JP2010533225A5 - - Google Patents

Download PDF

Info

Publication number
JP2010533225A5
JP2010533225A5 JP2010516020A JP2010516020A JP2010533225A5 JP 2010533225 A5 JP2010533225 A5 JP 2010533225A5 JP 2010516020 A JP2010516020 A JP 2010516020A JP 2010516020 A JP2010516020 A JP 2010516020A JP 2010533225 A5 JP2010533225 A5 JP 2010533225A5
Authority
JP
Japan
Prior art keywords
hydrogel
precursor
functional group
therapeutic agent
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010516020A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010533225A (ja
JP5693954B2 (ja
Filing date
Publication date
Priority claimed from US11/825,848 external-priority patent/US9125807B2/en
Application filed filed Critical
Publication of JP2010533225A publication Critical patent/JP2010533225A/ja
Publication of JP2010533225A5 publication Critical patent/JP2010533225A5/ja
Application granted granted Critical
Publication of JP5693954B2 publication Critical patent/JP5693954B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010516020A 2007-07-09 2008-05-14 ヒドロゲルポリマー組成物及び方法 Active JP5693954B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/825,848 US9125807B2 (en) 2007-07-09 2007-07-09 Adhesive hydrogels for ophthalmic drug delivery
US11/825,848 2007-07-09
PCT/US2008/006114 WO2009008946A1 (en) 2007-07-09 2008-05-14 Hydrogel polymeric compositions and methods

Publications (3)

Publication Number Publication Date
JP2010533225A JP2010533225A (ja) 2010-10-21
JP2010533225A5 true JP2010533225A5 (enExample) 2011-06-30
JP5693954B2 JP5693954B2 (ja) 2015-04-01

Family

ID=40228885

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010516020A Active JP5693954B2 (ja) 2007-07-09 2008-05-14 ヒドロゲルポリマー組成物及び方法

Country Status (8)

Country Link
US (5) US9125807B2 (enExample)
EP (1) EP2187980B1 (enExample)
JP (1) JP5693954B2 (enExample)
AU (1) AU2008275786B2 (enExample)
CA (1) CA2692545A1 (enExample)
DK (1) DK2187980T3 (enExample)
ES (1) ES2733673T3 (enExample)
WO (1) WO2009008946A1 (enExample)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9125807B2 (en) * 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US7862538B2 (en) * 2008-02-04 2011-01-04 Incept Llc Surgical delivery system for medical sealant
WO2010036427A1 (en) 2008-06-17 2010-04-01 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
AU2010213612B2 (en) 2009-02-12 2015-04-30 Incept, Llc Drug delivery through hydrogel plugs
EP2421505A4 (en) * 2009-04-22 2014-01-01 Univ Texas HYDROGELES FOR THE COMBINATORY RELEASE OF IMMUNOMODULATING BIOMOLECULES
EP2427233B1 (en) 2009-05-04 2016-12-21 Incept Llc Biomaterials for track and puncture closure
US20110189291A1 (en) * 2009-08-04 2011-08-04 Hu Yang Dendrimer hydrogels
AU2010314992B2 (en) 2009-11-09 2016-09-15 Spotlight Technology Partners Llc Polysaccharide based hydrogels
US8524215B2 (en) * 2010-08-02 2013-09-03 Janssen Biotech, Inc. Absorbable PEG-based hydrogels
EP2425814B1 (en) 2010-09-03 2013-06-19 Novagali Pharma S.A. A water-in-oil type emulsion for treating a disease of the eye
US9107822B2 (en) 2010-09-03 2015-08-18 Santen Sas Water-in oil type emulsion for treating a disease of the eye
NZ607103A (en) 2010-09-03 2015-09-25 Santen Sas A water-in-oil type emulsion for treating a disease of the eye
US8961501B2 (en) * 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
US10676501B2 (en) 2011-07-20 2020-06-09 Brigham Young University Hydrogel materials incorporating eluting ceragenin compound
WO2013029059A1 (en) * 2011-08-25 2013-02-28 Brigham Young University Medical devices incorporating ceragenin-containing composites
US10226417B2 (en) * 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
CN109200013A (zh) 2011-12-05 2019-01-15 因赛普特有限责任公司 医用有机凝胶方法和组合物
ITVR20120051A1 (it) * 2012-03-20 2013-09-21 Bbs Srl Composizione colorata per uso in metodi chirurgici oftalmici
CA2872399C (en) 2012-05-02 2021-01-12 Brigham Young University Ceragenin particulate materials and methods for making same
EP2879761A4 (en) * 2012-08-06 2016-03-02 Baylor College Medicine DISTRIBUTION DEVICE FOR THERAPEUTICS AND MANUFACTURING METHOD THEREFOR
