JP2010517955A5 - - Google Patents
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- Publication number
- JP2010517955A5 JP2010517955A5 JP2009547651A JP2009547651A JP2010517955A5 JP 2010517955 A5 JP2010517955 A5 JP 2010517955A5 JP 2009547651 A JP2009547651 A JP 2009547651A JP 2009547651 A JP2009547651 A JP 2009547651A JP 2010517955 A5 JP2010517955 A5 JP 2010517955A5
- Authority
- JP
- Japan
- Prior art keywords
- ono
- formula
- group
- linear
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)(O[C@@]1C[C@]([C@@](CCC([C@]2(C)C=C3)=CC3=O)[C@@]22F)[C@]3(C)C[C@@]2O)OC13C(COC(OCC(C(OCCCC*)=O)NC(CCCCC*)=O)=O)=* Chemical compound CC(C)(O[C@@]1C[C@]([C@@](CCC([C@]2(C)C=C3)=CC3=O)[C@@]22F)[C@]3(C)C[C@@]2O)OC13C(COC(OCC(C(OCCCC*)=O)NC(CCCCC*)=O)=O)=* 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89937607P | 2007-02-05 | 2007-02-05 | |
| US60/899,376 | 2007-02-05 | ||
| US92945607P | 2007-06-28 | 2007-06-28 | |
| US60/929,456 | 2007-06-28 | ||
| PCT/EP2008/050938 WO2008095806A1 (en) | 2007-02-05 | 2008-01-28 | Nitric oxide releasing steroids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010517955A JP2010517955A (ja) | 2010-05-27 |
| JP2010517955A5 true JP2010517955A5 (enExample) | 2011-03-17 |
| JP5216782B2 JP5216782B2 (ja) | 2013-06-19 |
Family
ID=39232800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009547651A Expired - Fee Related JP5216782B2 (ja) | 2007-02-05 | 2008-01-28 | 酸化窒素放出性ステロイド |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US8933062B2 (enExample) |
| EP (3) | EP2109617A1 (enExample) |
| JP (1) | JP5216782B2 (enExample) |
| KR (1) | KR20090107525A (enExample) |
| CN (1) | CN101652380A (enExample) |
| AU (1) | AU2008213046B2 (enExample) |
| BR (1) | BRPI0807078A2 (enExample) |
| CA (3) | CA2677441C (enExample) |
| ES (1) | ES2601102T3 (enExample) |
| IL (1) | IL199815A (enExample) |
| MX (1) | MX2009008334A (enExample) |
| NZ (1) | NZ579067A (enExample) |
| RU (1) | RU2442790C2 (enExample) |
| WO (3) | WO2008095809A1 (enExample) |
| ZA (1) | ZA200905067B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011243947A1 (en) | 2010-04-23 | 2012-12-06 | Piramal Enterprises Limited | Nitric oxide releasing prodrugs of therapeutic agents |
| US8846723B2 (en) | 2010-07-29 | 2014-09-30 | Eastman Chemical Company | Esters of O-substituted hydroxy carboxylic acids and preparations thereof |
| KR20140103099A (ko) | 2011-10-12 | 2014-08-25 | 아센디스 파마 옵탈몰로지 디비젼 에이/에스 | 안구 병태의 예방 및 치료 |
| EP2729220B1 (en) * | 2011-12-20 | 2015-11-04 | Oriflame Research and Development Ltd. | Compounds with anti-aging activities |
| WO2014056915A1 (en) | 2012-10-11 | 2014-04-17 | Ascendis Pharma A/S | Diagnosis, prevention and treatment of diseases of the joint |
| CA2897571C (en) | 2013-01-21 | 2018-12-18 | Apparao Satyam | Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group |
| RU2545416C1 (ru) * | 2014-02-18 | 2015-03-27 | Ксения Юрьевна Еременко | Способ лечения возрастной макулярной дистрофии |
| CN103880907A (zh) * | 2014-03-11 | 2014-06-25 | 天津金耀集团有限公司 | 丁酸氢化可的松半水合物 |
| AU2017359043B2 (en) | 2016-11-08 | 2022-06-16 | Regeneron Pharmaceuticals, Inc. | Steroids and protein-conjugates thereof |
| KR20200007905A (ko) | 2017-05-18 | 2020-01-22 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
