RU2010111103A - Соединения экстракта какао и способы их получения и применения - Google Patents
Соединения экстракта какао и способы их получения и применения Download PDFInfo
- Publication number
- RU2010111103A RU2010111103A RU2010111103/15A RU2010111103A RU2010111103A RU 2010111103 A RU2010111103 A RU 2010111103A RU 2010111103/15 A RU2010111103/15 A RU 2010111103/15A RU 2010111103 A RU2010111103 A RU 2010111103A RU 2010111103 A RU2010111103 A RU 2010111103A
- Authority
- RU
- Russia
- Prior art keywords
- cocoa
- composition
- food product
- epicatechin
- clause
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 59
- 150000001875 compounds Chemical class 0.000 title claims abstract 7
- 229940119429 cocoa extract Drugs 0.000 title claims abstract 6
- 239000000203 mixture Substances 0.000 claims abstract 18
- 239000000178 monomer Substances 0.000 claims abstract 12
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 claims abstract 11
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 claims abstract 11
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 claims abstract 11
- 235000012734 epicatechin Nutrition 0.000 claims abstract 11
- 229920000642 polymer Polymers 0.000 claims abstract 6
- 241001465754 Metazoa Species 0.000 claims abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 3
- 206010020772 Hypertension Diseases 0.000 claims abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 3
- 230000003647 oxidation Effects 0.000 claims abstract 2
- 238000007254 oxidation reaction Methods 0.000 claims abstract 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims abstract 2
- 244000299461 Theobroma cacao Species 0.000 claims 27
- 235000009470 Theobroma cacao Nutrition 0.000 claims 18
- 235000013305 food Nutrition 0.000 claims 17
- 235000019219 chocolate Nutrition 0.000 claims 9
- 239000007787 solid Substances 0.000 claims 9
- 239000000047 product Substances 0.000 claims 4
- 235000009508 confectionery Nutrition 0.000 claims 3
- 235000015872 dietary supplement Nutrition 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 239000000843 powder Substances 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 2
- 230000024883 vasodilation Effects 0.000 claims 2
- 230000036772 blood pressure Effects 0.000 claims 1
- ZWWCURLKEXEFQT-UHFFFAOYSA-N dinitrogen pentaoxide Chemical compound [O-][N+](=O)O[N+]([O-])=O ZWWCURLKEXEFQT-UHFFFAOYSA-N 0.000 claims 1
- 210000003038 endothelium Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000001196 vasorelaxation Effects 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
- C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63166196A | 1996-04-02 | 1996-04-02 | |
| US08/631,661 | 1996-04-02 | ||
| PCT/US1996/004497 WO1997036597A1 (en) | 1996-04-02 | 1996-04-02 | Cocoa extract compounds and methods for making and using the same |
| WOPCT/US96/04497 | 1996-04-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004103873/15A Division RU2394562C2 (ru) | 1996-04-02 | 2004-02-10 | Соединение экстракта какао и способы их получения и применения |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010111103A true RU2010111103A (ru) | 2011-09-27 |
Family
ID=26790948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010111103/15A RU2010111103A (ru) | 1996-04-02 | 2010-03-23 | Соединения экстракта какао и способы их получения и применения |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP1015006A4 (enExample) |
| JP (2) | JP2000506901A (enExample) |
| CN (1) | CN1159019C (enExample) |
| AU (1) | AU742198B2 (enExample) |
| BR (1) | BR9710955A (enExample) |
| CA (1) | CA2250792C (enExample) |
| PL (1) | PL329325A1 (enExample) |
| RU (1) | RU2010111103A (enExample) |
| WO (1) | WO1997036497A2 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6696485B1 (en) | 1996-04-02 | 2004-02-24 | Mars, Incorporated | Procyanidin and cyclo-oxygenase modulator compositions |
