JP2005526138A5 - - Google Patents
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- Publication number
- JP2005526138A5 JP2005526138A5 JP2004505324A JP2004505324A JP2005526138A5 JP 2005526138 A5 JP2005526138 A5 JP 2005526138A5 JP 2004505324 A JP2004505324 A JP 2004505324A JP 2004505324 A JP2004505324 A JP 2004505324A JP 2005526138 A5 JP2005526138 A5 JP 2005526138A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- alkyl
- pharmaceutically acceptable
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 14
- 229910052731 fluorine Inorganic materials 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 13
- 229910052801 chlorine Inorganic materials 0.000 claims 12
- 230000002265 prevention Effects 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 150000002431 hydrogen Chemical group 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 8
- 208000028867 ischemia Diseases 0.000 claims 7
- 210000000056 organ Anatomy 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 206010019280 Heart failures Diseases 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 6
- 206010016654 Fibrosis Diseases 0.000 claims 5
- 230000004761 fibrosis Effects 0.000 claims 5
- -1 methoxy, ethoxy Chemical group 0.000 claims 5
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 4
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 4
- 230000032683 aging Effects 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 229910052794 bromium Inorganic materials 0.000 claims 4
- 210000003169 central nervous system Anatomy 0.000 claims 4
- 208000015114 central nervous system disease Diseases 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 229910052740 iodine Inorganic materials 0.000 claims 4
- 230000002093 peripheral effect Effects 0.000 claims 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 206010027476 Metastases Diseases 0.000 claims 3
- 230000009692 acute damage Effects 0.000 claims 3
- 230000001451 cardiotoxic effect Effects 0.000 claims 3
- 230000009693 chronic damage Effects 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 230000010410 reperfusion Effects 0.000 claims 3
- 208000030090 Acute Disease Diseases 0.000 claims 2
- 206010001497 Agitation Diseases 0.000 claims 2
- 206010002383 Angina Pectoris Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000003495 Coccidiosis Diseases 0.000 claims 2
- 206010010356 Congenital anomaly Diseases 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 2
- 208000002249 Diabetes Complications Diseases 0.000 claims 2
- 206010012655 Diabetic complications Diseases 0.000 claims 2
- 208000005189 Embolism Diseases 0.000 claims 2
- 206010048554 Endothelial dysfunction Diseases 0.000 claims 2
- 208000007530 Essential hypertension Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 206010022562 Intermittent claudication Diseases 0.000 claims 2
- 206010023076 Isosporiasis Diseases 0.000 claims 2
- 206010023421 Kidney fibrosis Diseases 0.000 claims 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000028017 Psychotic disease Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 230000006793 arrhythmia Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000009787 cardiac fibrosis Effects 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 208000037976 chronic inflammation Diseases 0.000 claims 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims 2
- 230000036461 convulsion Effects 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000008694 endothelial dysfunction Effects 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 239000007943 implant Substances 0.000 claims 2
- 208000021156 intermittent vascular claudication Diseases 0.000 claims 2
- 201000004792 malaria Diseases 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 208000031225 myocardial ischemia Diseases 0.000 claims 2
- 210000001428 peripheral nervous system Anatomy 0.000 claims 2
- 231100000572 poisoning Toxicity 0.000 claims 2
- 230000000607 poisoning effect Effects 0.000 claims 2
- 238000004321 preservation Methods 0.000 claims 2