| CA3080857A1 (en) | 2017-11-07 | 2019-05-16 | Regeneron Pharmaceuticals, Inc. | Hydrophilic linkers for antibody drug conjugates |
| EA202091672A1 (ru) | 2018-01-08 | 2021-02-01 | Регенерон Фармасьютикалз, Инк. | Стероиды и их антитело-конъюгаты |
| WO2019217591A1 (en) | 2018-05-09 | 2019-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-msr1 antibodies and methods of use thereof |
| WO2020047496A1 (en) * | 2018-08-31 | 2020-03-05 | Aerie Pharmaceuticals, Inc. | Isoquinoline-steroid conjugates and uses thereof |
| WO2022135332A1 (zh) * | 2020-12-21 | 2022-06-30 | 映恩生物制药（苏州）有限公司 | 一种甾体偶联物 |
| JP7687973B2 (ja) * | 2022-01-24 | 2025-06-03 | 芳弘 二村 | フィブロネクチン活性化作用を介した表皮細胞増殖作用を呈するジテルペン誘導体 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3183252A (en) | 1963-09-05 | 1965-05-11 | Syntex Corp | 16-nitratoalkyl-pregnanes |
| US3494941A (en) * | 1967-12-04 | 1970-02-10 | American Home Prod | Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones |
| HU164115B (enExample) | 1971-05-07 | 1973-12-28 | ||
| IT1285770B1 (it) * | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
| IT1311922B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| ITMI20020148A1 (it) * | 2002-01-29 | 2003-07-29 | Nicox Sa | Nuovi corticosteroidi |
| EP1336602A1 (en) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| AU2006286838C1 (en) * | 2005-09-02 | 2013-05-02 | Ferrer Internacional S.A. | Nitrooxy derivatives of glucocorticoids |
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2008
- 2008-01-28 CN CN200880004081A patent/CN101652380A/zh active Pending
- 2008-01-28 WO PCT/EP2008/050948 patent/WO2008095809A1/en not_active Ceased
- 2008-01-28 JP JP2009547651A patent/JP5216782B2/ja not_active Expired - Fee Related
- 2008-01-28 US US12/525,970 patent/US8933062B2/en not_active Expired - Fee Related
- 2008-01-28 CA CA2677441A patent/CA2677441C/en not_active Expired - Fee Related
- 2008-01-28 EP EP08708270A patent/EP2109617A1/en not_active Withdrawn
- 2008-01-28 CA CA002677442A patent/CA2677442A1/en not_active Abandoned
- 2008-01-28 WO PCT/EP2008/050947 patent/WO2008095808A1/en not_active Ceased
- 2008-01-28 ES ES08708261.6T patent/ES2601102T3/es active Active
- 2008-01-28 BR BRPI0807078-4A2A patent/BRPI0807078A2/pt not_active IP Right Cessation
- 2008-01-28 MX MX2009008334A patent/MX2009008334A/es active IP Right Grant
- 2008-01-28 AU AU2008213046A patent/AU2008213046B2/en not_active Ceased
- 2008-01-28 US US12/526,005 patent/US20100041633A1/en not_active Abandoned
- 2008-01-28 EP EP08708261.6A patent/EP2118120B1/en active Active
- 2008-01-28 CA CA002677290A patent/CA2677290A1/en not_active Abandoned
- 2008-01-28 NZ NZ579067A patent/NZ579067A/en not_active IP Right Cessation
- 2008-01-28 RU RU2009132993/04A patent/RU2442790C2/ru not_active IP Right Cessation
- 2008-01-28 US US12/525,822 patent/US20100234334A1/en not_active Abandoned
- 2008-01-28 KR KR1020097016395A patent/KR20090107525A/ko not_active Abandoned
- 2008-01-28 WO PCT/EP2008/050938 patent/WO2008095806A1/en not_active Ceased
- 2008-01-28 EP EP08708271A patent/EP2109618A1/en not_active Withdrawn
-
2009
- 2009-07-12 IL IL199815A patent/IL199815A/en not_active IP Right Cessation
- 2009-07-20 ZA ZA200905067A patent/ZA200905067B/xx unknown
-
2014
- 2014-11-26 US US14/554,830 patent/US20150105547A1/en not_active Abandoned