EP1015006A4 - Cocoa extract compounds and methods for making and using the same - Google Patents

Cocoa extract compounds and methods for making and using the same

Info

Publication number
EP1015006A4
EP1015006A4 EP97929671A EP97929671A EP1015006A4 EP 1015006 A4 EP1015006 A4 EP 1015006A4 EP 97929671 A EP97929671 A EP 97929671A EP 97929671 A EP97929671 A EP 97929671A EP 1015006 A4 EP1015006 A4 EP 1015006A4
Authority
EP
European Patent Office
Prior art keywords
making
methods
same
cocoa extract
extract compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP97929671A
Other languages
German (de)
French (fr)
Other versions
EP1015006A2 (en
Inventor
Leo J Romanczyk Jr
John F Hammerstone Jr
Margaret M Buck
Laurie S Post
Giovanni G Cipolla
Craig A Mcclelland
Jeff A Mundt
Harold H Schmitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mars Inc
Original Assignee
Mars Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1996/004497 external-priority patent/WO1997036597A1/en
Application filed by Mars Inc filed Critical Mars Inc
Priority to EP08020626A priority Critical patent/EP2110134A1/en
Publication of EP1015006A2 publication Critical patent/EP1015006A2/en
Publication of EP1015006A4 publication Critical patent/EP1015006A4/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
EP97929671A 1996-04-02 1997-04-02 Cocoa extract compounds and methods for making and using the same Ceased EP1015006A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08020626A EP2110134A1 (en) 1996-04-02 1997-04-02 Cocoa extract compounds and methods for making and using the same

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US631661 1990-12-20
US63166196A 1996-04-02 1996-04-02
WOPCT/US96/04497 1996-04-02
PCT/US1996/004497 WO1997036597A1 (en) 1996-04-02 1996-04-02 Cocoa extract compounds and methods for making and using the same
PCT/US1997/005693 WO1997036497A2 (en) 1996-04-02 1997-04-02 Cocoa extract compounds and methods for making and using the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP08020626A Division EP2110134A1 (en) 1996-04-02 1997-04-02 Cocoa extract compounds and methods for making and using the same

Publications (2)

Publication Number Publication Date
EP1015006A2 EP1015006A2 (en) 2000-07-05
EP1015006A4 true EP1015006A4 (en) 2003-09-24

Family

ID=26790948

Family Applications (2)

Application Number Title Priority Date Filing Date
EP97929671A Ceased EP1015006A4 (en) 1996-04-02 1997-04-02 Cocoa extract compounds and methods for making and using the same
EP08020626A Withdrawn EP2110134A1 (en) 1996-04-02 1997-04-02 Cocoa extract compounds and methods for making and using the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP08020626A Withdrawn EP2110134A1 (en) 1996-04-02 1997-04-02 Cocoa extract compounds and methods for making and using the same

Country Status (10)

