JP2010518180A - 新規な化粧品及び/又は薬剤組成物及びそれらの用途 - Google Patents
新規な化粧品及び/又は薬剤組成物及びそれらの用途 Download PDFInfo
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- JP2010518180A JP2010518180A JP2009549838A JP2009549838A JP2010518180A JP 2010518180 A JP2010518180 A JP 2010518180A JP 2009549838 A JP2009549838 A JP 2009549838A JP 2009549838 A JP2009549838 A JP 2009549838A JP 2010518180 A JP2010518180 A JP 2010518180A
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- hydroalcoholic extract
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Abstract
【解決手段】 活性成分として、アリウム種の抽出物とシトリス種の抽出物と、−パウリニア種の抽出物及びテオブロマ種の抽出物のいずれか、−又はネコヤナギ種の抽出物及び硫酸亜鉛、を含む組成物。
【選択図】なし
Description
アリウム(Allium)種の抽出物、シトラス(Citrus)種の抽出物、及び
パウリニア(Paullinia)種の抽出物及びテオブロマ(Theobroma)種の抽出物のいずれか、
又はサリックス(Salix)種の抽出物及び硫酸亜鉛
を含む、新規な組成物を提供することである。
アリウム種の水性アルコール抽出物、シトラス種の水性アルコール抽出物、及び
パウリニア種の水性アルコール抽出物(粉砕されていてもいなくても良い)及びテオブロマ種の水性アルコール抽出物(粉砕されていてもいなくても良い)のいずれか、
又はサリックス種の水性抽出物(粉砕されていてもいなくても良い)及び硫酸亜鉛
を含む、組成物ある。
アリウム種の水性アルコール抽出物65%から93%、シトリス種の水性アルコール抽出物5%から33%、パウリニア種の水性抽出物0.25%から2.5%(粉砕されていてもいなくても良い)、及びテオブロマ種の水性抽出物0.25%から2.5%(粉砕されていてもいなくても良い)を含む組成物で、特にタマネギ(Allium cepa)の水性アルコール抽出物65%から93%、シトリスレモン(Citrus lemon)の水性アルコール抽出物5%から33%、パウリニア種の水性アルコール抽出物0.25%から2.5%(粉砕されていてもいなくても良い)、及びテオブロマ種の水性アルコール抽出物0.25%から2.5%(粉砕されていてもいなくても良い)を含む組成物である。
アリウム種の水性アルコール抽出物65%から93%、シトリス種の水性アルコール抽出物5%から33%、サリックス種の水性抽出物0.25%から2.5%(粉砕されていてもいなくても良い)、及び硫酸亜鉛0.1%から1%を含む組成物で、特にタマネギの水性アルコール抽出物65%から93%、シトリスレモンの水性アルコール抽出物5%から33%、サリックス種の水性アルコール抽出物0.25%から2.5%(粉砕されていてもいなくても良い)、及び硫酸亜鉛六水和物0.1%から1%を含む組成物である。
約87%のタマネギの水性アルコール抽出物、約12%のシトリスレモンの水性アルコール抽出物、約0.5%のガラナ(Paullinia cupana、粉砕されていてもいなくても良い)水性アルコール抽出物、及び約0.5%のテオブロマカカオ(Theobroma cacao)の水性アルコール抽出物を含むものと、
約87%のタマネギの水性アルコール抽出物、約12%のシトリスレモンの水性アルコール抽出物、約0.5%のホワイトウィロー(Salix alba)の水性抽出物(粉砕されていてもいなくても良い)と0.2%の硫酸亜鉛6水和物を含むものである。
[実施例1]
次の組成の組成物を調製した。
−タマネギの水性アルコール抽出物:87.04%
−シトリスレモンの水性アルコール抽出物:11.96%
−ガラナの粉砕した水性アルコール抽出物:0.50%
−テオブロマカカオの粉砕した水性アルコール抽出物:0.50%
次の組成の組成物を調製した。
−タマネギの水性アルコール抽出物:87.30%
