HUE032072T2 - Új kozmetikai és/vagy gyógyászati kompozíció és ennek alkalmazása - Google Patents

Description

mMmPwM: ffsf Ibtete (Piflídrfiip?: .dü of tilso obtepasite iteiödfóbste ante tesb §f$i$$bf|,:as·: saspó|>t&:

Igomg tete; sited tesi m$ teán esscs rpvs

bean <fe*es$feeö to tea Meretom Tbese oomposiii&amp;ns css bo ssed especially te txmmm fó:te§utape tea ispxrwte oí narr or )Γ; mr^seaUcas todtoattorvs te promofe ontogenesis, siteiafe fee syr«h*Sí$ öf ctipl mé termelted teremlifemters s?te schvtemn of ??íasícells. and tersed m tea beaten* of estei concern Amoco tea Iteefuse mte-neo-s tess may sx· ttod, fór **a«ípfe. sre tbs Fiasco pteení applletefóns No. 2 875 403.. 2 877 210.. 2:672 224 2 Bf? οή aoo 2 8# f 4öO sf Ifó Swiss palent appilostetere &amp;32 217 A

Tha applicant te etesj saw tompkor·,* tecn m tetess tes ess m cosmex's or temen teeraey te '.véreb tes· sípiitewfland bigb sfabíiy os ide conrpn&amp;dloms cfesanfcsö in m mmp> lea abjeoi of tea rnyentsön is toes se* eon:pos!soos cbmacrerfóers by m fecl fea» ttey se estei el Crime steme esd -mmmm.ml.Qipmmiz.mcm Site an exbaeíof Th&amp;o&amp;m* ψ$Ψ$

Among fesse tease widen are of more psterlar rterasi are <»TipöxfecnS as seized above, teaefteete tbaf teey tef«ia an ^eous-afóoheiic extrást dfA&amp;m species* pa aqpAoqsteöPte a^texb* φ'..\%% «*-4 -fro so sqrte teocx ,· te ..: -.tete 0' r m -a %mtea teems ana an emete>χ%-- mte" (átenged ot eoti of TAecémms sptec •oísíi spireses sxüacl (gtomjsfed rmnod sí ardra speers* and 28^ ««ιρ^δκ?.

Among the composites according te tea marten tease winch see of most psrSotear interest are composite as defined at»*. teeming ter 65% te 65% of an eqm-oas-aiontec exiract $Mim #ateaa. from 5% to 33% of an anew ateoite axbaef of ters cpectes. fnm 0 26% te 2.5% or an oq.mous~arooboiio«s!raof mteiaed or nor) of Poacey teld fte iöisf: fó 2.55: oi an aqteerr-ateoiic e^aof faromised or asbtef mptmva opeoes sard es?5eaa«y teoas sateilrtefi ftefteH to §3% of m sqrrtes-afóotec Sitef of A&amp;aar oepa ter 5% to 33% of an ateoavSteoteo estei ^ W „ X V !K !"> ' " ' ill O^OteSv ^fó«"S<r'.' ^ A <

to 2.5% ¢1 so squtes^alteitee astracf (aiomrsate er oof) o? iftooite»e spaoiOA 7m· term extef o? AStom qpsetes &amp; aqeeous-aitecic e»tet of Aterr «peelea ré^r^rSourá^; to exrraote and teve extefs oblatead froro as spec*» or tee seonc Aföito* if-Ady IM&amp;m) ana eopaoi* Aism espa. gxrrscf of Otero texte cr equeobs-ai^c e^ct % Coo.x apec^ refers ^Jcutody to ^ rrafiva exiraefs obtomed frorr ari species of ere fenaa Crte (fer^ly Ateteoete?) end e&amp;peofórry Ormterte

Fxrrpd (atomised or rroq te Fdrtera speem or aqrreoo^arcononc etecr fefomised or nor) of PmSMa speem refers parteiady to aqq«qSteoilc exiraefs te nairva asoaers opiate m ® of tee germs tete; ftentey

Saptedaoaaa) and sspsciarry F^otea ooeane.

