JP2011006427A5 - - Google Patents
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- Publication number
- JP2011006427A5 JP2011006427A5 JP2010173057A JP2010173057A JP2011006427A5 JP 2011006427 A5 JP2011006427 A5 JP 2011006427A5 JP 2010173057 A JP2010173057 A JP 2010173057A JP 2010173057 A JP2010173057 A JP 2010173057A JP 2011006427 A5 JP2011006427 A5 JP 2011006427A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- sugar
- hydrogen
- adjacent
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000178 monomer Substances 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 11
- 229940079593 drug Drugs 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 claims 2
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical group C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 claims 1
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 claims 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 244000299461 Theobroma cacao Species 0.000 claims 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 claims 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 claims 1
- 235000013361 beverage Nutrition 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 claims 1
- 235000001046 cacaotero Nutrition 0.000 claims 1
- 235000004883 caffeic acid Nutrition 0.000 claims 1
- 229940074360 caffeic acid Drugs 0.000 claims 1
- 125000004403 catechin group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000013985 cinnamic acid Nutrition 0.000 claims 1
- 229930016911 cinnamic acid Natural products 0.000 claims 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 claims 1
- 229940119429 cocoa extract Drugs 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims 1
- 235000001785 ferulic acid Nutrition 0.000 claims 1
- 229940114124 ferulic acid Drugs 0.000 claims 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 229930182830 galactose Natural products 0.000 claims 1
- 229940074391 gallic acid Drugs 0.000 claims 1
- 235000004515 gallic acid Nutrition 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002417 nutraceutical Substances 0.000 claims 1
- 235000021436 nutraceutical agent Nutrition 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- PCMORTLOPMLEFB-ONEGZZNKSA-N sinapic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-ONEGZZNKSA-N 0.000 claims 1
- PCMORTLOPMLEFB-UHFFFAOYSA-N sinapinic acid Natural products COC1=CC(C=CC(O)=O)=CC(OC)=C1O PCMORTLOPMLEFB-UHFFFAOYSA-N 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
- 230000024883 vasodilation Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63166196A | 1996-04-02 | 1996-04-02 | |
| PCT/US1996/004497 WO1997036597A1 (en) | 1996-04-02 | 1996-04-02 | Cocoa extract compounds and methods for making and using the same |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9535612A Division JP2000506901A (ja) | 1996-04-02 | 1997-04-02 | カカオ抽出化合物及び同一物を製造及び使用するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011006427A JP2011006427A (ja) | 2011-01-13 |
| JP2011006427A5 true JP2011006427A5 (enExample) | 2011-08-11 |
Family
ID=26790948
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9535612A Pending JP2000506901A (ja) | 1996-04-02 | 1997-04-02 | カカオ抽出化合物及び同一物を製造及び使用するための方法 |
