JP2010523480A5 - - Google Patents
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- Publication number
- JP2010523480A5 JP2010523480A5 JP2010500144A JP2010500144A JP2010523480A5 JP 2010523480 A5 JP2010523480 A5 JP 2010523480A5 JP 2010500144 A JP2010500144 A JP 2010500144A JP 2010500144 A JP2010500144 A JP 2010500144A JP 2010523480 A5 JP2010523480 A5 JP 2010523480A5
- Authority
- JP
- Japan
- Prior art keywords
- lactic acid
- vaginal
- weight
- oligomers
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 122
- 235000014655 lactic acid Nutrition 0.000 claims 61
- 239000004310 lactic acid Substances 0.000 claims 61
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 11
- 239000013638 trimer Substances 0.000 claims 10
- OZZQHCBFUVFZGT-UHFFFAOYSA-N 2-(2-hydroxypropanoyloxy)propanoic acid Chemical compound CC(O)C(=O)OC(C)C(O)=O OZZQHCBFUVFZGT-UHFFFAOYSA-N 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 208000015815 Rectal disease Diseases 0.000 claims 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims 6
- 229920001661 Chitosan Polymers 0.000 claims 5
- 206010061977 Genital infection female Diseases 0.000 claims 5
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 5
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 5
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 5
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 5
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 5
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 5
- 208000035143 Bacterial infection Diseases 0.000 claims 4
- 206010017533 Fungal infection Diseases 0.000 claims 4
- 208000031888 Mycoses Diseases 0.000 claims 4
- 208000036142 Viral infection Diseases 0.000 claims 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims 4
- 230000009385 viral infection Effects 0.000 claims 4
- 208000002874 Acne Vulgaris Diseases 0.000 claims 3
- 201000004384 Alopecia Diseases 0.000 claims 3
- 206010068172 Anal pruritus Diseases 0.000 claims 3
- 206010006326 Breath odour Diseases 0.000 claims 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 3
- 206010012438 Dermatitis atopic Diseases 0.000 claims 3
- 229920000896 Ethulose Polymers 0.000 claims 3
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 claims 3
- 208000032139 Halitosis Diseases 0.000 claims 3
- 208000008454 Hyperhidrosis Diseases 0.000 claims 3
- 208000034693 Laceration Diseases 0.000 claims 3
- 206010030113 Oedema Diseases 0.000 claims 3
- 206010036774 Proctitis Diseases 0.000 claims 3
- 206010036790 Productive cough Diseases 0.000 claims 3
- 208000003251 Pruritus Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 229920002472 Starch Polymers 0.000 claims 3
- 208000014151 Stomatognathic disease Diseases 0.000 claims 3
- 208000024780 Urticaria Diseases 0.000 claims 3
- 206010052428 Wound Diseases 0.000 claims 3
- 208000027418 Wounds and injury Diseases 0.000 claims 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 3
- 206010000496 acne Diseases 0.000 claims 3
- 231100000360 alopecia Toxicity 0.000 claims 3
- 201000008937 atopic dermatitis Diseases 0.000 claims 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 3
- 208000002925 dental caries Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 244000078703 ectoparasite Species 0.000 claims 3
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 claims 3
- 230000037315 hyperhidrosis Effects 0.000 claims 3
- 229920000609 methyl cellulose Polymers 0.000 claims 3
- 239000001923 methylcellulose Substances 0.000 claims 3
- 235000010981 methylcellulose Nutrition 0.000 claims 3
- 230000009854 mucosal lesion Effects 0.000 claims 3
- 229920005615 natural polymer Polymers 0.000 claims 3
- 230000001575 pathological effect Effects 0.000 claims 3
- 201000001245 periodontitis Diseases 0.000 claims 3
- 229920000058 polyacrylate Polymers 0.000 claims 3
- 201000004700 rosacea Diseases 0.000 claims 3
- 208000017520 skin disease Diseases 0.000 claims 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 3
- 210000003802 sputum Anatomy 0.000 claims 3
- 208000024794 sputum Diseases 0.000 claims 3
- 239000008107 starch Substances 0.000 claims 3
- 235000019698 starch Nutrition 0.000 claims 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 2
