JP2010523480A5 - - Google Patents
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- Publication number
- JP2010523480A5 JP2010523480A5 JP2010500144A JP2010500144A JP2010523480A5 JP 2010523480 A5 JP2010523480 A5 JP 2010523480A5 JP 2010500144 A JP2010500144 A JP 2010500144A JP 2010500144 A JP2010500144 A JP 2010500144A JP 2010523480 A5 JP2010523480 A5 JP 2010523480A5
- Authority
- JP
- Japan
- Prior art keywords
- lactic acid
- vaginal
- weight
- oligomers
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 122
- 235000014655 lactic acid Nutrition 0.000 claims 61
- 239000004310 lactic acid Substances 0.000 claims 61
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 11
- 239000013638 trimer Substances 0.000 claims 10
- OZZQHCBFUVFZGT-UHFFFAOYSA-N 2-(2-hydroxypropanoyloxy)propanoic acid Chemical compound CC(O)C(=O)OC(C)C(O)=O OZZQHCBFUVFZGT-UHFFFAOYSA-N 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 208000015815 Rectal disease Diseases 0.000 claims 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims 6
- 229920001661 Chitosan Polymers 0.000 claims 5
- 206010061977 Genital infection female Diseases 0.000 claims 5
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 5
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 5
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 5
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 5
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 5
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 5
- 208000035143 Bacterial infection Diseases 0.000 claims 4
- 206010017533 Fungal infection Diseases 0.000 claims 4
- 208000031888 Mycoses Diseases 0.000 claims 4
- 208000036142 Viral infection Diseases 0.000 claims 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims 4
- 230000009385 viral infection Effects 0.000 claims 4
- 208000002874 Acne Vulgaris Diseases 0.000 claims 3
- 201000004384 Alopecia Diseases 0.000 claims 3
- 206010068172 Anal pruritus Diseases 0.000 claims 3
- 206010006326 Breath odour Diseases 0.000 claims 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 3
- 206010012438 Dermatitis atopic Diseases 0.000 claims 3
- 229920000896 Ethulose Polymers 0.000 claims 3
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 claims 3
- 208000032139 Halitosis Diseases 0.000 claims 3
- 208000008454 Hyperhidrosis Diseases 0.000 claims 3
- 208000034693 Laceration Diseases 0.000 claims 3
- 206010030113 Oedema Diseases 0.000 claims 3
- 206010036774 Proctitis Diseases 0.000 claims 3
- 206010036790 Productive cough Diseases 0.000 claims 3
- 208000003251 Pruritus Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 229920002472 Starch Polymers 0.000 claims 3
- 208000014151 Stomatognathic disease Diseases 0.000 claims 3
- 208000024780 Urticaria Diseases 0.000 claims 3
- 206010052428 Wound Diseases 0.000 claims 3
- 208000027418 Wounds and injury Diseases 0.000 claims 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 3
- 206010000496 acne Diseases 0.000 claims 3
- 231100000360 alopecia Toxicity 0.000 claims 3
- 201000008937 atopic dermatitis Diseases 0.000 claims 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 3
- 208000002925 dental caries Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 244000078703 ectoparasite Species 0.000 claims 3
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 claims 3
- 230000037315 hyperhidrosis Effects 0.000 claims 3
- 229920000609 methyl cellulose Polymers 0.000 claims 3
- 239000001923 methylcellulose Substances 0.000 claims 3
- 235000010981 methylcellulose Nutrition 0.000 claims 3
- 230000009854 mucosal lesion Effects 0.000 claims 3
- 229920005615 natural polymer Polymers 0.000 claims 3
- 230000001575 pathological effect Effects 0.000 claims 3
- 201000001245 periodontitis Diseases 0.000 claims 3
- 229920000058 polyacrylate Polymers 0.000 claims 3
- 201000004700 rosacea Diseases 0.000 claims 3
- 208000017520 skin disease Diseases 0.000 claims 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 3
- 210000003802 sputum Anatomy 0.000 claims 3
- 208000024794 sputum Diseases 0.000 claims 3
- 239000008107 starch Substances 0.000 claims 3
- 235000019698 starch Nutrition 0.000 claims 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 2
- FEBUJFMRSBAMES-UHFFFAOYSA-N 2-[(2-{[3,5-dihydroxy-2-(hydroxymethyl)-6-phosphanyloxan-4-yl]oxy}-3,5-dihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-4-yl)oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl phosphinite Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(OC2C(C(OP)C(O)C(CO)O2)O)C(O)C(OC2C(C(CO)OC(P)C2O)O)O1 FEBUJFMRSBAMES-UHFFFAOYSA-N 0.000 claims 2