StecUatomite or not) of 00¾ Φ w-·

Parri&amp;dady ro aqaaous-afoofiaiic edreers and naiive exiractSfobrained te aü soec-H of tee genes Mfófóa pbiy hjalvmm) and sxptesiiy Ttetetea cacao *» cmotmmw****10 **» **» *** m m tmmmsrn: +** *» coding from ®* » <* * «*" W&amp;V** *» te ^ of on mm»**m extract of ^ *»" ass% 2·^ öf ^ «»"» «*** (*"«** * Sm fí0«: D.l%io 1% Ofxmc m'® *i#*»*««^*“ oi Ammi cej». forc, 5% » 33% Of 00 *qu*öute*te* Q^ M kötn °'25% ^ 2 5% 0130 *^^ααΜύ <* .«0 of Sm sot and from 01% to *% *« ·**· ^yom>

Emu oi Sato *·** « ·ρΜ» ^sct «MM* or not) s>f Sato ipasfce rate fo οο,βοοο «Μ» wed Ü® m amm of the genes Sato «Μ» «**·** **““* $*s* «ft»

The ,;;-,c $iíspiKítö USitd .n jof nso^ioiJS «ecom-ng to the inventor- may 0¾ io m iom of bn anhydrous saR or 3 potyhyöreied .safeíOSpsOíelly f f^is: T os mosi preferred compositions -acoos'Ofng to ih* istventas am. ?noss eontainmg 87% of an sdneons-sleohoilc extract of Ai?®m cops sprstoximoteiy 12% of a, oaueous-^ic extract of Dime ten* epproximotety 0.¾% of on *ψη<»*α** fr»«x {msed or oof) of te*#, aw 3ni:sppref«máí#í|J% of so sqiafout^^we*^ mam or non of Th&amp;Mcm uc#>. as wsii so boss containing approximately 8?% of an squeous-aioohol-c axfrert of Atönm cope. septoximafery 18% of so not) oi Ssüx sioa and 0 2% me sofpnsfe haifapydfPte,

Ano8iSf object of ms invention is s: mefesd .Ériihsi^si^f'Pf^i^ö^ Sigh tp;||gse:;^ pmpmstbo of » castor «ttttm cr^^iÉs:o##m#£WMI*«fe* #0l %mx ^ m sxtmotoi Paoifisb spécim? end so «Μ: : án ^.^ííto#f: $e;-iteo, io give the Facetted eomgssbsn.

According fo bo pmioresd conddions fert^gjWte^ b mat bo mate solute is prepared oy pjtfing. crossing end sailing be several hours in arnettsl and filtering, men mlpingite^

Id eing mis method of preparation for me cornpoxmoos sccordmg to free application, a reeoinnsended procedure is fo prepay bp master sobdon tom be oonsflrsdis. by piling, crespinp and miidp be áÉmrand the Dims, rnr^ng wmr 9o5 sfcohrs macerate m the cold to? 48 Cooro, fstonng be nnasbf sn'-mcn througs 0 22-mlcron biors to give &amp; waferosiconoi syrrnr.i ^ifh a io^y confenf of panvoios era men anjrrsfirrg ms s^rrscr cnov^ed ry -r.; acn::0: Iras nrastpr soiption 4$ tirpP:. tmafed, by s-mpie mixing, eibor wftb me^tfpas iafombed <>r not) oi Pm^nk spsebo and njoobromai|^% grryfi bp sxifsd {afornssed or not) of $&amp;8x species Pius bb ϊΐοο solpbaio

Compostboos suof= ss boss dosco&amp;M abw$ státifc^ fnmrpsiiijg proposes «fsicb msKs ten seiisols dvrtrxp in sasmete.; in co%rooifC appiscaboos. those corr^posbons may bo used ® miKukv for asfitroing ante sfab|iin| % osndi«dffs pfiectiag the skin, the scalp or other externa! pans of me pody, and especially for lowing down the loss of hair; slmplstln| ik cowth iecfeasmg do density, eiim-nating dandrnf? ofrssftsrg rbe srgos of agemg of te scalp and msahfig srry dlsmrders of the η,ΐ«§. ror top-cat oppf!oabon. those oompo^eonsanay thoo he apprmd drreeny to %», sbn or the scalp eppiroatinns daffy m me fe!w of selotions gr egoeentrsmd mfrons. for essrítpre. wüi? a conc^íiirsfismaf &amp; 8Ö%:. txdfbolily epprorrmamiy 20%

