JP2017537130A5 - - Google Patents
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- Publication number
- JP2017537130A5 JP2017537130A5 JP2017531184A JP2017531184A JP2017537130A5 JP 2017537130 A5 JP2017537130 A5 JP 2017537130A5 JP 2017531184 A JP2017531184 A JP 2017531184A JP 2017531184 A JP2017531184 A JP 2017531184A JP 2017537130 A5 JP2017537130 A5 JP 2017537130A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic agent
- hydrogel
- particles
- functional group
- xerogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 claims description 44
- 239000003814 drug Substances 0.000 claims description 36
- 229940124597 therapeutic agent Drugs 0.000 claims description 32
- 239000000017 hydrogel Substances 0.000 claims description 24
- 239000002245 particle Substances 0.000 claims description 22
- 239000002243 precursor Substances 0.000 claims description 19
- 125000000524 functional group Chemical group 0.000 claims description 18
- 239000007787 solid Substances 0.000 claims description 9
- 238000013268 sustained release Methods 0.000 claims description 8
- 239000012730 sustained-release form Substances 0.000 claims description 8
- 238000006065 biodegradation reaction Methods 0.000 claims description 5
- 230000003111 delayed effect Effects 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 238000011065 in-situ storage Methods 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 230000000269 nucleophilic effect Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 12
- 230000001934 delay Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462089994P | 2014-12-10 | 2014-12-10 | |
| US62/089,994 | 2014-12-10 | ||
| PCT/US2015/064975 WO2016094646A1 (en) | 2014-12-10 | 2015-12-10 | Hydrogel drug delivery implants |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020201207A Division JP2021046429A (ja) | 2014-12-10 | 2020-12-03 | ハイドロゲル薬物送達インプラント |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017537130A JP2017537130A (ja) | 2017-12-14 |
| JP2017537130A5 true JP2017537130A5 (enExample) | 2019-01-24 |
| JP7092502B2 JP7092502B2 (ja) | 2022-06-28 |
Family
ID=55070156
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017531184A Active JP7092502B2 (ja) | 2014-12-10 | 2015-12-10 | ハイドロゲル薬物送達インプラント |
| JP2020201207A Pending JP2021046429A (ja) | 2014-12-10 | 2020-12-03 | ハイドロゲル薬物送達インプラント |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020201207A Pending JP2021046429A (ja) | 2014-12-10 | 2020-12-03 | ハイドロゲル薬物送達インプラント |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20160166504A1 (enExample) |
| EP (2) | EP3858329A1 (enExample) |
| JP (2) | JP7092502B2 (enExample) |
| KR (1) | KR20170117384A (enExample) |
| CN (2) | CN120501693A (enExample) |
| AU (1) | AU2015360469B2 (enExample) |
| CA (1) | CA2969716C (enExample) |
| WO (1) | WO2016094646A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2964194B1 (en) | 2013-03-05 | 2022-08-17 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Thermoresponsive hydrogel containing polymer microparticles for noninvasive ocular drug delivery |
| US20220118416A1 (en) * | 2020-10-18 | 2022-04-21 | Pathak Holdings Llc | Crosslinked multilayered material compositions, methods for their preparation and applications thereof |
| US12629345B2 (en) | 2013-03-14 | 2026-05-19 | Pathak Holdings Llc | Methods, compositions, and devices for drug / live cell microarrays |
| MX2017007873A (es) | 2014-12-15 | 2017-11-06 | Univ Johns Hopkins | Formulaciones de sunitinib y metodos para uso de las mismas en el tratamiento de trastornos oculares. |
