RU2010107207A - NEW SYNTHETIC AGRONISTS TLR9 - Google Patents

NEW SYNTHETIC AGRONISTS TLR9 Download PDF

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RU2010107207A
RU2010107207A RU2010107207/10A RU2010107207A RU2010107207A RU 2010107207 A RU2010107207 A RU 2010107207A RU 2010107207/10 A RU2010107207/10 A RU 2010107207/10A RU 2010107207 A RU2010107207 A RU 2010107207A RU 2010107207 A RU2010107207 A RU 2010107207A
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disease
disorder
patient
immune response
comprises administering
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RU2010107207/10A
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RU2468819C2 (en
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Экамбар Р. КАНДИМАЛЛА (US)
Экамбар Р. КАНДИМАЛЛА
ПУТТА Малликарджуна РЕДДИ (US)
ПУТТА Малликарджуна РЕДДИ
Дацин ВАН (US)
Дацин ВАН
Дун ЮЙ (US)
Дун ЮЙ
Бхагат ЛАКШМИ (US)
Бхагат ЛАКШМИ
Судхир АГРАВАЛ (US)
Судхир АГРАВАЛ
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Идера Фармасьютикалз, Инк. (Us)
Идера Фармасьютикалз, Инк.
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Abstract

1. Иммуномодулирующее соединение, выбранное из соединений № 1-№169. ! 2. Композиция, включающая иммуномодулирующее соединение по п.1 и физиологически приемлемый носитель. ! 3. Способ получения иммунного ответа у пациента, способ включает введение пациенту соединения по п.1 в фармацевтически эффективном количестве. ! 4. Способ терапевтического лечения пациента, имеющего заболевание или расстройство, где модуляция иммунного ответа будет полезной, такой способ включает введение пациенту соединения по п.1 в фармацевтически приемлемом количестве. ! 5. Способ по п.4, где заболеванием или расстройством является рак, аутоиммунное расстройство, воспалительное расстройство, инфекционное заболевание, кожное заболевание, аллергия, астма или заболевание, вызванное патогеном или аллергеном. ! 6. Способ по п.4, дополнительно включающий введение одного или более химиотерапевтических соединений, нацеленных терапевтических средств, вакцин, антигенов, антител, цитотоксических средств, аллергенов, антибиотиков, антисмысловых олигонуклеотидов, агонистов TLR, ингибиторов киназ, пептидов, белков, ДНК вакцин, адъювантов, ко-стимулирующих молекул или их комбинаций. ! 7. Способ профилактического лечения пациента, имеющего заболевание или расстройство, где будет полезной модуляция иммунного ответа, такой способ включает введение пациенту соединения по п.1 в фармацевтически эффективном количестве. ! 8. Способ по п.7, где заболеванием или расстройством является рак, аутоиммунное расстройство, воспалительное расстройство, инфекционное заболевание, кожное заболевание, аллергия, астма или заболевание, вызванное патогеном или аллергеном. ! 9. � 1. Immunomodulatory compound selected from compounds No. 1-No. 169. ! 2. A composition comprising an immunomodulatory compound according to claim 1 and a physiologically acceptable carrier. ! 3. A method of obtaining an immune response in a patient, the method comprises administering to the patient a compound of claim 1 in a pharmaceutically effective amount. ! 4. A method for the therapeutic treatment of a patient having a disease or disorder where modulation of the immune response will be useful, such a method comprises administering to the patient the compound of claim 1 in a pharmaceutically acceptable amount. ! 5. The method of claim 4, wherein the disease or disorder is cancer, an autoimmune disorder, an inflammatory disorder, an infectious disease, a skin disease, an allergy, asthma, or a disease caused by a pathogen or allergen. ! 6. The method according to claim 4, further comprising administering one or more chemotherapeutic compounds, targeted therapeutic agents, vaccines, antigens, antibodies, cytotoxic agents, allergens, antibiotics, antisense oligonucleotides, TLR agonists, kinase inhibitors, peptides, proteins, vaccine DNA, adjuvants, co-stimulating molecules, or combinations thereof. ! 7. A method for the prophylactic treatment of a patient having a disease or disorder where modulation of the immune response is useful, such a method comprises administering to the patient a compound according to claim 1 in a pharmaceutically effective amount. ! 8. The method of claim 7, wherein the disease or disorder is cancer, an autoimmune disorder, an inflammatory disorder, an infectious disease, a skin disease, an allergy, asthma, or a disease caused by a pathogen or allergen. ! 9. �

