JP2017537130A5 - - Google Patents
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- Publication number
- JP2017537130A5 JP2017537130A5 JP2017531184A JP2017531184A JP2017537130A5 JP 2017537130 A5 JP2017537130 A5 JP 2017537130A5 JP 2017531184 A JP2017531184 A JP 2017531184A JP 2017531184 A JP2017531184 A JP 2017531184A JP 2017537130 A5 JP2017537130 A5 JP 2017537130A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- hydrogel
- particles
- functional group
- xerogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 claims description 44
- 239000003814 drug Substances 0.000 claims description 36
- 229940124597 therapeutic agent Drugs 0.000 claims description 32
- 239000000017 hydrogel Substances 0.000 claims description 24
- 239000002245 particle Substances 0.000 claims description 22
- 239000002243 precursor Substances 0.000 claims description 19
- 125000000524 functional group Chemical group 0.000 claims description 18
- 239000007787 solid Substances 0.000 claims description 9
- 238000013268 sustained release Methods 0.000 claims description 8
- 239000012730 sustained-release form Substances 0.000 claims description 8
- 238000006065 biodegradation reaction Methods 0.000 claims description 5
- 230000003111 delayed effect Effects 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 238000011065 in-situ storage Methods 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 230000000269 nucleophilic effect Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 12
- 230000001934 delay Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462089994P | 2014-12-10 | 2014-12-10 | |
| US62/089,994 | 2014-12-10 | ||
| PCT/US2015/064975 WO2016094646A1 (en) | 2014-12-10 | 2015-12-10 | Hydrogel drug delivery implants |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020201207A Division JP2021046429A (ja) | 2014-12-10 | 2020-12-03 | ハイドロゲル薬物送達インプラント |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537130A JP2017537130A (ja) | 2017-12-14 |
| JP2017537130A5 true JP2017537130A5 (enExample) | 2019-01-24 |
| JP7092502B2 JP7092502B2 (ja) | 2022-06-28 |
Family
ID=55070156
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017531184A Active JP7092502B2 (ja) | 2014-12-10 | 2015-12-10 | ハイドロゲル薬物送達インプラント |
| JP2020201207A Pending JP2021046429A (ja) | 2014-12-10 | 2020-12-03 | ハイドロゲル薬物送達インプラント |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020201207A Pending JP2021046429A (ja) | 2014-12-10 | 2020-12-03 | ハイドロゲル薬物送達インプラント |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20160166504A1 (enExample) |
| EP (2) | EP3229779B1 (enExample) |
| JP (2) | JP7092502B2 (enExample) |
| KR (1) | KR20170117384A (enExample) |
| CN (2) | CN107205922A (enExample) |
| AU (1) | AU2015360469B2 (enExample) |
| CA (1) | CA2969716C (enExample) |
| WO (1) | WO2016094646A1 (enExample) |
Families Citing this family (39)
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|---|---|---|---|---|
| ES2930433T3 (es) | 2013-03-05 | 2022-12-12 | Univ Pittsburgh Commonwealth Sys Higher Education | Hidrogel termosensible que contiene micropartículas de polímero para la administración ocular no invasiva de fármaco |
| CN107205940A (zh) | 2014-12-15 | 2017-09-26 | 约翰霍普金斯大学 | 舒尼替尼制剂及其在治疗眼部疾病中的使用方法 |
| US9855317B2 (en) | 2015-04-27 | 2018-01-02 | Reflex Medical, Inc. | Systems and methods for sympathetic cardiopulmonary neuromodulation |
| EP4279064A3 (en) * | 2015-05-12 | 2024-02-28 | Incept, LLC | Drug delivery from hydrogels |
| WO2017062770A1 (en) | 2015-10-08 | 2017-04-13 | Silverberg Noah | Punctal plug and bioadhesives |
| HK1257499A1 (zh) | 2015-11-12 | 2019-10-25 | Graybug Vision, Inc. | 用於治疗的聚集性微粒 |
| CA3006303C (en) | 2015-11-25 | 2023-11-14 | Incept, Llc | Shape changing drug delivery devices and methods |
| US11246879B2 (en) | 2016-02-09 | 2022-02-15 | Tulai Therapeutics, Inc. | Methods, agents, and devices for local neuromodulation of autonomic nerves |
