399226B2 (en) * | 2009-06-16 | 2013-03-19 | E I Du Pont De Nemours And Company | High eicosapentaenoic acid oils from improved optimized strains of Yarrowia lipolytica |
| WO2010147907A1 (en) | 2009-06-16 | 2010-12-23 | E. I. Du Pont De Nemours And Company | High eicosapentaenoic acid oils from improved optimized strains of yarrowia lipolytica |
| BRPI1009690A2 (pt) * | 2009-06-16 | 2015-08-25 | Du Pont | "célula hospedeira microbiana oleaginosa, óleo, método de elaboração de um óleo, método de aumento da eficiência de conversão de alongamento de c18 para c20 em uma célula hospedeira recombinante microbiana oleaginosa e método de aumento da eficiência de conversão de dessaturação (delta) 4 em uma célula hospedeira recombinante microbiana oleaginosa produtora de ácidos graxos póli-insaturados de cadeia longa" |
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| CA2993690C (en) | 2010-01-19 | 2022-03-22 | Dsm Ip Assets B.V. | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
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| SG10201504197SA (en) * | 2010-05-28 | 2015-06-29 | Solazyme Inc | Food Compositions Comprising Tailored Oils |
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| TW201207116A (en) | 2010-08-13 | 2012-02-16 | Univ Fu Jen Catholic | A method for producing oil by Cystofilobasidium spp. |
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| US8703473B2 (en) | 2010-08-26 | 2014-04-22 | E I Du Pont De Nemours And Company | Recombinant microbial host cells for high eicosapentaenoic acid production |
| AU2011293189B2 (en) * | 2010-08-26 | 2017-02-16 | E. I. Du Pont De Nemours And Company | Mutant HPGG motif and HDASH motif delta-5 desaturases and their use in making polyunsaturated fatty acids |
| EP3521408B1 (en) | 2010-11-03 | 2021-12-22 | Corbion Biotech, Inc. | Genetically-engineered chlorella or prototheca microbe and oil produced therefrom |
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| BR112013016769A2 (pt) | 2010-12-30 | 2016-10-11 | Du Pont | yarrowia lipolytica transformada e método para produzir pelo menos um produto não nativo de interesse |
| CN110066836A (zh) | 2011-02-02 | 2019-07-30 | 柯碧恩生物技术公司 | 产自重组产油微生物的定制油 |
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| JP6061866B2 (ja) * | 2011-02-11 | 2017-01-18 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | 微生物バイオマスから脂質含有組成物を得る方法 |
| US8759044B2 (en) | 2011-03-23 | 2014-06-24 | Butamax Advanced Biofuels Llc | In situ expression of lipase for enzymatic production of alcohol esters during fermentation |
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| US8969049B2 (en) | 2011-03-31 | 2015-03-03 | E I Du Pont De Nemours And Company | Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast |
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| EA035287B1 (ru) * | 2011-07-21 | 2020-05-25 | ДСМ АйПи АССЕТС Б.В. | Микроорганизмы, продуцирующие эйкозапентаеновую кислоту, композиции, содержащие жирные кислоты, и способы их получения и применения |
| ES2857173T3 (es) * | 2011-07-21 | 2021-09-28 | Dsm Ip Assets Bv | Aceites microbianos enriquecidos en ácidos grasos poliinsaturados |
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| JP2025539450A (ja) * | 2022-12-02 | 2025-12-05 | マラ リニューアブルズ コーポレーション | 操作された脂質特性を有する油組成物及びその生成方法 |
| CN116121093B (zh) * | 2022-12-12 | 2025-11-07 | 浙江大学杭州国际科创中心 | 一种用于表达细胞色素p450的工程酵母菌株及其应用 |
| WO2025207802A1 (en) | 2024-03-27 | 2025-10-02 | Nutrition & Biosciences USA 4, Inc. | Recombinant microbial strains comprising reduced beta-oxidation phenotypes and methods thereof |
| CN118703533B (zh) * | 2024-08-01 | 2025-11-21 | 湖南农业大学 | OsGAT3基因在调控水稻Cd、Cu或Mn含量及株高中的应用 |
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| ES2052564T3 (es) | 1986-07-08 | 1994-07-16 | Suntory Ltd | Procedimiento para la produccion de acido bishomo-gamma-linolenico y acido eicosapanteonico. |
