CN106619482B - 一种含壳聚糖季铵盐修饰的乳球蛋白的多孔缓释制剂 - Google Patents
一种含壳聚糖季铵盐修饰的乳球蛋白的多孔缓释制剂 Download PDFInfo
- Publication number
- CN106619482B CN106619482B CN201611197341.8A CN201611197341A CN106619482B CN 106619482 B CN106619482 B CN 106619482B CN 201611197341 A CN201611197341 A CN 201611197341A CN 106619482 B CN106619482 B CN 106619482B
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- China
- Prior art keywords
- lactoglobulin
- ammonium salt
- quaternary ammonium
- chitosan
- parts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201611197341.8A CN106619482B (zh) | 2016-12-22 | 2016-12-22 | 一种含壳聚糖季铵盐修饰的乳球蛋白的多孔缓释制剂 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201611197341.8A CN106619482B (zh) | 2016-12-22 | 2016-12-22 | 一种含壳聚糖季铵盐修饰的乳球蛋白的多孔缓释制剂 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106619482A CN106619482A (zh) | 2017-05-10 |
CN106619482B true CN106619482B (zh) | 2019-10-29 |
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ID=58834630
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201611197341.8A Active CN106619482B (zh) | 2016-12-22 | 2016-12-22 | 一种含壳聚糖季铵盐修饰的乳球蛋白的多孔缓释制剂 |
Country Status (1)
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CN (1) | CN106619482B (zh) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101181068A (zh) * | 2007-12-07 | 2008-05-21 | 华南理工大学 | 一种蛋白质与多糖共价复合改性的方法 |
CN102728287A (zh) * | 2012-06-07 | 2012-10-17 | 东南大学 | 一种表面多孔的plga微球的制备方法 |
KR101335473B1 (ko) * | 2011-09-16 | 2013-12-05 | 경상대학교산학협력단 | 저온 공중합 기술을 이용한 키토올리고당/베타락토글로불린 나노 전달체 및 그의 제조방법 |
CN105175799A (zh) * | 2015-05-27 | 2015-12-23 | 青岛农业大学 | 一种稳定性高的蛋白质-壳聚糖复凝聚交联微胶囊及其制备方法 |
-
2016
- 2016-12-22 CN CN201611197341.8A patent/CN106619482B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101181068A (zh) * | 2007-12-07 | 2008-05-21 | 华南理工大学 | 一种蛋白质与多糖共价复合改性的方法 |
KR101335473B1 (ko) * | 2011-09-16 | 2013-12-05 | 경상대학교산학협력단 | 저온 공중합 기술을 이용한 키토올리고당/베타락토글로불린 나노 전달체 및 그의 제조방법 |
CN102728287A (zh) * | 2012-06-07 | 2012-10-17 | 东南大学 | 一种表面多孔的plga微球的制备方法 |
CN105175799A (zh) * | 2015-05-27 | 2015-12-23 | 青岛农业大学 | 一种稳定性高的蛋白质-壳聚糖复凝聚交联微胶囊及其制备方法 |
Non-Patent Citations (4)
Title |
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"Characterization ofβ-lactoglobulin–chitosan interactions in aqueous solutions: A calorimetry, light scattering, electrophoretic mobility and solubility study";Demet Guzey et al.;《Food Hydrocolloids》;20061231;第20卷(第1期);第124-131页 * |
"Chemically modified bovine beta-lactoglobulin inhibits human papillomavirus infection";Lu Lu et al.;《Microbes and Infection》;20130319;第15卷(第6-7期);第506-510页 * |
"Formation of Hydrogel Particles by Thermal Treatment ofβ-Lactoglobulin-Chitosan Complexes";YOUN-HO HONG et al.;《Journal of Agricultural and Food Chemistry》;20070613;第55卷(第14期);第5653-5660页 * |
"PEG-PLGA多孔载药微球制备因素的优化";袁晓明;《医药前沿》;20151130;第5卷(第32期);第382-384页 * |
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Publication number | Publication date |
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CN106619482A (zh) | 2017-05-10 |
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Denomination of invention: A porous sustained-release preparation of lactoglobulin modified by chitosan quaternary ammonium salt Effective date of registration: 20200909 Granted publication date: 20191029 Pledgee: Xi'an investment and financing Company limited by guarantee Pledgor: XI'AN HUIPU BIOTECHNOLOGY Co.,Ltd. Registration number: Y2020610000139 |
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Date of cancellation: 20220506 Granted publication date: 20191029 Pledgee: Xi'an investment and financing Company limited by guarantee Pledgor: XI'AN HUIPU BIOTECHNOLOGY Co.,Ltd. Registration number: Y2020610000139 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A porous sustained-release preparation containing lactoglobulin modified by chitosan Quaternary ammonium cation Effective date of registration: 20230706 Granted publication date: 20191029 Pledgee: Xi'an Caijin Financing Guarantee Co.,Ltd. Pledgor: XI'AN HUIPU BIOTECHNOLOGY Co.,Ltd. Registration number: Y2023610000530 |
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