DE102007026037A1 - Gastroretentives System mit Alginat-Körper - Google Patents
Gastroretentives System mit Alginat-Körper Download PDFInfo
- Publication number
- DE102007026037A1 DE102007026037A1 DE102007026037A DE102007026037A DE102007026037A1 DE 102007026037 A1 DE102007026037 A1 DE 102007026037A1 DE 102007026037 A DE102007026037 A DE 102007026037A DE 102007026037 A DE102007026037 A DE 102007026037A DE 102007026037 A1 DE102007026037 A1 DE 102007026037A1
- Authority
- DE
- Germany
- Prior art keywords
- drug
- gastroretentives
- zinc
- calcium
- gastroretentive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 title 1
- 229940072056 alginate Drugs 0.000 title 1
- 235000010443 alginic acid Nutrition 0.000 title 1
- 229920000615 alginic acid Polymers 0.000 title 1
- 230000008961 swelling Effects 0.000 claims abstract description 55
- 239000003814 drug Substances 0.000 claims description 83
- 229940079593 drug Drugs 0.000 claims description 81
- 210000002784 stomach Anatomy 0.000 claims description 35
- 239000003826 tablet Substances 0.000 claims description 34
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 22
- 235000010413 sodium alginate Nutrition 0.000 claims description 22
- 239000000661 sodium alginate Substances 0.000 claims description 22
- 229940005550 sodium alginate Drugs 0.000 claims description 22
- 229920000642 polymer Polymers 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 17
- 239000012528 membrane Substances 0.000 claims description 16
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 14
- 159000000007 calcium salts Chemical class 0.000 claims description 14
- 230000003204 osmotic effect Effects 0.000 claims description 14
- 239000004480 active ingredient Substances 0.000 claims description 12
- 230000003628 erosive effect Effects 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 11
- -1 aluminum ions Chemical class 0.000 claims description 10
- 230000002496 gastric effect Effects 0.000 claims description 10
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 9
- 229910001424 calcium ion Inorganic materials 0.000 claims description 9
- 239000002357 osmotic agent Substances 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 7
- 235000010216 calcium carbonate Nutrition 0.000 claims description 7
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000000314 lubricant Substances 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 5
- 239000011230 binding agent Substances 0.000 claims description 5
- 150000003751 zinc Chemical class 0.000 claims description 5
- 239000011701 zinc Substances 0.000 claims description 5
- 229910052725 zinc Inorganic materials 0.000 claims description 5
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 4
- 239000000945 filler Substances 0.000 claims description 4
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 4
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 3
- 229920000148 Polycarbophil calcium Polymers 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 239000007942 layered tablet Substances 0.000 claims description 3
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 229950005134 polycarbophil Drugs 0.000 claims description 3
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 2
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims description 2
- 239000001639 calcium acetate Substances 0.000 claims description 2
- 235000011092 calcium acetate Nutrition 0.000 claims description 2
- 229960005147 calcium acetate Drugs 0.000 claims description 2
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims description 2
- 239000001354 calcium citrate Substances 0.000 claims description 2
- 239000001506 calcium phosphate Substances 0.000 claims description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
- 235000011010 calcium phosphates Nutrition 0.000 claims description 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
- 235000013337 tricalcium citrate Nutrition 0.000 claims description 2
- 239000004246 zinc acetate Substances 0.000 claims description 2
- 229940062776 zinc aspartate Drugs 0.000 claims description 2
- 239000011592 zinc chloride Substances 0.000 claims description 2
- 235000005074 zinc chloride Nutrition 0.000 claims description 2
- 229960001939 zinc chloride Drugs 0.000 claims description 2
- 239000011670 zinc gluconate Substances 0.000 claims description 2
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- 229960000306 zinc gluconate Drugs 0.000 claims description 2
- POEVDIARYKIEGF-CEOVSRFSSA-L zinc;(2s)-2-aminobutanedioate;hydron Chemical compound [Zn+2].[O-]C(=O)[C@@H](N)CC(O)=O.[O-]C(=O)[C@@H](N)CC(O)=O POEVDIARYKIEGF-CEOVSRFSSA-L 0.000 claims description 2
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims 1
- 239000008186 active pharmaceutical agent Substances 0.000 claims 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 abstract description 10
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 28
- 229920002301 cellulose acetate Polymers 0.000 description 16
- 210000004379 membrane Anatomy 0.000 description 15
- 235000019359 magnesium stearate Nutrition 0.000 description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 12
- 229910021485 fumed silica Inorganic materials 0.000 description 12
- 239000004615 ingredient Substances 0.000 description 11
- 230000002522 swelling effect Effects 0.000 description 10
- 239000002609 medium Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 239000012530 fluid Substances 0.000 description 8
- 210000001035 gastrointestinal tract Anatomy 0.000 description 8
- 239000002552 dosage form Substances 0.000 description 7
- 238000012377 drug delivery Methods 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007026037A DE102007026037A1 (de) | 2007-06-04 | 2007-06-04 | Gastroretentives System mit Alginat-Körper |
| MX2009013086A MX2009013086A (es) | 2007-06-04 | 2008-05-27 | Sistema gastrorretentivo con cuerpo de alginato. |
| AU2008258881A AU2008258881B2 (en) | 2007-06-04 | 2008-05-27 | Gastroretentive system comprising an alginate body |
| NZ581740A NZ581740A (en) | 2007-06-04 | 2008-05-27 | Gastroretentive system comprising an alginate body |
| EP08758774A EP2155172A2 (de) | 2007-06-04 | 2008-05-27 | Gastroretentives system mit alginat-körper |
| US12/451,926 US20100129445A1 (en) | 2007-06-04 | 2008-05-27 | Gastroretentive system comprising an alginate body |
| CA2689049A CA2689049C (en) | 2007-06-04 | 2008-05-27 | Gastroretentive system comprising an alginate body |
| KR1020107000051A KR101268215B1 (ko) | 2007-06-04 | 2008-05-27 | 알긴산 바디를 포함하는 위장 체류 시스템 |
| JP2010510670A JP5425058B2 (ja) | 2007-06-04 | 2008-05-27 | アルギン酸塩体を含む胃内滞留型システム |
| CN2008800187472A CN102215826A (zh) | 2007-06-04 | 2008-05-27 | 包括藻酸盐体的胃内滞留系统 |
| PCT/EP2008/004188 WO2008148478A2 (de) | 2007-06-04 | 2008-05-27 | Gastroretentives system mit alginat-körper |
| EP12170347A EP2497465A3 (de) | 2007-06-04 | 2008-05-27 | Gastroretentives System mit Alginat-Körper |
| RU2009147730/15A RU2468790C2 (ru) | 2007-06-04 | 2008-05-27 | Способная задерживаться в желудке система, содержащая вещество на основе альгината |
| ZA200908355A ZA200908355B (en) | 2007-06-04 | 2009-11-26 | Gastroretentive system comprising an alginate body |
| IL202518A IL202518A0 (en) | 2007-06-04 | 2009-12-03 | Gastroretentive system comprising an alginate body |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007026037A DE102007026037A1 (de) | 2007-06-04 | 2007-06-04 | Gastroretentives System mit Alginat-Körper |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102007026037A1 true DE102007026037A1 (de) | 2008-12-11 |
Family
ID=39942026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102007026037A Withdrawn DE102007026037A1 (de) | 2007-06-04 | 2007-06-04 | Gastroretentives System mit Alginat-Körper |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20100129445A1 (https=) |
| EP (2) | EP2497465A3 (https=) |
| JP (1) | JP5425058B2 (https=) |
| KR (1) | KR101268215B1 (https=) |
| CN (1) | CN102215826A (https=) |
| AU (1) | AU2008258881B2 (https=) |
| CA (1) | CA2689049C (https=) |
| DE (1) | DE102007026037A1 (https=) |
| IL (1) | IL202518A0 (https=) |
| MX (1) | MX2009013086A (https=) |
| NZ (1) | NZ581740A (https=) |
| RU (1) | RU2468790C2 (https=) |
| WO (1) | WO2008148478A2 (https=) |
| ZA (1) | ZA200908355B (https=) |
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| DE102011051653A1 (de) * | 2011-07-07 | 2013-01-10 | Lts Lohmann Therapie-Systeme Ag | Quellfähige Manteltablette |
| WO2014032676A1 (en) * | 2012-09-03 | 2014-03-06 | S-Biotek Holding Aps | A solid oral formulation for treatment and/or prevention of overweight and/or for stabilizing blood sugar levels in an individual. |
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| KR101118794B1 (ko) * | 2009-11-10 | 2012-06-13 | 동아제약주식회사 | 비스포스포네이트를 함유하는 약학 조성물 |
| WO2012083017A2 (en) | 2010-12-16 | 2012-06-21 | Celgene Corporation | Controlled release oral dosage forms of poorly soluble drugs and uses thereof |
| US9532977B2 (en) | 2010-12-16 | 2017-01-03 | Celgene Corporation | Controlled release oral dosage forms of poorly soluble drugs and uses thereof |
| DK2858604T3 (da) | 2012-06-07 | 2024-05-21 | Epitomee Medical Ltd | Ekspanderet anordning |
| EP2887925B1 (en) * | 2012-08-27 | 2017-02-22 | Evonik Röhm GmbH | Gastric resistant pharmaceutical or nutraceutical composition with resistance against the influence of ethanol |
| WO2015083171A1 (en) * | 2013-12-05 | 2015-06-11 | Tulip Medical Ltd. | Retentive devices and systems for in-situ release of pharmaceutical active agents |
| WO2017083348A1 (en) | 2015-11-11 | 2017-05-18 | Celgene Corporation | Controlled release oral dosage forms of poorly soluble drugs and uses thereof |
| CN108721246B (zh) * | 2018-05-29 | 2021-06-25 | 王喆明 | 高分子材料构建的多单元超长效口服制剂及其制备方法 |
| US11511093B2 (en) | 2019-10-11 | 2022-11-29 | Wonkwang University Center for Industry Academy Cooperation | Gastroretentive drug delivery device having expandable structure and manufacturing method therefor |
| KR102278915B1 (ko) | 2019-10-24 | 2021-07-19 | 중앙대학교 산학협력단 | 다공성 하이드로겔을 유효성분으로 함유하는 위 체류 및 약물 방출 제어형 경구용 제제 |
| EP4477215A3 (en) | 2020-12-08 | 2025-02-19 | Ruminant Biotech Corp Limited | Improvements to devices and methods for delivery of substances to animals |
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- 2008-05-27 CA CA2689049A patent/CA2689049C/en not_active Expired - Fee Related
- 2008-05-27 CN CN2008800187472A patent/CN102215826A/zh active Pending
- 2008-05-27 EP EP12170347A patent/EP2497465A3/de not_active Withdrawn
- 2008-05-27 KR KR1020107000051A patent/KR101268215B1/ko not_active Expired - Fee Related
- 2008-05-27 NZ NZ581740A patent/NZ581740A/en not_active IP Right Cessation
- 2008-05-27 RU RU2009147730/15A patent/RU2468790C2/ru not_active IP Right Cessation