- 201000004240 prostatic hypertrophy Diseases 0.000 claims 2
- 230000035939 shock Effects 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 210000001685 thyroid gland Anatomy 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- 208000003663 ventricular fibrillation Diseases 0.000 claims 2
- 230000009278 visceral effect Effects 0.000 claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010048610 Cardiotoxicity Diseases 0.000 claims 1
- GYZTWZKKXGLURP-UHFFFAOYSA-N FS(F)(F)(F)(F)N(C(=N)N)C(C1=CC=CC=C1)=O Chemical compound FS(F)(F)(F)(F)N(C(=N)N)C(C1=CC=CC=C1)=O GYZTWZKKXGLURP-UHFFFAOYSA-N 0.000 claims 1
- 231100000457 cardiotoxic Toxicity 0.000 claims 1
- 231100000259 cardiotoxicity Toxicity 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 claims 1
- 239000002831 pharmacologic agent Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000002861 ventricular Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10222192A DE10222192A1 (de) | 2002-05-18 | 2002-05-18 | Pentafluorsulfuranyl-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| PCT/EP2003/004669 WO2003097591A1 (de) | 2002-05-18 | 2003-05-05 | Pentafluorsulfanyl-benzoylguanidine, verfahren zu ihrer hertellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005526138A JP2005526138A (ja) | 2005-09-02 |
| JP2005526138A5 true JP2005526138A5 (enExample) | 2006-06-22 |
| JP4383341B2 JP4383341B2 (ja) | 2009-12-16 |
Family
ID=29285565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004505324A Expired - Fee Related JP4383341B2 (ja) | 2002-05-18 | 2003-05-05 | ペンタフルオロスルファニルベンゾイルグアニジン、それらの製造法、医薬または診断剤としてのそれらの使用、およびそれらを含有する医薬 |
Country Status (28)
| Country | Link |
|---|---|
| EP (1) | EP1509498B1 (enExample) |
| JP (1) | JP4383341B2 (enExample) |
| KR (1) | KR100977676B1 (enExample) |
| CN (1) | CN100506791C (enExample) |
| AR (1) | AR040034A1 (enExample) |
| AT (1) | ATE343563T1 (enExample) |
| AU (1) | AU2003242531B2 (enExample) |
| BR (1) | BR0311128A (enExample) |
| CA (1) | CA2486336C (enExample) |
| CY (1) | CY1105867T1 (enExample) |
| DE (2) | DE10222192A1 (enExample) |
| DK (1) | DK1509498T3 (enExample) |
| ES (1) | ES2274264T3 (enExample) |
| HR (1) | HRP20041078B1 (enExample) |
| IL (2) | IL165213A0 (enExample) |
| MA (1) | MA27277A1 (enExample) |
| ME (1) | MEP28908A (enExample) |
| MX (1) | MXPA04011497A (enExample) |
| MY (1) | MY139310A (enExample) |
| NO (1) | NO333288B1 (enExample) |
| PE (1) | PE20040452A1 (enExample) |
| PL (1) | PL209700B1 (enExample) |
| PT (1) | PT1509498E (enExample) |
| RS (1) | RS50772B (enExample) |
| RU (1) | RU2315752C2 (enExample) |
| TW (1) | TWI281467B (enExample) |
| WO (1) | WO2003097591A1 (enExample) |
| ZA (1) | ZA200408886B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7501440B2 (en) | 2003-03-07 | 2009-03-10 | Sanofi-Aventis Deutschland Gmbh | Substituted benzoylureidopyridylpiperidine-and-pyrrolidinecarboxylic acid derivatives, processes for preparing them and their use |
| DE10338554A1 (de) * | 2003-08-22 | 2005-03-31 | Aventis Pharma Deutschland Gmbh | Pentafluorosulfanylphenyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE10353205A1 (de) * | 2003-11-13 | 2005-06-16 | Aventis Pharma Deutschland Gmbh | Ortho-substituierte Pentafluorsulfuranyl-Benzole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als wertvolle Synthese-Zwischenstufen |
| DE10353204A1 (de) * | 2003-11-13 | 2005-06-16 | Aventis Pharma Deutschland Gmbh | Verfahren zur Herstellung von 4-Pentafluorsulfanyl-benzoylguanidinen |
| OA13285A (en) * | 2003-11-13 | 2007-01-31 | Sanofi Aventis Deutschland | Pentafluorosulfanyl benzoylguanidines, method for their production, their use as medicaments or diagnostic agents and medicament containing the same. |
| DE102004043938A1 (de) * | 2004-09-11 | 2006-03-30 | Sanofi-Aventis Deutschland Gmbh | Pentafluorosulfanylphenyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE102004043937A1 (de) * | 2004-09-11 | 2006-03-30 | Sanofi-Aventis Deutschland Gmbh | Ortho-substituierte Pentafluorsulfuranyl-Benzole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Synthese-Zwischenstufen |
