CN120501693A - 水凝胶药物递送植入物 - Google Patents

水凝胶药物递送植入物

Info

Publication number
CN120501693A
CN120501693A CN202510552462.2A CN202510552462A CN120501693A CN 120501693 A CN120501693 A CN 120501693A CN 202510552462 A CN202510552462 A CN 202510552462A CN 120501693 A CN120501693 A CN 120501693A
Authority
CN
China
Prior art keywords
hydrogel
particles
therapeutic agent
precursor
xerogel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202510552462.2A
Other languages
English (en)
Chinese (zh)
Inventor
P·贾勒特
R·埃尔-海克
A·S·索内
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incept LLC
Original Assignee
Incept LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incept LLC filed Critical Incept LLC
Publication of CN120501693A publication Critical patent/CN120501693A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202510552462.2A 2014-12-10 2015-12-10 水凝胶药物递送植入物 Pending CN120501693A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462089994P 2014-12-10 2014-12-10
US62/089,994 2014-12-10
CN201580075658.1A CN107205922A (zh) 2014-12-10 2015-12-10 水凝胶药物递送植入物
PCT/US2015/064975 WO2016094646A1 (en) 2014-12-10 2015-12-10 Hydrogel drug delivery implants

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201580075658.1A Division CN107205922A (zh) 2014-12-10 2015-12-10 水凝胶药物递送植入物

Publications (1)

Publication Number Publication Date
CN120501693A true CN120501693A (zh) 2025-08-19

Family

ID=55070156

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201580075658.1A Pending CN107205922A (zh) 2014-12-10 2015-12-10 水凝胶药物递送植入物
CN202510552462.2A Pending CN120501693A (zh) 2014-12-10 2015-12-10 水凝胶药物递送植入物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201580075658.1A Pending CN107205922A (zh) 2014-12-10 2015-12-10 水凝胶药物递送植入物

Country Status (8)

