JP2010540643A5 - - Google Patents
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- Publication number
- JP2010540643A5 JP2010540643A5 JP2010528032A JP2010528032A JP2010540643A5 JP 2010540643 A5 JP2010540643 A5 JP 2010540643A5 JP 2010528032 A JP2010528032 A JP 2010528032A JP 2010528032 A JP2010528032 A JP 2010528032A JP 2010540643 A5 JP2010540643 A5 JP 2010540643A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- cycloalkyl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 131
- 125000003118 aryl group Chemical group 0.000 claims 109
- 125000001072 heteroaryl group Chemical group 0.000 claims 107
- 125000000753 cycloalkyl group Chemical group 0.000 claims 85
- 125000000623 heterocyclic group Chemical group 0.000 claims 76
- 125000003545 alkoxy group Chemical group 0.000 claims 75
- 229910052736 halogen Inorganic materials 0.000 claims 60
- 150000002367 halogens Chemical class 0.000 claims 60
- 125000004414 alkyl thio group Chemical group 0.000 claims 45
- 125000001188 haloalkyl group Chemical group 0.000 claims 42
- 125000004438 haloalkoxy group Chemical group 0.000 claims 39
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 34
- 125000003342 alkenyl group Chemical group 0.000 claims 32
- 125000004103 aminoalkyl group Chemical group 0.000 claims 28
- 125000004104 aryloxy group Chemical group 0.000 claims 27
- 229910052739 hydrogen Inorganic materials 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 20
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 20
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 20
- 125000003282 alkyl amino group Chemical group 0.000 claims 19
- -1 amino Aminoalkyl Chemical group 0.000 claims 18
- 125000001424 substituent group Chemical group 0.000 claims 18
- 125000003710 aryl alkyl group Chemical group 0.000 claims 17
- 125000001769 aryl amino group Chemical group 0.000 claims 15
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 15
- 125000005110 aryl thio group Chemical group 0.000 claims 15
- 125000005843 halogen group Chemical group 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000005241 heteroarylamino group Chemical group 0.000 claims 13
- 125000002252 acyl group Chemical group 0.000 claims 12
- 125000005236 alkanoylamino group Chemical group 0.000 claims 12
- 125000004659 aryl alkyl thio group Chemical group 0.000 claims 12
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 12
- 125000005418 aryl aryl group Chemical group 0.000 claims 12
- 125000004658 aryl carbonyl amino group Chemical group 0.000 claims 12
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 12
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 12
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims 12
- 125000005114 heteroarylalkoxy group Chemical group 0.000 claims 12
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 12
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 12
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 12
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 12
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000005325 aryloxy aryl group Chemical group 0.000 claims 6
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000003107 substituted aryl group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000010067 Pituitary ACTH Hypersecretion Diseases 0.000 claims 1
- 208000020627 Pituitary-dependent Cushing syndrome Diseases 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical class OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- OVCXRBARSPBVMC-UHFFFAOYSA-N triazolopyridine Chemical compound C=1N2C(C(C)C)=NN=C2C=CC=1C=1OC=NC=1C1=CC=C(F)C=C1 OVCXRBARSPBVMC-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97650607P | 2007-10-01 | 2007-10-01 | |
| US60/976,506 | 2007-10-01 | ||
| US12/206,801 | 2008-09-09 | ||
| US12/206,801 US8119658B2 (en) | 2007-10-01 | 2008-09-09 | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| PCT/US2008/076984 WO2009045753A1 (en) | 2007-10-01 | 2008-09-19 | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540643A JP2010540643A (ja) | 2010-12-24 |
| JP2010540643A5 true JP2010540643A5 (enExample) | 2011-07-28 |
