JP2010535242A5 - - Google Patents

Download PDF

Info

Publication number
JP2010535242A5
JP2010535242A5 JP2010520185A JP2010520185A JP2010535242A5 JP 2010535242 A5 JP2010535242 A5 JP 2010535242A5 JP 2010520185 A JP2010520185 A JP 2010520185A JP 2010520185 A JP2010520185 A JP 2010520185A JP 2010535242 A5 JP2010535242 A5 JP 2010535242A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
disorder
tcg
disease
aacg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010520185A
Other languages
English (en)
Japanese (ja)
Other versions
JP5563455B2 (ja
JP2010535242A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/071738 external-priority patent/WO2009018431A2/en
Publication of JP2010535242A publication Critical patent/JP2010535242A/ja
Publication of JP2010535242A5 publication Critical patent/JP2010535242A5/ja
Application granted granted Critical
Publication of JP5563455B2 publication Critical patent/JP5563455B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010520185A 2007-08-01 2008-07-31 Ｔｌｒ９の新規な合成アゴニスト Active JP5563455B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US95325107P 2007-08-01 2007-08-01
US60/953,251 2007-08-01
US98360107P 2007-10-30 2007-10-30
US60/983,601 2007-10-30
US98715107P 2007-11-12 2007-11-12
US60/987,151 2007-11-12
US1529207P 2007-12-20 2007-12-20
US61/015,292 2007-12-20
PCT/US2008/071738 WO2009018431A2 (en) 2007-08-01 2008-07-31 Novel synthetic agonists of tlr9

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014120860A Division JP5816720B2 (ja) 2007-08-01 2014-06-11 Ｔｌｒ９の新規な合成アゴニスト

Publications (3)

Publication Number Publication Date
JP2010535242A JP2010535242A (ja) 2010-11-18
JP2010535242A5 true JP2010535242A5 (https=) 2013-05-02
JP5563455B2 JP5563455B2 (ja) 2014-07-30

Family

ID=40305273

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010520185A Active JP5563455B2 (ja) 2007-08-01 2008-07-31 Ｔｌｒ９の新規な合成アゴニスト
JP2014120860A Active JP5816720B2 (ja) 2007-08-01 2014-06-11 Ｔｌｒ９の新規な合成アゴニスト

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014120860A Active JP5816720B2 (ja) 2007-08-01 2014-06-11 Ｔｌｒ９の新規な合成アゴニスト

Country Status (12)