| US7968140B2 (en) | 1997-09-08 | 2011-06-28 | Mars, Incorporated | Chocolates and chocolate liquor having an enhanced polyphenol content |
| US6312753B1 (en) | 1996-09-06 | 2001-11-06 | Mars, Incorporated | Cocoa components, edible products having enriched polyphenol content, methods of making same and medical uses |
| US6207842B1 (en) * | 1997-10-09 | 2001-03-27 | Mars Incorporated | Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives |
| AU2004200273B2 (en) * | 1998-03-12 | 2008-02-07 | Mars, Incorporated | Products Containing Polyphenol(s) and L-Arginine to stimulate nitric oxide production |
| US8507018B2 (en) | 1998-03-12 | 2013-08-13 | Mars, Incorporated | Products containing polyphenol(s) and L-arginine and methods of use thereof |
| US6805883B2 (en) | 1998-03-12 | 2004-10-19 | Mars, Incorporated | Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide |
| RU2269268C2 (ru) * | 1998-03-12 | 2006-02-10 | Марс, Инкорпорейтед | Продукты, содержащие полифенол(ы) и l-аргинин, для стимуляции продукции окиси азота |
| US7011856B2 (en) * | 1998-08-05 | 2006-03-14 | Amino Up Chemical Co., Ltd. | Composition for the treatment of symptoms and conditions associated with aging |
| US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| WO2000054792A1 (en) * | 1999-03-17 | 2000-09-21 | Morinaga & Co., Ltd. | Drugs, foods, drinks and feeds containing cocoa component |
| JP3260134B2 (ja) | 1999-10-08 | 2002-02-25 | 信孝 鈴木 | 月経困難症、子宮内膜症の治療薬 |
| US6524630B2 (en) * | 2000-03-22 | 2003-02-25 | Mars, Incorporated | Use of cocoa procyanidins combined with acelylsalicyclic acid as an anti-platelet therapy |
| WO2001078529A2 (en) * | 2000-04-14 | 2001-10-25 | Mars, Incorporated | Compositions and methods for improving vascular health |
| US6627232B1 (en) * | 2000-06-09 | 2003-09-30 | Mars Incorporated | Method for extracting cocoa procyanidins |
| DE10037983B4 (de) | 2000-08-03 | 2006-04-13 | Stefan Zikeli | Polymerzusammensetzung und daraus hergestellter Formkörper mit einem Gehalt an Alkaloid |
| FR2812873B1 (fr) | 2000-08-11 | 2003-08-01 | Barry Callebaut France | Procede de production de polyphenols a partir de feves de cacao |
| JP4763139B2 (ja) * | 2001-02-21 | 2011-08-31 | 株式会社アミノアップ化学 | 新規な多価フェノール重合体及びその用途 |
| AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
| US7972632B2 (en) | 2003-02-28 | 2011-07-05 | Unigen Pharmaceuticals, Inc. | Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors |
| US7108868B2 (en) * | 2002-03-22 | 2006-09-19 | Unigen Pharmaceuticals, Inc. | Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia |
| US7514107B2 (en) * | 2002-03-21 | 2009-04-07 | Mars, Incorporated | Treatment of diseases involving defective gap junctional communication |
| FR2838055B1 (fr) * | 2002-04-05 | 2006-06-09 | Cep | Nouvelle utilisation d'un extrait de cacao et les compositions cosmetiques et/ou dermatologiques a cet effet |
| US8034387B2 (en) | 2002-04-30 | 2011-10-11 | Unigen, Inc. | Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
| US8945518B2 (en) | 2002-04-30 | 2015-02-03 | Unigen, Inc. | Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions |
| CA2484192C (en) | 2002-04-30 | 2012-10-02 | Unigen Pharmaceuticals, Inc. | Formulation of a mixture of free-b-ring flavonoids and flavans as a therapeutic agent |
| KR20030097398A (ko) * | 2002-06-21 | 2003-12-31 | 이노천 | 양념육용 폴리페놀을 함유한 소스 |
| US20040220119A1 (en) | 2003-04-04 | 2004-11-04 | Unigen Pharmaceuticals, Inc. | Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care |
| TWI279231B (en) * | 2003-10-02 | 2007-04-21 | Asahi Breweries Ltd | Neutralization agent of vacuolization toxin |
| JP2007508316A (ja) * | 2003-10-10 | 2007-04-05 | マーズ インコーポレイテッド | ＥｒｂＢ２キナーゼ過剰発現に関連する病気の治療 |
| AU2005209317B2 (en) * | 2004-01-28 | 2011-07-07 | Mars, Incorporated | Compositions and methods of use of A-type procyanidins |
