JP2005529182A5 - - Google Patents
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- Publication number
- JP2005529182A5 JP2005529182A5 JP2004513243A JP2004513243A JP2005529182A5 JP 2005529182 A5 JP2005529182 A5 JP 2005529182A5 JP 2004513243 A JP2004513243 A JP 2004513243A JP 2004513243 A JP2004513243 A JP 2004513243A JP 2005529182 A5 JP2005529182 A5 JP 2005529182A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- treatment
- prevention
- pharmaceutically acceptable
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 239000001257 hydrogen Substances 0.000 claims 23
- 150000002431 hydrogen Chemical group 0.000 claims 18
- 239000003814 drug Substances 0.000 claims 15
- 230000002265 prevention Effects 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 12
- 210000000056 organ Anatomy 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 10
- 210000003169 central nervous system Anatomy 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 208000035475 disorder Diseases 0.000 claims 9
- 238000004519 manufacturing process Methods 0.000 claims 7
- 206010019280 Heart failures Diseases 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 6
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 4
- 206010016654 Fibrosis Diseases 0.000 claims 4
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 4
- 230000001451 cardiotoxic effect Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 230000004761 fibrosis Effects 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 208000028867 ischemia Diseases 0.000 claims 4
- 230000002093 peripheral effect Effects 0.000 claims 4
- 238000001356 surgical procedure Methods 0.000 claims 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 4
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 3
- 206010027476 Metastases Diseases 0.000 claims 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 230000000747 cardiac effect Effects 0.000 claims 3
- 230000007547 defect Effects 0.000 claims 3
- 230000000302 ischemic effect Effects 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 230000010410 reperfusion Effects 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 239000011593 sulfur Chemical group 0.000 claims 3
- 208000003663 ventricular fibrillation Diseases 0.000 claims 3
- 206010001497 Agitation Diseases 0.000 claims 2
- 206010002383 Angina Pectoris Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000003495 Coccidiosis Diseases 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 2
- 206010048554 Endothelial dysfunction Diseases 0.000 claims 2
- 208000007530 Essential hypertension Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 206010022562 Intermittent claudication Diseases 0.000 claims 2
- 206010023076 Isosporiasis Diseases 0.000 claims 2
- 206010023421 Kidney fibrosis Diseases 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 230000009692 acute damage Effects 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000032683 aging Effects 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 230000006793 arrhythmia Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000009787 cardiac fibrosis Effects 0.000 claims 2
- 231100000457 cardiotoxic Toxicity 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 230000009693 chronic damage Effects 0.000 claims 2
- 208000037976 chronic inflammation Diseases 0.000 claims 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims 2
- 230000036461 convulsion Effects 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 230000006806 disease prevention Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000008694 endothelial dysfunction Effects 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 208000021156 intermittent vascular claudication Diseases 0.000 claims 2
- 230000037356 lipid metabolism Effects 0.000 claims 2