Country Link
EP (2) EP1015006A4 (en)
JP (2) JP2000506901A (en)
CN (1) CN1159019C (en)
AU (1) AU742198B2 (en)
BR (1) BR9710955A (en)
CA (1) CA2250792C (en)
HK (1) HK1020881A1 (en)
PL (1) PL329325A1 (en)
RU (1) RU2010111103A (en)
WO (1) WO1997036497A2 (en)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696485B1 (en) 1996-04-02 2004-02-24 Mars, Incorporated Procyanidin and cyclo-oxygenase modulator compositions
US6312753B1 (en) 1996-09-06 2001-11-06 Mars, Incorporated Cocoa components, edible products having enriched polyphenol content, methods of making same and medical uses
US7968140B2 (en) 1997-09-08 2011-06-28 Mars, Incorporated Chocolates and chocolate liquor having an enhanced polyphenol content
US6207842B1 (en) * 1997-10-09 2001-03-27 Mars Incorporated Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
AU2004200273B2 (en) * 1998-03-12 2008-02-07 Mars, Incorporated Products Containing Polyphenol(s) and L-Arginine to stimulate nitric oxide production
US8507018B2 (en) 1998-03-12 2013-08-13 Mars, Incorporated Products containing polyphenol(s) and L-arginine and methods of use thereof
US6805883B2 (en) 1998-03-12 2004-10-19 Mars, Incorporated Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide
WO1999045797A1 (en) * 1998-03-12 1999-09-16 Mars, Incorporated Products containing polyphenol(s) and l-arginine to stimulate nitric oxide production
US7011856B2 (en) * 1998-08-05 2006-03-14 Amino Up Chemical Co., Ltd. Composition for the treatment of symptoms and conditions associated with aging
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
KR100509249B1 (en) * 1999-03-17 2005-08-22 모리나가 세이카 가부시키가이샤 Drugs, foods, drinks and feeds containing cocoa component
JP3260134B2 (en) 1999-10-08 2002-02-25 信孝 鈴木 Drugs for dysmenorrhea and endometriosis
CN100548304C (en) * 2000-03-22 2009-10-14 马尔斯公司 The cocoa procyanidin of application and aspirin associating is as anti-platelet therapy
KR20030005280A (en) 2000-04-14 2003-01-17 마아즈, 인코오포레이티드 Compositions and methods for improving vascular health
US6627232B1 (en) * 2000-06-09 2003-09-30 Mars Incorporated Method for extracting cocoa procyanidins
DE10037983B4 (en) * 2000-08-03 2006-04-13 Stefan Zikeli Polymer composition and molded articles containing it containing alkaloid
FR2812873B1 (en) 2000-08-11 2003-08-01 Barry Callebaut France PROCESS FOR PRODUCING POLYPHENOLS FROM COCOA BEANS
JP4763139B2 (en) * 2001-02-21 2011-08-31 株式会社アミノアップ化学 Novel polyhydric phenol polymer and its use
US7972632B2 (en) 2003-02-28 2011-07-05 Unigen Pharmaceuticals, Inc. Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors
US7108868B2 (en) 2002-03-22 2006-09-19 Unigen Pharmaceuticals, Inc. Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia
US7514107B2 (en) * 2002-03-21 2009-04-07 Mars, Incorporated Treatment of diseases involving defective gap junctional communication
FR2838055B1 (en) * 2002-04-05 2006-06-09 Cep NOVEL USE OF A COCOA EXTRACT AND COSMETIC AND / OR DERMATOLOGICAL COMPOSITIONS THEREFOR
AU2003228777C1 (en) 2002-04-30 2009-08-13 Unigen, Inc. Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent
US8945518B2 (en) 2002-04-30 2015-02-03 Unigen, Inc. Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions
US8034387B2 (en) 2002-04-30 2011-10-11 Unigen, Inc. Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments
KR20030097398A (en) * 2002-06-21 2003-12-31 이노천 A sauce for seasoned meat containing polyphenol
BRPI0409179A (en) 2003-04-04 2006-05-02 Unigen Pharmaceuticals Inc formulation of dual cyclooxygenase (cox) and lipoxygenase (lox) inhibitors for mammalian skin care
TWI279231B (en) * 2003-10-02 2007-04-21 Asahi Breweries Ltd Neutralization agent of vacuolization toxin
JP2007508316A (en) * 2003-10-10 2007-04-05 マーズ　インコーポレイテッド Treatment of diseases associated with ErbB2 kinase overexpression
EP1713467B1 (en) * 2004-01-28 2012-08-01 Mars, Incorporated Compositions and methods of use of a-type procyanidins
EP1852430B1 (en) 2005-02-25 2019-07-03 Nagasaki University Method of producing proanthocyanidin oligomer
JP4681363B2 (en) * 2005-03-04 2011-05-11 美智士 谷 Malignant tumor therapeutic agent and food and drink containing the same
JP4942953B2 (en) * 2005-06-30 2012-05-30 サントリーホールディングス株式会社 Analysis method of procyanidins
KR100761248B1 (en) 2006-10-12 2007-10-04 주식회사 유니젠 Composition for treating atopic dermatitis comprising extracts of bamboo and scutellaria
WO2008059064A1 (en) 2006-11-17 2008-05-22 Barry Callebaut Ag Method for producing a soluble cocoa product from cocoa powder
US8609174B2 (en) 2006-11-17 2013-12-17 Barry Callebaut Ag Method for producing a soluble cocoa product from cocoa powder
GB0724716D0 (en) 2007-12-19 2008-01-30 Barry Callebaut Ag Process
GB0801119D0 (en) 2008-01-22 2008-02-27 Barry Callebaut Ag Composition
FR2927811B1 (en) * 2008-02-27 2010-09-10 Unither Dev PHARMACEUTICAL DYE EXTRACT FROM CRANBERRY CONCENTRATED WITH PROANTHOCYANIDINES A.
JP5462491B2 (en) * 2009-01-21 2014-04-02 株式会社 エフェクト Proanthocyanidin trimer
EP2414509B1 (en) 2009-04-03 2015-09-23 DianaPlantSciences S.A.S. Production and extraction of procyanidins from plant cell cultures
JP5569716B2 (en) * 2009-06-23 2014-08-13 独立行政法人国立循環器病研究センター Drug for inhibiting lectin-like oxidized LDL receptor
SG181810A1 (en) * 2009-12-17 2012-07-30 Univ Singapore Method of preparing derivatives/oligomers of epicatechin and applications thereof
CA2791629C (en) 2010-03-05 2019-04-23 Mars, Incorporated Palatable beverages and compositions with cocoa extract
CN103237457A (en) 2010-10-04 2013-08-07 戴安娜植物科学有限公司 Production and extraction of procyanidins from plant cells cultures
MX2013006503A (en) * 2010-12-07 2015-05-26 Hershey Co Compounds influencing fatty acid uptake and metabolism and the production of inflammatory agents and methods of isolating them from cocoa products.
US9572852B2 (en) * 2011-02-08 2017-02-21 The Product Makers (Australia) Pty Ltd Sugar extracts
US20150027477A1 (en) * 2012-02-16 2015-01-29 Kamata Co., Ltd. Filter containing built-in capsule, cigarette provided with filter and cigarette substitute provided with filter
ITTV20120064A1 (en) * 2012-04-19 2013-10-20 R I Group Srl EXTRACT FOR TREATMENT OF CEFALEE PRIMITIVE
CN103113384B (en) * 2013-02-27 2015-05-20 安徽农业大学 Catechin derivative named Fuzhuansu B, and preparation method and application thereof
WO2016046375A1 (en) * 2014-09-25 2016-03-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) Theobroma cacao extract for use in the treatment or prevention of receptor tyrosine kinases related disorders
TW201733605A (en) * 2016-02-29 2017-10-01 明治股份有限公司 Cocoa-derived water extract, beverage containing the same, method for producing cocoa extract, and method for extracting polyphenols
EP3747276A1 (en) 2019-06-04 2020-12-09 ODC Lizenz AG Cocoa-based frozen desserts and methods of their manufacture