| CA2599295C (en) * | 2005-02-25 | 2014-10-14 | Nagasaki University | Method of producing proanthocyanidin oligomer |
| JP4681363B2 (ja) * | 2005-03-04 | 2011-05-11 | 美智士 谷 | 悪性腫瘍治療剤及びそれを含む飲食品 |
| JP4942953B2 (ja) * | 2005-06-30 | 2012-05-30 | サントリーホールディングス株式会社 | プロシアニジンの分析方法 |
| KR100761248B1 (ko) | 2006-10-12 | 2007-10-04 | 주식회사 유니젠 | 대나무 및 황금 추출물을 유효성분으로 함유하는 아토피성피부염 치료를 위한 조성물 |
| US8609174B2 (en) | 2006-11-17 | 2013-12-17 | Barry Callebaut Ag | Method for producing a soluble cocoa product from cocoa powder |
| ES2401926T3 (es) | 2006-11-17 | 2013-04-25 | Barry Callebaut Ag | Método para la producción de un producto de cacao soluble a partir de cacao en polvo |
| GB0724716D0 (en) | 2007-12-19 | 2008-01-30 | Barry Callebaut Ag | Process |
| GB0801119D0 (en) | 2008-01-22 | 2008-02-27 | Barry Callebaut Ag | Composition |
| FR2927811B1 (fr) * | 2008-02-27 | 2010-09-10 | Unither Dev | Colorant pharmaceutique extrait de cranberry concentre en proanthocyanidines a. |
| JP5462491B2 (ja) * | 2009-01-21 | 2014-04-02 | 株式会社 エフェクト | プロアントシアニジン三量体 |
| CN102414312A (zh) | 2009-04-03 | 2012-04-11 | 戴安娜植物科学有限公司 | 从植物细胞培养物中生产和抽提原花青素 |
| US9167840B2 (en) | 2009-04-03 | 2015-10-27 | DianaPlantScience, Inc. | Production and extraction of procyanidins from plant cell cultures |
| JP5569716B2 (ja) * | 2009-06-23 | 2014-08-13 | 独立行政法人国立循環器病研究センター | レクチン様酸化ｌｄｌ受容体阻害用医薬品 |
| CN102933569A (zh) * | 2009-12-17 | 2013-02-13 | 新加坡国立大学 | 表儿茶素衍生物/低聚物的制备方法及其应用 |
| JP5801327B2 (ja) | 2010-03-05 | 2015-10-28 | マース インコーポレーテッドＭａｒｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | カカオ抽出物を含む美味しい飲料および組成物 |
| WO2012078797A1 (en) * | 2010-12-07 | 2012-06-14 | The Hershey Company | Compounds influencing fatty acid uptake and metabolism and the production of inflammatory agents and methods of isolating them from cocoa products |
| AU2012214104C1 (en) * | 2011-02-08 | 2017-08-03 | Poly Gain Pte Ltd | Sugar extracts |
| WO2013121608A1 (ja) * | 2012-02-16 | 2013-08-22 | 株式会社カマタ | カプセル内蔵フィルターとこのフィルターを備えたタバコ及びタバコ代用品 |
| ITTV20120064A1 (it) * | 2012-04-19 | 2013-10-20 | R I Group Srl | Estratto per trattamento delle cefalee primitive |
| CN103113384B (zh) * | 2013-02-27 | 2015-05-20 | 安徽农业大学 | 一种名为茯砖素b的儿茶素类衍生物及其制备方法和应用 |
| WO2016046375A1 (en) * | 2014-09-25 | 2016-03-31 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Theobroma cacao extract for use in the treatment or prevention of receptor tyrosine kinases related disorders |
| TW201733605A (zh) * | 2016-02-29 | 2017-10-01 | 明治股份有限公司 | 可可水萃物、含它之飲食品、可可萃取物之製造方法、及多酚之萃取方法 |
| EP3747276B1 (en) | 2019-06-04 | 2024-11-06 | ODC Lizenz AG | Cocoa-based frozen desserts and methods of their manufacture |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1584725A (enExample) * | 1968-01-30 | 1970-01-02 | ||
| GB1575004A (en) * | 1976-03-23 | 1980-09-17 | Iverni Della Beffa Spa | Pharmacologically active polyphenolic substances |
| JPS6011912B2 (ja) * | 1981-07-30 | 1985-03-28 | 日本新薬株式会社 | タンニン |
| JPS58154571A (ja) * | 1982-03-08 | 1983-09-14 | Nippon Shinyaku Co Ltd | 新規タンニン |
| JPS6116982A (ja) * | 1984-07-03 | 1986-01-24 | Kikkoman Corp | 抗酸化剤 |
| NL8403748A (nl) * | 1984-12-10 | 1986-07-01 | Zaan Cacaofab Bv | Cacaopoeder. |
| US4698360B1 (en) * | 1985-04-09 | 1997-11-04 | D Investigations Pharmacologiq | Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof |
| GB8518289D0 (en) * | 1985-07-19 | 1985-08-29 | Inverni Della Beffa Spa | Obtaining proanthocyanidine a2 |
| JPS6425726A (en) * | 1987-04-24 | 1989-01-27 | Yuutoku Yakuhin Kogyo Kk | Agent for eliminating active oxygen free radical |
| FR2618675B1 (fr) * | 1987-07-30 | 1990-03-23 | Bonnaure Mallet Martine | Composition pharmaceutique destinee au traitement des maladies parodontales comportant a titre de principe actif, au moins un monomere et/ou oligomere procyanidolique |