US9395468B2 (en) 2012-08-27 2016-07-19 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
JP6294352B2 (ja) 2013-01-07 2018-03-14 ブリガム・ヤング・ユニバーシティBrigham Young University 細胞増殖を減少させ、ある特定の疾患を治療する方法
CA2939952C (en) 2013-03-05 2022-03-22 Morgan V. Fedorchak Thermoresponsive hydrogel containing polymer microparticles for noninvasive ocular drug delivery
CN110420211A (zh) 2013-03-15 2019-11-08 布莱阿姆青年大学 治疗炎症、自身免疫性疾病和疼痛的方法
US10568893B2 (en) 2013-03-15 2020-02-25 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
US11690855B2 (en) 2013-10-17 2023-07-04 Brigham Young University Methods for treating lung infections and inflammation
EP3570093B1 (en) 2013-11-15 2021-09-15 Tangible Science, Inc. Contact lens with a hydrophilic layer
US20150203527A1 (en) 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
CA2844321C (en) 2014-02-27 2021-03-16 Brigham Young University Cationic steroidal antimicrobial compounds
US10220045B2 (en) 2014-03-13 2019-03-05 Brigham Young University Compositions and methods for forming stabilized compositions with reduced CSA agglomeration
US9931350B2 (en) 2014-03-14 2018-04-03 Brigham Young University Anti-infective and osteogenic compositions and methods of use
US10238665B2 (en) 2014-06-26 2019-03-26 Brigham Young University Methods for treating fungal infections
US10441595B2 (en) 2014-06-26 2019-10-15 Brigham Young University Methods for treating fungal infections
US10227376B2 (en) 2014-08-22 2019-03-12 Brigham Young University Radiolabeled cationic steroid antimicrobials and diagnostic methods
US10155788B2 (en) 2014-10-07 2018-12-18 Brigham Young University Cationic steroidal antimicrobial prodrug compositions and uses thereof
US20160106587A1 (en) * 2014-10-16 2016-04-21 Incept, Llc Ocular gels or hydrogels and microinjectors
US10550187B2 (en) 2014-10-24 2020-02-04 Incept, Llc Extra luminal scaffold
EP3229851A4 (en) 2014-12-09 2018-08-01 Tangible Science LLC Medical device coating with a biocompatible layer
KR20170117384A (ko) * 2014-12-10 2017-10-23 인셉트, 엘엘씨 히드로겔 약물 전달 임플란트
EP3230393B1 (en) * 2014-12-12 2019-04-24 Marcella Chiari New clickable polymers and gels for microarray and other applications
EP4445952A3 (en) 2014-12-15 2025-01-15 The Johns Hopkins University Sunitinib formulations and methods for use thereof in treatment of glaucoma
EP3261620B1 (en) * 2015-02-24 2022-11-09 The Board of Trustees of the University of Illinois Methods and compositions for treating dry eye disease and other eye disorders
WO2016172553A1 (en) 2015-04-22 2016-10-27 Savage Paul B Methods for the synthesis of ceragenins
WO2016172543A1 (en) 2015-04-22 2016-10-27 Savage Paul B Methods for the synthesis of ceragenins
EP3288626B8 (en) 2015-04-27 2025-12-10 Tulavi Therapeutics, Inc. Substances and compositions for use in blocking nerve regeneration
JP2018515529A (ja) * 2015-05-12 2018-06-14 インセプト・リミテッド・ライアビリティ・カンパニーIncept,Llc ハイドロゲルからの薬物送達
AU2016297642A1 (en) 2015-07-22 2018-02-15 Incept, Llc Coated punctal plug
JP7096152B2 (ja) 2015-10-06 2022-07-05 オーラ・インコーポレーテッド 一過性受容体電位カチオンチャネルサブファミリーmメンバー8(trpm8)拮抗薬及び使用方法
US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
SG11201803663XA (en) 2015-11-12 2018-05-30 Graybug Vision Inc Aggregating microparticles for therapy
BR112018010671A8 (pt) 2015-11-25 2019-02-26 Incept Llc dispositivos e métodos de distribuição de fármaco com mudança de forma
WO2017139487A1 (en) 2016-02-09 2017-08-17 Northwind Medical, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
US10226550B2 (en) 2016-03-11 2019-03-12 Brigham Young University Cationic steroidal antimicrobial compositions for the treatment of dermal tissue
US11395853B2 (en) 2016-06-23 2022-07-26 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biomimetic drug delivery of an immunomodulatory agent for the treatment of ocular conditions
EP3478287A4 (en) 2016-06-29 2020-04-08 Tulavi Therapeutics, Inc. TREATMENT OF SEPTICEMIA AND ASSOCIATED INFLAMMATORY CONDITIONS BY LOCAL NEUROMODULATION OF THE AUTONOMOUS NERVOUS SYSTEM