Country Link
US (1) US20160166504A1 (enExample)
EP (2) EP3229779B1 (enExample)
JP (2) JP7092502B2 (enExample)
KR (1) KR20170117384A (enExample)
CN (2) CN107205922A (enExample)
AU (1) AU2015360469B2 (enExample)
CA (1) CA2969716C (enExample)
WO (1) WO2016094646A1 (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2930433T3 (es) 2013-03-05 2022-12-12 Univ Pittsburgh Commonwealth Sys Higher Education Hidrogel termosensible que contiene micropartículas de polímero para la administración ocular no invasiva de fármaco
US20220118416A1 (en) * 2020-10-18 2022-04-21 Pathak Holdings Llc Crosslinked multilayered material compositions, methods for their preparation and applications thereof
EP3233056B1 (en) 2014-12-15 2023-11-15 The Johns Hopkins University Sunitinib formulations and methods for use thereof in treatment of ocular disorders
WO2016176333A1 (en) 2015-04-27 2016-11-03 Reflex Medical, Inc. Systems and mehtods for sympathetic cardiopulmonary neuromodulation
JP2018515529A (ja) * 2015-05-12 2018-06-14 インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ ハイドロゲルからの薬物送達
US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
BR112018009644A2 (pt) 2015-11-12 2018-11-06 Graybug Vision Inc micropartículas agregantes sólidas modificadas na superfície, material injetável, processo para preparação de micropartículas agregantes sólidas modificadas na superfície, método para tratamento de um distúrbio ocular, e, uso de micropartículas agregantes sólidas modificadas na superfície
AU2016361579B2 (en) 2015-11-25 2022-08-04 Incept, Llc Shape changing drug delivery devices and methods
US11246879B2 (en) 2016-02-09 2022-02-15 Tulai Therapeutics, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
WO2017165449A1 (en) * 2016-03-22 2017-09-28 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Thermoresponsive hydrogel containing polymer microparticles for noninvasive ocular biologic delivery
WO2018005848A1 (en) 2016-06-29 2018-01-04 Bright, Corinne Treatment of sepsis and related inflammatory conditions by local neuromodulation of the autonomic nervous system
US11504431B2 (en) * 2016-07-20 2022-11-22 Emory University Formulations for the suprachoroidal space of an eye and methods
KR102520771B1 (ko) * 2016-09-23 2023-04-12 인셉트, 엘엘씨 전안방내 약물 전달 데포
CN111201040A (zh) 2017-05-10 2020-05-26 灰色视觉公司 用于医学疗法的缓释微粒及其悬浮液
WO2019043699A1 (en) 2017-08-30 2019-03-07 Hadasit Medical Research Services And Development Ltd. DEVICES, KITS AND METHODS FOR REDUCING AND / OR PREVENTING INTRA-ABDOMINAL ADHESIONS
JP7217473B2 (ja) * 2017-11-06 2023-02-03 コニカミノルタ株式会社 ハイドロゲル粒子およびその製造方法、ハイドロゲル粒子を内包する細胞または細胞構造体、ハイドロゲル粒子を用いた細胞活性の評価方法、並びにハイドロゲル粒子の徐放性製剤としての使用
ES2980138T3 (es) * 2018-02-20 2024-09-30 Advanced Aesthetic Tech Inc Hidrogeles de alta concentración y procedimientos relacionados
CA3105343A1 (en) 2018-07-02 2020-01-09 Corinne Bright Methods and devices for in situ formed nerve cap
US20210315587A1 (en) 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
CN112752568A (zh) * 2018-08-15 2021-05-04 微思有限公司 具有用于流动路径修饰的可生物降解材料的持续释出部件及相应的药物输送装置
CN110772376A (zh) * 2019-11-20 2020-02-11 韩熠 一种用于婴幼儿及儿童的医用眼贴及其制备方法
AU2021206966A1 (en) * 2020-01-14 2022-08-04 Mochida Pharmaceutical Co., Ltd. Combination and method for treating subject using alginic acid salt
DK3861985T3 (da) 2020-02-06 2023-07-24 Ocular Therapeutix Inc Sammensætninger og fremgangsmåder til behandling af øjensygdomme
US20230136938A1 (en) * 2020-03-25 2023-05-04 Fukuoka University Agent to be used in intraocular membrane detachment surgery
DK3884929T3 (da) * 2020-03-25 2023-09-25 Ocular Therapeutix Inc Øjenimplantat indeholdende en tyrosinkinase-inhibitor
CN115768385A (zh) * 2020-04-27 2023-03-07 视觉治疗股份有限公司 治疗过敏性结膜炎的方法
US20230201110A1 (en) * 2020-05-15 2023-06-29 Georgia Tech Research Corporation Methods and Compositions For Reducing Intraocular Pressure
BR112023004378A2 (pt) 2020-09-24 2023-04-04 Ocular Therapeutix Inc Insertos intracanaliculares biodegradáveis de liberação sustentada que compreendem um hidrogel e uma ciclosporina
WO2022066891A1 (en) 2020-09-24 2022-03-31 Ocular Therapeutix, Inc. Sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent
US12343454B2 (en) 2020-11-12 2025-07-01 Pramand LLC Hydrogels formed in situ and composition design for intrauterine use
CN116888198A (zh) * 2021-02-05 2023-10-13 花王株式会社 水凝胶结构体
CN113230019A (zh) * 2021-04-16 2021-08-10 南京佑羲医药科技有限公司 一种用于眼球玻璃体内植入的长效缓释给药装置
IL314115A (en) * 2022-02-01 2024-09-01 Ocular Therapeutix Inc Controlled release implant for biological agents and corresponding treatment methods
US12251466B2 (en) 2022-04-20 2025-03-18 Pramand LLC Single solution hydrogels with covalent bonding formed in situ, composition design and medical procedures using the hydrogels
CN115671036A (zh) * 2022-11-15 2023-02-03 上海交通大学医学院附属第九人民医院 用于治疗眼底和眼内疾病的凝胶药物
WO2024215649A1 (en) 2023-04-11 2024-10-17 Ocular Therapeutix, Inc. Ocular implant comprising axitinib polymorph iv
CN116687840B (zh) * 2023-08-03 2023-10-20 四川省医学科学院·四川省人民医院 一种用于治疗眼部病状的凝胶制剂及其制备方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3640741A (en) 1970-02-24 1972-02-08 Hollister Inc Composition containing gel
US3865108A (en) 1971-05-17 1975-02-11 Ortho Pharma Corp Expandable drug delivery device
US4002173A (en) 1974-07-23 1977-01-11 International Paper Company Diester crosslinked polyglucan hydrogels and reticulated sponges thereof
DE2437629C3 (de) 1974-08-05 1978-09-21 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von unlöslichen in Wasser nur wenig quellbaren Polymerisaten von N-Vinyllactamen
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4207893A (en) 1977-08-29 1980-06-17 Alza Corporation Device using hydrophilic polymer for delivering drug to biological environment
US5160745A (en) 1986-05-16 1992-11-03 The University Of Kentucky Research Foundation Biodegradable microspheres as a carrier for macromolecules
US4741872A (en) 1986-05-16 1988-05-03 The University Of Kentucky Research Foundation Preparation of biodegradable microspheres useful as carriers for macromolecules
IL82834A (en) 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5304595A (en) 1988-11-21 1994-04-19 Collagen Corporation Collagen-polymer conjugates
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
IL90193A (en) 1989-05-04 1993-02-21 Biomedical Polymers Int Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
ATE203885T1 (de) * 1994-09-08 2001-08-15 Stryker Technologies Corp Bandscheibenkern aus hydrogel
US6371975B2 (en) 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
EP1027016A4 (en) 1997-10-27 2006-03-08 Univ California METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REFERRING RETINAL RIPPLE
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
MXPA03007665A (es) 2001-02-26 2004-03-16 Univ Duke Polimeros dendriticos novedosos y sus usos biomedicos.
US6913765B2 (en) * 2001-03-21 2005-07-05 Scimed Life Systems, Inc. Controlling resorption of bioresorbable medical implant material
US20040131582A1 (en) 2002-02-26 2004-07-08 Grinstaff Mark W. Novel dendritic polymers and their biomedical uses
ES2379466T3 (es) * 2003-06-26 2012-04-26 Psivida Us, Inc. Sistema de suministro de fármacos de liberación sostenida bioerosionables
US7129210B2 (en) 2003-07-23 2006-10-31 Covalent Medical, Inc. Tissue adhesive sealant
WO2006031358A2 (en) 2004-08-13 2006-03-23 Hyperbranch Medical Technology, Inc. Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
WO2006031388A2 (en) 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
JP2008520783A (ja) * 2004-11-16 2008-06-19 ユニベルシテ・ド・リエージュ ヒドロゲルマトリックスおよびマイクロキャリアを含む活性物質供給システム
WO2007001926A2 (en) 2005-06-24 2007-01-04 Hyperbranch Medical Technology, Inc. Low-swelling hydrogel sealants for wound repair
WO2007005249A2 (en) 2005-06-29 2007-01-11 Hyperbranch Medical Technology, Inc. Nanoparticles and dendritic-polymer-based hydrogels comprising them
US9125807B2 (en) * 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
EP3960215B1 (en) 2009-12-15 2024-10-16 Incept, LLC Implants and biodegradable fiducial markers
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
US10226417B2 (en) * 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
AU2012347926B2 (en) * 2011-12-05 2018-03-15 Incept, Llc Medical organogel processes and compositions
EP2817031A4 (en) * 2012-02-22 2015-08-05 Tufts College COMPOSITIONS AND METHOD FOR THE ORGANIC ADMINISTRATION OF A THERAPEUTIC ACTIVE SUBSTANCE
US9987367B2 (en) * 2012-09-06 2018-06-05 Nanyang Technological University Hyaluronic acid-based drug delivery systems

