RU2010107207A - Новые синтетические агонисты tlr9 - Google Patents
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Abstract
1. Иммуномодулирующее соединение, выбранное из соединений № 1-№169. ! 2. Композиция, включающая иммуномодулирующее соединение по п.1 и физиологически приемлемый носитель. ! 3. Способ получения иммунного ответа у пациента, способ включает введение пациенту соединения по п.1 в фармацевтически эффективном количестве. ! 4. Способ терапевтического лечения пациента, имеющего заболевание или расстройство, где модуляция иммунного ответа будет полезной, такой способ включает введение пациенту соединения по п.1 в фармацевтически приемлемом количестве. ! 5. Способ по п.4, где заболеванием или расстройством является рак, аутоиммунное расстройство, воспалительное расстройство, инфекционное заболевание, кожное заболевание, аллергия, астма или заболевание, вызванное патогеном или аллергеном. ! 6. Способ по п.4, дополнительно включающий введение одного или более химиотерапевтических соединений, нацеленных терапевтических средств, вакцин, антигенов, антител, цитотоксических средств, аллергенов, антибиотиков, антисмысловых олигонуклеотидов, агонистов TLR, ингибиторов киназ, пептидов, белков, ДНК вакцин, адъювантов, ко-стимулирующих молекул или их комбинаций. ! 7. Способ профилактического лечения пациента, имеющего заболевание или расстройство, где будет полезной модуляция иммунного ответа, такой способ включает введение пациенту соединения по п.1 в фармацевтически эффективном количестве. ! 8. Способ по п.7, где заболеванием или расстройством является рак, аутоиммунное расстройство, воспалительное расстройство, инфекционное заболевание, кожное заболевание, аллергия, астма или заболевание, вызванное патогеном или аллергеном. ! 9. �
Claims (9)
1. Иммуномодулирующее соединение, выбранное из соединений № 1-№169.
2. Композиция, включающая иммуномодулирующее соединение по п.1 и физиологически приемлемый носитель.
3. Способ получения иммунного ответа у пациента, способ включает введение пациенту соединения по п.1 в фармацевтически эффективном количестве.
4. Способ терапевтического лечения пациента, имеющего заболевание или расстройство, где модуляция иммунного ответа будет полезной, такой способ включает введение пациенту соединения по п.1 в фармацевтически приемлемом количестве.
5. Способ по п.4, где заболеванием или расстройством является рак, аутоиммунное расстройство, воспалительное расстройство, инфекционное заболевание, кожное заболевание, аллергия, астма или заболевание, вызванное патогеном или аллергеном.
6. Способ по п.4, дополнительно включающий введение одного или более химиотерапевтических соединений, нацеленных терапевтических средств, вакцин, антигенов, антител, цитотоксических средств, аллергенов, антибиотиков, антисмысловых олигонуклеотидов, агонистов TLR, ингибиторов киназ, пептидов, белков, ДНК вакцин, адъювантов, ко-стимулирующих молекул или их комбинаций.
7. Способ профилактического лечения пациента, имеющего заболевание или расстройство, где будет полезной модуляция иммунного ответа, такой способ включает введение пациенту соединения по п.1 в фармацевтически эффективном количестве.
8. Способ по п.7, где заболеванием или расстройством является рак, аутоиммунное расстройство, воспалительное расстройство, инфекционное заболевание, кожное заболевание, аллергия, астма или заболевание, вызванное патогеном или аллергеном.
9. Способ по п.7, дополнительно включающий введение одного или более химиотерапевтических соединений, нацеленных терапевтических средств, вакцин, антигенов, антител, цитотоксических средств, аллергенов, антибиотиков, антисмысловых олигонуклеотидов, агонистов TLR, ингибиторов киназ, пептидов, белков, ДНК вакцин, адъювантов, ко-стимулирующих молекул или их комбинаций.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95325107P | 2007-08-01 | 2007-08-01 | |
US60/953,251 | 2007-08-01 | ||
US98360107P | 2007-10-30 | 2007-10-30 | |
US60/983,601 | 2007-10-30 | ||
US98715107P | 2007-11-12 | 2007-11-12 | |
US60/987,151 | 2007-11-12 | ||
US1529207P | 2007-12-20 | 2007-12-20 | |
US61/015,292 | 2007-12-20 | ||
PCT/US2008/071738 WO2009018431A2 (en) | 2007-08-01 | 2008-07-31 | Novel synthetic agonists of tlr9 |
Publications (2)
Publication Number | Publication Date |
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RU2010107207A true RU2010107207A (ru) | 2011-09-10 |
RU2468819C2 RU2468819C2 (ru) | 2012-12-10 |
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Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2010107207/10A RU2468819C2 (ru) | 2007-08-01 | 2008-07-31 | Новые синтетические агонисты tlr9 |