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1584725A (en) * 1968-01-30 1970-01-02
JPS5832875A (en) * 1981-07-30 1983-02-25 Nippon Shinyaku Co Ltd Tannin
JPS58154571A (en) * 1982-03-08 1983-09-14 Nippon Shinyaku Co Ltd Novel tannin
US4698360A (en) * 1985-04-09 1987-10-06 Societe Civile D'investigations Pharmacologiques D'aquitaine Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof
US4704292A (en) * 1984-12-10 1987-11-03 Cacaofabriek De Zaan B.V. Cocoa
US4797421A (en) * 1984-07-03 1989-01-10 Kikkoman Corporation Antioxidant comprising proanthocyanidin as principal component
EP0301975A2 (en) * 1987-07-30 1989-02-01 Martine Andrée Bonnaure-Mallet Monomeric and/or oligomeric procyanidines for the treatment of parodontal diseases
US4863956A (en) * 1985-07-19 1989-09-05 Inverni Della Beffa Spa Process for obtaining proanthocyanidine A2, pharmaceutical compositions and their therapeutic use
WO1994029404A1 (en) * 1993-06-14 1994-12-22 Berkem Polyphenol derivative compositions and preparation thereof
WO1996010404A1 (en) * 1994-10-03 1996-04-11 Mars, Incorporated Antineoplastic cocoa extracts, methods for making, using
WO1996030033A1 (en) * 1995-03-24 1996-10-03 Jlb, Inc. Method of treating or preventing non-viral microbial infection

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1575004A (en) * 1976-03-23 1980-09-17 Iverni Della Beffa Spa Pharmacologically active polyphenolic substances
JPS6425726A (en) * 1987-04-24 1989-01-27 Yuutoku Yakuhin Kogyo Kk Agent for eliminating active oxygen free radical
CA2128293C (en) * 1993-12-06 2002-09-03 Masayuki Tanabe Fruit polyphenols and medicinal compositions containing them