Also Published As

Publication number Publication date
JP2021046429A (ja) 2021-03-25
US20160166504A1 (en) 2016-06-16
EP3858329A1 (en) 2021-08-04
JP7092502B2 (ja) 2022-06-28
CA2969716A1 (en) 2016-06-16
AU2015360469A1 (en) 2017-06-22
KR20170117384A (ko) 2017-10-23
JP2017537130A (ja) 2017-12-14
AU2015360469B2 (en) 2021-03-25
WO2016094646A1 (en) 2016-06-16
EP3229779B1 (en) 2021-02-03
EP3229779A1 (en) 2017-10-18
CN107205922A (zh) 2017-09-26
CA2969716C (en) 2023-12-19

Similar Documents

Publication Publication Date Title
JP7599732B2 (ja) ハイドロゲルからの薬物送達
JP7092502B2 (ja) ハイドロゲル薬物送達インプラント
US11890343B2 (en) Medical organogel processes and compositions
JP7486539B2 (ja) 前房内薬物送達デポ
CN108601725B (zh) 形状改变的药物递送装置和方法
US20160106587A1 (en) Ocular gels or hydrogels and microinjectors
HK40057028A (en) Hydrogel drug delivery implants
HK40023142A (en) Medical organogel processes and compositions
HK40002938A (en) Medical organogel processes and compositions
HK1203367B (zh) 醫用有機凝膠方法和組合物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination