JP2010529056A5 - - Google Patents
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- Publication number
- JP2010529056A5 JP2010529056A5 JP2010510670A JP2010510670A JP2010529056A5 JP 2010529056 A5 JP2010529056 A5 JP 2010529056A5 JP 2010510670 A JP2010510670 A JP 2010510670A JP 2010510670 A JP2010510670 A JP 2010510670A JP 2010529056 A5 JP2010529056 A5 JP 2010529056A5
- Authority
- JP
- Japan
- Prior art keywords
- active agent
- osmotic
- zinc
- active
- agent component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013543 active substance Substances 0.000 claims 10
- 230000003204 osmotic effect Effects 0.000 claims 8
- 230000014759 maintenance of location Effects 0.000 claims 4
- 210000002784 stomach Anatomy 0.000 claims 4
- 239000008186 active pharmaceutical agent Substances 0.000 claims 3
- 230000002496 gastric effect Effects 0.000 claims 3
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 2
- -1 aluminum ions Chemical class 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 239000011247 coating layer Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 239000000314 lubricant Substances 0.000 claims 2
- 239000002357 osmotic agent Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 150000003751 zinc Chemical class 0.000 claims 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims 1
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 230000000181 anti-adherent effect Effects 0.000 claims 1
- 229940009098 aspartate Drugs 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 claims 1
- 230000000149 penetrating effect Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
- 239000004246 zinc acetate Substances 0.000 claims 1
- 229940062776 zinc aspartate Drugs 0.000 claims 1
- 239000011592 zinc chloride Substances 0.000 claims 1
- 235000005074 zinc chloride Nutrition 0.000 claims 1
- 239000011670 zinc gluconate Substances 0.000 claims 1
- 235000011478 zinc gluconate Nutrition 0.000 claims 1
- 229960000306 zinc gluconate Drugs 0.000 claims 1
- POEVDIARYKIEGF-CEOVSRFSSA-L zinc;(2s)-2-aminobutanedioate;hydron Chemical compound [Zn+2].[O-]C(=O)[C@@H](N)CC(O)=O.[O-]C(=O)[C@@H](N)CC(O)=O POEVDIARYKIEGF-CEOVSRFSSA-L 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007026037.9 | 2007-06-04 | ||
| DE102007026037A DE102007026037A1 (de) | 2007-06-04 | 2007-06-04 | Gastroretentives System mit Alginat-Körper |
| PCT/EP2008/004188 WO2008148478A2 (de) | 2007-06-04 | 2008-05-27 | Gastroretentives system mit alginat-körper |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010529056A JP2010529056A (ja) | 2010-08-26 |
| JP2010529056A5 true JP2010529056A5 (https=) | 2010-10-07 |
| JP5425058B2 JP5425058B2 (ja) | 2014-02-26 |
Family
ID=39942026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510670A Expired - Fee Related JP5425058B2 (ja) | 2007-06-04 | 2008-05-27 | アルギン酸塩体を含む胃内滞留型システム |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20100129445A1 (https=) |
| EP (2) | EP2155172A2 (https=) |
| JP (1) | JP5425058B2 (https=) |
| KR (1) | KR101268215B1 (https=) |
| CN (1) | CN102215826A (https=) |
| AU (1) | AU2008258881B2 (https=) |
| CA (1) | CA2689049C (https=) |
| DE (1) | DE102007026037A1 (https=) |
| IL (1) | IL202518A0 (https=) |
| MX (1) | MX2009013086A (https=) |
| NZ (1) | NZ581740A (https=) |
| RU (1) | RU2468790C2 (https=) |
| WO (1) | WO2008148478A2 (https=) |
| ZA (1) | ZA200908355B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101118794B1 (ko) * | 2009-11-10 | 2012-06-13 | 동아제약주식회사 | 비스포스포네이트를 함유하는 약학 조성물 |