| US5650432A (en) * | 1995-03-24 | 1997-07-22 | Jlb, Inc. | Method of treating or preventing non-viral microbial infection |
| FR2706478B1 (fr) * | 1993-06-14 | 1995-09-08 | Ovi Sa | Compositions de dérivés phénoliques, leur préparation et leurs applications comme anti-oxydants. |
| CA2128293C (en) * | 1993-12-06 | 2002-09-03 | Masayuki Tanabe | Fruit polyphenols and medicinal compositions containing them |
| US5554645A (en) * | 1994-10-03 | 1996-09-10 | Mars, Incorporated | Antineoplastic cocoa extracts and methods for making and using the same |
-
1997
- 1997-04-02 PL PL97329325A patent/PL329325A1/xx not_active Application Discontinuation
- 1997-04-02 BR BR9710955-0A patent/BR9710955A/pt not_active Application Discontinuation
- 1997-04-02 AU AU33674/97A patent/AU742198B2/en not_active Expired
- 1997-04-02 EP EP97929671A patent/EP1015006A4/en not_active Ceased
- 1997-04-02 JP JP9535612A patent/JP2000506901A/ja active Pending
- 1997-04-02 EP EP08020626A patent/EP2110134A1/en not_active Withdrawn
- 1997-04-02 CN CNB971951810A patent/CN1159019C/zh not_active Expired - Lifetime
- 1997-04-02 CA CA2250792A patent/CA2250792C/en not_active Expired - Lifetime
- 1997-04-02 WO PCT/US1997/005693 patent/WO1997036497A2/en not_active Ceased
-
2010
- 2010-03-23 RU RU2010111103/15A patent/RU2010111103A/ru not_active Application Discontinuation
- 2010-07-30 JP JP2010173057A patent/JP2011006427A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU3367497A (en) | 1997-10-22 |
| HK1020881A1 (en) | 2000-05-26 |
| BR9710955A (pt) | 2001-03-13 |
| PL329325A1 (en) | 1999-03-29 |
| AU742198B2 (en) | 2001-12-20 |
| JP2000506901A (ja) | 2000-06-06 |
| CA2250792C (en) | 2011-09-13 |
| WO1997036497A2 (en) | 1997-10-09 |
| EP2110134A1 (en) | 2009-10-21 |
| EP1015006A2 (en) | 2000-07-05 |
| JP2011006427A (ja) | 2011-01-13 |
| EP1015006A4 (en) | 2003-09-24 |
| CN1159019C (zh) | 2004-07-28 |
| WO1997036497A3 (en) | 1997-12-24 |
| CN1221344A (zh) | 1999-06-30 |
| CA2250792A1 (en) | 1997-10-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2010111103A (ru) | Соединения экстракта какао и способы их получения и применения | |
| JP6936932B2 (ja) | フラボノイド組成物及び使用方法 | |
| KR100795327B1 (ko) | 근장력 증강제 | |
| US5932624A (en) | Vitamin supplement composition | |
| CA2260892A1 (en) | Appetite suppression | |
| US5990175A (en) | Prevention of migraine | |
| US4438138A (en) | Reduction of cholesterol with meta-chloro α-t-butylaminopropiophenone | |
| KR101704589B1 (ko) | 후박 추출물 및 신이 추출물의 혼합물을 유효성분으로 함유하는 치주조직 성장 촉진용 및 치주염 예방 또는 치료용 약학적 조성물 | |
| JPH08225453A (ja) | リポプロテイン（ａ）低下剤及びコレステロール低下剤並びにこれを含有する医薬 | |
| US20040043442A1 (en) | Use of betaine in functional products having blood pressure lowering effects | |
| US6656920B2 (en) | Composition and method for promoting oral health | |
| US7138148B2 (en) | Use of extracts of Ginkgo biloba for preparing a medicament intended to treat sarcopenia | |
| Debbas et al. | Preventive effects of an immunostimulating product on recurrent infections of chronic bronchitis in the elderly | |
| EP1677627B1 (en) | Dietetic preparation with hyaluronate for treatment of osteoporosis | |
| JPH11255656A (ja) | 抗アトピー性皮膚炎組成物 | |
| JP2010111646A (ja) | 潰瘍性大腸炎治療剤 | |
| WO1995022324A1 (en) | Treatment of migraine headaches and formulations | |
| JP2001122777A (ja) | 抗潰瘍剤 | |
| WO2005074961A1 (ja) | 体脂肪調整剤 | |
| WO2000066118A1 (fr) | Compositions pour le traitement de l'infarctus cerebral | |
| US20020107184A1 (en) | Method for treating melanoma | |
| US4650668A (en) | Composition for relieving toothache pain and other forms of intense pain | |
| KR101901410B1 (ko) | 5,6-디하이드로에르고스테롤 글리코시드 유도체를 유효성분으로 포함하는 관절염의 예방, 개선 또는 치료용 조성물 | |
| JPH07255419A (ja) | （＋）カテキンを配合した健康食品および医薬品 | |
| JP2005126429A (ja) | 免疫賦活剤、食品及び液状食品組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20140903 |