For ftoerneric. cpp!iCOiions; the cofopeshions may also tie ödírísnisfered as food seppmmer-rs -n the form o? grannies, sosifne oapnfes or dneks, doyrondmg on ms brat form reqwrec srd sncfead of o&amp;rg the pfrxioef ·η fee loon of so aqnooas ak'obof-c 8ofeüöí».t^Mt*8«f!·:*δ ^ pro*#* - « *y te* <&amp;&amp;**} fa** *« wk**5**· ** zj ********** §'f?*ae- divs?5^. vv:KS:^;8;;v;· OS' SSSCOiXiSfy exp'gettoe d? the ΟροδΟΟδ-ΟΐΡΟηΟγ:·; Solution Vil=h Sispef-omsCa: !.,cí.. CVoposIK-os eucb as those deseoped $xm also show properties TO^v raay therefore to sdmlfvstersd to tomans or amoiats as fstediiim especial as therapeutic or pihy!*át niedronee

so py&amp;atar, these composái*» way be use* fc? fcestiög deabaiesls. "m paftkoiarty <tefmam:s doe % fmm cutaneous p&amp;eteriat and v03i iofectrons. ageing of the skin. bleaching sod -.sPstcniog Q> &amp;s skin. vrio-go. acrodetitsahes, aunt-irsd-K-ed fsetimci easing of toe sk=o sod yanous ecnd-rlons related to eunfbys {phoiodurn'siasis). &amp;t-o os any origin !ís%íOíoeto?y c-r papule pustule), sene rosacea, topos ef^hemetosus. sensitive #nn.. mseit svngo, e<ly of oty stun. sSoouhe*. Udders alopecia of any o«§*.. hair toss, pjtydavs cajs.b$. p$m. sensitiva scarp. ytm? aatr. psohasrs and parapMi»»» of toe scalp, dyshidrosis. wests suid coon, scarsas angular cnaihs and oedsros, or soy orseases capable of .aaocu::g the OSilS cfs tneraey. Épe íCompdsitÉos also hasa as étidet on caernYascbiahsaben ss5d so iftp tip ssitlotipo of wouods, stiaohonsofaoy ori^rn bums. fetotchias§&amp; Bsfsgafs disessa; cutaneous porphyria. aR§*msiaá ma^na* mmmMi They may also be used m iherspy for trsuttnp disorders of korstinisatrory as wed as kerataSc fusions, hypeikmatoses ff®#ig karafodorirsa! dyskeratosis, larfrrs dissass. porakerafesls, kátiÉyo#!: «»9ί:::;§^f©isiiB^»i. i>chso:i;cati«o scaly domiatosis;. prungo. chersids and pustulosis. F^sy ««y rosy be used itrfs<s% fiaamorreoidal pressars. ih;s>ebofio s%ctioos: syrnpiufns associated wits veno-iyiYrpnasc iosutrrcrerrcy. heavy saps mi paresthesia:

The cornpositibgl fóipJi f.el seat or: 1¾ ^íÉtW':'-t^c:8R#"^as^s*f:'U»: ooü^oassdS:: st; aus »* : phaorsaveubeat compositions cesífaldiop ea etfeuíM #ü Sa fa® acavo taps^ddt;. stfetber veth sfanaa;o: pngm»*atjví?*.jf:: : tne*t exolpesds aodfor aOítlhvdsi

Tease pppfmaceutlsaí Wt :-M sf: paraaferftl touses, py iocal ípoieaí r^>p’lcaflO:f íö m m>- aad tae ma&amp;m. or by áeeetlorp fcr escasople py sats^tafsopus sajeespd. Tíío p-foasctaes maycgtsd p§ p^f exiopfsih §:ΙβϋΙ% cpstéd^ Msfets< capsules, soft oapsefosv ssfüifpds. ffei^adipjl#^···^^· lorrp faqu<rod. it wstPe Ρ«8|ΐ^..ϋ#^$;.:^ι^^·^:·8ίδ·':!Μ8'?ί:ΐ?.

