ES2386188T3 - Anticuerpo monoclonal que se une a Met en tejidos fijados en formalina e incluidos en parafina y métodos relacionados - Google Patents

Anticuerpo monoclonal que se une a Met en tejidos fijados en formalina e incluidos en parafina y métodos relacionados Download PDF

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Publication number
ES2386188T3
ES2386188T3 ES08828206T ES08828206T ES2386188T3 ES 2386188 T3 ES2386188 T3 ES 2386188T3 ES 08828206 T ES08828206 T ES 08828206T ES 08828206 T ES08828206 T ES 08828206T ES 2386188 T3 ES2386188 T3 ES 2386188T3
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ES
Spain
Prior art keywords
met
antibody
met4
tissue
expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08828206T
Other languages
English (en)
Spanish (es)
Inventor
Boliang Cao
George F. Vande Woude
Beatrice S. Knudsen
Ping Xu Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Van Andel Research Institute
Fred Hutchinson Cancer Center
Original Assignee
Van Andel Research Institute
Fred Hutchinson Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Van Andel Research Institute, Fred Hutchinson Cancer Center filed Critical Van Andel Research Institute
Application granted granted Critical
Publication of ES2386188T3 publication Critical patent/ES2386188T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ES08828206T 2007-08-24 2008-08-25 Anticuerpo monoclonal que se une a Met en tejidos fijados en formalina e incluidos en parafina y métodos relacionados Active ES2386188T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/845,023 US7892770B2 (en) 2007-08-24 2007-08-24 Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods
US845023 2007-08-24
PCT/US2008/074249 WO2009029591A2 (en) 2007-08-24 2008-08-25 Monoclonal antibody which binds met in formalin-fixed and paraffin-embedded tissues and related methods

Publications (1)

Publication Number Publication Date
ES2386188T3 true ES2386188T3 (es) 2012-08-13

Family

ID=40193999

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08828206T Active ES2386188T3 (es) 2007-08-24 2008-08-25 Anticuerpo monoclonal que se une a Met en tejidos fijados en formalina e incluidos en parafina y métodos relacionados

Country Status (6)

Country Link
US (2) US7892770B2 (enExample)
EP (1) EP2195345B1 (enExample)
JP (1) JP4806469B2 (enExample)
CA (1) CA2715103C (enExample)
ES (1) ES2386188T3 (enExample)
WO (1) WO2009029591A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60233574D1 (de) 2001-07-10 2009-10-15 Univ R Verfahren und zusammensetzungen zum nachweis des aktivierungszustands multipler proteine in einzelzellen
KR101214780B1 (ko) * 2004-09-15 2012-12-21 인터젠엑스 인크. 미세유동 장치
US7892770B2 (en) * 2007-08-24 2011-02-22 Van Andel Research Institute Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods
EP2287197A1 (en) * 2009-08-21 2011-02-23 Pierre Fabre Medicament Anti-cMET antibody and its use for the detection and the diagnosis of cancer
GB201004551D0 (en) 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
WO2011150454A1 (en) 2010-06-01 2011-12-08 Monash University ANTIBODIES DIRECTED TO THE UNPROCESSED RECEPTOR TYROSINE KINASE c-MET
EP2402370A1 (en) * 2010-06-29 2012-01-04 Pierre Fabre Médicament Novel antibody for the diagnosis and/or prognosis of cancer
CN103562223B (zh) 2010-11-03 2017-02-22 阿尔金-X有限公司 抗c‑Met抗体
WO2012178038A1 (en) 2011-06-24 2012-12-27 The Broad Institute, Inc. Methods of treating cancer
US9201074B2 (en) 2011-09-20 2015-12-01 Eli Lilly And Company Anti-c-Met antibodies
US9926364B2 (en) 2011-11-03 2018-03-27 Argen-X N.V. Chimeric human-llama antigens and methods of use
WO2013096868A2 (en) 2011-12-22 2013-06-27 Children's Medical Center Corporation Saposin-a derived peptides and uses thereof
US9260531B2 (en) * 2012-05-09 2016-02-16 Eli Lilly And Company Anti-c-met antibodies
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
CN107002119A (zh) 2014-03-24 2017-08-01 豪夫迈·罗氏有限公司 使用c‑met拮抗剂的癌症治疗及前者与hgf表达的关联
CA2961323C (en) 2014-09-16 2021-11-30 Symphogen A/S Anti-met antibodies and compositions
GB201521894D0 (en) 2015-12-11 2016-01-27 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against various cancers
HK1255541A1 (zh) 2015-12-11 2019-08-23 Immatics Biotechnologies Gmbh 用於多种癌症免疫治疗的新型肽和肽组合物
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
BR112021016149A2 (pt) 2019-02-26 2021-10-13 Janssen Biotech, Inc. Terapias de combinação e estratificação de pacientes com anticorpos biespecíficos anti-egfr/c-met
WO2020230091A1 (en) 2019-05-14 2020-11-19 Janssen Biotech, Inc. Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors
AU2020349462A1 (en) 2019-09-16 2022-03-03 Regeneron Pharmaceuticals, Inc. Radiolabeled MET binding proteins for immuno-PET imaging
JOP20220184A1 (ar) 2020-02-12 2023-01-30 Janssen Biotech Inc علاج مصابي السرطان ممن لديهم طفرات تخطي c-Met إكسون14

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5917017A (en) * 1994-06-08 1999-06-29 President And Fellows Of Harvard College Diphtheria toxin vaccines bearing a mutated R domain
EP1373896A2 (en) * 2001-03-12 2004-01-02 MonoGen, Inc. Cell-based detection and differentiation of disease states
US7892770B2 (en) * 2007-08-24 2011-02-22 Van Andel Research Institute Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods

Also Published As

Publication number Publication date
EP2195345B1 (en) 2012-05-30
US8309315B2 (en) 2012-11-13
EP2195345A2 (en) 2010-06-16
US20100285504A1 (en) 2010-11-11
CA2715103A1 (en) 2009-03-05
US20090053737A1 (en) 2009-02-26
JP4806469B2 (ja) 2011-11-02
JP2010536886A (ja) 2010-12-02
CA2715103C (en) 2013-10-15
US7892770B2 (en) 2011-02-22
WO2009029591A2 (en) 2009-03-05
WO2009029591A3 (en) 2009-05-28

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