- 241000416162 Astragalus gummifer Species 0.000 claims 2
- 241000222122 Candida albicans Species 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 229920002148 Gellan gum Polymers 0.000 claims 2
- 229920002907 Guar gum Polymers 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 241000701806 Human papillomavirus Species 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- 229920000881 Modified starch Polymers 0.000 claims 2
- 229920000148 Polycarbophil calcium Polymers 0.000 claims 2
- 229920002305 Schizophyllan Polymers 0.000 claims 2
- 241000700584 Simplexvirus Species 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- 229920001615 Tragacanth Polymers 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 235000010980 cellulose Nutrition 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 239000000665 guar gum Substances 0.000 claims 2
- 235000010417 guar gum Nutrition 0.000 claims 2
- 229960002154 guar gum Drugs 0.000 claims 2
- 239000006210 lotion Substances 0.000 claims 2
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 2
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 235000019426 modified starch Nutrition 0.000 claims 2
- 229920001277 pectin Polymers 0.000 claims 2
- 239000001814 pectin Substances 0.000 claims 2
- 235000010987 pectin Nutrition 0.000 claims 2
- 229950005134 polycarbophil Drugs 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 239000002453 shampoo Substances 0.000 claims 2
- 235000010413 sodium alginate Nutrition 0.000 claims 2
- 239000000661 sodium alginate Substances 0.000 claims 2
- 229940005550 sodium alginate Drugs 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 235000010487 tragacanth Nutrition 0.000 claims 2
- 239000000196 tragacanth Substances 0.000 claims 2
- 229940116362 tragacanth Drugs 0.000 claims 2
- 210000001215 vagina Anatomy 0.000 claims 2
- 229940044959 vaginal cream Drugs 0.000 claims 2
- 239000000522 vaginal cream Substances 0.000 claims 2
- -1 vaginal cup Substances 0.000 claims 2
- 229940044952 vaginal foam Drugs 0.000 claims 2
- 239000000259 vaginal foam Substances 0.000 claims 2
- 229940044950 vaginal gel Drugs 0.000 claims 2
- 239000000029 vaginal gel Substances 0.000 claims 2
- 229940098946 vaginal ointment Drugs 0.000 claims 2
- 229940044953 vaginal ring Drugs 0.000 claims 2
- 239000006213 vaginal ring Substances 0.000 claims 2
- 229940120293 vaginal suppository Drugs 0.000 claims 2
- 239000006216 vaginal suppository Substances 0.000 claims 2
- 229940044977 vaginal tablet Drugs 0.000 claims 2
- 239000000003 vaginal tablet Substances 0.000 claims 2
- 229920001285 xanthan gum Polymers 0.000 claims 2
- 239000000230 xanthan gum Substances 0.000 claims 2
- 235000010493 xanthan gum Nutrition 0.000 claims 2
- 229940082509 xanthan gum Drugs 0.000 claims 2
- 241000186046 Actinomyces Species 0.000 claims 1
- 208000019751 Anorectal disease Diseases 0.000 claims 1
- 206010003693 Atrophic vulvovaginitis Diseases 0.000 claims 1
- 208000004926 Bacterial Vaginosis Diseases 0.000 claims 1
- 206010007134 Candida infections Diseases 0.000 claims 1
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- 201000007336 Cryptococcosis Diseases 0.000 claims 1
- 241000221204 Cryptococcus neoformans Species 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- 208000006374 Uterine Cervicitis Diseases 0.000 claims 1
- 206010046914 Vaginal infection Diseases 0.000 claims 1
- 201000008100 Vaginitis Diseases 0.000 claims 1
- 208000037009 Vaginitis bacterial Diseases 0.000 claims 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229940095731 candida albicans Drugs 0.000 claims 1
- 201000003984 candidiasis Diseases 0.000 claims 1
- 206010008323 cervicitis Diseases 0.000 claims 1
- 229960005168 croscarmellose Drugs 0.000 claims 1
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 claims 1
- 239000012669 liquid formulation Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000010808 postmenopausal atrophic vaginitis Diseases 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 208000000143 urethritis Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200700508 | 2007-03-30 | ||
| DKPA200700508 | 2007-03-30 | ||
