JP2010527607A5 - - Google Patents

Info

Publication number

JP2010527607A5

JP2010527607A5 JP2010509392A JP2010509392A JP2010527607A5 JP 2010527607 A5 JP2010527607 A5 JP 2010527607A5 JP 2010509392 A JP2010509392 A JP 2010509392A JP 2010509392 A JP2010509392 A JP 2010509392A JP 2010527607 A5 JP2010527607 A5 JP 2010527607A5

Authority

JP

Japan

Prior art keywords

domain

peptide

protein

composition

host cell

Prior art date

2008-05-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 14
• 239000000203 mixture Substances 0.000 claims 10
• 108020001580 protein domains Proteins 0.000 claims 9
• 102000004169 proteins and genes Human genes 0.000 claims 9
• 108090000623 proteins and genes Proteins 0.000 claims 9
• 210000004027 cell Anatomy 0.000 claims 8
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
• 108020004707 nucleic acids Proteins 0.000 claims 6
• 102000039446 nucleic acids Human genes 0.000 claims 6
• 150000007523 nucleic acids Chemical class 0.000 claims 6
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 5
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 5
• 239000003809 bile pigment Substances 0.000 claims 4
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
• 239000013604 expression vector Substances 0.000 claims 3
• 102000016359 Fibronectins Human genes 0.000 claims 2
• 108010067306 Fibronectins Proteins 0.000 claims 2
• 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 claims 2
• 101100242312 Oryza sativa subsp. japonica OSK1 gene Proteins 0.000 claims 2
• 101100533605 Oryza sativa subsp. japonica SKP1 gene Proteins 0.000 claims 2
• 102000000470 PDZ domains Human genes 0.000 claims 2
• 108050008994 PDZ domains Proteins 0.000 claims 2
• 229940083963 Peptide antagonist Drugs 0.000 claims 2
• 239000002202 Polyethylene glycol Substances 0.000 claims 2
• 102000014400 SH2 domains Human genes 0.000 claims 2
• 108050003452 SH2 domains Proteins 0.000 claims 2
• 102000000395 SH3 domains Human genes 0.000 claims 2
• 108050008861 SH3 domains Proteins 0.000 claims 2
• 102000002938 Thrombospondin Human genes 0.000 claims 2
• 108060008245 Thrombospondin Proteins 0.000 claims 2
• 108050002897 Ubiquitin domains Proteins 0.000 claims 2
• 102000012275 Ubiquitin domains Human genes 0.000 claims 2
• 125000000539 amino acid group Chemical group 0.000 claims 2
• 150000001413 amino acids Chemical group 0.000 claims 2
• 239000005557 antagonist Substances 0.000 claims 2
• 239000012062 aqueous buffer Substances 0.000 claims 2
• 229920001577 copolymer Polymers 0.000 claims 2
• 239000012537 formulation buffer Substances 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 239000001963 growth medium Substances 0.000 claims 2
• 210000004901 leucine-rich repeat Anatomy 0.000 claims 2
• 239000003446 ligand Substances 0.000 claims 2
• 238000012986 modification Methods 0.000 claims 2
• 230000004048 modification Effects 0.000 claims 2
• 239000000816 peptidomimetic Substances 0.000 claims 2
• 229920001223 polyethylene glycol Polymers 0.000 claims 2
• 229920000642 polymer Polymers 0.000 claims 2
• 108091033319 polynucleotide Proteins 0.000 claims 2
• 102000040430 polynucleotide Human genes 0.000 claims 2
• 239000002157 polynucleotide Substances 0.000 claims 2
• 239000003053 toxin Substances 0.000 claims 2
• 231100000765 toxin Toxicity 0.000 claims 2
• 108700012359 toxins Proteins 0.000 claims 2
• WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 claims 1
• 102000017916 BDKRB1 Human genes 0.000 claims 1
• 102000004506 Blood Proteins Human genes 0.000 claims 1
• 108010017384 Blood Proteins Proteins 0.000 claims 1
• 108010044231 Bradykinin B1 Receptor Proteins 0.000 claims 1
• 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 claims 1
• 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 claims 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
• 108091026890 Coding region Proteins 0.000 claims 1
• 108020004414 DNA Proteins 0.000 claims 1
• 229920002307 Dextran Polymers 0.000 claims 1
• 241000588724 Escherichia coli Species 0.000 claims 1
• IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
• 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 1
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 1
• 102400000322 Glucagon-like peptide 1 Human genes 0.000 claims 1
• 102400000326 Glucagon-like peptide 2 Human genes 0.000 claims 1
• 101800000221 Glucagon-like peptide 2 Proteins 0.000 claims 1
• 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims 1
• 108010056852 Myostatin Proteins 0.000 claims 1
• WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
• 229930182556 Polyacetal Natural products 0.000 claims 1
• 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
• GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims 1
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 239000000556 agonist Substances 0.000 claims 1
• 125000001931 aliphatic group Chemical group 0.000 claims 1
• 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 108020001507 fusion proteins Proteins 0.000 claims 1
• 102000037865 fusion proteins Human genes 0.000 claims 1
• TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 claims 1
• 229920001519 homopolymer Polymers 0.000 claims 1
• 230000002209 hydrophobic effect Effects 0.000 claims 1
• 150000004668 long chain fatty acids Chemical class 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 claims 1
• 229920001583 poly(oxyethylated polyols) Polymers 0.000 claims 1
• 229920006324 polyoxymethylene Polymers 0.000 claims 1
• 229920005606 polypropylene copolymer Polymers 0.000 claims 1
• 229920001451 polypropylene glycol Polymers 0.000 claims 1
• 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
• 235000013772 propylene glycol Nutrition 0.000 claims 1
• 230000003248 secreting effect Effects 0.000 claims 1
• 150000003384 small molecules Chemical class 0.000 claims 1