Country Link
US (2) US7960362B2 (https=)
EP (3) EP2650369B1 (https=)
JP (2) JP5563455B2 (https=)
KR (1) KR20100053598A (https=)
CN (3) CN101878311A (https=)
AU (1) AU2008282172B2 (https=)
BR (1) BRPI0813981A2 (https=)
CA (1) CA2693266C (https=)
ES (2) ES2539353T3 (https=)
IN (1) IN2010KN00195A (https=)
RU (1) RU2468819C2 (https=)
WO (1) WO2009018431A2 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7276489B2 (en) * 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
US8158768B2 (en) * 2002-12-23 2012-04-17 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same
US7354907B2 (en) * 2003-02-07 2008-04-08 Idera Pharmaceuticals, Inc. Short immunomodulatory oligonucleotides
MXPA05013658A (es) * 2003-06-11 2006-03-02 Hybridon Inc Oligonucleotidos inmunomoduladores estabilizados.
MXPA06000619A (es) * 2003-07-15 2006-04-11 Hybridon Inc Estimulacion sinergistica del sistema inmune usando oligonucleotidos inmunoestimuladores y/o compuestos inmunomeros en conjunto con citocinas y/o agentes quimioterapeuticos o terapia de radiacion.
AU2004275876B2 (en) * 2003-09-25 2011-03-31 Coley Pharmaceutical Gmbh Nucleic acid-lipophilic conjugates
KR20100053598A (ko) * 2007-08-01 2010-05-20 이데라 파마슈티칼즈, 인코포레이티드 Ｔｌｒ９의 신규한 합성 효능제
EP2391718A2 (en) * 2009-01-30 2011-12-07 Idera Pharmaceuticals, Inc. Novel synthetic agonists of tlr9
CN103800906B (zh) 2009-03-25 2017-09-22 德克萨斯大学系统董事会 用于刺激哺乳动物对病原体的先天免疫抵抗力的组合物
US8709419B2 (en) 2010-08-17 2014-04-29 Hoffmann-La Roche, Inc. Combination therapy
US20120045433A1 (en) * 2010-08-17 2012-02-23 Kapil Dhingra Combination therapy
US9295669B2 (en) 2010-12-14 2016-03-29 Hoffman La-Roche Inc. Combination therapy for proliferative disorders
JP6385957B2 (ja) * 2013-01-08 2018-09-05 イデラ ファーマシューティカルズ インコーポレイテッドＩｄｅｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． トール様受容体に基づく免疫応答を調節するための免疫調節オリゴヌクレオチド（ｉｒｏ）化合物
AR095882A1 (es) 2013-04-22 2015-11-18 Hoffmann La Roche Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9
GB2514591A (en) * 2013-05-30 2014-12-03 Mologen Ag Predictive biomarker for cancer therapy
TR201908550T4 (tr) 2014-06-04 2019-07-22 Exicure Inc Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi.
US20170298178A1 (en) * 2014-09-12 2017-10-19 Vantage Specialty Chemicals, Inc. Derivatives of 1,3-propanediol
WO2016044839A2 (en) 2014-09-19 2016-03-24 The Board Of Regents Of The University Of Texas System Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds
JP6991857B2 (ja) * 2014-10-10 2022-01-13 イデラ ファーマシューティカルズ インコーポレイテッド Ｔｌｒ９アゴニストをチェックポイント阻害剤と共に用いるがんの治療
US11213593B2 (en) 2014-11-21 2022-01-04 Northwestern University Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
WO2017052403A1 (ru) * 2015-09-25 2017-03-30 Анатолий Викторович ЗАЗУЛЯ Изготовление таблетки с механизмом повышения терапевтической эффективности лекарственного средства нанодозой микрорнк
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
MX2019002925A (es) 2016-09-15 2019-09-05 Idera Pharmaceuticals Inc Modulacion inmune con agonistas de tlr9 para el tratamiento del cancer.
WO2018106945A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
US11426566B2 (en) 2016-12-14 2022-08-30 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with a TLR modulator
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
CN109206481B (zh) 2017-07-05 2023-08-18 尚华医药科技(江西)有限公司 一种肽类化合物、其应用及含其的组合物
WO2019066571A2 (ko) 2017-09-28 2019-04-04 연세대학교 산학협력단 골수유래 면역반응 억제세포의 제조방법, 이에 의해 제조된 골수유래 면역반응 억제세포 및 그 용도
WO2021007160A1 (en) 2019-07-05 2021-01-14 Tambo, Inc. Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
WO2021174024A1 (en) 2020-02-28 2021-09-02 First Wave Bio, Inc. Methods of treating iatrogenic autoimmune colitis
JP2023532717A (ja) 2020-07-02 2023-07-31 ヴィーブ ヘルスケア カンパニー 長期作用型抗レトロウイルス剤を用いたｈｉｖウイルス寛解の達成方法
CN116056765A (zh) 2020-08-07 2023-05-02 坦伯公司 反式环辛烯生物正交剂及在癌症和免疫疗法中的用途