AdirunlsPaboo Is also eossmle by ma oxdat műié. fer exam^e. i» the form of sopposltoaas or by tbe parmvtaisf ?ουΐο( for: exaropte la the fórra 0? cqocraPre scsuboas or iafeslor'S «fcrocapsules or ubpraots, py tog pesxxjtsfiaeus roots: for essmpsip to the tboY; of ^ byotief rpuras euop aíí: those: iasolvirsg: aerosols or nasal sprays. I'Pese pttófroaceutíca? oempossbons are pfepars-d by eerweesoaet rxatfíods· ;n vehict: pharmacaetsoany ciast. oí§«ok or lnof|anic excipients arc added to

These pemposnions way Pigiefore be soirds of liquids, presented In any of ihe phsrmsceuheat toffps mm8$j «sod id Ρυργορ p:öd:C:ne. m fen- example pram o>' sugsr-oeaiixi tahrefs. 05¾. bxenaes. capsules, orpps. grapuses. rpjedfSfers: prepafaisons. omlmenp. sreant$ os' gebe topárad by stsndafd rrseU-ods iffpr ise prsdrreioo ot arain or suoer-costod flbtetp; ppsfep ifefjsefs: add daro .psiapneisapspias: if is itesspa fc o»es ibr exampfe. lactose; corn starch or o;..::abts; car-sera fw sett Qersiine e-apsides οι k-i supposlurrfras ooffipfrse fóf ex'drepse, rats. vrSxeSi serrfs-saiid or eouro ps>pO:S. naruríé or rrsoísstied o>h esc. SultaPte vebsersis for sna preparation of ^otubiomi. tor orers'-c-se. csyKia^e sorutfens, ssrnsdssons ur 3 vs ups. comprise. for example, wafer. afeodols, geoerof polyols, sucrose, -nyeri soppy gsooosa. vegetable ofs, sic. popre carrier* fer mjesooepsures or =mpfenis cernp-íse, fos sxampse. co;X>iymers of glyoxaiio adsl and sac Do add Thu supuu feqsespsp as defmed above may be blended with ide exoiments oss;aüv employed is- pnarmacerfeeas epmgesttea, pob p ppm^pmipsife! ls#ss,::;sfareii rnppglm glppfe oopa ppfe:|ppg|;:p^ vsíhsues. fetfy spsfenees of ananas or veg&amp;tebs* oögsn, paraffin derivatives. $ycofe. vstknjs #ettm§ agents, dispeople w aTiolssPrs and preservatives. fe> M^p%.|E'8@Bwhgmdfén^|:|® #|s^|:^í3v«:p<f'Ét síxöÍ |»H@ííT! sesü f s ?^sy epildíabdlyes: sasi; as( öiiuents. dismipraferS: Pnders, iyfeneams; wsdlpg sosnte, siaoiNssp amoisisgís, pfbs^rvas^s, evaxÉmeffe edorsms; fíavocsrs or fragrances. fPteners and buffering agsnfs. pb also sivgpiís or solubilisers, refördap OSPÍOSO: prossoro^o^fyibl ®r sniWbpis, 11ís: feveilbn also inotedss ghsoBssosüoss cemposPss ssofaio:?ig: sfiiteasf m&amp;M··ifc drog* Ütesd áseve .as-ssÉvs: io|fidf8«f.í

When mpg sós compositions obialssed according tó ebe invention, dosp may #?y within relatively wiP limits and must he M aeMPi feie pornos? Peng Deafed and fee suondlüosx dzsemed, Pharmaceutical compesfeie normally oemsín irosn 0.2 to 500 mg. Isom 1 fo 200 mg, of aehve ^gradients as defined simvs. m me torn* of dry esfeam For mai 0.06 and id mg&amp;g, preferably from 0.1 to δ mg/Ks. partotady from 0.1 to =#.|©-§0^=mg as appropstafcr an adott :%pÉ|§jiendÖ§:pf#$^:##lfaffes approximately from 0,0¾ fa 6 mg/kg. preferably from 0 f to 5 mg&amp;g The daily dose fedf life divided, especially when | large gmhp! of active ingredient is If |e aProwfetered .:S^ííiFis^:^'K^^|^iÉife0ríííi^liiieirQV^-ba- given hdlöt^ so as Jd Htissytviyt^ tHd of th« frsy^fidorv in a nommsfectlve matter in vsew' of fee mature of ins products, a hearaaae nr eebume shomd obviously 0s adasd when they are fo be ased m ifeutn or sobs fesm. EXAtUPtEg:; ppmgie h A composition was prepared comammg; ·· m ppoes· stsxfeotio extrást of Ahm « Ifit* %: · m agdsoas'afpoopife mdraet of (¾¾ ΐ&amp;ηο»?" t1 ·% % - m afon-isad aoasoys-^conoiic eaftscf of P»s0n$mmmi 0 £0 d. ·· an ssornisad aqsaoos-aicohoiio extract oi nwoProma sacao: 0 £g % ' \ \n >v x ve ^ c!«;> f v i O' \ ap eno Πη«ι(Η; w ' ' t-' "V1 Pt 0

