JP2010519915A5 - - Google Patents

Download PDF

Info

Publication number
JP2010519915A5
JP2010519915A5 JP2009552038A JP2009552038A JP2010519915A5 JP 2010519915 A5 JP2010519915 A5 JP 2010519915A5 JP 2009552038 A JP2009552038 A JP 2009552038A JP 2009552038 A JP2009552038 A JP 2009552038A JP 2010519915 A5 JP2010519915 A5 JP 2010519915A5
Authority
JP
Japan
Prior art keywords
nucleoside
analog
integer
inosine
cytosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2009552038A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010519915A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CA2008/000473 external-priority patent/WO2008106803A1/en
Publication of JP2010519915A publication Critical patent/JP2010519915A/ja
Publication of JP2010519915A5 publication Critical patent/JP2010519915A5/ja
Abandoned legal-status Critical Current

Links

JP2009552038A 2007-03-07 2008-03-07 二本鎖のロックされた核酸組成物 Abandoned JP2010519915A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90546107P 2007-03-07 2007-03-07
US95027107P 2007-07-17 2007-07-17
PCT/CA2008/000473 WO2008106803A1 (en) 2007-03-07 2008-03-07 Double-stranded locked nucleic acid compositions

Publications (2)

Publication Number Publication Date
JP2010519915A JP2010519915A (ja) 2010-06-10
JP2010519915A5 true JP2010519915A5 (enExample) 2011-10-27

Family

ID=39737757

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009552038A Abandoned JP2010519915A (ja) 2007-03-07 2008-03-07 二本鎖のロックされた核酸組成物

Country Status (10)

Country Link
US (1) US20090041809A1 (enExample)
EP (1) EP2125853A1 (enExample)
JP (1) JP2010519915A (enExample)
KR (1) KR20100051041A (enExample)
CN (1) CN101687900A (enExample)
AU (1) AU2008222523A1 (enExample)
BR (1) BRPI0808442A2 (enExample)
CA (1) CA2680060A1 (enExample)
MX (1) MX2009009530A (enExample)
WO (1) WO2008106803A1 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0228540D0 (en) * 2002-12-06 2003-01-15 Glaxo Group Ltd Novel compositions
AU2009255947B2 (en) 2008-06-06 2014-12-18 Aurora Algae, Inc. Vcp-based vectors for algal cell transformation
BRPI0914224A2 (pt) 2008-06-19 2019-09-24 Variation Biotechnologies Inc composições e métodos para tratar a gripe
WO2010107503A1 (en) 2009-03-19 2010-09-23 Millipore Corporation Removal of microorganisms from fluid samples using nanofiber filtration media
US20110097418A1 (en) * 2009-05-29 2011-04-28 Variation Biotechnologies, Inc. Compositions and methods for treating influenza
US8809046B2 (en) 2011-04-28 2014-08-19 Aurora Algae, Inc. Algal elongases
US8865468B2 (en) 2009-10-19 2014-10-21 Aurora Algae, Inc. Homologous recombination in an algal nuclear genome
AU2010270722B2 (en) 2009-07-06 2015-06-04 Variation Biotechnologies, Inc. Methods for preparing vesicles and formulations produced therefrom
WO2011005772A1 (en) 2009-07-06 2011-01-13 Variation Biotechnologies, Inc. Methods for preparing vesicles and formulations produced therefrom
US8709765B2 (en) 2009-07-20 2014-04-29 Aurora Algae, Inc. Manipulation of an alternative respiratory pathway in photo-autotrophs
US9395356B2 (en) * 2009-10-02 2016-07-19 The National Veterinary Institute Piscine reovirus immunogenic compositions
US8846388B2 (en) * 2009-10-16 2014-09-30 Zoetis Llc Infectious clones of torque teno virus
CA2802721C (en) * 2010-06-25 2015-08-18 Idera Pharmaceuticals, Inc. Novel agonists of toll-like receptor 3 and methods of their use
CA2840079C (en) 2010-07-06 2018-07-03 Variation Biotechnologies Inc. Compositions and methods for treating influenza
CN108579207A (zh) 2010-08-10 2018-09-28 Emd密理博公司 用于去除反转录病毒的方法
EP2655612B1 (en) 2010-12-23 2017-07-19 Shell Internationale Research Maatschappij B.V. Gene disruptants producing fatty acyl-coa derivatives
MX359103B (es) 2011-01-13 2018-09-14 Variation Biotechnologies Inc Composiciones y sus usos en el tratamiento de infecciones virales.
MX357319B (es) 2011-01-13 2018-07-04 Variation Biotechnologies Inc Metodo para preparar vesiculas y formulaciones producidas de las mismas.
US8722359B2 (en) 2011-01-21 2014-05-13 Aurora Algae, Inc. Genes for enhanced lipid metabolism for accumulation of lipids
CN103459006B (zh) 2011-04-01 2016-01-06 Emd密理博公司 含有纳米纤维的复合材料结构
JP2014519810A (ja) 2011-04-28 2014-08-21 オーロラ アルギー,インコーポレイテッド 藻類のデサチュラーゼ
WO2013096680A1 (en) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
US20140356399A1 (en) 2012-01-12 2014-12-04 Variation Biotechnologies, Inc. Compositions and methods for treating viral infections
CA2894467A1 (en) 2012-01-27 2013-08-01 Variation Biotechnologies Inc. Methods for preparing thermostable compositions comprising a lipid component and thermolabile therapeutic agents
WO2013142124A1 (en) 2012-03-21 2013-09-26 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
WO2013166065A1 (en) 2012-04-30 2013-11-07 Aurora Algae, Inc. ACP Promoter
US9157101B2 (en) 2012-12-21 2015-10-13 Algenol Biotech LLC Cyanobacterium sp. for production of compounds
AR095882A1 (es) 2013-04-22 2015-11-18 Hoffmann La Roche Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9
US9994831B2 (en) 2013-12-12 2018-06-12 The Regents Of The University Of California Methods and compositions for modifying a single stranded target nucleic acid
KR20200058600A (ko) 2014-06-26 2020-05-27 이엠디 밀리포어 코포레이션 개선된 먼지 포집 능력을 갖는 필터 구조
EP3206751A4 (en) 2014-10-14 2018-06-13 The J. David Gladstone Institutes Compositions and methods for reactivating latent immunodeficiency virus
MX2017008289A (es) 2014-12-23 2017-10-02 Algenol Biotech LLC Metodos para aumentar la estabilidad de la produccion de compuestos en celulas huesped microbianas.
KR102206959B1 (ko) 2015-04-17 2021-01-25 이엠디 밀리포어 코포레이션 접선방향 유동 여과 모드에서 작동되는 나노섬유 한외여과막을 사용하여 샘플에서 목적하는 생물학적 물질을 정제하는 방법
EP3303634B1 (en) 2015-06-03 2023-08-30 The Regents of The University of California Cas9 variants and methods of use thereof
US10138489B2 (en) 2016-10-20 2018-11-27 Algenol Biotech LLC Cyanobacterial strains capable of utilizing phosphite
JP7159308B2 (ja) 2017-07-21 2022-10-24 メルク・ミリポア・リミテッド ラテラルフローデバイスおよびこれを用いる試料中の検体を検出する方法
WO2019066571A2 (ko) 2017-09-28 2019-04-04 연세대학교 산학협력단 골수유래 면역반응 억제세포의 제조방법, 이에 의해 제조된 골수유래 면역반응 억제세포 및 그 용도
CN112352052A (zh) * 2018-05-04 2021-02-09 托利斯有限公司 激活上皮细胞和髓样细胞的tlr3配体
WO2020041456A1 (en) 2018-08-22 2020-02-27 The Regents Of The University Of California Variant type v crispr/cas effector polypeptides and methods of use thereof
US12460189B2 (en) 2018-11-09 2025-11-04 Inari Agriculture Technology, Inc. RNA-guided nucleases and DNA binding proteins
CA3130789A1 (en) 2019-03-07 2020-09-10 The Regents Of The University Of California Crispr-cas effector polypeptides and methods of use thereof
JP2022543735A (ja) * 2019-07-02 2022-10-14 エヌエー ヴァクシン インスティテュート 新規のリボ核酸、及びそれを基にする薬剤学的組成物
CA3186367A1 (en) * 2020-08-14 2022-02-17 Tanya DAIGLE Artificial expression constructs for modulating gene expression in striatal neurons
US20240216364A1 (en) 2021-04-28 2024-07-04 Enyo Pharma Strong potentiation of tlr3 agonists effects using fxr agonists as a combined treatment

