JP2011041833A - 脈管分岐部を治療する内部人工器官展開システム - Google Patents
脈管分岐部を治療する内部人工器官展開システム Download PDFInfo
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Abstract
【解決手段】 特に、1対の異種ステント(12、14)を備え、その一方が分岐部(30)のすぐ近くで血管の広がった部分を治療するのに特に適しているステントシステム(10)と、ステント(12、14)を選択的に送出するように適合されているハンドピース(102)を含むステント送出システム(100)が開示される。
【選択図】 図1
Description
IIb/IIIa阻害剤(例えばインターグリリン、アブシキマブ)、セラトニンアンタゴニスト、および5−HT吸収阻害剤;コレステロール低下剤;血管拡張剤;および内因性血管活性メカニズムを妨害する薬剤が挙げられる。ポリヌクレオチドのシーケンスは、p15、p16、p18、p19、p21、p27、p53、p57、Rb、nFkBおよびE2Fデコイなどの抗再狭窄剤、チミジンキナーゼ(「TK」)およびそれらの組み合わせ、ならびに細胞増殖の妨害に有用な他の薬剤としても機能する。活性物質の選択は、所望の臨床結果、および特定の患者の病状および禁忌の性質を考慮して行うことができる。
Claims (36)
- 近位端および遠位端を有する、細長い可撓性の本体と、
第1の構成を有する、本体上の第1ステントと、
第2の異なる構成を有する、本体上の第2ステントとを備える展開システム。 - 前記ステントを前記可撓性本体上に保持するための着脱式抑制部を備える、請求項1に記載の展開システム。
- さらに、少なくとも1つのステントを拡張するために少なくとも1つの膨張性バルーンを備える、前記請求項のいずれかに記載の展開システム。
- さらに、前記可撓性本体の少なくとも一部を通って軸方向に延びるガイドワイヤ管腔を備える、前記請求項のいずれかに記載の展開システム。
- 前記ガイドワイヤ管腔が近位アクセス口および遠位アクセス口を有し、
前記近位アクセス口が前記可撓性本体に沿って、前記近位端から遠位方向に間隔をおいて配置される、前記請求項のいずれかに記載の展開システム。 - 前記ガイドワイヤ管腔が近位アクセス口および遠位アクセス口を有し、
前記近位アクセス口が前記可撓性本体の近位端に配置される、前記請求項のいずれかに記載の展開システム。 - 前記着脱式抑制部が、軸方向に移動可能で、前記可撓性本体の長さ方向に沿って延びる制御要素を備える、前記請求項のいずれかに記載の展開システム。
- 前記着脱式抑制部が管状の外装を備える、前記請求項のいずれかに記載の展開システム。
- 前記着脱式抑制部が引っ張りワイヤを備える、前記請求項のいずれかに記載の展開システム。
- 前記着脱式抑制部が溶解性の中膜を備える、前記請求項のいずれかに記載の展開システム。
- 前記第1および第2ステントが異なる幾何学的拡張形状を有する、前記請求項のいずれかに記載の展開システム。
- 前記第1ステントが、近位端、遠位端および全体を通して実質的に一定の半径を有する、実質的に円筒形の抑制されていない拡張形状を有する、前記請求項のいずれかに記載の展開システム。
- 前記第2ステントが、近位端が遠位端より小さい直径を有する、抑制されていない拡張形状を有する、前記請求項のいずれかに記載の展開システム。
- 前記第2ステントの拡張した直径が、前記遠位方向に放射状に外側にテーパ状になる、前記請求項のいずれかに記載の展開システム。
- 前記第1および第2ステントが、ステントをカテーテルから外すと、前記第1ステントの近位端および前記第2ステントの遠位端が、植え込まれた状態で、約4mm以内の距離だけ分離されるように、カテーテルによって運ばれる、前記請求項のいずれかに記載の展開システム。
- 前記第1ステントの近位端と前記第2ステントの遠位端との間の距離が約2mm以内である、前記請求項のいずれかに記載の展開システム。
- 前記第1ステントの近位端と前記第2ステントの遠位端との間の距離が約1mm以内である、前記請求項のいずれかに記載の展開システム。
- 前記近位端上のハンドピースと、前記ハンドピース上の制御装置とを備え、
前記制御装置が、前記第1ステントの部分的展開を示す第1位置と、前記第1ステントの完全な展開を示す第2位置とを有する、前記請求項のいずれかに記載の展開システム。 - 前記制御装置がさらに、前記第2ステントの部分的展開を示す第3位置を備える、前記請求項のいずれかに記載の展開システム。
- 前記制御装置がさらに、前記第2ステントの完全な展開を示す第4位置を備える、前記請求項のいずれかに記載の展開システム。
- 主要脈管の第1および第2枝脈管への脈管分岐部の近傍で第1および第2ステントを展開する方法であって、
その上に第1および第2ステントを有する送出カテーテルを用意する工程と、