in %' aicotas fo; 48 doers is* me coin, iledng thfouyh a 0.22‘micncm ». oofienhng fire ásan|felife5fe and ardssfing fo 3(^ aiaohoL TAe agaeodO'afeohoifo aafracf of fernso was psaparsd oy p^^ind. crfes^issa arrd reiifing the OfOia. inacsxesrrg sn ffes afgsfex fer di: hegre ;r: dw cafa, fSienog feroegh « Odd-fiewee oner, oofeeng the asaonoiü: firnafs ano sd^siing fo 3Ce aioonoi. :A master sbidfion r^ ektraeferof Mám simple m«§,;::me« ^asoas*afeeissiig etdracfs of Pauferisa coAssa and rtwoere^a cessa wsreaddssd^^tellfe master.smsrnmaeigwe fho nsgyfrad combi-md expasr.

Oxamoiti. A oomposihos· was propasad aonfaísuiig: • an aqoepas-aloGhoffc axfrscf of Ai%?rr cepe: ST 30 % ao extras o? Csryst&amp;ti&amp;fg: *<ρ·&amp; >.' ·: Sf5 3|öí?íÍS3íj: gii|iJíKíí:ÍSf ^8$$ Μ ^Χί^ίί A ^ , síbe sulphate höKShvöíöís:; {i ** '>Λ

Th« aqueoua^fcohois e« of *®*s c»p&amp; v*a$ iK&amp;eared fey #3smq.as$ rrtfírftg tN macaraling m 8* áscohd töt 4« bmu ki M $M> ^ou§h * 022-m*c?w Mm. «ofrtfwe m a#s&amp;«8 K> 3iA alcohol Ís::ap^®*ihh süsd MM** kmr, was pmm$ by ^n$. s&amp;3ft>R9 3¾} -«MceraMe is 3^' alsötófcr df ΡομοτΙο lbs sold, Sifting through a Ö?2-ralcron te. coifecstag íh* «conolfc:Íi|iuj and adjus^O ío 30s alcohol. Á mm® mMm mMtm 8* Φνψψψ, ápguos : eximc? öí Sete síbe sód fbe zinc sylpbofe hsxaiíydralo wsroaoded >0 Éis mester solarise give the r eqd ;md: édÉideddÉfSOt^

Iiisiii A fosa Süppíomosd was· iparod Ρθ^Υ4||: * a dry extract <sf Mm ö ''04 * - a dry exirasfof ($w$ f&amp;w ! -!ti ^ > a d?y sxfract of Ρ®Φ$$ wperm. ^ * ^á:d?Y oxtraef pf 33!#o&amp;íomo escao $%$"&amp; -fals was obtained by adding so aroma to the compost obiaiasd * Example I loo thro tha m<xn*> ίο gf*s a powder whipfrdqb^ s food sqppiimsnt ÍMSiiMí A mmte mtico «or scarp Irsstmesd was prepared irons *he feiioviepds^^^·::. · composttiOd obisieod <n txaswgte 1 -’ '* ífxoipier|:qópíÍ«ió|Af pqddmiigrdibbl ·ο§«α

The bis* wee prepare by simple mbinp t* id* cc*pca$*i MM In Exacts 1 and an axopianl ixiil&amp;i A cmdicinsi infers ter aoaip uesfeerc wax prepared from the fefevwog onmnonesfe .*. -.v 4fv?t^ - composrim obtained «a example * :, sxcipnmrqsp bodubiog pednsoe/arosrsa) i!