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1584725A (en) * 1968-01-30 1970-01-02
JPS5832875A (en) * 1981-07-30 1983-02-25 Nippon Shinyaku Co Ltd Tannin
JPS58154571A (en) * 1982-03-08 1983-09-14 Nippon Shinyaku Co Ltd Novel tannin
US4797421A (en) * 1984-07-03 1989-01-10 Kikkoman Corporation Antioxidant comprising proanthocyanidin as principal component
US4704292A (en) * 1984-12-10 1987-11-03 Cacaofabriek De Zaan B.V. Cocoa
US4698360A (en) * 1985-04-09 1987-10-06 Societe Civile D'investigations Pharmacologiques D'aquitaine Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof
US4698360B1 (en) * 1985-04-09 1997-11-04 D Investigations Pharmacologiq Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof
US4863956A (en) * 1985-07-19 1989-09-05 Inverni Della Beffa Spa Process for obtaining proanthocyanidine A2, pharmaceutical compositions and their therapeutic use
EP0301975A2 (en) * 1987-07-30 1989-02-01 Martine Andrée Bonnaure-Mallet Monomeric and/or oligomeric procyanidines for the treatment of parodontal diseases
WO1994029404A1 (en) * 1993-06-14 1994-12-22 Berkem Polyphenol derivative compositions and preparation thereof
WO1996010404A1 (en) * 1994-10-03 1996-04-11 Mars, Incorporated Antineoplastic cocoa extracts, methods for making, using
WO1996030033A1 (en) * 1995-03-24 1996-10-03 Jlb, Inc. Method of treating or preventing non-viral microbial infection

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
AN B-J ET AL: "STRUCTURE DETERMINATION OF GLUCOSYLTRANSFERASE INHIBITORS FROM CACAO BEAN HUSK", AGRICULTURAL CHEMISTRY AND BIOTECHNOLOGY, XX, KR, vol. 6, no. 37, 1994, pages 498 - 502, XP001087855, ISSN: 1229-2737 *
CHENG, JUEI TANG ET AL: "Antihypertensive principles from the leaves of Melastoma candidum", PLANTA MED. ( 1993 ), 59(5), 405-7, XP001088259 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; OTSUKA, HIROSHI ET AL: "Studies on antiinflammatory agents. VI. Antiinflammatory constituents of Cinnamomum sieboldii Meissn", XP002248248, retrieved from STN Database accession no. 96:223079 HCA *
HONG, CHUANG-YE ET AL: "The inhibitory effect of tannins on lipid peroxidation of rat heart mitochondria", J. PHARM. PHARMACOL. ( 1995 ), 47(2), 138-42, XP001087938 *
KOLODZIEJ, H. ET AL: "Moderate cytotoxicity of proanthocyanidins to human tumor cell lines", PHYTOTHER. RES. ( 1995 ), VOLUME DATE 1995, 9(6), 410-15, XP001088174 *
PORTER L J ET AL: "CACAO PROCYANIDINS: MAJOR FLAVANOIDS AND IDENTIFICATION OF SOME MINOR METABOLITES", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 5, no. 30, 1991, pages 1657 - 1663, XP001084175, ISSN: 0031-9422 *
ROHRBACH M S ET AL: "STRUCTURAL DETERMINANTS OF THE PLATELET AGONIST ACTIVITY OF COTTON BRACT CONDENSED TANNIN", ENVIRONMENTAL RESEARCH, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 52, no. 2, August 1990 (1990-08-01), pages 199 - 209, XP002166001, ISSN: 0013-9351 *
See also references of WO9736497A3 *
VENNAT B ET AL: "PROCYANIDINS FROM THE ROOTS OF FRAGARIA VESCA: CHARACTERIZATION AND PHARMACOLOGICAL APPROACH", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, JP, vol. 2, no. 36, February 1988 (1988-02-01), pages 828 - 833, XP001087909, ISSN: 0009-2363 *
YAKUGAKU ZASSHI (1982), 102(2), 162-72 *

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WO1997036497A3 (en) 1997-12-24
CN1221344A (en) 1999-06-30
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HK1020881A1 (en) 2000-05-26
PL329325A1 (en) 1999-03-29

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