| JP5611044B2 JP5611044B2 (ja) | 2014-10-22 |
Family
ID=40523804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010528032A Expired - Fee Related JP5611044B2 (ja) | 2007-10-01 | 2008-09-19 | トリアゾロピリジンである１１β−水酸化ステロイド脱水素酵素タイプ１阻害剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8119658B2 (enExample) |
| EP (1) | EP2205598A1 (enExample) |
| JP (1) | JP5611044B2 (enExample) |
| KR (1) | KR20100085081A (enExample) |
| CN (1) | CN101883772B (enExample) |
| AR (1) | AR068601A1 (enExample) |
| AU (1) | AU2008309101B2 (enExample) |
| BR (1) | BRPI0817656A2 (enExample) |
| CA (1) | CA2701355A1 (enExample) |
| CL (1) | CL2008002916A1 (enExample) |
| CO (1) | CO6280485A2 (enExample) |
| EA (2) | EA201391705A1 (enExample) |
| IL (1) | IL204799A (enExample) |
| MX (1) | MX2010003565A (enExample) |
| NZ (1) | NZ584386A (enExample) |
| PE (2) | PE20121704A1 (enExample) |
| SG (1) | SG190638A1 (enExample) |
| TW (1) | TW200916470A (enExample) |
| WO (1) | WO2009045753A1 (enExample) |
| ZA (1) | ZA201002043B (enExample) |
Families Citing this family (64)
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| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
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| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| US8722894B2 (en) | 2007-09-14 | 2014-05-13 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
| CA2697399C (en) | 2007-09-14 | 2016-01-19 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones |
| MX2010002536A (es) | 2007-09-14 | 2010-08-10 | Ortho Mcneil Janssen Pharm | 4-fenil-3,4,5,6-tetrahidro-2h, 1'h-[1,4]bipiridinil-2'-onas 1',3'-disubstituidas. |
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| BRPI0918055A2 (pt) | 2008-09-02 | 2015-12-01 | Addex Pharmaceuticals Sa | derivados de 3-azabiciclo[3,1,0]hexila como moduladores de receptores metabotrópicos de glutamato. |
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| SG176021A1 (en) | 2009-05-12 | 2011-12-29 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
| ES2409006T3 (es) | 2009-05-12 | 2013-06-24 | Janssen Pharmaceuticals Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de los receptores mGluR2 |
| CN102725290B (zh) | 2009-07-27 | 2016-03-09 | 吉利德科学股份有限公司 | 作为离子通道调节剂的稠合杂环化合物 |
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-
2008
- 2008-09-09 US US12/206,801 patent/US8119658B2/en active Active
- 2008-09-19 EP EP08835346A patent/EP2205598A1/en not_active Withdrawn
- 2008-09-19 BR BRPI0817656 patent/BRPI0817656A2/pt not_active IP Right Cessation
- 2008-09-19 CN CN2008801187338A patent/CN101883772B/zh not_active Expired - Fee Related
- 2008-09-19 WO PCT/US2008/076984 patent/WO2009045753A1/en not_active Ceased
- 2008-09-19 NZ NZ584386A patent/NZ584386A/en unknown
- 2008-09-19 MX MX2010003565A patent/MX2010003565A/es not_active Application Discontinuation
- 2008-09-19 EA EA201391705A patent/EA201391705A1/ru unknown
- 2008-09-19 KR KR1020107009665A patent/KR20100085081A/ko not_active Ceased
- 2008-09-19 CA CA2701355A patent/CA2701355A1/en not_active Abandoned
- 2008-09-19 EA EA201000563A patent/EA019706B1/ru not_active IP Right Cessation
- 2008-09-19 SG SG2013035027A patent/SG190638A1/en unknown
- 2008-09-19 AU AU2008309101A patent/AU2008309101B2/en not_active Ceased
- 2008-09-19 JP JP2010528032A patent/JP5611044B2/ja not_active Expired - Fee Related
- 2008-09-30 PE PE2012001254A patent/PE20121704A1/es not_active Application Discontinuation
- 2008-09-30 CL CL2008002916A patent/CL2008002916A1/es unknown
- 2008-09-30 PE PE2008001701A patent/PE20091219A1/es not_active Application Discontinuation
- 2008-09-30 AR ARP080104279A patent/AR068601A1/es not_active Application Discontinuation
- 2008-10-01 TW TW097137800A patent/TW200916470A/zh unknown
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- 2010-03-25 CO CO10035487A patent/CO6280485A2/es active IP Right Grant
- 2010-03-28 IL IL204799A patent/IL204799A/en not_active IP Right Cessation
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2011
- 2011-08-03 US US13/197,273 patent/US8541444B2/en active Active
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