| PCT/EP2008/002505 WO2008119518A1 (en) | 2007-03-30 | 2008-03-28 | Use of oligomers of lactic acid in the treatment of gynaecological disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013160602A Division JP5793542B2 (ja) | 2007-03-30 | 2013-08-01 | 婦人科の障害の治療における乳酸オリゴマーの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523480A JP2010523480A (ja) | 2010-07-15 |
| JP2010523480A5 true JP2010523480A5 (https=) | 2013-02-28 |
| JP5409596B2 JP5409596B2 (ja) | 2014-02-05 |
Family
ID=39494560
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500144A Expired - Fee Related JP5409596B2 (ja) | 2007-03-30 | 2008-03-28 | 婦人科の障害の治療における乳酸オリゴマーの使用 |
| JP2013160602A Expired - Fee Related JP5793542B2 (ja) | 2007-03-30 | 2013-08-01 | 婦人科の障害の治療における乳酸オリゴマーの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013160602A Expired - Fee Related JP5793542B2 (ja) | 2007-03-30 | 2013-08-01 | 婦人科の障害の治療における乳酸オリゴマーの使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US8425894B2 (https=) |
| EP (2) | EP2142186B1 (https=) |
| JP (2) | JP5409596B2 (https=) |
| KR (1) | KR101518014B1 (https=) |
| CN (2) | CN101677980B (https=) |
| AU (1) | AU2008234064B2 (https=) |
| BR (1) | BRPI0809330B8 (https=) |
| CA (1) | CA2681803C (https=) |
| CY (1) | CY1115310T1 (https=) |
| DK (1) | DK2142186T3 (https=) |
| ES (1) | ES2482190T3 (https=) |
| HR (1) | HRP20140559T1 (https=) |
| MX (1) | MX2009010445A (https=) |
| PL (1) | PL2142186T3 (https=) |
| PT (1) | PT2142186E (https=) |
| RU (1) | RU2459620C2 (https=) |
| SI (1) | SI2142186T1 (https=) |
| WO (1) | WO2008119518A1 (https=) |
| ZA (1) | ZA200907215B (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2482190T3 (es) | 2007-03-30 | 2014-08-01 | Laccure Ab | Uso de oligómeros de ácido láctico en el tratamiento de infecciones ginecológicas |
| CN101797269B (zh) * | 2010-03-23 | 2012-01-04 | 杨霞 | 一种调节女性阴道微生态的生理平衡液 |
| RU2422147C1 (ru) * | 2010-03-29 | 2011-06-27 | Государственное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия имени академика Е.А. Вагнера Федерального агентства по здравоохранению и социальному развитию" | Способ лечения неспецифического аэробного вагинита |
| WO2012158779A1 (en) | 2011-05-17 | 2012-11-22 | Reprotect, Inc. | Reusable intravaginal delivery device, system, and method |
| CN102274333A (zh) * | 2011-08-22 | 2011-12-14 | 谢英华 | 一种治疗阴道炎的外洗中药 |
| CN102579829B (zh) * | 2012-03-06 | 2013-09-18 | 康莉 | 一种治疗牛放线菌病的中药组合物及其制备方法 |
| EA201590008A1 (ru) | 2012-06-13 | 2015-05-29 | Ивофем, Инк. | Композиции и способы повышения эффективности бактерицидных средств контрацепции |
| CN104470498B (zh) * | 2012-07-16 | 2017-08-08 | 莱克瑞股份公司 | 含有低聚乳酸的药物组合物 |
| CN102885850B (zh) * | 2012-10-15 | 2013-08-07 | 山东省医疗器械研究所 | 一种治疗阴道炎的多孔凝胶颗粒剂 |
| JP2017501227A (ja) | 2013-12-19 | 2017-01-12 | エヴォフェム，インク． | アルギン酸をベースとする抗菌性化合物を使用して炎症と疾患を阻害するための組成物及び方法 |
| US9895311B2 (en) * | 2014-09-25 | 2018-02-20 | Pharmiva Ab | Foam-forming compositions and methods for delivering an active to a body cavity |
| WO2017174731A1 (en) | 2016-04-06 | 2017-10-12 | Gedea Biotech Ab | Glucono delta-lactone for treatment of vaginal fungal infections |
| US10249017B2 (en) * | 2016-08-11 | 2019-04-02 | Intel Corporation | Apparatus and method for shared resource partitioning through credit management |
| US20190209502A1 (en) * | 2016-09-12 | 2019-07-11 | Evofem, Inc. | Combination gel for sexually transmitted infections |
| US11419835B2 (en) | 2016-10-04 | 2022-08-23 | Evofem, Inc. | Method of treatment and prevention of bacterial vaginosis |
| CA3040422A1 (en) | 2016-10-13 | 2018-04-19 | Catalent U.K. Swindon Zydis Limited | Lyophilized pharmaceutical compositions for vaginal delivery |
| ES2968763T3 (es) * | 2018-03-29 | 2024-05-13 | The Materia Company Ltd | Formulación intravaginal |
| CN113423470B (zh) * | 2019-02-13 | 2024-07-09 | 三吉油脂株式会社 | 化妆品配合剂、化妆品及其制造方法 |
| WO2023165971A1 (en) | 2022-03-01 | 2023-09-07 | Laccure Ab | Process for preparation of compositions of oligomers of lactic acid |
| CN119768161B (zh) * | 2023-07-07 | 2026-04-03 | 长春圣博玛生物材料有限公司 | 肌肉萎缩 |
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| JP2007258526A (ja) | 2006-03-24 | 2007-10-04 | Konica Minolta Holdings Inc | 有機エレクトロルミネッセンス素子、及び有機エレクトロルミネッセンスディスプレイ |
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| ES2482190T3 (es) | 2007-03-30 | 2014-08-01 | Laccure Ab | Uso de oligómeros de ácido láctico en el tratamiento de infecciones ginecológicas |
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2008
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2009
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