JP2010536886A5 - - Google Patents
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- Publication number
- JP2010536886A5 JP2010536886A5 JP2010522103A JP2010522103A JP2010536886A5 JP 2010536886 A5 JP2010536886 A5 JP 2010536886A5 JP 2010522103 A JP2010522103 A JP 2010522103A JP 2010522103 A JP2010522103 A JP 2010522103A JP 2010536886 A5 JP2010536886 A5 JP 2010536886A5
- Authority
- JP
- Japan
- Prior art keywords
- met
- antigen
- binding fragment
- specific mab
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 11
- 210000004408 hybridoma Anatomy 0.000 claims description 5
- 239000000427 antigen Substances 0.000 claims 17
- 102000036639 antigens Human genes 0.000 claims 17
- 108091007433 antigens Proteins 0.000 claims 17
- 239000012634 fragment Substances 0.000 claims 17
- 239000000523 sample Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 7
- 239000013068 control sample Substances 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102000008022 Proto-Oncogene Proteins c-met Human genes 0.000 claims 2
- 108010089836 Proto-Oncogene Proteins c-met Proteins 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 4
- 210000002307 prostate Anatomy 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 2
- 239000011534 wash buffer Substances 0.000 description 2
- 241000283707 Capra Species 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 101710120037 Toxin CcdB Proteins 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007423 screening assay Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/845,023 US7892770B2 (en) | 2007-08-24 | 2007-08-24 | Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods |
| US11/845,023 | 2007-08-24 | ||
| PCT/US2008/074249 WO2009029591A2 (en) | 2007-08-24 | 2008-08-25 | Monoclonal antibody which binds met in formalin-fixed and paraffin-embedded tissues and related methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010536886A JP2010536886A (ja) | 2010-12-02 |
| JP2010536886A5 true JP2010536886A5 (enExample) | 2011-06-30 |
| JP4806469B2 JP4806469B2 (ja) | 2011-11-02 |
Family
ID=40193999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010522103A Expired - Fee Related JP4806469B2 (ja) | 2007-08-24 | 2008-08-25 | ホルマリン固定およびパラフィン包埋された組織においてＭｅｔを結合するモノクローナル抗体および関連する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7892770B2 (enExample) |
| EP (1) | EP2195345B1 (enExample) |
| JP (1) | JP4806469B2 (enExample) |
| CA (1) | CA2715103C (enExample) |
| ES (1) | ES2386188T3 (enExample) |
| WO (1) | WO2009029591A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60233574D1 (de) | 2001-07-10 | 2009-10-15 | Univ R | Verfahren und zusammensetzungen zum nachweis des aktivierungszustands multipler proteine in einzelzellen |
| KR101214780B1 (ko) * | 2004-09-15 | 2012-12-21 | 인터젠엑스 인크. | 미세유동 장치 |
| US7892770B2 (en) * | 2007-08-24 | 2011-02-22 | Van Andel Research Institute | Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods |
| EP2287197A1 (en) * | 2009-08-21 | 2011-02-23 | Pierre Fabre Medicament | Anti-cMET antibody and its use for the detection and the diagnosis of cancer |
| GB201004551D0 (en) | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
| WO2011150454A1 (en) | 2010-06-01 | 2011-12-08 | Monash University | ANTIBODIES DIRECTED TO THE UNPROCESSED RECEPTOR TYROSINE KINASE c-MET |
| EP2402370A1 (en) * | 2010-06-29 | 2012-01-04 | Pierre Fabre Médicament | Novel antibody for the diagnosis and/or prognosis of cancer |
| CN103562223B (zh) | 2010-11-03 | 2017-02-22 | 阿尔金-X有限公司 | 抗c‑Met抗体 |
| WO2012178038A1 (en) | 2011-06-24 | 2012-12-27 | The Broad Institute, Inc. | Methods of treating cancer |
| US9201074B2 (en) | 2011-09-20 | 2015-12-01 | Eli Lilly And Company | Anti-c-Met antibodies |
| US9926364B2 (en) | 2011-11-03 | 2018-03-27 | Argen-X N.V. | Chimeric human-llama antigens and methods of use |
| WO2013096868A2 (en) | 2011-12-22 | 2013-06-27 | Children's Medical Center Corporation | Saposin-a derived peptides and uses thereof |
| US9260531B2 (en) * | 2012-05-09 | 2016-02-16 | Eli Lilly And Company | Anti-c-met antibodies |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| CN107002119A (zh) | 2014-03-24 | 2017-08-01 | 豪夫迈·罗氏有限公司 | 使用c‑met拮抗剂的癌症治疗及前者与hgf表达的关联 |
| CA2961323C (en) | 2014-09-16 | 2021-11-30 | Symphogen A/S | Anti-met antibodies and compositions |
| GB201521894D0 (en) | 2015-12-11 | 2016-01-27 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various cancers |
| HK1255541A1 (zh) | 2015-12-11 | 2019-08-23 | Immatics Biotechnologies Gmbh | 用於多种癌症免疫治疗的新型肽和肽组合物 |
| TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法 |
| BR112021016149A2 (pt) | 2019-02-26 | 2021-10-13 | Janssen Biotech, Inc. | Terapias de combinação e estratificação de pacientes com anticorpos biespecíficos anti-egfr/c-met |
| WO2020230091A1 (en) | 2019-05-14 | 2020-11-19 | Janssen Biotech, Inc. | Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors |
| AU2020349462A1 (en) | 2019-09-16 | 2022-03-03 | Regeneron Pharmaceuticals, Inc. | Radiolabeled MET binding proteins for immuno-PET imaging |
| JOP20220184A1 (ar) | 2020-02-12 | 2023-01-30 | Janssen Biotech Inc | علاج مصابي السرطان ممن لديهم طفرات تخطي c-Met إكسون14 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5917017A (en) * | 1994-06-08 | 1999-06-29 | President And Fellows Of Harvard College | Diphtheria toxin vaccines bearing a mutated R domain |
| EP1373896A2 (en) * | 2001-03-12 | 2004-01-02 | MonoGen, Inc. | Cell-based detection and differentiation of disease states |
| US7892770B2 (en) * | 2007-08-24 | 2011-02-22 | Van Andel Research Institute | Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods |
-
2007
- 2007-08-24 US US11/845,023 patent/US7892770B2/en not_active Expired - Fee Related
-
2008
- 2008-08-25 CA CA2715103A patent/CA2715103C/en not_active Expired - Fee Related
- 2008-08-25 EP EP08828206A patent/EP2195345B1/en not_active Not-in-force
- 2008-08-25 JP JP2010522103A patent/JP4806469B2/ja not_active Expired - Fee Related
- 2008-08-25 US US12/679,247 patent/US8309315B2/en not_active Expired - Fee Related
- 2008-08-25 ES ES08828206T patent/ES2386188T3/es active Active
- 2008-08-25 WO PCT/US2008/074249 patent/WO2009029591A2/en not_active Ceased
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