- 201000004792 malaria Diseases 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 208000031225 myocardial ischemia Diseases 0.000 claims 2
- 210000001428 peripheral nervous system Anatomy 0.000 claims 2
- 231100000572 poisoning Toxicity 0.000 claims 2
- 230000000607 poisoning effect Effects 0.000 claims 2
- 244000144977 poultry Species 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 238000004321 preservation Methods 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 2
- 230000035939 shock Effects 0.000 claims 2
- 230000001732 thrombotic effect Effects 0.000 claims 2
- 210000001685 thyroid gland Anatomy 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- AJDQRQQNNLZLPM-UHFFFAOYSA-N n-(diaminomethylidene)benzamide Chemical class NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 claims 1
- 239000002831 pharmacologic agent Substances 0.000 claims 1
- 208000037921 secondary disease Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10226462A DE10226462A1 (de) | 2002-06-13 | 2002-06-13 | Fluorierte Cycloalkyl-derivatisierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
| PCT/EP2003/005738 WO2003106410A1 (de) | 2002-06-13 | 2003-06-02 | Fluorierte cycloalkyl-derivatisierte benzoylguanidine und ihre verwendung als medikament |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005529182A JP2005529182A (ja) | 2005-09-29 |
| JP2005529182A5 true JP2005529182A5 (enExample) | 2006-07-06 |
| JP4383343B2 JP4383343B2 (ja) | 2009-12-16 |
Family
ID=29594510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004513243A Expired - Lifetime JP4383343B2 (ja) | 2002-06-13 | 2003-06-02 | フッ素化シクロアルキル誘導体化ベンゾイルグアニジン及び薬物としてのそれらの使用 |
Country Status (25)
| Country | Link |
|---|---|
| EP (2) | EP1515947B1 (enExample) |
| JP (1) | JP4383343B2 (enExample) |
| KR (1) | KR20050010052A (enExample) |
| CN (1) | CN1295213C (enExample) |
| AR (1) | AR040201A1 (enExample) |
| AT (1) | ATE442353T1 (enExample) |
| AU (1) | AU2003250821B8 (enExample) |
| BR (1) | BR0312134A (enExample) |
| CA (1) | CA2489245A1 (enExample) |
| DE (2) | DE10226462A1 (enExample) |
| DK (1) | DK1515947T3 (enExample) |
| ES (1) | ES2333216T3 (enExample) |
| HR (1) | HRP20041175A2 (enExample) |
| MA (1) | MA27234A1 (enExample) |
| MX (2) | MXPA04011361A (enExample) |
| MY (1) | MY130810A (enExample) |
| NO (1) | NO20050078L (enExample) |
| PE (1) | PE20040559A1 (enExample) |
| PL (1) | PL372054A1 (enExample) |
| PT (1) | PT1515947E (enExample) |
| RS (1) | RS105904A (enExample) |
| RU (1) | RU2305093C2 (enExample) |
| TW (1) | TWI291460B (enExample) |
| WO (1) | WO2003106410A1 (enExample) |
| ZA (1) | ZA200409418B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10338554A1 (de) * | 2003-08-22 | 2005-03-31 | Aventis Pharma Deutschland Gmbh | Pentafluorosulfanylphenyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE102004043938A1 (de) * | 2004-09-11 | 2006-03-30 | Sanofi-Aventis Deutschland Gmbh | Pentafluorosulfanylphenyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE102004054847A1 (de) * | 2004-11-13 | 2006-05-24 | Sanofi-Aventis Deutschland Gmbh | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| AU2007283113A1 (en) | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU2009253961A1 (en) * | 2008-06-06 | 2009-12-10 | Ucb Pharma, S.A. | Compounds comprising a cyclobutoxy group |
| UY31968A (es) | 2008-07-09 | 2010-01-29 | Sanofi Aventis | Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| BR112012003973A2 (pt) | 2009-08-26 | 2015-09-08 | Sanofi Sa | hidratos de fluoroglicosídeo heteroaromático cristalinos, produtos farmacêuticos compreendendo estes compostos e seu uso |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| US8809325B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof |
| WO2012120050A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683701B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8895547B2 (en) | 2011-03-08 | 2014-11-25 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| RU2518740C1 (ru) * | 2013-03-22 | 2014-06-10 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" | СРЕДСТВО, ИНГИБИРУЮЩЕЕ Na+/H+-ОБМЕН, И ДИГИДРОХЛОРИД 2-(3,4-МЕТИЛЕНДИОКСИФЕНИЛ)-9-МОРФОЛИНОЭТИЛИМИДАЗО[1,2-a]БЕНЗИМИДАЗОЛА |
| RU2765117C2 (ru) * | 2019-09-24 | 2022-01-25 | Федеральное государственное автономное образовательное учреждение высшего образования "Уральский федеральный университет имени первого Президента России Б.Н. Ельцина" | Применение натриевой соли диэтилового эфира 4-оксо-1,4-дигидропиразоло[5,1-с]-1,2,4-триазин-3,8-дикарбоновой кислоты, моногидрата в качестве средства лечения и профилактики поздних осложнений сахарного диабета |
| CN113274380A (zh) * | 2021-05-13 | 2021-08-20 | 武汉理工大学 | S0859在制备治疗脑缺血再灌注损伤药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5665739A (en) * | 1992-12-15 | 1997-09-09 | Hoechst Aktiengesellschaft | Substituted benzoylguanidines, process and their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them |
| TW250479B (enExample) * | 1992-12-15 | 1995-07-01 | Hoechst Ag | |
| DE4417004A1 (de) * | 1994-05-13 | 1995-11-16 | Hoechst Ag | Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| US6057322A (en) * | 1995-01-30 | 2000-05-02 | Hoechst Aktiengesellschaft | Basically-substituted benzoylguanidines, a process for preparing them, their use as a medicament or diagnostic agent, and a medicament containing them |
| DE19517848A1 (de) * | 1995-05-16 | 1996-11-21 | Merck Patent Gmbh | Fluorhaltige Benzoylguanidine |
| DE19526381A1 (de) * | 1995-07-19 | 1997-01-23 | Hoechst Ag | 4-Fluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
2002
- 2002-06-13 DE DE10226462A patent/DE10226462A1/de not_active Withdrawn
-
2003
- 2003-05-05 MX MXPA04011361A patent/MXPA04011361A/es unknown
- 2003-06-02 KR KR10-2004-7020290A patent/KR20050010052A/ko not_active Ceased
- 2003-06-02 RU RU2005100508/04A patent/RU2305093C2/ru not_active IP Right Cessation
- 2003-06-02 PT PT03759904T patent/PT1515947E/pt unknown
- 2003-06-02 EP EP03759904A patent/EP1515947B1/de not_active Expired - Lifetime
- 2003-06-02 RS YUP-1059/04A patent/RS105904A/sr unknown
- 2003-06-02 PL PL03372054A patent/PL372054A1/xx not_active Application Discontinuation
- 2003-06-02 CN CNB038136139A patent/CN1295213C/zh not_active Expired - Fee Related
- 2003-06-02 HR HR20041175A patent/HRP20041175A2/xx not_active Application Discontinuation
- 2003-06-02 ES ES03759904T patent/ES2333216T3/es not_active Expired - Lifetime
- 2003-06-02 MX MXPA04012231A patent/MXPA04012231A/es active IP Right Grant
- 2003-06-02 BR BR0312134-8A patent/BR0312134A/pt not_active IP Right Cessation
- 2003-06-02 CA CA002489245A patent/CA2489245A1/en not_active Abandoned
- 2003-06-02 WO PCT/EP2003/005738 patent/WO2003106410A1/de not_active Ceased
- 2003-06-02 JP JP2004513243A patent/JP4383343B2/ja not_active Expired - Lifetime
- 2003-06-02 AU AU2003250821A patent/AU2003250821B8/en not_active Ceased
- 2003-06-02 DK DK03759904.0T patent/DK1515947T3/da active
- 2003-06-02 EP EP09005497A patent/EP2103598A1/de not_active Withdrawn
- 2003-06-02 AT AT03759904T patent/ATE442353T1/de not_active IP Right Cessation
- 2003-06-02 DE DE50311897T patent/DE50311897D1/de not_active Expired - Lifetime
- 2003-06-11 PE PE2003000580A patent/PE20040559A1/es not_active Application Discontinuation
- 2003-06-11 AR ARP030102093A patent/AR040201A1/es unknown
- 2003-06-11 TW TW092115780A patent/TWI291460B/zh not_active IP Right Cessation
- 2003-06-12 MY MYPI20032196A patent/MY130810A/en unknown
-
2004
- 2004-11-23 ZA ZA200409418A patent/ZA200409418B/xx unknown
- 2004-12-08 MA MA27988A patent/MA27234A1/fr unknown
-
2005
- 2005-01-06 NO NO20050078A patent/NO20050078L/no not_active Application Discontinuation
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