| WO2017165449A1 (en) * | 2016-03-22 | 2017-09-28 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Thermoresponsive hydrogel containing polymer microparticles for noninvasive ocular biologic delivery |
| CA3031761A1 (en) | 2016-06-29 | 2018-01-04 | Tulavi Therapeutics, Inc. | Treatment of sepsis and related inflammatory conditions by local neuromodulation of the autonomic nervous system |
| WO2018017899A1 (en) * | 2016-07-20 | 2018-01-25 | Emory University | Formulations for the suprachoroidal space of an eye and methods |
| AU2017331444B2 (en) * | 2016-09-23 | 2023-08-17 | Incept, Llc | Intracameral drug delivery depots |
| CN111201040A (zh) | 2017-05-10 | 2020-05-26 | 灰色视觉公司 | 用于医学疗法的缓释微粒及其悬浮液 |
| US11872328B2 (en) * | 2017-08-30 | 2024-01-16 | Hadasit Medical Research Services And Development Ltd. | Devices, kits and methods for reducing and/or preventing intra-abdominal adhesions |
| EP3708605A4 (en) * | 2017-11-06 | 2020-12-16 | Konica Minolta, Inc. | HYDROGEL PARTICLE AND ITS PRODUCTION PROCESS, CELL OR CELLULAR STRUCTURE EACH CONTAINING A HYDROGEL PARTICLE, PROCESS FOR EVALUATING THE ACTIVITY OF A CELL USING A HYDROGEL PARTICLE, AND USE OF A PARTICLE OF HYDROGEL AS A LONG-RELEASE PREPARATION |
| WO2019164931A1 (en) * | 2018-02-20 | 2019-08-29 | Advanced Aesthetic Technologies, Inc. | High concentration hydrogels and related methods |
| US20210315587A1 (en) | 2018-07-02 | 2021-10-14 | Tulavi Therapeutics, Inc. | Methods and devices for in situ formed nerve cap with rapid release |
| AU2019299519B2 (en) | 2018-07-02 | 2025-03-06 | Incept Llc | Methods and devices for in situ formed nerve cap |
| WO2020035819A1 (en) * | 2018-08-15 | 2020-02-20 | Microsert Ltd. | Sustained release component and corresponding drug delivery device with biodegradable material for flow path modification |
| US20220118416A1 (en) * | 2020-10-18 | 2022-04-21 | Pathak Holdings Llc | Crosslinked multilayered material compositions, methods for their preparation and applications thereof |
| WO2020102810A1 (en) | 2018-11-16 | 2020-05-22 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Thermoresponsive gel eye drop for ocular delivery of cysteamine |
| CN110772376A (zh) * | 2019-11-20 | 2020-02-11 | 韩熠 | 一种用于婴幼儿及儿童的医用眼贴及其制备方法 |
| JP7667747B2 (ja) * | 2020-01-14 | 2025-04-23 | 持田製薬株式会社 | アルギン酸塩を使用した対象の処置のための組合せ及び方法 |
| WO2021158968A1 (en) | 2020-02-06 | 2021-08-12 | Ocular Therapeutix, Inc. | Compositions and methods for treating ocular diseases |
| PT3884929T (pt) | 2020-03-25 | 2023-08-09 | Ocular Therapeutix Inc | Implante ocular contendo um inibidor da tirosina cinase |
| CN115209926B (zh) * | 2020-03-25 | 2024-05-14 | 学校法人福冈大学 | 用于眼内膜剥离术的制剂 |
| CA3177005A1 (en) * | 2020-04-27 | 2021-11-04 | Michael Goldstein | Methods of treating allergic conjunctivitis |
| EP4149400B1 (en) * | 2020-05-15 | 2026-04-22 | Georgia Tech Research Corporation | Methods and compositions for reducing intraocular pressure |
| KR102893953B1 (ko) | 2020-09-24 | 2025-12-02 | 오큘라 테라퓨틱스, 인코포레이티드 | 하이드로겔 및 사이클로스포린을 포함하는 지속 방출 생분해성 소관내 삽입체 |
| JP2023542939A (ja) | 2020-09-24 | 2023-10-12 | オキュラ セラピューティクス，インコーポレイテッド | ヒドロゲル及び活性薬剤を含む徐放性生分解性小管内挿入物 |
| US12343454B2 (en) | 2020-11-12 | 2025-07-01 | Pramand LLC | Hydrogels formed in situ and composition design for intrauterine use |
| CN116888198A (zh) * | 2021-02-05 | 2023-10-13 | 花王株式会社 | 水凝胶结构体 |
| CN113230019A (zh) * | 2021-04-16 | 2021-08-10 | 南京佑羲医药科技有限公司 | 一种用于眼球玻璃体内植入的长效缓释给药装置 |
| US12582767B2 (en) | 2021-12-30 | 2026-03-24 | Taiyo Weber | Compressible, minimally invasive implants and related systems and methods |
| EP4415688A2 (en) * | 2022-02-01 | 2024-08-21 | Ocular Therapeutix, Inc. | A controlled release implant for biologics and corresponding methods of treatment |
