CA2680060A1

CA2680060A1 - Double-stranded locked nucleic acid compositions

Double-stranded locked nucleic acid compositions Download PDF

Info

Publication number: CA2680060A1
Authority: CA; Canada
Prior art keywords: formula; nucleoside; integer; analogue; inosine
Prior art date: 2007-03-07
Legal status : Abandoned

Application number

CA002680060A

Other languages

English (en)

French (fr)

Inventor

Peter Emtage

Current Assignee

Nventa Biopharmaceuticals Corp

Original Assignee

Individual

Priority date

2007-03-07

Filing date

2008-03-07

Publication date

2008-09-12

2008-03-07 Application filed by Individual filed Critical Individual

2008-09-12 Publication of CA2680060A1 publication Critical patent/CA2680060A1/en

Status Abandoned legal-status Critical Current

Links

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150000007523 nucleic acids Chemical class 0.000 title claims abstract description 138
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239000002777 nucleoside Substances 0.000 claims abstract description 248
125000003835 nucleoside group Chemical group 0.000 claims abstract description 77
150000003833 nucleoside derivatives Chemical class 0.000 claims description 152
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims description 120
229930010555 Inosine Natural products 0.000 claims description 80
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NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical class C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims description 77
150000001875 compounds Chemical class 0.000 claims description 76
UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims description 70
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ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims description 54
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