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| US5246842A (en) | 1991-10-30 | 1993-09-21 | The United States Of America As Represented By The Secretary Of Agriculture | Production of eicosapentaenoic acid from filamentous fungi utilizing lactose as a primary carbon source |
| DK0956013T3 (da) | 1996-10-11 | 2003-08-04 | Scarista Ltd | Farmaceutisk præparat indeholdende eicosapentaensyre og/eller stearidonsyre |
| US5968809A (en) | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| US6825017B1 (en) | 1998-12-07 | 2004-11-30 | Washington State University Research Foundation | Desaturases and methods of using them for synthesis of polyunsaturated fatty acids |
| EP1088552B1 (en) * | 1999-09-30 | 2006-04-19 | Loders Croklaan B.V. | Compositions containing pinolenic acid and its use a health component |
| EP1279400A1 (en) | 2001-07-25 | 2003-01-29 | Target Hit sa | Modifying the fatty acid composition of cell membranes of organs and tissues |
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| WO2004018598A1 (ja) | 2002-08-07 | 2004-03-04 | Kao Corporation | 油脂組成物 |
| AU2003301007B2 (en) | 2002-12-20 | 2008-01-31 | The Procter & Gamble Company | Tufted laminate web |
| US7125672B2 (en) | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
| US7238482B2 (en) * | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US8313911B2 (en) * | 2003-05-07 | 2012-11-20 | E I Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7214491B2 (en) | 2003-05-07 | 2007-05-08 | E. I. Du Pont De Nemours And Company | Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts |
| US7267976B2 (en) | 2003-07-02 | 2007-09-11 | E.I. Du Pont De Nemours And Company | Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts |
| US7504259B2 (en) * | 2003-11-12 | 2009-03-17 | E. I. Du Pont De Nemours And Company | Δ12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast |
| US7550651B2 (en) | 2004-06-25 | 2009-06-23 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7465564B2 (en) | 2004-08-10 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Production of γ-linolenic acid in oleaginous yeast |
| US7550286B2 (en) * | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
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| WO2007061742A1 (en) | 2005-11-23 | 2007-05-31 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| US20070225370A1 (en) | 2006-03-21 | 2007-09-27 | Joar Opheim | Nutritional Compositions and Methods |
| US7943823B2 (en) | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7709239B2 (en) | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| DK2129777T3 (en) | 2007-04-03 | 2016-01-25 | Du Pont | MULTIZYMER AND USE THEREOF FOR THE PRODUCTION OF polyunsaturated fatty acids |
| US8188338B2 (en) * | 2007-04-10 | 2012-05-29 | E. I. Du Pont De Nemours And Company | Delta-8 desaturases and their use in making polyunsaturated fatty acids |
-
2008
- 2008-10-03 US US12/244,822 patent/US8323935B2/en active Active
- 2008-10-03 WO PCT/US2008/078642 patent/WO2009046231A1/en not_active Ceased
- 2008-10-03 EP EP08835977A patent/EP2195415A1/en not_active Withdrawn
- 2008-10-03 CN CN200880118875.4A patent/CN101970638B/zh not_active Expired - Fee Related
- 2008-10-03 JP JP2010528141A patent/JP5711968B2/ja not_active Expired - Fee Related
- 2008-10-03 US US12/244,950 patent/US20090117253A1/en not_active Abandoned
- 2008-10-03 CA CA2701094A patent/CA2701094A1/en not_active Abandoned
-
2012
- 2012-07-20 US US13/554,429 patent/US8735108B2/en active Active
-
2013
- 2013-02-28 US US13/780,532 patent/US8822185B2/en active Active
-
2014
- 2014-07-22 US US14/337,593 patent/US9617571B2/en active Active
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