Claims (9)

1. Иммуномодулирующее соединение, выбранное из соединений № 1-№169.1. Immunomodulatory compound selected from compounds No. 1-No. 169. 2. Композиция, включающая иммуномодулирующее соединение по п.1 и физиологически приемлемый носитель.2. A composition comprising an immunomodulatory compound according to claim 1 and a physiologically acceptable carrier. 3. Способ получения иммунного ответа у пациента, способ включает введение пациенту соединения по п.1 в фармацевтически эффективном количестве.3. A method of obtaining an immune response in a patient, the method comprises administering to the patient a compound according to claim 1 in a pharmaceutically effective amount. 4. Способ терапевтического лечения пациента, имеющего заболевание или расстройство, где модуляция иммунного ответа будет полезной, такой способ включает введение пациенту соединения по п.1 в фармацевтически приемлемом количестве.4. A method for the therapeutic treatment of a patient having a disease or disorder where modulation of the immune response will be useful, such a method comprises administering to the patient the compound of claim 1 in a pharmaceutically acceptable amount. 5. Способ по п.4, где заболеванием или расстройством является рак, аутоиммунное расстройство, воспалительное расстройство, инфекционное заболевание, кожное заболевание, аллергия, астма или заболевание, вызванное патогеном или аллергеном.5. The method of claim 4, wherein the disease or disorder is cancer, an autoimmune disorder, an inflammatory disorder, an infectious disease, a skin disease, an allergy, asthma, or a disease caused by a pathogen or allergen. 6. Способ по п.4, дополнительно включающий введение одного или более химиотерапевтических соединений, нацеленных терапевтических средств, вакцин, антигенов, антител, цитотоксических средств, аллергенов, антибиотиков, антисмысловых олигонуклеотидов, агонистов TLR, ингибиторов киназ, пептидов, белков, ДНК вакцин, адъювантов, ко-стимулирующих молекул или их комбинаций.6. The method according to claim 4, further comprising administering one or more chemotherapeutic compounds, targeted therapeutic agents, vaccines, antigens, antibodies, cytotoxic agents, allergens, antibiotics, antisense oligonucleotides, TLR agonists, kinase inhibitors, peptides, proteins, vaccine DNA, adjuvants, co-stimulating molecules, or combinations thereof. 7. Способ профилактического лечения пациента, имеющего заболевание или расстройство, где будет полезной модуляция иммунного ответа, такой способ включает введение пациенту соединения по п.1 в фармацевтически эффективном количестве.7. A method for the prophylactic treatment of a patient having a disease or disorder where modulation of the immune response is useful, such a method comprises administering to the patient a compound according to claim 1 in a pharmaceutically effective amount. 8. Способ по п.7, где заболеванием или расстройством является рак, аутоиммунное расстройство, воспалительное расстройство, инфекционное заболевание, кожное заболевание, аллергия, астма или заболевание, вызванное патогеном или аллергеном.8. The method of claim 7, wherein the disease or disorder is cancer, an autoimmune disorder, an inflammatory disorder, an infectious disease, a skin disease, an allergy, asthma, or a disease caused by a pathogen or allergen. 9. Способ по п.7, дополнительно включающий введение одного или более химиотерапевтических соединений, нацеленных терапевтических средств, вакцин, антигенов, антител, цитотоксических средств, аллергенов, антибиотиков, антисмысловых олигонуклеотидов, агонистов TLR, ингибиторов киназ, пептидов, белков, ДНК вакцин, адъювантов, ко-стимулирующих молекул или их комбинаций. 9. The method according to claim 7, further comprising administering one or more chemotherapeutic compounds, targeted therapeutic agents, vaccines, antigens, antibodies, cytotoxic agents, allergens, antibiotics, antisense oligonucleotides, TLR agonists, kinase inhibitors, peptides, proteins, vaccine DNA, adjuvants, co-stimulating molecules, or combinations thereof.
RU2010107207/10A 2007-08-01 2008-07-31 New synthetic tlr9 agonists RU2468819C2 (en)