- FEBUJFMRSBAMES-UHFFFAOYSA-N 2-[(2-{[3,5-dihydroxy-2-(hydroxymethyl)-6-phosphanyloxan-4-yl]oxy}-3,5-dihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-4-yl)oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl phosphinite Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(OC2C(C(OP)C(O)C(CO)O2)O)C(O)C(OC2C(C(CO)OC(P)C2O)O)O1 FEBUJFMRSBAMES-UHFFFAOYSA-N 0.000 claims 2
- 241000416162 Astragalus gummifer Species 0.000 claims 2
- 241000222122 Candida albicans Species 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 229920002148 Gellan gum Polymers 0.000 claims 2
- 229920002907 Guar gum Polymers 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 241000701806 Human papillomavirus Species 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- 229920000881 Modified starch Polymers 0.000 claims 2
- 229920000148 Polycarbophil calcium Polymers 0.000 claims 2
- 229920002305 Schizophyllan Polymers 0.000 claims 2
- 241000700584 Simplexvirus Species 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- 229920001615 Tragacanth Polymers 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 235000010980 cellulose Nutrition 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 239000000665 guar gum Substances 0.000 claims 2
- 235000010417 guar gum Nutrition 0.000 claims 2
- 229960002154 guar gum Drugs 0.000 claims 2
- 239000006210 lotion Substances 0.000 claims 2
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 2
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 235000019426 modified starch Nutrition 0.000 claims 2
- 229920001277 pectin Polymers 0.000 claims 2
- 239000001814 pectin Substances 0.000 claims 2
- 235000010987 pectin Nutrition 0.000 claims 2
- 229950005134 polycarbophil Drugs 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 239000002453 shampoo Substances 0.000 claims 2
- 235000010413 sodium alginate Nutrition 0.000 claims 2
- 239000000661 sodium alginate Substances 0.000 claims 2
- 229940005550 sodium alginate Drugs 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 235000010487 tragacanth Nutrition 0.000 claims 2
- 239000000196 tragacanth Substances 0.000 claims 2
- 229940116362 tragacanth Drugs 0.000 claims 2
- 210000001215 vagina Anatomy 0.000 claims 2
- 229940044959 vaginal cream Drugs 0.000 claims 2
- 239000000522 vaginal cream Substances 0.000 claims 2
- -1 vaginal cup Substances 0.000 claims 2
- 229940044952 vaginal foam Drugs 0.000 claims 2
- 239000000259 vaginal foam Substances 0.000 claims 2
- 229940044950 vaginal gel Drugs 0.000 claims 2
- 239000000029 vaginal gel Substances 0.000 claims 2
- 229940098946 vaginal ointment Drugs 0.000 claims 2
- 229940044953 vaginal ring Drugs 0.000 claims 2
- 239000006213 vaginal ring Substances 0.000 claims 2
- 229940120293 vaginal suppository Drugs 0.000 claims 2
- 239000006216 vaginal suppository Substances 0.000 claims 2
- 229940044977 vaginal tablet Drugs 0.000 claims 2
- 239000000003 vaginal tablet Substances 0.000 claims 2
- 229920001285 xanthan gum Polymers 0.000 claims 2
- 239000000230 xanthan gum Substances 0.000 claims 2
- 235000010493 xanthan gum Nutrition 0.000 claims 2
- 229940082509 xanthan gum Drugs 0.000 claims 2
- 241000186046 Actinomyces Species 0.000 claims 1
- 208000019751 Anorectal disease Diseases 0.000 claims 1
- 206010003693 Atrophic vulvovaginitis Diseases 0.000 claims 1
- 208000004926 Bacterial Vaginosis Diseases 0.000 claims 1
- 206010007134 Candida infections Diseases 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- 201000007336 Cryptococcosis Diseases 0.000 claims 1
- 241000221204 Cryptococcus neoformans Species 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- 208000006374 Uterine Cervicitis Diseases 0.000 claims 1
- 206010046914 Vaginal infection Diseases 0.000 claims 1
- 201000008100 Vaginitis Diseases 0.000 claims 1
- 208000037009 Vaginitis bacterial Diseases 0.000 claims 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229940095731 candida albicans Drugs 0.000 claims 1
- 201000003984 candidiasis Diseases 0.000 claims 1
- 206010008323 cervicitis Diseases 0.000 claims 1
- 229960005168 croscarmellose Drugs 0.000 claims 1
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 claims 1
- 239000012669 liquid formulation Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000010808 postmenopausal atrophic vaginitis Diseases 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 208000000143 urethritis Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200700508 | 2007-03-30 | ||
