JP2019534025A5 - - Google Patents

Download PDF

Info

Publication number
JP2019534025A5
JP2019534025A5 JP2019524385A JP2019524385A JP2019534025A5 JP 2019534025 A5 JP2019534025 A5 JP 2019534025A5 JP 2019524385 A JP2019524385 A JP 2019524385A JP 2019524385 A JP2019524385 A JP 2019524385A JP 2019534025 A5 JP2019534025 A5 JP 2019534025A5
Authority
JP
Japan
Prior art keywords
nucleoside
oligonucleotide
region
capture probe
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019524385A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019534025A (ja
JP7033591B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2017/078695 external-priority patent/WO2018087200A1/en
Publication of JP2019534025A publication Critical patent/JP2019534025A/ja
Publication of JP2019534025A5 publication Critical patent/JP2019534025A5/ja
Application granted granted Critical
Publication of JP7033591B2 publication Critical patent/JP7033591B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019524385A 2016-11-11 2017-11-09 治療用オリゴヌクレオチドの捕捉および検出 Expired - Fee Related JP7033591B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16198340 2016-11-11
EP16198340.8 2016-11-11
PCT/EP2017/078695 WO2018087200A1 (en) 2016-11-11 2017-11-09 Therapeutic oligonucleotides capture and detection

Publications (3)

Publication Number Publication Date
JP2019534025A JP2019534025A (ja) 2019-11-28
JP2019534025A5 true JP2019534025A5 (enExample) 2020-01-16
JP7033591B2 JP7033591B2 (ja) 2022-03-10

Family

ID=60413165

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019524385A Expired - Fee Related JP7033591B2 (ja) 2016-11-11 2017-11-09 治療用オリゴヌクレオチドの捕捉および検出

Country Status (4)

Country Link
US (1) US20190284621A1 (enExample)
EP (1) EP3538671A1 (enExample)
JP (1) JP7033591B2 (enExample)
WO (1) WO2018087200A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2019101298A (ru) 2016-07-01 2020-08-03 Ф. Хоффманн-Ля Рош Аг Антисмысловые олигонуклеотиды для модулирования экспрессии htra1
EP3568481A1 (en) * 2017-01-13 2019-11-20 Roche Innovation Center Copenhagen A/S Antisense oligonucleotides for modulating relb expression
US20190055564A1 (en) * 2017-06-01 2019-02-21 F. Hoffmann-La Roche Ag Antisense oligonucleotides for modulating htra1 expression
WO2021095829A1 (ja) * 2019-11-14 2021-05-20 積水メディカル株式会社 オリゴヌクレオチドの検出又は定量方法
WO2021144587A1 (en) * 2020-01-16 2021-07-22 Dnae Diagnostics Limited Compositions, kits and methods for isolating target polynucleotides
WO2022099216A1 (en) * 2020-11-09 2022-05-12 Children's Medical Center Corporation Systems and methods for high throughput screening of molecular interactions
GB202217984D0 (en) * 2022-11-30 2023-01-11 Qbiotix Ltd Assays