| US12251466B2 (en) * | 2022-04-20 | 2025-03-18 | Pramand LLC | Single solution hydrogels with covalent bonding formed in situ, composition design and medical procedures using the hydrogels |
| CN115671036A (zh) * | 2022-11-15 | 2023-02-03 | 上海交通大学医学院附属第九人民医院 | 用于治疗眼底和眼内疾病的凝胶药物 |
| AU2024251447A1 (en) | 2023-04-11 | 2025-08-21 | Ocular Therapeutix, Inc. | Ocular implant comprising axitinib polymorph iv |
| CN116687840B (zh) * | 2023-08-03 | 2023-10-20 | 四川省医学科学院·四川省人民医院 | 一种用于治疗眼部病状的凝胶制剂及其制备方法 |
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| US3640741A (en) | 1970-02-24 | 1972-02-08 | Hollister Inc | Composition containing gel |
| US3865108A (en) | 1971-05-17 | 1975-02-11 | Ortho Pharma Corp | Expandable drug delivery device |
| US4002173A (en) | 1974-07-23 | 1977-01-11 | International Paper Company | Diester crosslinked polyglucan hydrogels and reticulated sponges thereof |
| DE2437629C3 (de) | 1974-08-05 | 1978-09-21 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von unlöslichen in Wasser nur wenig quellbaren Polymerisaten von N-Vinyllactamen |
| US4014335A (en) | 1975-04-21 | 1977-03-29 | Alza Corporation | Ocular drug delivery device |
| US4207893A (en) | 1977-08-29 | 1980-06-17 | Alza Corporation | Device using hydrophilic polymer for delivering drug to biological environment |
| US4741872A (en) | 1986-05-16 | 1988-05-03 | The University Of Kentucky Research Foundation | Preparation of biodegradable microspheres useful as carriers for macromolecules |
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| US5410016A (en) | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| ATE203885T1 (de) * | 1994-09-08 | 2001-08-15 | Stryker Technologies Corp | Bandscheibenkern aus hydrogel |
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| US6958212B1 (en) | 1999-02-01 | 2005-10-25 | Eidgenossische Technische Hochschule Zurich | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds |
| MXPA03007665A (es) | 2001-02-26 | 2004-03-16 | Univ Duke | Polimeros dendriticos novedosos y sus usos biomedicos. |
| US6913765B2 (en) * | 2001-03-21 | 2005-07-05 | Scimed Life Systems, Inc. | Controlling resorption of bioresorbable medical implant material |
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| US9125807B2 (en) * | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
| CA2782899C (en) | 2009-12-15 | 2019-06-11 | Incept, Llc | Implants and biodegradable fiducial markers |
| US8961501B2 (en) | 2010-09-17 | 2015-02-24 | Incept, Llc | Method for applying flowable hydrogels to a cornea |
| US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
| US9205150B2 (en) | 2011-12-05 | 2015-12-08 | Incept, Llc | Medical organogel processes and compositions |
| US20150037422A1 (en) * | 2012-02-22 | 2015-02-05 | Trustees Of Tufts College | Compositions and methods for ocular delivery of a therapeutic agent |
| WO2014039012A1 (en) | 2012-09-06 | 2014-03-13 | Nanyang Technological University | Hyaluronic acid-based drug delivery systems |
-
2015
- 2015-12-10 CN CN201580075658.1A patent/CN107205922A/zh active Pending
- 2015-12-10 CA CA2969716A patent/CA2969716C/en active Active
- 2015-12-10 EP EP15820375.2A patent/EP3229779B1/en active Active
- 2015-12-10 EP EP20214440.8A patent/EP3858329A1/en active Pending
- 2015-12-10 JP JP2017531184A patent/JP7092502B2/ja active Active
- 2015-12-10 CN CN202510552462.2A patent/CN120501693A/zh active Pending
- 2015-12-10 US US14/965,258 patent/US20160166504A1/en not_active Abandoned
- 2015-12-10 KR KR1020177018919A patent/KR20170117384A/ko not_active Ceased
- 2015-12-10 WO PCT/US2015/064975 patent/WO2016094646A1/en not_active Ceased
- 2015-12-10 AU AU2015360469A patent/AU2015360469B2/en active Active
-
2020
- 2020-12-03 JP JP2020201207A patent/JP2021046429A/ja active Pending
-
2025
- 2025-07-02 US US19/258,825 patent/US20260060921A1/en active Pending
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