−シトリスレモンの水性アルコール抽出物:12.00%
−ホワイトウィローの粉砕した水性抽出物:0.50%
−硫酸亜鉛6水和物:0.20%
次の組成の食品サプルメントを調製した。
−タマネギの乾燥抽出物:87.04%
−シトリスレモンの乾燥抽出物:11.96%
−ガラナの乾燥抽出物:0.50%
−テオブロマカカオの乾燥抽出物:0.50%
次の成分から頭皮処理用の化粧用ローションを調製した。
−実施例1で得た組成物:21ml
−賦形剤qsp(香水/アローマを含む):100ml
次の成分から頭皮処理用の医薬用ローションを調製した。
−実施例2で得た組成物:40ml
−賦形剤qsp(香水/アローマを含む):100ml
次の成分の錠剤を調製した。
−実施例3で得た組成物:100mg
−賦形剤qsp(香水/アローマを含む):300mg
(賦形剤の詳細:ラクトース、滑石、でんぷん、ステアリン酸マグネシウム)
次のように薬用軟膏を調製した。
−実施例3で得た組成物:5ml
−賦形剤qsp(香水/アローマを含む):100ml
ハミルトン・スケールのIIからIVの相当する禿の程度が僅かから中程度の35歳から55歳の20人の男性ボランティアを実施例4の組成物を使用して処置を施した(ハミルトン・スケール:タイプIは僅かに生え際が交代している。タイプIIは、生え際がこめかみまで後退し、頭頂領域が薄くなっている。タイプIIIは、こめかみの後退と頭頂の禿のスポットが一致している。タイプIVは、こめかみ以外が禿ている。タイプVは、頭頂の髪が喪失している。)
第1日:頭皮から髪が現れる点の髪の断面の一時的なサイトの位置の確認、及び研究する領域の接写写真の撮影。
第1〜2日:製品の塗布なし。シャンプーなし。
第3日:第1日と同じ領域の新規な接写写真の撮影、及び処置の開始。
第3〜42日:1日に2回、頭皮への製品の塗布(各回2〜3スプレイ)。
第42日:毛細管及び皮膚耐性の評価、頭皮から髪が現れる点の髪の断面の一時的なサイトの位置の確認、及び研究する領域の接写写真の撮影。
第42〜43日:製品の塗布なし。シャンプーなし。
第44日:第1日と同じ領域の新規な接写写真の撮影。
第44〜84日:1日に2回、頭皮へ、そして頭皮から髪が現れる点の髪の断面のサイトへの製品の塗布(各回2〜3スプレイ)。
第84日:毛細管及び皮膚耐性の評価、頭皮から髪が現れる点の髪の断面の研究している領域の一時的なサイトの位置の確認、及び研究する領域の接写写真の撮影。
第84〜85日:製品の塗布なし。シャンプーなし。
第86日:第1日と同じ領域の新規な接写写真の撮影。
−処置の6週間後の、大きな抗髪喪失効果:統計的なA/T(anagenic/telogenic)比は44.91%と大きく増加した。
−処置の12週間後の、大きな抗髪喪失効果:統計的なA/T比は46.78%と大きく増加した。
−良好な臨床的な耐性:皮膚科の試験の間、髪の反応は観察されなかった。
−良好な本来備わっている臨床的な耐性:それにもかかわらず1人のボランティアが皮膚の不快を経験した。
本発明の製品を、アンギオキット(Angiokit)プレート上でテストした。周知法を使用して、線維芽細胞との共培養の内皮細胞の成長をチェックし、毛細構造(細管)を観察した。異なった濃度でテストした製品は、ウェル中の各プレート上へ導入した。あるウェルはアクチベータ(VEGF)を追加受け入れし、他のウェルはインヒビタ(Suramine)を受け入れた。いくつかのウェルはコントロールとして機能した。
Claims (13)
- 活性成分として、アリウム種(Allium species)の抽出物、シトリス種(Citrus species)の抽出物、
−パウリニア種(Paullinia species)の抽出物及びテオブロマ種(Theobroma species)の抽出物のいずれか、
−又はネコヤナギ種(Salix species)の抽出物及び硫酸亜鉛
を含むことを特徴とする組成物。 - 活性成分として、アリウム種(Allium species)の水性アルコール抽出物、シトリス種(Citrus species)の水性アルコール抽出物、
−パウリニア種(Paullinia species)の水性アルコール抽出物(粉砕されていてもいなくても良い)及びテオブロマ種(Theobroma species)の水性アルコール抽出物(粉砕されていてもいなくても良い)のいずれか、
−又はネコヤナギ種(Salix species)の水性抽出物(粉砕されていてもいなくても良い)及び硫酸亜鉛