| DKPA200700508 | 2007-03-30 | ||
| PCT/EP2008/002505 WO2008119518A1 (en) | 2007-03-30 | 2008-03-28 | Use of oligomers of lactic acid in the treatment of gynaecological disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013160602A Division JP5793542B2 (ja) | 2007-03-30 | 2013-08-01 | 婦人科の障害の治療における乳酸オリゴマーの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523480A JP2010523480A (ja) | 2010-07-15 |
| JP2010523480A5 true JP2010523480A5 (https=) | 2013-02-28 |
| JP5409596B2 JP5409596B2 (ja) | 2014-02-05 |
Family
ID=39494560
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500144A Expired - Fee Related JP5409596B2 (ja) | 2007-03-30 | 2008-03-28 | 婦人科の障害の治療における乳酸オリゴマーの使用 |
| JP2013160602A Expired - Fee Related JP5793542B2 (ja) | 2007-03-30 | 2013-08-01 | 婦人科の障害の治療における乳酸オリゴマーの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013160602A Expired - Fee Related JP5793542B2 (ja) | 2007-03-30 | 2013-08-01 | 婦人科の障害の治療における乳酸オリゴマーの使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US8425894B2 (https=) |
| EP (2) | EP2142186B1 (https=) |
| JP (2) | JP5409596B2 (https=) |
| KR (1) | KR101518014B1 (https=) |
| CN (2) | CN101677980B (https=) |
| AU (1) | AU2008234064B2 (https=) |
| BR (1) | BRPI0809330B8 (https=) |
| CA (1) | CA2681803C (https=) |
| CY (1) | CY1115310T1 (https=) |
| DK (1) | DK2142186T3 (https=) |
| ES (1) | ES2482190T3 (https=) |
| HR (1) | HRP20140559T1 (https=) |
| MX (1) | MX2009010445A (https=) |
| PL (1) | PL2142186T3 (https=) |
| PT (1) | PT2142186E (https=) |
| RU (1) | RU2459620C2 (https=) |
| SI (1) | SI2142186T1 (https=) |
| WO (1) | WO2008119518A1 (https=) |
| ZA (1) | ZA200907215B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009010445A (es) | 2007-03-30 | 2010-01-29 | Laccure Ab | Uso de oligomeros de acido lactico en el tratamiento de trastornos ginecologicos. |
| CN101797269B (zh) * | 2010-03-23 | 2012-01-04 | 杨霞 | 一种调节女性阴道微生态的生理平衡液 |
| RU2422147C1 (ru) * | 2010-03-29 | 2011-06-27 | Государственное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия имени академика Е.А. Вагнера Федерального агентства по здравоохранению и социальному развитию" | Способ лечения неспецифического аэробного вагинита |
| US9155873B2 (en) | 2011-05-17 | 2015-10-13 | Reprotect, Inc. | Reusable intravaginal delivery device, system, and method |
| CN102274333A (zh) * | 2011-08-22 | 2011-12-14 | 谢英华 | 一种治疗阴道炎的外洗中药 |
| CN102579829B (zh) * | 2012-03-06 | 2013-09-18 | 康莉 | 一种治疗牛放线菌病的中药组合物及其制备方法 |
| CN110693812A (zh) | 2012-06-13 | 2020-01-17 | 伊沃菲姆股份有限公司 | 用于增强避孕杀微生物剂有效性的组合物和方法 |
| KR102089117B1 (ko) * | 2012-07-16 | 2020-04-16 | 라큐어 에이비 | 올리고머 락트산을 포함하는 약제학적 조성물 |
| CN102885850B (zh) * | 2012-10-15 | 2013-08-07 | 山东省医疗器械研究所 | 一种治疗阴道炎的多孔凝胶颗粒剂 |
| AU2014368971B2 (en) | 2013-12-19 | 2020-02-06 | Evofem, Inc. | Compositions and methods for inhibiting inflammation and diseases using an alginic acid-based antimicrobial compound |
| US9895311B2 (en) * | 2014-09-25 | 2018-02-20 | Pharmiva Ab | Foam-forming compositions and methods for delivering an active to a body cavity |
| CA3013809C (en) | 2016-04-06 | 2024-01-02 | Gedea Biotech Ab | Glucono delta-lactone for treatment of vaginal fungal infections |
| US10249017B2 (en) * | 2016-08-11 | 2019-04-02 | Intel Corporation | Apparatus and method for shared resource partitioning through credit management |
| WO2018049326A1 (en) * | 2016-09-12 | 2018-03-15 | Evofem Biosciences, Inc. | Combination gel for sexually transmitted infections |
| CN110225750A (zh) | 2016-10-04 | 2019-09-10 | 伊沃菲姆股份有限公司 | 细菌性阴道病的治疗和预防方法 |
| MX384337B (es) * | 2016-10-13 | 2025-03-14 | Catalent Uk Swindon Zydis Ltd | Composiciones farmacéuticas liofilizadas para suministro vaginal. |
| HUE064590T2 (hu) * | 2018-03-29 | 2024-03-28 | The Materia Company Ltd | Intravaginális készítmény |
| CN113423470B (zh) * | 2019-02-13 | 2024-07-09 | 三吉油脂株式会社 | 化妆品配合剂、化妆品及其制造方法 |
| US20250161348A1 (en) | 2022-03-01 | 2025-05-22 | Combe Incorporated | Process for preparation of compositions of oligomers of lactic acid |
| AU2023452829A1 (en) * | 2023-07-07 | 2026-02-19 | Changchun Sinobiomaterials Co., Ltd. | Muscle atrophy |
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-
2008
- 2008-03-28 MX MX2009010445A patent/MX2009010445A/es active IP Right Grant
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