| JP2010173057A Pending JP2011006427A (ja) | 1996-04-02 | 2010-07-30 | カカオ抽出化合物及び同一物を製造及び使用するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9535612A Pending JP2000506901A (ja) | 1996-04-02 | 1997-04-02 | カカオ抽出化合物及び同一物を製造及び使用するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP2110134A1 (enExample) |
| JP (2) | JP2000506901A (enExample) |
| CN (1) | CN1159019C (enExample) |
| AU (1) | AU742198B2 (enExample) |
| BR (1) | BR9710955A (enExample) |
| CA (1) | CA2250792C (enExample) |
| PL (1) | PL329325A1 (enExample) |
| RU (1) | RU2010111103A (enExample) |
| WO (1) | WO1997036497A2 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6696485B1 (en) | 1996-04-02 | 2004-02-24 | Mars, Incorporated | Procyanidin and cyclo-oxygenase modulator compositions |
| US7968140B2 (en) | 1997-09-08 | 2011-06-28 | Mars, Incorporated | Chocolates and chocolate liquor having an enhanced polyphenol content |
| US6312753B1 (en) | 1996-09-06 | 2001-11-06 | Mars, Incorporated | Cocoa components, edible products having enriched polyphenol content, methods of making same and medical uses |
| US6207842B1 (en) * | 1997-10-09 | 2001-03-27 | Mars Incorporated | Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives |
| AU2004200273B2 (en) * | 1998-03-12 | 2008-02-07 | Mars, Incorporated | Products Containing Polyphenol(s) and L-Arginine to stimulate nitric oxide production |
| US8507018B2 (en) | 1998-03-12 | 2013-08-13 | Mars, Incorporated | Products containing polyphenol(s) and L-arginine and methods of use thereof |
| US6805883B2 (en) | 1998-03-12 | 2004-10-19 | Mars, Incorporated | Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide |
| EP1894566A1 (en) * | 1998-03-12 | 2008-03-05 | Mars, Incorporated | Products containing polyphenol(s) and L-arginine to stimulate nitric oxide production |
| US7011856B2 (en) * | 1998-08-05 | 2006-03-14 | Amino Up Chemical Co., Ltd. | Composition for the treatment of symptoms and conditions associated with aging |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| CN1262281C (zh) | 1999-03-17 | 2006-07-05 | 森永制果株式会社 | 含有可可组分的药品、饮食品和饲料 |
| JP3260134B2 (ja) | 1999-10-08 | 2002-02-25 | 信孝 鈴木 | 月経困難症、子宮内膜症の治療薬 |
| CA2403691C (en) * | 2000-03-22 | 2011-02-01 | Harold H. Schmitz | The use of cocoa procyanidins combined with acetylsalicylic acid as an anti-platelet therapy |
| MXPA02009956A (es) * | 2000-04-14 | 2003-02-12 | Mars Inc | Composiciones y metodos para mejorar la salud vascular. |
| US6627232B1 (en) * | 2000-06-09 | 2003-09-30 | Mars Incorporated | Method for extracting cocoa procyanidins |
| DE10037983B4 (de) | 2000-08-03 | 2006-04-13 | Stefan Zikeli | Polymerzusammensetzung und daraus hergestellter Formkörper mit einem Gehalt an Alkaloid |
| FR2812873B1 (fr) | 2000-08-11 | 2003-08-01 | Barry Callebaut France | Procede de production de polyphenols a partir de feves de cacao |
| JP4763139B2 (ja) * | 2001-02-21 | 2011-08-31 | 株式会社アミノアップ化学 | 新規な多価フェノール重合体及びその用途 |
| AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
| US7972632B2 (en) | 2003-02-28 | 2011-07-05 | Unigen Pharmaceuticals, Inc. | Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors |
| US7108868B2 (en) | 2002-03-22 | 2006-09-19 | Unigen Pharmaceuticals, Inc. | Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia |
| US7514107B2 (en) * | 2002-03-21 | 2009-04-07 | Mars, Incorporated | Treatment of diseases involving defective gap junctional communication |
| FR2838055B1 (fr) * | 2002-04-05 | 2006-06-09 | Cep | Nouvelle utilisation d'un extrait de cacao et les compositions cosmetiques et/ou dermatologiques a cet effet |
| US8034387B2 (en) | 2002-04-30 | 2011-10-11 | Unigen, Inc. | Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
| US8945518B2 (en) | 2002-04-30 | 2015-02-03 | Unigen, Inc. | Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions |
| NZ535988A (en) | 2002-04-30 | 2005-09-30 | Unigen Pharmaceuticals Inc | Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent |
| KR20030097398A (ko) * | 2002-06-21 | 2003-12-31 | 이노천 | 양념육용 폴리페놀을 함유한 소스 |
| AU2004228021B2 (en) | 2003-04-04 | 2010-09-02 | Unigen, Inc. | Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care |
| TWI279231B (en) * | 2003-10-02 | 2007-04-21 | Asahi Breweries Ltd | Neutralization agent of vacuolization toxin |
| CN1889944A (zh) * | 2003-10-10 | 2007-01-03 | 马尔斯公司 | ErbB2激酶过量表达相关疾病的治疗 |
| CA2554071C (en) * | 2004-01-28 | 2013-05-07 | Mars, Incorporated | A-type procyanidins useful in the treatment of nitric oxide mediated disorders |
| BRPI0607773B1 (pt) | 2005-02-25 | 2019-07-23 | Nagasaki University | Método para produção de um oligômero de proantocianidina |
| JP4681363B2 (ja) * | 2005-03-04 | 2011-05-11 | 美智士 谷 | 悪性腫瘍治療剤及びそれを含む飲食品 |
| JP4942953B2 (ja) * | 2005-06-30 | 2012-05-30 | サントリーホールディングス株式会社 | プロシアニジンの分析方法 |
| KR100761248B1 (ko) | 2006-10-12 | 2007-10-04 | 주식회사 유니젠 | 대나무 및 황금 추출물을 유효성분으로 함유하는 아토피성피부염 치료를 위한 조성물 |
| US8609174B2 (en) | 2006-11-17 | 2013-12-17 | Barry Callebaut Ag | Method for producing a soluble cocoa product from cocoa powder |
| US8372456B2 (en) | 2006-11-17 | 2013-02-12 | Barry Callebaut Ag | Method for producing a soluble cocoa product from cocoa powder |
| GB0724716D0 (en) | 2007-12-19 | 2008-01-30 | Barry Callebaut Ag | Process |
| GB0801119D0 (en) | 2008-01-22 | 2008-02-27 | Barry Callebaut Ag | Composition |
| FR2927811B1 (fr) * | 2008-02-27 | 2010-09-10 | Unither Dev | Colorant pharmaceutique extrait de cranberry concentre en proanthocyanidines a. |
| JP5462491B2 (ja) * | 2009-01-21 | 2014-04-02 | 株式会社 エフェクト | プロアントシアニジン三量体 |
| KR20120059451A (ko) | 2009-04-03 | 2012-06-08 | 다이아나플랜트사이언스, 아이엔씨. | 식물 세포 배양 유래 프로시아니딘의 생산 및 추출 |
| JP5569716B2 (ja) * | 2009-06-23 | 2014-08-13 | 独立行政法人国立循環器病研究センター | レクチン様酸化ｌｄｌ受容体阻害用医薬品 |
| WO2011073950A1 (en) * | 2009-12-17 | 2011-06-23 | National University Of Singapore | Method of preparing derivatives/oligomers of epicatechin and applications thereof |
| US8623442B2 (en) | 2010-03-05 | 2014-01-07 | Mars, Incorporated. | Palatable beverages and compositions with cocoa extract |
| CN103237457A (zh) | 2010-10-04 | 2013-08-07 | 戴安娜植物科学有限公司 | 从植物细胞培养物产生和提取原花青素 |
| WO2012078797A1 (en) * | 2010-12-07 | 2012-06-14 | The Hershey Company | Compounds influencing fatty acid uptake and metabolism and the production of inflammatory agents and methods of isolating them from cocoa products |
| CN103561585B (zh) * | 2011-02-08 | 2016-05-25 | 产品制造者(澳大利亚)有限公司 | 糖提取物 |
| US20150027477A1 (en) * | 2012-02-16 | 2015-01-29 | Kamata Co., Ltd. | Filter containing built-in capsule, cigarette provided with filter and cigarette substitute provided with filter |