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Country | Link |
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US (2) | US7960362B2 (ru) |
EP (3) | EP2173912A4 (ru) |
JP (2) | JP5563455B2 (ru) |
KR (1) | KR20100053598A (ru) |
CN (3) | CN101878311A (ru) |
AU (1) | AU2008282172B2 (ru) |
BR (1) | BRPI0813981A2 (ru) |
CA (1) | CA2693266C (ru) |
ES (2) | ES2585239T3 (ru) |
HK (1) | HK1216430A1 (ru) |
IN (1) | IN2010KN00195A (ru) |
RU (1) | RU2468819C2 (ru) |
WO (1) | WO2009018431A2 (ru) |
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AU2021300632A1 (en) | 2020-07-02 | 2023-02-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of achieving HIV viral remission using long-acting antiretroviral agents |
EP4192506A1 (en) | 2020-08-07 | 2023-06-14 | Tambo, Inc. | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
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US20030026782A1 (en) * | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
DK1003850T3 (da) * | 1997-06-06 | 2009-09-07 | Univ California | Inhibitorer af DNA-immunstimulatorisk sekvensaktivitet |
US6562798B1 (en) * | 1998-06-05 | 2003-05-13 | Dynavax Technologies Corp. | Immunostimulatory oligonucleotides with modified bases and methods of use thereof |
US6673613B2 (en) * | 2000-07-26 | 2004-01-06 | Cognis Corporation | Use of CYP52A2A promoter to increase gene expression in yeast |
US6503734B1 (en) * | 2000-07-26 | 2003-01-07 | Cognis Corporation | Cytochrome b5 gene and protein of Candida tropicalis and methods relating thereto |
DE60142410D1 (de) * | 2000-12-27 | 2010-07-29 | Dynavax Tech Corp | Immunomodulatorische polynukleotide und verfahren zur deren verwendung |
RU2194502C2 (ru) * | 2000-12-27 | 2002-12-20 | Наровлянский Александр Наумович | Иммуномодулятор - метаболик - детоксикант - адаптоген - радиопротектор |
US20030199466A1 (en) * | 2001-06-21 | 2003-10-23 | Fearon Karen L. | Chimeric immunomodulatory compounds and methods of using the same - ll |
US7276489B2 (en) | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
KR101309501B1 (ko) * | 2002-12-23 | 2013-09-24 | 다이나박스 테크놀로지 코퍼레이션 | 면역자극성 서열 올리고뉴클레오타이드 및 이의 이용방법 |
CA2524071A1 (en) * | 2003-04-29 | 2004-11-11 | Centocor, Inc. | Toll-like receptor 9 effector agents and uses thereof |
CN102604957B (zh) * | 2003-06-11 | 2015-10-07 | 艾德拉药物股份有限公司 | 稳定的免疫调节寡核苷酸 |
US20050244410A1 (en) * | 2004-04-29 | 2005-11-03 | Ashlyn Bassiri | Toll-like receptor 9 effector agents and uses thereof |
US20060014713A1 (en) * | 2004-06-15 | 2006-01-19 | Hybridon, Inc. | Immunostimulatory oligonucleotide multimers |
EP2982679A1 (en) * | 2005-10-12 | 2016-02-10 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
CN101351228A (zh) * | 2005-11-07 | 2009-01-21 | 艾德拉药物股份有限公司 | 包含经修饰的免疫刺激性二核苷酸的基于寡核苷酸的化合物之免疫刺激特性 |
JP2009521218A (ja) * | 2005-12-20 | 2009-06-04 | イデラ ファーマシューティカルズ インコーポレイテッド | 異なる長さのパリンドロームセグメントを含むパリンドローム免疫調節オリゴヌクレオチド(imo(tm))の免疫賦活作用 |
JP2010512421A (ja) * | 2006-12-12 | 2010-04-22 | イデラ ファーマシューティカルズ インコーポレイテッド | Tlr9の合成アゴニスト |
WO2008131074A1 (en) * | 2007-04-19 | 2008-10-30 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of toll-like receptor-9 agonists, toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment or prevention of toll-like receptor-4-associated disorders |
EP2173912A4 (en) * | 2007-08-01 | 2013-03-20 | Idera Pharmaceuticals Inc | NEW SYNTHETIC AGONISTS OF TLR9 |
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US20110311518A1 (en) | 2011-12-22 |
JP5563455B2 (ja) | 2014-07-30 |
EP2650369A1 (en) | 2013-10-16 |
CN105177014B (zh) | 2018-04-06 |
EP2821488A3 (en) | 2015-04-29 |
JP2010535242A (ja) | 2010-11-18 |
EP2821488A2 (en) | 2015-01-07 |
EP2650369B1 (en) | 2015-04-29 |
CA2693266A1 (en) | 2009-02-05 |
WO2009018431A2 (en) | 2009-02-05 |
EP2821488B1 (en) | 2016-07-27 |
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EP2173912A4 (en) | 2013-03-20 |
CN102864151A (zh) | 2013-01-09 |
CA2693266C (en) | 2015-06-30 |
US20090053206A1 (en) | 2009-02-26 |
EP2173912A2 (en) | 2010-04-14 |
RU2468819C2 (ru) | 2012-12-10 |
CN105177014A (zh) | 2015-12-23 |
CN101878311A (zh) | 2010-11-03 |
US8361986B2 (en) | 2013-01-29 |
US7960362B2 (en) | 2011-06-14 |
HK1216430A1 (zh) | 2016-11-11 |
AU2008282172A1 (en) | 2009-02-05 |
KR20100053598A (ko) | 2010-05-20 |
JP2014205691A (ja) | 2014-10-30 |
IN2010KN00195A (ru) | 2015-08-28 |
ES2585239T3 (es) | 2016-10-04 |
CN102864151B (zh) | 2015-07-08 |
JP5816720B2 (ja) | 2015-11-18 |
ES2539353T3 (es) | 2015-06-30 |
BRPI0813981A2 (pt) | 2017-05-09 |
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