The infers was prooarfe by ssmple sniXsog of me ecxfeositjon oofameo so r:,xa?Rp* «ad 3n ;*, fesm>

ExESli; vyyfh the hylfowf 5¾ íidín'ífifgjlf 00 pcfe fXfpstbbi , composition obfeusd in £,*«mpte 3 ϊ5^ • exdpiooí qs.p fsoolí-icjlog pertliíae/aroeiöl -v”? ^ (•>scid«nf delaid: iaotose. teioum. afirsbí ai ^dOSíMíd stoarato.· liiiliil:

As ddpReelür^^medldiciosa wasprigarax aa mi 'bomgosiiion obtsined in Exampiaíl 55 ϊ><: - axdpie-n qsp (iaoludinq parfdmaAafomal 5 — '

JlJi» mm *m »55 »«*»« «ft» k> <***m Μ» l«« «- «of» mm mb mmtrnmm^mmmbm0mmb < (»< w* W* '· *W* <**** «*** <W* * mm morn * ft, mm »5 «**« of ft· **#«**·* *» iff «*8 c( la mmt «5 ·* WW ®* }:: \y)y IV: ,iSi0ii£S3SiC5,t '.: ' :: ;;:£ ,,:,¾ ,,, V íiJSriSíi I- :’ 11¾ sx5t?x:0; was sis following· D* t: to»S«, <>S ft, l«R*»l «. mmmvm <«»

Dap 1-2' no application of produso as sharoppoUfl: D«> ' , ΤΛ Of»' , X ^ w- =1 (W ,!" ' 'Vi?'

Cap 3*42; application of tee pmp«ette the %&amp;&amp;&amp;&amp;&amp;&amp;**

Day 42: ovpteeooo of cap»Dsy sap $Dn teteiapote Deacon of toe temporal site, sfoss οοαιοηΙορ ot if® o&amp;r a? ihe ppsat $f éteargénse-tom #5« scalp, macrophctography of the region siodtea Days 42 · 43' ns appücsiton of product ana no eharnpoeino,:

Day 44' fresh toacropnotepraphy of if® sams tegmw &amp;<&amp;/ *>

Dap 44 - §4 apples of the product «dm* to a® scalp f^o a day (20 <* «** occwm*. to Do ^ :>f sross-sectteri of too hair at IPs point of emeoasnoa from tee scate, i Day &amp;4: evaluation of osspitlafy and stew ioferai'oe: Deacon of the Ipfoporal site et tee rdf I* stedteíi ρ&amp;«^»8ρι®ο$§ Of ffte Pair at tee ppte? of emergence ftom tee scalp. otetexplxlostephy of tee iogsoa stediete Days 84-85 no appiioarion of IPs pexte and no shampo;>og.

Day 86: new inaersphotssgraphy: of ifitesarnte sápién ss afiSiayxr apa study showed:

> a aigteteotpf woplf: of ffitetefsnf:; etshstisaily ^fÉ^t;É#fh#e # Ife AfT : teiOif'anspaoldfteipipoteSiOtil of i*4Ap|> ^significant aatl-haiiloss effectiveness after 12 weete; of tfpoto'ont: statistically Significant i no ease in the AO ratio rasa t .. v s- - te, >·\< o qs. \ u a' " ' v ,x Nn a 5¾ hv. < 0" o' ^ *\ \ 3 aa x -i gpid sofaepfivoteiloivaf foteraisce: tetef htee? %p product of thoapvssnffOP: woo tasted on ΑοιίΡΚΙplates: Using woDxnown teats, tie d&amp;ve%ioen? of ondeihefiai ce?jS ^ : ^otefuro with fterobissfs was chocked., ono too fonoaiion of cepillary sfted&amp;res ftuhutes} was ebsafveo : no P'oocrf tested Í.i^^'^n^t^^:wesd#€Í^í^fc<«atÉi#k.bte:^rf^nst^v:,iorfsin wells adoifioneiiy socteved an aasyater tVSGF) while otrsx walls rscoweo a« inhtelsr fUi8asxfpe},®oase: wefts Toe noteent medium wss ohaaped at dsys 3,4, ?. to ^dill-and^e^'^'to^8^ aidsy i§,

Tfte sesufD observed on day 15 showed tee* ?n* orcduci has proncunood angeogenic activity

Claims (1)

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