| ITTV20120064A1 (it) * | 2012-04-19 | 2013-10-20 | R I Group Srl | Estratto per trattamento delle cefalee primitive |
| CN103113384B (zh) * | 2013-02-27 | 2015-05-20 | 安徽农业大学 | 一种名为茯砖素b的儿茶素类衍生物及其制备方法和应用 |
| WO2016046375A1 (en) * | 2014-09-25 | 2016-03-31 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Theobroma cacao extract for use in the treatment or prevention of receptor tyrosine kinases related disorders |
| TW201733605A (zh) * | 2016-02-29 | 2017-10-01 | 明治股份有限公司 | 可可水萃物、含它之飲食品、可可萃取物之製造方法、及多酚之萃取方法 |
| EP3747276B1 (en) | 2019-06-04 | 2024-11-06 | ODC Lizenz AG | Cocoa-based frozen desserts and methods of their manufacture |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1584725A (enExample) * | 1968-01-30 | 1970-01-02 | ||
| GB1575004A (en) * | 1976-03-23 | 1980-09-17 | Iverni Della Beffa Spa | Pharmacologically active polyphenolic substances |
| JPS6011912B2 (ja) * | 1981-07-30 | 1985-03-28 | 日本新薬株式会社 | タンニン |
| JPS58154571A (ja) * | 1982-03-08 | 1983-09-14 | Nippon Shinyaku Co Ltd | 新規タンニン |
| JPS6116982A (ja) * | 1984-07-03 | 1986-01-24 | Kikkoman Corp | 抗酸化剤 |
| NL8403748A (nl) * | 1984-12-10 | 1986-07-01 | Zaan Cacaofab Bv | Cacaopoeder. |
| US4698360B1 (en) * | 1985-04-09 | 1997-11-04 | D Investigations Pharmacologiq | Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof |
| GB8518289D0 (en) * | 1985-07-19 | 1985-08-29 | Inverni Della Beffa Spa | Obtaining proanthocyanidine a2 |
| JPS6425726A (en) * | 1987-04-24 | 1989-01-27 | Yuutoku Yakuhin Kogyo Kk | Agent for eliminating active oxygen free radical |
| FR2618675B1 (fr) * | 1987-07-30 | 1990-03-23 | Bonnaure Mallet Martine | Composition pharmaceutique destinee au traitement des maladies parodontales comportant a titre de principe actif, au moins un monomere et/ou oligomere procyanidolique |
| US5650432A (en) * | 1995-03-24 | 1997-07-22 | Jlb, Inc. | Method of treating or preventing non-viral microbial infection |
| FR2706478B1 (fr) * | 1993-06-14 | 1995-09-08 | Ovi Sa | Compositions de dérivés phénoliques, leur préparation et leurs applications comme anti-oxydants. |
| CA2128293C (en) * | 1993-12-06 | 2002-09-03 | Masayuki Tanabe | Fruit polyphenols and medicinal compositions containing them |
| US5554645A (en) * | 1994-10-03 | 1996-09-10 | Mars, Incorporated | Antineoplastic cocoa extracts and methods for making and using the same |
-
1997
- 1997-04-02 PL PL97329325A patent/PL329325A1/xx not_active Application Discontinuation
- 1997-04-02 AU AU33674/97A patent/AU742198B2/en not_active Expired
- 1997-04-02 EP EP08020626A patent/EP2110134A1/en not_active Withdrawn
- 1997-04-02 CA CA2250792A patent/CA2250792C/en not_active Expired - Lifetime
- 1997-04-02 CN CNB971951810A patent/CN1159019C/zh not_active Expired - Lifetime
- 1997-04-02 EP EP97929671A patent/EP1015006A4/en not_active Ceased
- 1997-04-02 BR BR9710955-0A patent/BR9710955A/pt not_active Application Discontinuation
- 1997-04-02 JP JP9535612A patent/JP2000506901A/ja active Pending
- 1997-04-02 WO PCT/US1997/005693 patent/WO1997036497A2/en not_active Ceased
-
2010
- 2010-03-23 RU RU2010111103/15A patent/RU2010111103A/ru not_active Application Discontinuation
- 2010-07-30 JP JP2010173057A patent/JP2011006427A/ja active Pending
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