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692899A (en) * 1969-12-17 1972-09-19 Us Health Education & Welfare Inhibition of transplanted tumor growth by polyinosinic-polycytidylic acid in mice
US4024241A (en) * 1974-09-27 1977-05-17 The United States Of America As Represented By The Secretary Of Health, Education And Welfare Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid
US3952097A (en) * 1974-09-27 1976-04-20 The United States Of America As Represented By The Department Of Health, Education And Welfare Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid
US4349538A (en) * 1979-12-07 1982-09-14 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid
US6239116B1 (en) * 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
ES2366201T3 (es) * 1994-07-15 2011-10-18 University Of Iowa Research Foundation Oligonucleótidos inmunmoduladores.
US7157089B1 (en) * 1996-11-26 2007-01-02 Stressgen Biotechnologies Corporation Immune responses using compositions containing stress proteins
JP3756313B2 (ja) * 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
CA2203843C (en) * 1997-04-28 2013-07-23 Her Majesty The Queen, In Right Of Canada, As Represented By The Ministe R Of National Defence Liposome-encapsulated poly iclc
US6794499B2 (en) * 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US6083482A (en) * 1999-05-11 2000-07-04 Icn Pharmaceuticals, Inc. Conformationally locked nucleosides and oligonucleotides
AT410173B (de) * 2000-06-08 2003-02-25 Cistem Biotechnologies Gmbh Antigene zusammensetzung
AU2003203079B9 (en) * 2002-02-04 2009-01-15 Oncothyreon Inc. Immunostimulatory, covalently lipidated oligonucleotides
WO2005102278A1 (en) * 2002-07-03 2005-11-03 Oncovir, Inc. Method for preparation of poly-iclc and uses thereof
GB0228540D0 (en) * 2002-12-06 2003-01-15 Glaxo Group Ltd Novel compositions
JP4716517B2 (ja) * 2003-06-09 2011-07-06 アルナイラム ファーマシューティカルズ, インコーポレイテッド 神経変性疾患を治療する方法
WO2006054129A1 (en) * 2004-11-19 2006-05-26 Institut Gustave Roussy Improved treatment of cancer by double-stranded rna
US7834064B2 (en) * 2005-01-03 2010-11-16 Andres Mario Salazar Clinical method for the immunomodulatory and vaccine adjuvant use of poly-ICLC and other dsRNAs
CA2626977A1 (en) * 2005-10-27 2007-05-03 Rosetta Inpharmatics Llc Nucleic acid amplification using non-random primers
KR20080086440A (ko) * 2005-11-01 2008-09-25 알닐람 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제의 RNAi 억제

Similar Documents

Publication Publication Date Title
JP2010519915A5 (enExample)
AU2023229522B2 (en) Compositions and methods for synthesizing 5'-Capped RNAs
JP6640290B2 (ja) 核酸の非特異的標的の捕捉方法
CN102124020B (zh) 自回避分子识别系统用于dna扩增
DE69232816T2 (de) Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen
JP2010525813A5 (enExample)
DK2173760T4 (en) Carbocyclic bicyclic nukleinsyreanaloge
RU2014130600A (ru) Антисмысловые нуклеиновые кислоты
AU2008260277A1 (en) N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
NZ598943A (en) Hbv antisense inhibitors
JP2012502657A5 (enExample)
JP2011502502A5 (enExample)
CA2459347A1 (en) Locked nucleic acid (lna) compositions and uses thereof
CN101978071A (zh) 用于杂交核酸的方法
JP2021505129A5 (enExample)
ES2300375T3 (es) Composiciones y metodos para la deteccion del virus de la inmunodeficiencia humana 2 (hiv-2).
Kumar et al. Design, synthesis, biophysical and primer extension studies of novel acyclic butyl nucleic acid (BuNA)
JP2019534025A5 (enExample)
WO2010040033A4 (en) Methods and compositions for modulating an immune response with immunogenic oligonucleotides
JP2011517959A (ja) チクングニヤウイルスを検出するための方法
WO2010090969A1 (en) Tetrahydropyran nucleic acid analogs
ES2383947T3 (es) Composiciones, métodos y equipos para la detección de ácidos nucleicos del vih-1 y vih-2
De Bouvere et al. Hexitol nucleic acids (HNA): synthesis and properties
EP4342999B1 (en) Compositions, kits and methods for isolating target polynucleotides
HK40084740B (en) Compositions, kits and methods for isolating target polynucleotides