| EP3288626B8 (en) | 2015-04-27 | 2025-12-10 | Tulavi Therapeutics, Inc. | Substances and compositions for use in blocking nerve regeneration |
| WO2016183296A1 (en) | 2015-05-12 | 2016-11-17 | Incept, Llc | Drug delivery from hydrogels |
| WO2017062770A1 (en) | 2015-10-08 | 2017-04-13 | Silverberg Noah | Punctal plug and bioadhesives |
| US10441548B2 (en) | 2015-11-12 | 2019-10-15 | Graybug Vision, Inc. | Aggregating microparticles for medical therapy |
| AU2016361579B2 (en) | 2015-11-25 | 2022-08-04 | Incept, Llc | Shape changing drug delivery devices and methods |
| WO2017139487A1 (en) | 2016-02-09 | 2017-08-17 | Northwind Medical, Inc. | Methods, agents, and devices for local neuromodulation of autonomic nerves |
| US20190099365A1 (en) * | 2016-03-22 | 2019-04-04 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Thermoresponsive hydrogel containing polymer microparticles for noninvasive ocular biologic delivery |
| AU2017290353B2 (en) | 2016-06-29 | 2023-05-18 | Tulavi Therapeutics, Inc. | Treatment of sepsis and related inflammatory conditions by local neuromodulation of the autonomic nervous system |
| WO2018017899A1 (en) * | 2016-07-20 | 2018-01-25 | Emory University | Formulations for the suprachoroidal space of an eye and methods |
| KR102814241B1 (ko) * | 2016-09-23 | 2025-05-29 | 인셉트, 엘엘씨 | 전안방내 약물 전달 데포 |
| WO2018067882A1 (en) | 2016-10-05 | 2018-04-12 | Titan Pharmaceuticals, Inc. | Implantable devices for drug delivery with reduced burst release |
| MX2019013363A (es) | 2017-05-10 | 2020-01-13 | Graybug Vision Inc | Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica. |
| WO2019043699A1 (en) | 2017-08-30 | 2019-03-07 | Hadasit Medical Research Services And Development Ltd. | DEVICES, KITS AND METHODS FOR REDUCING AND / OR PREVENTING INTRA-ABDOMINAL ADHESIONS |
| WO2019088292A1 (ja) * | 2017-11-06 | 2019-05-09 | コニカミノルタ株式会社 | ハイドロゲル粒子およびその製造方法、ハイドロゲル粒子を内包する細胞または細胞構造体、ハイドロゲル粒子を用いた細胞活性の評価方法、並びにハイドロゲル粒子の徐放性製剤としての使用 |
| US20210221962A1 (en) * | 2018-02-20 | 2021-07-22 | Advanced Aesthetic Technologies, Inc. | High concentration hydrogels and related methods |
| AU2019299519B2 (en) | 2018-07-02 | 2025-03-06 | Incept Llc | Methods and devices for in situ formed nerve cap |
| US20210315587A1 (en) | 2018-07-02 | 2021-10-14 | Tulavi Therapeutics, Inc. | Methods and devices for in situ formed nerve cap with rapid release |
| CN112752568A (zh) * | 2018-08-15 | 2021-05-04 | 微思有限公司 | 具有用于流动路径修饰的可生物降解材料的持续释出部件及相应的药物输送装置 |
| US12599577B2 (en) | 2018-11-16 | 2026-04-14 | University of Pittsburgh—of the Commonwealth System of Higher Education | Thermoresponsive gel eye drop for ocular delivery of cysteamine |
| CN110772376A (zh) * | 2019-11-20 | 2020-02-11 | 韩熠 | 一种用于婴幼儿及儿童的医用眼贴及其制备方法 |
| AU2021206966A1 (en) * | 2020-01-14 | 2022-08-04 | Mochida Pharmaceutical Co., Ltd. | Combination and method for treating subject using alginic acid salt |
| CN115066232B (zh) | 2020-02-06 | 2024-12-10 | 视尔普斯眼科公司 | 用于治疗眼病的组合物和方法 |
| EP4129353A4 (en) * | 2020-03-25 | 2024-05-29 | Fukuoka University | Agent to be used in intraocular membrane detachment surgery |
| CA3171563A1 (en) * | 2020-03-25 | 2021-09-30 | Charles D. Blizzard | Ocular implant containing a tyrosine kinase inhibitor |
| EP4142664A4 (en) | 2020-04-27 | 2024-05-29 | Ocular Therapeutix, Inc. | METHODS FOR TREATING ALLERGIC CONJUNCTIVITIS |
| EP4149400B1 (en) * | 2020-05-15 | 2026-04-22 | Georgia Tech Research Corporation | Methods and compositions for reducing intraocular pressure |