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US95325107P 2007-08-01 2007-08-01
US60/953,251 2007-08-01
US98360107P 2007-10-30 2007-10-30
US60/983,601 2007-10-30
US98715107P 2007-11-12 2007-11-12
US60/987,151 2007-11-12
US1529207P 2007-12-20 2007-12-20
US61/015,292 2007-12-20
PCT/US2008/071738 WO2009018431A2 (en) 2007-08-01 2008-07-31 Novel synthetic agonists of tlr9

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KR (1) KR20100053598A (en)
CN (3) CN101878311A (en)
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7276489B2 (en) * 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
US8158768B2 (en) * 2002-12-23 2012-04-17 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same
US7354907B2 (en) * 2003-02-07 2008-04-08 Idera Pharmaceuticals, Inc. Short immunomodulatory oligonucleotides
JP4874801B2 (en) * 2003-06-11 2012-02-15 イデラ ファーマシューティカルズ インコーポレイテッド Stabilized immunomodulatory oligonucleotide
JP2007531699A (en) * 2003-07-15 2007-11-08 イデラ ファーマシューティカルズ インコーポレイテッド Synergistic stimulation of the immune system using immunostimulatory oligonucleotides and / or immunomeric compounds in combination with cytokines and / or chemotherapeutic agents or radiation therapy
CA2536139A1 (en) * 2003-09-25 2005-04-07 Coley Pharmaceutical Group, Inc. Nucleic acid-lipophilic conjugates
EP2821488B1 (en) * 2007-08-01 2016-07-27 Idera Pharmaceuticals, Inc. Novel synthetic agonists of TLR9
JP2012516352A (en) * 2009-01-30 2012-07-19 イデラ ファーマシューティカルズ インコーポレイテッド Synthetic agonist of TLR9
BRPI1009842B8 (en) 2009-03-25 2021-05-25 Univ Texas use of tlr9 agonist and tlr2/6 agonist in the preparation of a pharmaceutical composition for treating, inhibiting or attenuating a microbial infection, as well as a pharmaceutically acceptable composition comprising said agonists
US20120045433A1 (en) * 2010-08-17 2012-02-23 Kapil Dhingra Combination therapy
US8709419B2 (en) 2010-08-17 2014-04-29 Hoffmann-La Roche, Inc. Combination therapy
US9295669B2 (en) 2010-12-14 2016-03-29 Hoffman La-Roche Inc. Combination therapy for proliferative disorders
EP2943251B1 (en) * 2013-01-08 2018-10-10 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
AR095882A1 (en) 2013-04-22 2015-11-18 Hoffmann La Roche ANTIBODY COMBINATION THERAPY AGAINST HUMAN CSF-1R WITH A TLR9 AGONIST
GB2514591A (en) * 2013-05-30 2014-12-03 Mologen Ag Predictive biomarker for cancer therapy
EP3164113B1 (en) 2014-06-04 2019-03-27 Exicure, Inc. Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
WO2016040956A1 (en) * 2014-09-12 2016-03-17 Vantage Specialty Chemicals, Inc. Derivatives of 1,3-propanediol
WO2016044839A2 (en) 2014-09-19 2016-03-24 The Board Of Regents Of The University Of Texas System Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds
CA2964155A1 (en) * 2014-10-10 2016-04-14 Idera Pharmaceuticals, Inc. Treatment of cancer using tlr9 agonist with checkpoint inhibitors
JP2017537619A (en) 2014-11-21 2017-12-21 ノースウェスタン ユニバーシティ Sequence-specific intracellular uptake of spherical nucleic acid nanoparticle complexes
WO2017052403A1 (en) * 2015-09-25 2017-03-30 Анатолий Викторович ЗАЗУЛЯ Preparing a tablet with a mechanism for enhancing the therapeutic effectiveness of a drug using a nano-dose of microrna
US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
MX2019002925A (en) 2016-09-15 2019-09-05 Idera Pharmaceuticals Inc Immune modulation with tlr9 agonists for cancer treatment.
EP4252629A3 (en) 2016-12-07 2023-12-27 Biora Therapeutics, Inc. Gastrointestinal tract detection methods, devices and systems