| JP6143675B2 (ja) | 2010-12-16 | 2017-06-07 | セルジーン コーポレイション | 難溶性薬物の制御放出経口剤形及びその使用 |
| US9532977B2 (en) | 2010-12-16 | 2017-01-03 | Celgene Corporation | Controlled release oral dosage forms of poorly soluble drugs and uses thereof |
| DE102011051653A1 (de) * | 2011-07-07 | 2013-01-10 | Lts Lohmann Therapie-Systeme Ag | Quellfähige Manteltablette |
| WO2013183058A2 (en) | 2012-06-07 | 2013-12-12 | Tulip Medical Ltd. | Expanded device |
| RU2015110825A (ru) | 2012-08-27 | 2016-10-20 | Эвоник Индустрис Аг | Устойчивая к действию желудочного сока фармацевтическая или нутрицевтическая композиция со стойкостью к влиянию этанола |
| WO2014032676A1 (en) * | 2012-09-03 | 2014-03-06 | S-Biotek Holding Aps | A solid oral formulation for treatment and/or prevention of overweight and/or for stabilizing blood sugar levels in an individual. |
| EP3091962B1 (en) * | 2013-12-05 | 2022-06-08 | Epitomee Medical Ltd. | Retentive devices and systems for in-situ release of pharmaceutical active agents |
| EP3373916A1 (en) | 2015-11-11 | 2018-09-19 | Celgene Corporation | Controlled release oral dosage forms of poorly soluble drugs and uses thereof |
| CN108721246B (zh) * | 2018-05-29 | 2021-06-25 | 王喆明 | 高分子材料构建的多单元超长效口服制剂及其制备方法 |
| US11511093B2 (en) | 2019-10-11 | 2022-11-29 | Wonkwang University Center for Industry Academy Cooperation | Gastroretentive drug delivery device having expandable structure and manufacturing method therefor |
| KR102278915B1 (ko) | 2019-10-24 | 2021-07-19 | 중앙대학교 산학협력단 | 다공성 하이드로겔을 유효성분으로 함유하는 위 체류 및 약물 방출 제어형 경구용 제제 |
| HUE067496T2 (hu) | 2020-12-08 | 2024-10-28 | Ruminant Biotech Corp Ltd | Az állatoknak szánt anyagok bejuttatására szolgáló eszközök és módszerek fejlesztése |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4207890A (en) | 1977-01-04 | 1980-06-17 | Mcneilab, Inc. | Drug-dispensing device and method |
| US4735804A (en) * | 1985-05-10 | 1988-04-05 | Merck & Co., Inc. | Drug delivery device which can be retained in the stomach for a controlled period of time |
| US4695463A (en) * | 1985-05-24 | 1987-09-22 | Warner-Lambert Company | Delivery system for active ingredients and preparation thereof |
| US4816262A (en) | 1986-08-28 | 1989-03-28 | Universite De Montreal | Controlled release tablet |
| IL87710A (en) | 1987-09-18 | 1992-06-21 | Ciba Geigy Ag | Covered floating retard form for controlled release in gastric juice |
| DE3803482A1 (de) | 1988-02-05 | 1989-08-17 | Lohmann Therapie Syst Lts | Schwimmfaehiges orales therapeutisches system |
| US4983401A (en) | 1989-05-22 | 1991-01-08 | Kinaform Technology, Inc. | Sustained release pharmaceutical preparations having pH controlled membrane coatings |
| US5198227A (en) | 1990-01-22 | 1993-03-30 | Mcneil-Ppc, Inc. | Dual subcoated simulated capsule medicament |
| US5198229A (en) * | 1991-06-05 | 1993-03-30 | Alza Corporation | Self-retaining gastrointestinal delivery device |
| DE69207863T2 (de) | 1991-11-13 | 1996-06-05 | Glaxo Canada | Vorrichtung zur kontrollierten Wirkstoffreigabe |
| CA2175225C (en) * | 1993-10-29 | 2004-09-21 | Keith Graeme Hutchison | Gelatin capsule fill able to foam |
| DE4419818C2 (de) | 1994-06-07 | 1998-10-22 | Lohmann Therapie Syst Lts | Wirkstoffträger zur kontrollierten Freisetzung von Wirkstoffen im Gastrointestinaltrakt mit verzögerter Pyloruspassage und Verfahren zur Herstellung desselben |