を含むことを特徴とする組成物。 - アリウム種の水性アルコール抽出物65%から93%、シトリス種の水性アルコール抽出物5%から33%、パウリニア種の水性アルコール抽出物0.25%から2.5%(粉砕されていてもいなくても良い)、及びテオブロマ種の水性アルコール抽出物0.25%から2.5%(粉砕されていてもいなくても良い)を含む請求項1又は2に記載の組成物。
- タマネギ(Allium cepa)の水性アルコール抽出物65%から93%、シトリスレモン(Citrus lemon)の水性アルコール抽出物5%から33%、パウリニア種の水性アルコール抽出物0.25%から2.5%(粉砕されていてもいなくても良い)、及びテオブロマ種の水性アルコール抽出物0.25%から2.5%(粉砕されていてもいなくても良い)を含む請求項3に記載の組成物。
- アリウム種の水性アルコール抽出物65%から93%、シトリス種の水性アルコール抽出物5%から33%、ネコヤナギ種の水性抽出物0.25%から2.5%(粉砕されていてもいなくても良い)、及び硫酸亜鉛0.1%から1%を含む請求項1又は2に記載の組成物。
- タマネギの水性アルコール抽出物65%から93%、シトリスレモンの水性アルコール抽出物5%から33%、ネコヤナギ種の水性抽出物0.25%から2.5%(粉砕されていてもいなくても良い)、及び硫酸亜鉛六水和物0.1%から1%を含む請求項5に記載の組成物。
- タマネギの水性アルコール抽出物約87%、シトリスレモンの水性アルコール抽出物約12%、ガラナ(Paullinia cupana)の粉砕された水性アルコール抽出物約0.5%及びテオブロマカカオ(Theobroma cacao)の粉砕された水性アルコール抽出物約0.5%を含む請求項4に記載の組成物。
- タマネギの水性アルコール抽出物約87%、シトリスレモンの水性アルコール抽出物約12%、ホワイトウィロー(Salix alba)約0.5%、及び硫酸亜鉛六水和物約0.2%を含む請求項6に記載の組成物。
- アリウム種及びシトリス種の抽出物を含むマスタ溶液に、
パウリニア種及びテオブロマ種の抽出物のいずれかを混合し、
又はネコヤナギ種の抽出物及び硫酸亜鉛を混合し、
所定の組成物を調製することを特徴とする方法。 - アルコール中で、数時間アリウム種及びシトリス種を、ピッキングし、洗浄し、粉砕しかつ柔軟化し、次いで混合物を濾過し、アルコール性抽出物を調整し、かつ混合物を他の成分と混合して、マスタ溶液を調製する請求項9記載の方法。
- 髪の損失を遅くし、その成長を促進し、髪の密度を増加させ、フケを除去し、頭皮の老化の信号を処置し、及び爪の不具合を処置することを含む、皮膚、頭皮又は他の外部から見える人体の部分の全てのトラブルを制御し及び/又は安定化することを特徴とする請求項1〜8のいずれか1項に記載の組成物を化粧品として使用する方法。
- 頭皮、皮膚病、瘢痕形成疾患、角質化又は角化性病変の疾患、及び循環又は血管性疾患の全ての疾患を処置するための薬剤調製用に、請求項1〜8のいずれか1項に記載の組成物を使用する方法。
- 髪と頭皮に悪影響を及ぼす病気を処置するために、髪の再生を刺激しかつ促進するために使用し、あるいは皮膚一般に悪影響を及ぼす病気、瘢痕形成疾患、角質化又は角化性病変の疾患、循環又は血管性疾患の疾患及び悪性の転移癌を処置して、腫瘍を安定化することを含む、請求項1〜8のいずれか1項に記載の組成物を含む薬剤。
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PCT/FR2008/000152 WO2008113912A2 (fr) | 2007-02-13 | 2008-02-08 | Nouvelles compositions cosmetiques et/ ou pharmaceutiques et leurs applications |
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JP2014506586A (ja) * | 2011-02-23 | 2014-03-17 | レガシー ヘルスケア リミテッド | 化学療法及び放射線療法によって惹起される脱毛症(cria)を予防し、criaの衝撃を低減し、及びcria後の毛髪の再成長の出現を改善するための組成物の新規な使用 |
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