CN109641077A (zh) 2016-07-13 2019-04-16 马萨诸塞眼科耳科诊所 用于治疗视网膜脱离和其他眼部疾病的方法和聚合物组合物
US10463532B2 (en) * 2016-07-26 2019-11-05 Masatoshi Murata Method for placing implant in choroid that can less invasively and simply place implant in choroid in optic disc-macula area
EP4197527A1 (en) 2016-09-23 2023-06-21 Incept, LLC Intracameral drug delivery depots
US10959433B2 (en) 2017-03-21 2021-03-30 Brigham Young University Use of cationic steroidal antimicrobials for sporicidal activity
EP3621654A4 (en) 2017-05-10 2021-02-17 Graybug Vision, Inc. PROLONGED-RELEASE MICROPARTICLES AND SUSPENSIONS OF THESE INTENDED FOR MEDICAL THERAPY
GB201721840D0 (en) * 2017-12-22 2018-02-07 Waterford Institute Of Tech Microemulsion for opthalmic drug delivery
BR112020014071A2 (pt) * 2018-01-12 2020-12-01 Pykus Therapeutics, Inc. métodos, formulações contendo polímero e composições de polímero para tratamento de descolamento da retina e outros distúrbios oculares
WO2019217678A1 (en) * 2018-05-09 2019-11-14 North Carolina State University Applicator for corneal therapeutics
CN112384256A (zh) 2018-05-15 2021-02-19 因赛普特有限责任公司 栓塞组合物及方法
CN117598837A (zh) 2018-07-02 2024-02-27 图拉维治疗股份有限公司 原位形成神经帽的方法和装置
US20210315587A1 (en) 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
AU2020262932B2 (en) * 2019-04-25 2025-11-13 Ocular Therapeutix, Inc. Intracanalicular hydrogel inserts for the delivery of anesthetics
US12186328B2 (en) 2019-05-23 2025-01-07 Brigham Young University Use of CSA compounds to stimulate stem cells and hair growth
PT3861985T (pt) 2020-02-06 2023-08-03 Ocular Therapeutix Inc Composições e métodos para tratar doenças oculares
ES2952677T3 (es) 2020-03-25 2023-11-03 Ocular Therapeutix Inc Implante ocular que contiene un inhibidor de tirosina cinasa
WO2021222117A1 (en) 2020-04-27 2021-11-04 Ocular Therapeutix, Inc. Methods of treating allergic conjunctivitis
JP2023542939A (ja) 2020-09-24 2023-10-12 オキュラ セラピューティクス,インコーポレイテッド ヒドロゲル及び活性薬剤を含む徐放性生分解性小管内挿入物
DK3973952T3 (da) 2020-09-24 2024-03-18 Ocular Therapeutix Inc Bionedbrydelige intrakanalikulære indsatser med vedvarende frigivelse omfattende en hydrogel og cyclosporin
US12343454B2 (en) 2020-11-12 2025-07-01 Pramand LLC Hydrogels formed in situ and composition design for intrauterine use
WO2023097213A1 (en) 2021-11-24 2023-06-01 Pykus Therapeutics, Inc. Hydrogel formulations and methods and devices for focal administration of the same
WO2023154464A1 (en) * 2022-02-11 2023-08-17 Fairleigh Dickinson University Locally administered compositions and methods of use thereof
US20250366470A1 (en) * 2022-04-14 2025-12-04 Fairleigh Dickinson University Antimicrobial monomer coatings and methods of making and using same
US20250268816A1 (en) * 2022-04-26 2025-08-28 University Of Maryland, Baltimore Extended-release formulation containing cresol
CN115770212B (zh) * 2022-11-24 2025-05-30 杭州德柯医疗科技有限公司 载有消融剂的可注射型凝胶组合物及其制备方法
CN120897764A (zh) 2023-04-11 2025-11-04 视尔普斯眼科公司 包含阿西替尼多晶型物iv的眼部植入物
US12233157B1 (en) 2024-07-24 2025-02-25 Pykus Therapeutics, Inc. Hydrogel formulations and methods and devices for administration of the same

Family Cites Families (196)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1662130A (en) 1926-05-03 1928-03-13 Ralph W Rogers Power transmission gearing
US3995635A (en) * 1971-09-09 1976-12-07 Alza Corporation Ocular insert
US3949750A (en) 1974-10-07 1976-04-13 Freeman Jerre M Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same
JPS585320A (ja) 1981-07-01 1983-01-12 Toray Ind Inc グラフト共重合体
US4693887A (en) 1983-09-15 1987-09-15 The Kendall Company Microphase separated hydrogels for controlled release of bioactive materials
US4740534A (en) 1985-08-30 1988-04-26 Sanyo Chemical Industries, Ltd. Surgical adhesive
US4760131A (en) 1986-04-23 1988-07-26 Collagen Corporation Wound-healing composition
US5160745A (en) 1986-05-16 1992-11-03 The University Of Kentucky Research Foundation Biodegradable microspheres as a carrier for macromolecules