前記第1および第2ステントが前記分岐部の近傍にくるように、前記カテーテルを配置する工程と、
前記第1ステントを枝脈管に、前記第2ステントを前記主要脈管に展開する工程とを含み、
前記第2ステントが、近位端で第1直径まで、遠位端でこれより大きい第2直径まで拡張する方法。 - 前記展開工程が、前記ステントの少なくとも1つの中でバルーンを膨張させることを含む、請求項21に記載の方法。
- 前記展開工程が、少なくとも1つのステントの自己拡張を可能にすることを含む、請求項21または22に記載の方法。
- 前記第2ステントの遠位端が、前記第1ステントの近位端の近傍に配置される、請求項21〜23のいずれかに記載の方法。
- 前記第2ステントの遠位端が、前記第1ステントの近位端より大きい直径にまで拡張する、請求項21〜24のいずれかに記載の方法。
- 前記第2ステントの遠位端が、前記第1ステントの近位端の直径の少なくとも約110%の直径にまで拡張する、請求項21〜25のいずれかに記載の方法。
- 前記第2ステントの遠位端が、前記第1ステントの近位端の直径の少なくとも約105%の直径にまで拡張する、請求項21〜26のいずれかに記載の方法。
- さらに、
実質的に円筒形のステントを第1枝脈管に展開する工程と、
テーパ状のステントを前記主要脈管に展開する工程とを含み、
前記実質的に円筒形のステントと前記テーパ状のステントとの両方が、同じカテーテルから展開される、請求項21〜27のいずれかに記載の方法。 - 前記実質的に円筒形のステントと前記テーパ状のステントの少なくとも一方が、送出カテーテルの外装を近位方向に後退させることによって、送出カテーテルから展開される、請求項21〜28のいずれかに記載の脈管分岐部を治療する方法。
- 前記テーパ状のステントが、相対的により小さい直径の第1端とより大きい直径の第2端とを有し、
前記円筒形のステントが、前記第2端に隣接して配置される、請求項21〜29のいずれかに記載の脈管分岐部を治療する方法。 - さらに、
前記分岐部の近傍に前記カテーテルを配置する工程と、
前記第1ステントを前記第1枝脈管に部分的に展開する工程と、
前記第1ステントの位置を視覚化できるように造影剤を導入する工程と、
前記第1ステントを前記第1枝脈管に完全に展開する工程とを含む、請求項21〜30のいずれかに記載の方法。 - さらに、前記第2ステントを前記主要脈管に部分的に展開する工程を含む、請求項21〜31のいずれかに記載の分岐部を治療する方法。
- さらに、前記主要脈管に部分的に展開した前記第2ステントを視覚化できるように造影剤を導入する工程を含む、請求項21〜32のいずれかに記載の分岐部を治療する方法。
- さらに、前記第2ステントを前記主要脈管に完全に展開する工程を含む、請求項21〜33のいずれかに記載の分岐部を治療する方法。
- 前記第1ステントを完全に展開する工程が、管状の外装を近位方向に後退させることを含む、請求項21〜34のいずれかに記載の分岐部を治療する方法。
- 前記第2ステントを完全に展開する工程が、前記管状の外装を近位方向に後退させることを含む、請求項21〜35のいずれかに記載の分岐部を治療する方法。
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US20050096726A1 (en) | 2005-05-05 |
US20030125791A1 (en) | 2003-07-03 |
US7238197B2 (en) | 2007-07-03 |
US20080046064A1 (en) | 2008-02-21 |
AU2009202028B2 (en) | 2011-03-24 |
US20070100425A1 (en) | 2007-05-03 |
JP2005536284A (ja) | 2005-12-02 |
US7125419B2 (en) | 2006-10-24 |
AU2003259932C1 (en) | 2009-09-03 |
US8603157B2 (en) | 2013-12-10 |
US8236041B2 (en) | 2012-08-07 |
CA2495234A1 (en) | 2004-03-04 |
US20030114912A1 (en) | 2003-06-19 |
WO2004017865A1 (en) | 2004-03-04 |
CA2495234C (en) | 2011-10-04 |
AU2009202028A2 (en) | 2009-07-02 |
AU2003259932A1 (en) | 2004-03-11 |
US7686845B2 (en) | 2010-03-30 |
AU2003259932B2 (en) | 2009-03-05 |
EP1539042A1 (en) | 2005-06-15 |
AU2009202028A1 (en) | 2009-06-11 |
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