| DE4431653C2 (de) | 1994-09-06 | 2000-01-20 | Lohmann Therapie Syst Lts | Manteltablette zur kontrollierten Freisetzung von Wirkstoffen, ein Verfahren zu ihrer Herstellung und ihre Verwendung |
| US20020002364A1 (en) * | 1995-10-05 | 2002-01-03 | Karsten Cremer | Osmotic device for the continuous release of active compounds into the fluids of the gastrointestinal tract |
| DE19537090A1 (de) | 1995-10-05 | 1997-04-10 | Lohmann Therapie Syst Lts | Osmotische Vorrichtung zur kontinuierlichen Freisetzung von Wirkstoffen in die Flüssigkeiten des Gastrointestinaltraktes |
| FR2784583B1 (fr) * | 1998-10-16 | 2002-01-25 | Synthelabo | Composition pharmaceutique a residence gastrique et a liberation controlee |
| US6797283B1 (en) | 1998-12-23 | 2004-09-28 | Alza Corporation | Gastric retention dosage form having multiple layers |
| US6497902B1 (en) * | 1999-12-01 | 2002-12-24 | The Regents Of The University Of Michigan | Ionically crosslinked hydrogels with adjustable gelation time |
| US6488962B1 (en) | 2000-06-20 | 2002-12-03 | Depomed, Inc. | Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms |
| JP2004501190A (ja) | 2000-06-23 | 2004-01-15 | テバ ファーマシューティカル インダストリーズ リミティド | 治療薬の胃部保留および制御された放出のための急速膨張する組成物とその組成物を含む剤形 |
| ES2265022T3 (es) * | 2001-03-14 | 2007-02-01 | Pfizer Products Inc. | Comprimido farmaceutico y procedimiento para su fabricacion. |
| EP1245227A1 (en) | 2001-03-31 | 2002-10-02 | Jagotec Ag | A pharmaceutical tablet system that floats in the stomach for programmed release of active substance and process of producing buoyant material contained in same |
| RU2325152C2 (ru) | 2001-07-04 | 2008-05-27 | Сан Фармасьютикл Индастриз Лимитид | Удерживаемая в желудке система регулируемой доставки лекарственного средства |
| US20040219186A1 (en) | 2001-08-16 | 2004-11-04 | Ayres James W. | Expandable gastric retention device |
| IN191024B (https=) * | 2001-09-25 | 2003-09-13 | J B Chemicals And Pharmaceutic | |
| WO2004002445A2 (en) | 2002-06-26 | 2004-01-08 | Cadila Healthcare Limited | Novel floating dosage form |
| US20060003003A1 (en) | 2004-06-28 | 2006-01-05 | Bakker Johan A | Oral sustained release formulation of tedisamil with gastric retention properties |
-
2007
- 2007-06-04 DE DE102007026037A patent/DE102007026037A1/de not_active Withdrawn
-
2008
- 2008-05-27 JP JP2010510670A patent/JP5425058B2/ja not_active Expired - Fee Related
- 2008-05-27 US US12/451,926 patent/US20100129445A1/en not_active Abandoned
- 2008-05-27 MX MX2009013086A patent/MX2009013086A/es not_active Application Discontinuation
- 2008-05-27 CN CN2008800187472A patent/CN102215826A/zh active Pending
- 2008-05-27 NZ NZ581740A patent/NZ581740A/en not_active IP Right Cessation
- 2008-05-27 RU RU2009147730/15A patent/RU2468790C2/ru not_active IP Right Cessation
- 2008-05-27 WO PCT/EP2008/004188 patent/WO2008148478A2/de not_active Ceased
- 2008-05-27 CA CA2689049A patent/CA2689049C/en not_active Expired - Fee Related
- 2008-05-27 AU AU2008258881A patent/AU2008258881B2/en not_active Expired - Fee Related
- 2008-05-27 KR KR1020107000051A patent/KR101268215B1/ko not_active Expired - Fee Related
- 2008-05-27 EP EP08758774A patent/EP2155172A2/de not_active Withdrawn
- 2008-05-27 EP EP12170347A patent/EP2497465A3/de not_active Withdrawn
-
2009
- 2009-11-26 ZA ZA200908355A patent/ZA200908355B/xx unknown
- 2009-12-03 IL IL202518A patent/IL202518A0/en unknown
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