US4741872A (en) 1986-05-16 1988-05-03 The University Of Kentucky Research Foundation Preparation of biodegradable microspheres useful as carriers for macromolecules
US4803075A (en) 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
US4979959A (en) 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
US4952581A (en) 1987-04-03 1990-08-28 The Trustees Of Columbia University In The City Of New York Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
IL82834A (en) 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US4853224A (en) 1987-12-22 1989-08-01 Visionex Biodegradable ocular implants
US5041292A (en) 1988-08-31 1991-08-20 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5475052A (en) 1988-11-21 1995-12-12 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
US5304595A (en) 1988-11-21 1994-04-19 Collagen Corporation Collagen-polymer conjugates
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5550187A (en) 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5614587A (en) 1988-11-21 1997-03-25 Collagen Corporation Collagen-based bioadhesive compositions
US5936035A (en) 1988-11-21 1999-08-10 Cohesion Technologies, Inc. Biocompatible adhesive compositions
US5565519A (en) 1988-11-21 1996-10-15 Collagen Corporation Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
US5306500A (en) 1988-11-21 1994-04-26 Collagen Corporation Method of augmenting tissue with collagen-polymer conjugates
US5527856A (en) 1988-11-21 1996-06-18 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
IL90193A (en) 1989-05-04 1993-02-21 Biomedical Polymers Int Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same
US5487897A (en) 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
US4952851A (en) 1989-12-13 1990-08-28 Hughes Aircraft Company Electronic CRT centering alignment apparatus
US5227372A (en) 1990-03-07 1993-07-13 Children's Medical Center Corporation Method for retaining ophthalmological agents in ocular tissues
US5292362A (en) 1990-07-27 1994-03-08 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5266325A (en) * 1990-09-28 1993-11-30 Hydro Med Science Division Of National Patent Development Corp. Preparation of homogeneous hydrogel copolymers
US5626863A (en) 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5380536A (en) 1990-10-15 1995-01-10 The Board Of Regents, The University Of Texas System Biocompatible microcapsules
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5462990A (en) 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
ATE197125T1 (de) 1992-02-28 2000-11-15 Univ Texas Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung
US5296228A (en) 1992-03-13 1994-03-22 Allergan, Inc. Compositions for controlled delivery of pharmaceutical compounds
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
EP0659073B1 (en) 1992-09-10 2001-12-19 Children's Medical Center Corporation Biodegradable polymer matrices for sustained delivery of local anesthetic agents
JPH06306250A (ja) * 1993-04-27 1994-11-01 Hoya Corp 作用物質含有高分子ゲル
US5800373A (en) 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
ATE169483T1 (de) 1993-04-28 1998-08-15 Focal Inc Vorrichtung, produkt und verwendung betreffend die intraluminale photothermoformgebung
US5565215A (en) 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
WO1995005161A1 (en) * 1993-08-13 1995-02-23 Vitaphore Corporation Hydrogel-based microsphere drug delivery systems
US5578638A (en) 1993-11-05 1996-11-26 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5650173A (en) 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
DE4341113B4 (de) 1993-12-02 2006-04-13 IFAC Institut für angewandte Colloidtechnologie GmbH & Co. KG Stabile multiple X/O/Y-Emulsion
WO1995015748A1 (en) 1993-12-08 1995-06-15 Vitaphore Corporation Microsphere drug delivery system
US5717614A (en) 1994-05-04 1998-02-10 National Instruments Corporation System and method for handling events in an instrumentation system
US5480914A (en) 1994-05-06 1996-01-02 Allergan, Inc. Nonaqueous thixotropic drug delivery suspensions and methods of their use
IL114193A (en) 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
US5583114A (en) 1994-07-27 1996-12-10 Minnesota Mining And Manufacturing Company Adhesive sealant composition
US5665840A (en) 1994-11-18 1997-09-09 Novartis Corporation Polymeric networks from water-soluble prepolymers
EP0713707A1 (en) 1994-11-23 1996-05-29 Collagen Corporation In situ crosslinkable, injectable collagen composition for tissue augmention
US5629922A (en) 1995-02-22 1997-05-13 Massachusetts Institute Of Technology Electron tunneling device using ferromagnetic thin films
US5565188A (en) 1995-02-24 1996-10-15 Nanosystems L.L.C. Polyalkylene block copolymers as surface modifiers for nanoparticles
US5618850A (en) 1995-03-09 1997-04-08 Focal, Inc. Hydroxy-acid cosmetics
US6962979B1 (en) 1995-03-14 2005-11-08 Cohesion Technologies, Inc. Crosslinkable biomaterial compositions containing hydrophobic and hydrophilic crosslinking agents
JP4209941B2 (ja) 1995-03-23 2009-01-14 ジェンザイム・コーポレーション ゲルの基材への改善された接着性のための下塗り用のレドックスおよび光開始剤システム
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US6413539B1 (en) * 1996-10-31 2002-07-02 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
IL118469A (en) 1995-06-15 2000-08-13 Tanabe Seiyaku Co Naphthalene derivatives their preparation and intermediates thereof
US6540993B1 (en) 1995-06-27 2003-04-01 Wyeth Method of treating inflammatory bowel disease using a topical formulation of IL-11
US5947921A (en) * 1995-12-18 1999-09-07 Massachusetts Institute Of Technology Chemical and physical enhancers and ultrasound for transdermal drug delivery
EP0842209B1 (en) 1995-07-28 2006-10-11 Genzyme Corporation Multiblock biodegradable hydrogels for use as controlled release agents for drugs and tissue treatment agents
US6678553B2 (en) 1995-11-21 2004-01-13 Intraabrain International Nv Device for enhanced delivery of biologically active substances and compounds in an organism
FR2741628B1 (fr) 1995-11-29 1998-02-06 Centre Nat Rech Scient Nouveaux hydrogels a base de copolymeres trisequences et leur application notamment a la liberation progressive de principes actifs
US6833408B2 (en) 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
PT876165E (pt) 1995-12-18 2006-10-31 Angiotech Biomaterials Corp Composicoes de polimeros reticulados e processos para a sua utilizacao
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
GB9616672D0 (en) 1996-08-08 1996-09-25 Scherer Ltd R P Pharmaceutical compositions
US20020064546A1 (en) 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
WO1998012274A1 (en) 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US7009034B2 (en) * 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US6566406B1 (en) 1998-12-04 2003-05-20 Incept, Llc Biocompatible crosslinked polymers
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
US6071875A (en) 1996-12-04 2000-06-06 Alcon Laboratories, Inc. TGFα for the treatment of ocular hypertension and glaucoma
US5888493A (en) 1996-12-05 1999-03-30 Sawaya; Assad S. Ophthalmic aqueous gel formulation and related methods
WO1998035631A1 (en) 1997-02-14 1998-08-20 Pathak Chandrashekar Biocompatible polymers and methods for their use
CA2199556C (en) 1997-03-10 2006-10-03 James Arthur Auger Polyolefin pipe
US6371975B2 (en) 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
EP1009291B8 (en) 1997-03-20 2006-01-11 Genzyme Corporation Biodegradable tissue retractor
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
CN1271277A (zh) 1997-07-18 2000-10-25 因菲米德有限公司 用于生物活性物质控释的生物可降解的大分子的单体
ZA987019B (en) 1997-08-06 1999-06-04 Focal Inc Hemostatic tissue sealants
JP2001520979A (ja) 1997-10-27 2001-11-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 網膜傷の閉鎖のための方法及び医薬組成物
US6335335B2 (en) 1997-11-05 2002-01-01 Senju Pharmaceutical Co., Ltd. Prolonged-action eye drop
AU1307399A (en) 1997-11-06 1999-05-31 Orbon Corporation Stabilized, dry pharmaceutical compositions for drug delivery and methods of preparing same
FR2773320B1 (fr) 1998-01-05 2000-03-03 Optisinvest Dispositif pour le transfert intraoculaire de produits actifs par iontophorese
US5981607A (en) * 1998-01-20 1999-11-09 Allergan Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers
SE9800853D0 (sv) 1998-03-16 1998-03-16 Pharmacia & Upjohn Bv Intraocular lens
US6007833A (en) 1998-03-19 1999-12-28 Surmodics, Inc. Crosslinkable macromers bearing initiator groups
US6196993B1 (en) 1998-04-20 2001-03-06 Eyelab Group, Llc Ophthalmic insert and method for sustained release of medication to the eye
US6156531A (en) 1998-07-20 2000-12-05 Sulzer Carbomedics Inc. Cross-linking tissue with a compound having a C8 to C40 aliphatic chain
US6316011B1 (en) 1998-08-04 2001-11-13 Madash, Llc End modified thermal responsive hydrogels
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6703047B2 (en) 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6179862B1 (en) 1998-08-14 2001-01-30 Incept Llc Methods and apparatus for in situ formation of hydrogels
US6605294B2 (en) 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
JP4159254B2 (ja) 1998-08-14 2008-10-01 インセプト エルエルシー ヒドロゲルのインサイチュ形成のための方法および装置
EP1117378A2 (en) 1998-10-05 2001-07-25 The Penn State Research Foundation Compositions and methods for enhancing receptor-mediated cellular internalization
US6110484A (en) 1998-11-24 2000-08-29 Cohesion Technologies, Inc. Collagen-polymer matrices with differential biodegradability
US20080114092A1 (en) 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
WO2004073708A1 (en) 1998-12-17 2004-09-02 Dean Thomas R Brinzolamide and brimonidine for treating ocular conditions
US6528107B2 (en) 1999-01-19 2003-03-04 Sulzer Carbomedics Inc. Method for producing antimicrobial antithrombogenic medical devices
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US6410045B1 (en) 1999-02-22 2002-06-25 Clyde Lewis Schultz Drug delivery system for antiglaucomatous medication
US20020197300A1 (en) 1999-02-22 2002-12-26 Schultz Clyde L. Drug delivery system for anti-glaucomatous medication
US6217896B1 (en) * 1999-04-01 2001-04-17 Uab Research Foundation Conjunctival inserts for topical delivery of medication or lubrication
US6177514B1 (en) 1999-04-09 2001-01-23 Sulzer Carbomedics Inc. Blocked functional reagants for cross-linking biological tissues
US6322593B1 (en) 1999-04-09 2001-11-27 Sulzer Carbomedics Inc. Method for treating cross-linked biological tissues
WO2000060956A1 (en) 1999-04-12 2000-10-19 Cornell Research Foundation, Inc. Hydrogel-forming system with hydrophobic and hydrophilic components
US6716445B2 (en) 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
US6312725B1 (en) 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US6132986A (en) 1999-04-23 2000-10-17 Sulzer Carbomedics Inc. Tissue crosslinking for bioprostheses using activated difunctional or polyfunctional acids
US6539251B2 (en) 1999-05-25 2003-03-25 Iomed, Inc. Ocular iontophoretic apparatus
US6319240B1 (en) 1999-05-25 2001-11-20 Iomed, Inc. Methods and apparatus for ocular iontophoresis
KR100698559B1 (ko) * 1999-06-11 2007-03-21 넥타르 테라퓨틱스 에이엘, 코포레이션 키토산 및 폴리(에틸렌 글리콜) 또는 관련 폴리머로부터유래되는 하이드로겔
EP1218437B1 (en) 1999-08-27 2009-06-17 AngioDevice International GmbH Compositions that form interpenetrating polymer networks for use as high strength medical sealants
US6710126B1 (en) 1999-11-15 2004-03-23 Bio Cure, Inc. Degradable poly(vinyl alcohol) hydrogels
US6479079B1 (en) 1999-12-13 2002-11-12 Sulzer Carbomedics Inc. Anticalcification treatments for fixed biomaterials
US6656200B2 (en) 2000-04-07 2003-12-02 Collagen Matrix, Inc. Embolization device
US20050277864A1 (en) 2000-04-14 2005-12-15 David Haffner Injectable gel implant for glaucoma treatment
US20040175410A1 (en) 2000-04-26 2004-09-09 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors
FR2810884B1 (fr) * 2000-06-30 2002-10-11 B F Internat Lab Base pour composition cosmetique aqueuse parfumee, sans alcool, et composition cosmetique aqueuse parfumee, sans alcool, comprenant une telle base
MXPA02012206A (es) 2000-07-14 2003-06-04 Allergan Inc Composiciones que contienen componentes terapeuticamente activos que tienen solubilidad mejorada.
EP1992317B1 (en) 2000-08-30 2012-02-29 Johns Hopkins University Devices for intraocular drug delivery
US6579519B2 (en) 2000-09-18 2003-06-17 Registrar, University Of Delhi Sustained release and long residing ophthalmic formulation and the process of preparing the same
US6610033B1 (en) 2000-10-13 2003-08-26 Incept, Llc Dual component medicinal polymer delivery system and methods of use
WO2002040056A2 (en) 2000-11-06 2002-05-23 Alcon, Inc Carrageenan viscoelastics for ocular surgery
US6703039B2 (en) 2000-12-06 2004-03-09 Bausch & Lomb Incorporated Reversible gelling system for ocular drug delivery
US6596471B2 (en) 2000-12-21 2003-07-22 Carbomedics Inc. Method of cross-linking tissue with a bis-maleimide compound
MXPA03007665A (es) 2001-02-26 2004-03-16 Univ Duke Polimeros dendriticos novedosos y sus usos biomedicos.
US6777000B2 (en) 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
US6713081B2 (en) 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
US20020198209A1 (en) 2001-05-03 2002-12-26 Allergan Sales Inc. Compositions having enhanced pharmacokinetic characteristics
US6747090B2 (en) 2001-07-16 2004-06-08 Pharmacia Groningen Bv Compositions capable of forming hydrogels in the eye
US20030185892A1 (en) 2001-08-17 2003-10-02 Bell Steve J. D. Intraocular delivery compositions and methods
EA006746B1 (ru) * 2001-11-09 2006-04-28 Айтек Фармасьютикалз Способы лечения глазных неоваскулярных заболеваний
US20040116524A1 (en) 2002-02-04 2004-06-17 Cohen Ben Z. Method of administering opthalmic fluids
US20040131582A1 (en) 2002-02-26 2004-07-08 Grinstaff Mark W. Novel dendritic polymers and their biomedical uses
AU2003279730A1 (en) * 2002-09-30 2004-04-19 Fibrogen, Inc. Dry tissue sealant compositions
US20050043220A1 (en) * 2002-11-08 2005-02-24 Guyer David R. Methods and compositions for treating macular degeneration
KR20040040782A (ko) * 2002-11-08 2004-05-13 선바이오(주) 신규한 헥사-암 폴리에틸렌글리콜과 유도체 및 그의합성방법
US20060039979A1 (en) 2002-12-04 2006-02-23 Kazuhito Yamada Drug delivery system using subconjunctival depot
JP2004196787A (ja) 2002-12-04 2004-07-15 Santen Pharmaceut Co Ltd 結膜下デポによるドラッグデリバリーシステム
WO2004073551A2 (en) * 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
US8545830B2 (en) * 2003-03-24 2013-10-01 University Of Tennessee Research Foundation Multi-functional polymeric materials and their uses
US20050074497A1 (en) * 2003-04-09 2005-04-07 Schultz Clyde L. Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
US20060093673A1 (en) * 2003-06-27 2006-05-04 Coury Arthur J Controlled release of anti-arrhythmic agents
US7129210B2 (en) 2003-07-23 2006-10-31 Covalent Medical, Inc. Tissue adhesive sealant
KR101160702B1 (ko) 2003-08-20 2012-06-28 산텐 세이야꾸 가부시키가이샤 미립자 테논낭하 투여 약물 전달 시스템
US7941211B2 (en) * 2003-11-17 2011-05-10 Zeavision, Llc. Preloading with macular pigment to improve photodynamic treatment of retinal vascular disorders
US20050256065A1 (en) * 2004-01-26 2005-11-17 Permasight Method for stabilizing changes in corneal curvature in an eye by administering compositions containing stabilizing ophthalmic agents
US8685435B2 (en) * 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
US7589057B2 (en) 2004-04-30 2009-09-15 Allergan, Inc. Oil-in-water method for making alpha-2 agonist polymeric drug delivery systems
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US20060182781A1 (en) 2004-04-30 2006-08-17 Allergan, Inc. Methods for treating ocular conditions with cyclic lipid contraining microparticles
US20050288197A1 (en) * 2004-06-08 2005-12-29 Ocularis Pharma, Inc. Silicone polymer topical eye compositions and methods of use
ATE439123T1 (de) 2004-07-02 2009-08-15 Novagali Pharma Sa Verwendung von emulsionen zur intra- und periocularen injection
FR2872975A1 (fr) 2004-07-06 2006-01-13 Thomson Licensing Sa Procede et dispositif pour choisir un mode de codage
JP4731876B2 (ja) 2004-07-08 2011-07-27 パナソニック株式会社 通信システム、無線lan基地局制御装置および無線lan基地局装置
WO2006031358A2 (en) 2004-08-13 2006-03-23 Hyperbranch Medical Technology, Inc. Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
WO2006031388A2 (en) 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
US7919112B2 (en) 2004-08-26 2011-04-05 Pathak Holdings, Llc Implantable tissue compositions and method
US20080038317A1 (en) 2004-09-10 2008-02-14 Chin-Ming Chang Therapeutic Lacrimal Canalicular Inserts And Related Methods
US7857849B2 (en) 2004-10-05 2010-12-28 The Board Of Trustees Of The Leland Stanford Junior Iniversity Artificial corneal implant
US8790632B2 (en) 2004-10-07 2014-07-29 Actamax Surgical Materials, Llc Polymer-based tissue-adhesive form medical use
ATE412400T1 (de) 2004-11-09 2008-11-15 Novagali Pharma Sa Öl-in-wasser-emulsion mit niedriger konzentration des kationischen mittels und positivem zetapotential
JP2008530127A (ja) 2005-02-09 2008-08-07 マクサイト, インコーポレイテッド 眼の処置のための処方物
US20060233858A1 (en) 2005-03-08 2006-10-19 Allergan, Inc. Systems and methods providing targeted intraocular drug delivery
WO2007001926A2 (en) 2005-06-24 2007-01-04 Hyperbranch Medical Technology, Inc. Low-swelling hydrogel sealants for wound repair
WO2007005249A2 (en) 2005-06-29 2007-01-11 Hyperbranch Medical Technology, Inc. Nanoparticles and dendritic-polymer-based hydrogels comprising them
JP5179381B2 (ja) 2006-02-17 2013-04-10 ノバルティス アーゲー ヒドロゲルコンタクトレンズの滅菌方法
US8795709B2 (en) 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
EP2023941B1 (en) 2006-04-24 2016-12-21 Incept, LLC Protein crosslinkers, crosslinking methods and applications thereof
US7868132B2 (en) * 2006-04-25 2011-01-11 E. I. Du Pont De Nemours And Company Method for preparing multi-arm poly (ethylene glycol) amines
US7872068B2 (en) 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
US20090227981A1 (en) 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20080220047A1 (en) 2007-03-05 2008-09-11 Sawhney Amarpreet S Low-swelling biocompatible hydrogels
US9125807B2 (en) * 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
CA2711455C (en) 2008-02-13 2016-06-07 Hyperbranch Medical Technology, Inc. Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
US20100104654A1 (en) 2008-10-27 2010-04-29 Allergan, Inc. Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof
US20100158980A1 (en) 2008-12-18 2010-06-24 Casey Kopczynski Drug delivery devices for delivery of therapeutic agents

Similar Documents

Publication Publication Date Title
JP2010533225A5 (enExample)
Bi et al. Reactive oxygen species-responsive gel-based microneedle patches for prolonged and intelligent psoriasis management
CN110167624B (zh) 核-壳微针装置及其用途
JP5881606B2 (ja) 脊髄損傷治療用製剤
JP6986758B2 (ja) デンドリマー−生体接着性ポリマーヒドロゲルナノ接着剤およびその使用
JP2019529455A5 (enExample)
US20150141910A1 (en) Microneedles for therapeutic agent delivery with improved mechanical properties
ES2904329T3 (es) Composiciones selectivamente polimerizables
JP2012517330A5 (enExample)
RU2018109536A (ru) Сшиваемые in situ полисахаридные композиции и варианты их применения
JP2010507686A5 (enExample)
BRPI0509459A (pt) sistemas de distribuição de droga intraocular com liberação sustentada contendo retinóide e métodos de fabricação relacionados
WO2005070008A3 (en) Polymer no donor predrug nanofiber coating for medical devices and therapy
IL182650A0 (en) Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
JP2013514152A5 (enExample)
WO2019143293A1 (en) Self-implantable micro-drug-reservoirs for localized and controlled ocular drug delivery
JP2009524692A5 (enExample)
KR20170040798A (ko) 수용체 티로신 키나제 억제제의 안정한 가용성 제제 및 그의 제조 방법
BRPI0510472A (pt) implantes intra-oculares de liberação prolongada antiexcitotóxicos e métodos relacionados
MX350711B (es) Composicion y metodo para tratar enfermedades oftalmicas.
CN104606129A (zh) 罗哌卡因长效注射用温敏凝胶及其制备方法
US20200030238A1 (en) Microspheres containing therapeutic agents and related methods of use
KR102117260B1 (ko) 녹내장 치료용 약물을 포함하는 콘택트 렌즈 및 그 제조방법
Bahuon et al. Polyester–Polydopamine Copolymers for Intravitreal Drug Delivery: Role of Polydopamine Drug-Binding Properties in Extending Drug Release
CN105411746B (zh) 一种纳米多层复合止血贴及其制备方法与应用