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
KR100414936B1 (ko) 1997-09-12 2004-01-13 엑시콘 에이/에스 이환 및 삼환 뉴클레오시드, 뉴클레오타이드 및올리고뉴클레오타이드 동족체
NZ513402A (en) 1999-02-12 2003-06-30 Sankyo Co Novel nucleosides and oligonucleotide analogues
PT1178999E (pt) 1999-05-04 2007-06-26 Santaris Pharma As Análogos de l-ribo-lna
EP1228245A4 (en) 1999-11-12 2004-03-17 Isis Pharmaceuticals Inc PROCESS FOR QUANTIFYING OLIGONUCLEOTIDES
DK2752488T3 (da) 2002-11-18 2020-04-20 Roche Innovation Ct Copenhagen As Antisense-design
US20070077570A1 (en) 2005-05-31 2007-04-05 Applera Corporation Multiplexed amplification of short nucleic acids
WO2007025281A2 (en) * 2005-08-24 2007-03-01 Applera Corporation A method to quantify sirnas, mirnas and polymorphic mirnas
CN101321877B (zh) 2005-10-03 2013-04-10 应用生物系统有限责任公司 用于扩增核酸的组合物、方法和试剂盒
ES2516815T3 (es) 2006-01-27 2014-10-31 Isis Pharmaceuticals, Inc. Análogos de ácidos nucleicos bicíclicos modificados en la posición 6
CA2651453C (en) 2006-05-11 2014-10-14 Isis Pharmaceuticals, Inc. 5'-modified bicyclic nucleic acid analogs
US7666854B2 (en) 2006-05-11 2010-02-23 Isis Pharmaceuticals, Inc. Bis-modified bicyclic nucleic acid analogs
EP1914317A1 (en) 2006-10-21 2008-04-23 Biolytix AG A method for qualitative and quantitative detection of short nucleic acid sequences of about 8 to 50 nucleotides in length
WO2008150729A2 (en) 2007-05-30 2008-12-11 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
EP2173760B2 (en) 2007-06-08 2015-11-04 Isis Pharmaceuticals, Inc. Carbocyclic bicyclic nucleic acid analogs
AU2008272918B2 (en) 2007-07-05 2012-09-13 Isis Pharmaceuticals, Inc. 6-disubstituted bicyclic nucleic acid analogs
US8546556B2 (en) 2007-11-21 2013-10-01 Isis Pharmaceuticals, Inc Carbocyclic alpha-L-bicyclic nucleic acid analogs
WO2010036698A1 (en) 2008-09-24 2010-04-01 Isis Pharmaceuticals, Inc. Substituted alpha-l-bicyclic nucleosides
US9012421B2 (en) 2009-08-06 2015-04-21 Isis Pharmaceuticals, Inc. Bicyclic cyclohexose nucleic acid analogs
US8846637B2 (en) 2010-06-08 2014-09-30 Isis Pharmaceuticals, Inc. Substituted 2′-amino and 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
CN104136451A (zh) 2011-09-07 2014-11-05 玛瑞纳生物技术有限公司 具有构象限制的单体的核酸化合物的合成和用途
CA2865575C (en) 2012-02-27 2024-01-16 Cellular Research, Inc. Compositions and kits for molecular counting
US9221864B2 (en) 2012-04-09 2015-12-29 Isis Pharmaceuticals, Inc. Tricyclic nucleic acid analogs
WO2013153911A1 (ja) 2012-04-12 2013-10-17 国立大学法人東京大学 核酸の定量方法、検出プローブ、検出プローブセット、及び核酸の検出方法
US9816120B2 (en) 2013-01-09 2017-11-14 The Penn State Research Foundation Low sequence bias single-stranded DNA ligation

Similar Documents

Publication Publication Date Title
JP2019534025A5 (enExample)
Van Dijk et al. Library preparation methods for next-generation sequencing: tone down the bias
ES2841077T3 (es) Enriquecimiento de dianas por extensión del cebador de sonda individual
WO2003051901A3 (en) Pseudonucleotide comprising an intercalator
JP2007532100A5 (enExample)
JP2013518598A (ja) ランダム化配列を含むプライマー及び特異的プライマーを用いる核酸の等温増幅並びにその使用
JP2017504360A5 (enExample)
EP2614154A1 (en) Method for reducing adapter-dimer formation
RU2007132657A (ru) Олигонуклеотид с двойственной специфичностью и способы, в которых он используется
KR20100074188A (ko) 축퇴 올리고뉴클레오티드 및 이의 용도
JP2022160661A (ja) 単一分子配列決定のための一本鎖環状ｄｎａ鋳型の作成
JP2011502502A5 (enExample)
JP7033591B2 (ja) 治療用オリゴヌクレオチドの捕捉および検出
WO2020219838A1 (en) Methods and enzymatic compositions for forming libraries of adapter ligated nucleic acid molecules
EP3692166A1 (en) Circularization methods for single molecule sequencing sample preparation
WO2013158215A1 (en) Oligonucleotides and methods for the preparationof rna libraries
JP6847364B2 (ja) オリゴカチオン複合プライマー配列を使用する等温増幅
CN109517888B (zh) 使用等位基因特异的反应性引物的核酸扩增方法
US11761033B2 (en) Methods to amplify highly uniform and less error prone nucleic acid libraries
EP3638810A1 (en) Methods of library construction for target polynucleotides
Johannsen et al. Enzymatic polymerisation involving 2′-amino-LNA nucleotides
WO2011133695A2 (en) Materials and methods for nucleic acid fractionation by solid phase entrapment and enzyme-mediated detachment
EP3044326A1 (en) Application of oligo-dt molecules to avoid generation of high molecular pcr products induced by polya-carrier
JP2013513359A5 (enExample)
CN112424378A (zh) 利用核酸内切酶介导的移动平衡（EM-SEq）进行核酸扩增的方法