| EP3973952B1 (en) | 2020-09-24 | 2024-02-14 | Ocular Therapeutix, Inc. | Sustained release biodegradable intracanalicular inserts comprising a hydrogel and cyclosporine |
| EP4216929A1 (en) | 2020-09-24 | 2023-08-02 | Ocular Therapeutix, Inc. | Sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent |
| US12343454B2 (en) | 2020-11-12 | 2025-07-01 | Pramand LLC | Hydrogels formed in situ and composition design for intrauterine use |
| US20220142653A1 (en) | 2020-11-12 | 2022-05-12 | Pramand LLC | Transcervical access systems for intrauterine fluid exchange, such as placement of hydrogels formed in situ |
| US12605311B2 (en) | 2021-02-05 | 2026-04-21 | Kao Corporation | Hydrogel structure |
| CN113230019A (zh) * | 2021-04-16 | 2021-08-10 | 南京佑羲医药科技有限公司 | 一种用于眼球玻璃体内植入的长效缓释给药装置 |
| CN113367883A (zh) * | 2021-06-08 | 2021-09-10 | 复旦大学附属眼耳鼻喉科医院 | 一种原位成胶个体化配适的角膜绷带镜 |
| US12582767B2 (en) | 2021-12-30 | 2026-03-24 | Taiyo Weber | Compressible, minimally invasive implants and related systems and methods |
| IL314115A (en) * | 2022-02-01 | 2024-09-01 | Ocular Therapeutix Inc | Controlled release implant for biological agents and corresponding treatment methods |
| US12251466B2 (en) * | 2022-04-20 | 2025-03-18 | Pramand LLC | Single solution hydrogels with covalent bonding formed in situ, composition design and medical procedures using the hydrogels |
| CN115671036A (zh) * | 2022-11-15 | 2023-02-03 | 上海交通大学医学院附属第九人民医院 | 用于治疗眼底和眼内疾病的凝胶药物 |
| JP2026520094A (ja) | 2023-04-11 | 2026-06-22 | オキュラ セラピューティクス，インコーポレイテッド | アキシチニブ多形ｉｖを含む眼科インプラント |
| CN116687840B (zh) * | 2023-08-03 | 2023-10-20 | 四川省医学科学院·四川省人民医院 | 一种用于治疗眼部病状的凝胶制剂及其制备方法 |
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| US3640741A (en) | 1970-02-24 | 1972-02-08 | Hollister Inc | Composition containing gel |
| US3865108A (en) | 1971-05-17 | 1975-02-11 | Ortho Pharma Corp | Expandable drug delivery device |
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| DE2437629C3 (de) | 1974-08-05 | 1978-09-21 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von unlöslichen in Wasser nur wenig quellbaren Polymerisaten von N-Vinyllactamen |
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| US10226417B2 (en) * | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
| US9205150B2 (en) * | 2011-12-05 | 2015-12-08 | Incept, Llc | Medical organogel processes and compositions |
| HK1205461A1 (zh) * | 2012-02-22 | 2015-12-18 | Trustees Of Tufts College | 用於眼部传输治疗剂的组合物和方法 |
| CN104602712A (zh) | 2012-09-06 | 2015-05-06 | 南洋理工大学 | 基于透明质酸的药物递送系统 |
-
2015
- 2015-12-10 AU AU2015360469A patent/AU2015360469B2/en active Active
- 2015-12-10 KR KR1020177018919A patent/KR20170117384A/ko not_active Ceased
- 2015-12-10 CN CN202510552462.2A patent/CN120501693A/zh active Pending
- 2015-12-10 EP EP20214440.8A patent/EP3858329A1/en active Pending
- 2015-12-10 WO PCT/US2015/064975 patent/WO2016094646A1/en not_active Ceased
- 2015-12-10 CN CN201580075658.1A patent/CN107205922A/zh active Pending
- 2015-12-10 CA CA2969716A patent/CA2969716C/en active Active
- 2015-12-10 JP JP2017531184A patent/JP7092502B2/ja active Active
- 2015-12-10 US US14/965,258 patent/US20160166504A1/en not_active Abandoned
- 2015-12-10 EP EP15820375.2A patent/EP3229779B1/en active Active
-
2020
- 2020-12-03 JP JP2020201207A patent/JP2021046429A/ja active Pending
-
2025
- 2025-07-02 US US19/258,825 patent/US20260060921A1/en active Pending
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