- 2008-05-27 JP JP2010510670A patent/JP5425058B2/ja not_active Expired - Fee Related
- 2008-05-27 AU AU2008258881A patent/AU2008258881B2/en not_active Expired - Fee Related
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| US4207890A (en) | 1977-01-04 | 1980-06-17 | Mcneilab, Inc. | Drug-dispensing device and method |
| EP0259219A2 (en) | 1986-08-28 | 1988-03-09 | Universite De Montreal | Controlled release tablet |
| US4996058A (en) | 1987-09-18 | 1991-02-26 | Ciba-Geigy Corporation | Covered retard forms |
| EP0326816A1 (de) | 1988-02-05 | 1989-08-09 | LTS Lohmann Therapie-Systeme GmbH & Co. KG | Schwimmfähiges orales therapeutisches System |
| US4983401A (en) | 1989-05-22 | 1991-01-08 | Kinaform Technology, Inc. | Sustained release pharmaceutical preparations having pH controlled membrane coatings |
| US5296233A (en) | 1990-01-22 | 1994-03-22 | Mcneil-Ppc, Inc. | Dual subcoated simulated capsule-like medicament |
| EP0542364A1 (en) | 1991-11-13 | 1993-05-19 | Glaxo Canada Inc. | Controlled release device |
| DE4419818A1 (de) | 1994-06-07 | 1995-12-14 | Lohmann Therapie Syst Lts | Wirkstoffträger zur kontrollierten Freisetzung von Wirkstoffen im Gastrointestinaltrakt mit verzögerter Pyloruspassage |
| EP0779807A1 (de) | 1994-09-06 | 1997-06-25 | LTS LOHMANN Therapie-Systeme GmbH | Manteltablette mit spitzem kern |
| EP0797429A1 (de) | 1995-10-05 | 1997-10-01 | LTS LOHMANN Therapie-Systeme GmbH | Osmotische vorrichtung zur kontinuierlichen freisetzung von wirkstoffen in die flüssigkeiten des gastrointestinaltraktes |
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| WO2002000213A1 (en) | 2000-06-23 | 2002-01-03 | Teva Pharmaceutical Industries Ltd. | Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition |
| WO2002085332A1 (en) | 2001-03-31 | 2002-10-31 | Jagotec Ag | A pharmaceutical tablet system that floats on gastric fluid for multipulse release of active substance and respective processes of producing same and a cup-shaped envelope of same |
| WO2003011255A1 (en) | 2001-07-04 | 2003-02-13 | Sun Pharmaceutical Industries Limited | Gastric retention controlled drug delivery system |
| US20060013876A1 (en) | 2002-06-26 | 2006-01-19 | Lohray Braj B | Novel floating dosage form |
| WO2005079384A2 (en) | 2004-02-13 | 2005-09-01 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Expandable gastric retention device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102011051653A1 (de) * | 2011-07-07 | 2013-01-10 | Lts Lohmann Therapie-Systeme Ag | Quellfähige Manteltablette |
| WO2014032676A1 (en) * | 2012-09-03 | 2014-03-06 | S-Biotek Holding Aps | A solid oral formulation for treatment and/or prevention of overweight and/or for stabilizing blood sugar levels in an individual. |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100028621A (ko) | 2010-03-12 |
| WO2008148478A3 (de) | 2009-04-09 |
| CA2689049C (en) | 2014-07-08 |
| CA2689049A1 (en) | 2008-12-11 |
| AU2008258881B2 (en) | 2013-12-19 |
| EP2155172A2 (de) | 2010-02-24 |
| JP2010529056A (ja) | 2010-08-26 |
| EP2497465A3 (de) | 2012-11-21 |
| RU2468790C2 (ru) | 2012-12-10 |
| ZA200908355B (en) | 2010-07-28 |
| MX2009013086A (es) | 2010-01-18 |
| WO2008148478A8 (de) | 2009-02-05 |
| EP2497465A2 (de) | 2012-09-12 |
| WO2008148478A2 (de) | 2008-12-11 |
| NZ581740A (en) | 2011-05-27 |
| US20100129445A1 (en) | 2010-05-27 |
| AU2008258881A1 (en) | 2008-12-11 |
| IL202518A0 (en) | 2010-06-30 |
| RU2009147730A (ru) | 2011-06-27 |
| JP5425058B2 (ja) | 2014-02-26 |
| KR101268215B1 (ko) | 2013-05-31 |
| CN102215826A (zh) | 2011-10-12 |
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