WO2018112223A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with a tlr modulator
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
CN109206481B (en) 2017-07-05 2023-08-18 尚华医药科技(江西)有限公司 Peptide compound, application thereof and composition containing peptide compound
WO2019066571A2 (en) 2017-09-28 2019-04-04 연세대학교 산학협력단 Method for producing myeloid-derived suppressor cells, myeloid-derived suppressor cells produced thereby, and uses thereof
US20220259254A1 (en) 2019-07-05 2022-08-18 Tambo, Inc. Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
WO2021174024A1 (en) 2020-02-28 2021-09-02 First Wave Bio, Inc. Methods of treating iatrogenic autoimmune colitis
JP2023532717A (en) 2020-07-02 2023-07-31 ヴィーブ ヘルスケア カンパニー Methods of achieving HIV viral remission with long-acting antiretroviral agents
EP4192506A1 (en) 2020-08-07 2023-06-14 Tambo, Inc. Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030026782A1 (en) * 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
JP4101888B2 (en) * 1997-06-06 2008-06-18 ダイナバックス テクノロジーズ コーポレイション Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
US6562798B1 (en) * 1998-06-05 2003-05-13 Dynavax Technologies Corp. Immunostimulatory oligonucleotides with modified bases and methods of use thereof
US6673613B2 (en) * 2000-07-26 2004-01-06 Cognis Corporation Use of CYP52A2A promoter to increase gene expression in yeast
US6503734B1 (en) * 2000-07-26 2003-01-07 Cognis Corporation Cytochrome b5 gene and protein of Candida tropicalis and methods relating thereto
RU2194502C2 (en) * 2000-12-27 2002-12-20 Наровлянский Александр Наумович Immunomodulator metabolite detoxicant - adaptogen radioprotector
CA2430691A1 (en) * 2000-12-27 2002-07-04 Dynavax Technologies Corporation Immunomodulatory polynucleotides and methods of using the same
EP1404873B1 (en) * 2001-06-21 2013-05-22 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same
US7276489B2 (en) 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
PT1992635E (en) * 2002-12-23 2012-03-20 Dynavax Tech Corp Immunostimulatory sequence oligonucleotides and methods of using the same
CA2524071A1 (en) * 2003-04-29 2004-11-11 Centocor, Inc. Toll-like receptor 9 effector agents and uses thereof
JP4874801B2 (en) * 2003-06-11 2012-02-15 イデラ ファーマシューティカルズ インコーポレイテッド Stabilized immunomodulatory oligonucleotide
US20050244410A1 (en) * 2004-04-29 2005-11-03 Ashlyn Bassiri Toll-like receptor 9 effector agents and uses thereof
WO2006002038A2 (en) * 2004-06-15 2006-01-05 Hybridon, Inc. Immunostimulatory oligonucleotide multimers
ES2542989T3 (en) * 2005-10-12 2015-08-13 Idera Pharmaceuticals, Inc. Immuno-regulatory oligonucleotide compounds (IRO) to modulate the Toll-like receptor-based immune response
MX2008006005A (en) * 2005-11-07 2008-10-01 Idera Pharmaceuticals Inc Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides.
WO2007075626A2 (en) * 2005-12-20 2007-07-05 Idera Pharmaceuticals, Inc. Immunostimulatory activity of palindromic immune modulatory oligonucleotides (imo tm) contiaining different lengths of palindromic segments
CN101610671A (en) * 2006-12-12 2009-12-23 艾德拉药物股份有限公司 Synthetic TLR9 activator
US8188058B2 (en) * 2007-04-19 2012-05-29 University of Pittsburgh—of the Commonwealth System of Higher Education Use of toll-like receptor-9 agonists, toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment or prevention of toll-like receptor-4-associated disorders
EP2821488B1 (en) * 2007-08-01 2016-07-27 Idera Pharmaceuticals, Inc. Novel synthetic agonists of TLR9

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