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030026782A1 (en) * 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
EP1003850B1 (en) * 1997-06-06 2009-05-27 The Regents of the University of California Inhibitors of dna immunostimulatory sequence activity
US6562798B1 (en) * 1998-06-05 2003-05-13 Dynavax Technologies Corp. Immunostimulatory oligonucleotides with modified bases and methods of use thereof
US6673613B2 (en) * 2000-07-26 2004-01-06 Cognis Corporation Use of CYP52A2A promoter to increase gene expression in yeast
US6503734B1 (en) * 2000-07-26 2003-01-07 Cognis Corporation Cytochrome b5 gene and protein of Candida tropicalis and methods relating thereto
RU2194502C2 (ru) * 2000-12-27 2002-12-20 Наровлянский Александр Наумович Иммуномодулятор - метаболик - детоксикант - адаптоген - радиопротектор
KR100881923B1 (ko) * 2000-12-27 2009-02-04 다이나박스 테크놀로지 코퍼레이션 면역자극 폴리뉴클레오티드 및 그것의 사용 방법
EP2423335B1 (en) * 2001-06-21 2014-05-14 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same
US7276489B2 (en) 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
JP5102959B2 (ja) * 2002-12-23 2012-12-19 ダイナバックス テクノロジーズ コーポレイション 免疫刺激配列オリゴヌクレオチド及びその使用方法
CA2524071A1 (en) * 2003-04-29 2004-11-11 Centocor, Inc. Toll-like receptor 9 effector agents and uses thereof
MXPA05013658A (es) * 2003-06-11 2006-03-02 Hybridon Inc Oligonucleotidos inmunomoduladores estabilizados.
US20050244410A1 (en) * 2004-04-29 2005-11-03 Ashlyn Bassiri Toll-like receptor 9 effector agents and uses thereof
JP4942646B2 (ja) * 2004-06-15 2012-05-30 イデラ ファーマシューティカルズ インコーポレイテッド 免疫賦活オリゴヌクレオチドマルチマー
EP2982679A1 (en) * 2005-10-12 2016-02-10 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
EP2371956A3 (en) * 2005-11-07 2012-01-04 Idera Pharmaceuticals Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
MX2008008279A (es) * 2005-12-20 2009-03-04 Idera Pharmaceuticals Inc Actividad inmunoestimuladora de oligonucleotidos inmunoestimuladores palindromicos que contienen diferentes longitudes de segmentos palindromicos.
CN101610671A (zh) * 2006-12-12 2009-12-23 艾德拉药物股份有限公司 合成的tlr9激动剂
WO2008131074A1 (en) * 2007-04-19 2008-10-30 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Use of toll-like receptor-9 agonists, toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment or prevention of toll-like receptor-4-associated disorders
KR20100053598A (ko) * 2007-08-01 2010-05-20 이데라 파마슈티칼즈, 인코포레이티드 Ｔｌｒ９의 신규한 합성 효능제

Similar Documents

Publication Publication Date Title
JP2010535242A5 (https=)
JP7213566B2 (ja) 病原体ワクチンならびにその製造および使用方法
JP2013507905A5 (https=)
RU2010107207A (ru) Новые синтетические агонисты tlr9
CN1604795B (zh) 具有提高的活性的组合基序免疫刺激寡肽
JP6697384B2 (ja) 予防的および治療的使用のための免疫刺激剤としての球状の核酸ベース構築物
JP4942646B2 (ja) 免疫賦活オリゴヌクレオチドマルチマー
JP2010532996A5 (https=)
AU2006304205C1 (en) Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
JP2008501807A5 (https=)
CA2752694A1 (en) Synthetic rna-based agonists of tlr7
JP2010512421A5 (https=)
US20160194642A1 (en) Spherical nucleic acid-based constructs as immunoregulatory agents
US12473553B2 (en) RNA nanostructures and methods of making and using RNA nanostructures
JP2009515823A5 (https=)
HRP20150566T1 (hr) Kompozicija za inhibiciju ekspresije gena i njegova upotreba
JP2010507386A (ja) オリゴリボヌクレオチドおよびその使用
JP2010504982A (ja) Ｔｌｒのリガンドと抗ウイルス剤との組成物
CN101160401A (zh) 免疫刺激寡核苷酸
WO2005083076A1 (ja) インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド
CN101820908A (zh) 包含改性糖部分的免疫刺激寡核苷酸类似物
KR20250111403A (ko) Cpg 양친매성 물질 및 이의 용도
CN103596594A (zh) 自身凝胶化核酸
WO2017007027A1 (ja) 免疫刺激オリゴヌクレオチド複合体
JP2023527525A (ja) インターフェロン誘導オリゴヌクレオチド二重鎖および使用方法