| BRPI0807137A2 (pt) * | 2007-02-09 | 2014-04-15 | Pfizer Ltd | Agentes antiparasitários |
| EP2468722B1 (en) * | 2007-03-23 | 2014-10-01 | UBE Industries, Ltd. | Process for producing arylsulfur halotetrafluorides |
| JP5418226B2 (ja) * | 2007-08-28 | 2014-02-19 | 宇部興産株式会社 | ペンタフルオロスルファニルベンゼン化合物の製造方法、及び新規なペンタフルオロスルファニルベンゼン化合物 |
| RU2372331C1 (ru) * | 2008-05-14 | 2009-11-10 | Сергей Михайлович Игумнов | СПОСОБ ПОЛУЧЕНИЯ ДИ(C1-C6 алкил)АМИНОТРИФТОРСУЛЬФУРАНОВ |
| JP5439745B2 (ja) * | 2008-05-27 | 2014-03-12 | 宇部興産株式会社 | ハロゲノメチルペンタフルオロスルファニルベンゼン化合物及びその製造方法 |
| EP2789603B1 (en) * | 2011-12-06 | 2016-08-10 | Ube Industries, Ltd. | Method for producing pentafluorosulfanyl benzoic acid |
| CN108003034B (zh) * | 2017-12-26 | 2020-07-03 | 金凯(辽宁)化工有限公司 | 一种2-甲基-5-氨基三氟甲苯的制备方法 |
| RU2765117C2 (ru) * | 2019-09-24 | 2022-01-25 | Федеральное государственное автономное образовательное учреждение высшего образования "Уральский федеральный университет имени первого Президента России Б.Н. Ельцина" | Применение натриевой соли диэтилового эфира 4-оксо-1,4-дигидропиразоло[5,1-с]-1,2,4-триазин-3,8-дикарбоновой кислоты, моногидрата в качестве средства лечения и профилактики поздних осложнений сахарного диабета |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4417004A1 (de) * | 1994-05-13 | 1995-11-16 | Hoechst Ag | Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19517848A1 (de) * | 1995-05-16 | 1996-11-21 | Merck Patent Gmbh | Fluorhaltige Benzoylguanidine |
| DE19526381A1 (de) * | 1995-07-19 | 1997-01-23 | Hoechst Ag | 4-Fluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| GB9606015D0 (en) * | 1996-03-22 | 1996-05-22 | Rhone Poulenc Agriculture | New herbicides |
-
2002
- 2002-05-18 DE DE10222192A patent/DE10222192A1/de not_active Withdrawn
-
2003
- 2003-04-25 PE PE2003000415A patent/PE20040452A1/es not_active Application Discontinuation
- 2003-05-05 RU RU2004137115/04A patent/RU2315752C2/ru not_active IP Right Cessation
- 2003-05-05 ES ES03752723T patent/ES2274264T3/es not_active Expired - Lifetime
- 2003-05-05 CA CA2486336A patent/CA2486336C/en not_active Expired - Fee Related
- 2003-05-05 ME MEP-289/08A patent/MEP28908A/xx unknown
- 2003-05-05 WO PCT/EP2003/004669 patent/WO2003097591A1/de not_active Ceased
- 2003-05-05 PL PL371784A patent/PL209700B1/pl unknown
- 2003-05-05 RS YUP-990/04A patent/RS50772B/sr unknown
- 2003-05-05 KR KR1020047018590A patent/KR100977676B1/ko not_active Expired - Fee Related
- 2003-05-05 DK DK03752723T patent/DK1509498T3/da active
- 2003-05-05 CN CNB038113198A patent/CN100506791C/zh not_active Expired - Fee Related
- 2003-05-05 PT PT03752723T patent/PT1509498E/pt unknown
- 2003-05-05 DE DE50305498T patent/DE50305498D1/de not_active Expired - Lifetime
- 2003-05-05 MX MXPA04011497A patent/MXPA04011497A/es active IP Right Grant
- 2003-05-05 AU AU2003242531A patent/AU2003242531B2/en not_active Ceased
- 2003-05-05 EP EP03752723A patent/EP1509498B1/de not_active Expired - Lifetime
- 2003-05-05 BR BR0311128-8A patent/BR0311128A/pt not_active IP Right Cessation
- 2003-05-05 IL IL16521303A patent/IL165213A0/xx unknown
- 2003-05-05 HR HRP20041078AA patent/HRP20041078B1/hr not_active IP Right Cessation
- 2003-05-05 JP JP2004505324A patent/JP4383341B2/ja not_active Expired - Fee Related
- 2003-05-05 AT AT03752723T patent/ATE343563T1/de active
- 2003-05-15 TW TW092113151A patent/TWI281467B/zh not_active IP Right Cessation
- 2003-05-16 MY MYPI20031822A patent/MY139310A/en unknown
- 2003-05-16 AR ARP030101716A patent/AR040034A1/es active IP Right Grant
-
2004
- 2004-11-03 ZA ZA2004/08886A patent/ZA200408886B/en unknown
- 2004-11-15 IL IL165213A patent/IL165213A/en not_active IP Right Cessation
- 2004-11-16 MA MA27949A patent/MA27277A1/fr unknown
- 2004-12-14 NO NO20045447A patent/NO333288B1/no not_active IP Right Cessation
-
2006
- 2006-12-20 CY CY20061101825T patent/CY1105867T1/el unknown
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