ZA200905067B - Nitric oxide releasing steroids - Google Patents

Nitric oxide releasing steroids

Info

Publication number
ZA200905067B
ZA200905067B ZA200905067A ZA200905067A ZA200905067B ZA 200905067 B ZA200905067 B ZA 200905067B ZA 200905067 A ZA200905067 A ZA 200905067A ZA 200905067 A ZA200905067 A ZA 200905067A ZA 200905067 B ZA200905067 B ZA 200905067B
Authority
ZA
South Africa
Prior art keywords
nitric oxide
oxide releasing
steroids
releasing steroids
nitric
Prior art date
Application number
ZA200905067A
Other languages
English (en)
Inventor
Francesca Benedini
Stefano Biondi
Ennio Ongini
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of ZA200905067B publication Critical patent/ZA200905067B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200905067A 2007-02-05 2009-07-20 Nitric oxide releasing steroids ZA200905067B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89937607P 2007-02-05 2007-02-05
US92945607P 2007-06-28 2007-06-28
PCT/EP2008/050938 WO2008095806A1 (en) 2007-02-05 2008-01-28 Nitric oxide releasing steroids

Publications (1)

Publication Number Publication Date
ZA200905067B true ZA200905067B (en) 2010-04-28

Family

ID=39232800

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200905067A ZA200905067B (en) 2007-02-05 2009-07-20 Nitric oxide releasing steroids

Country Status (15)

Country Link
US (4) US20100041633A1 (enExample)
EP (3) EP2109618A1 (enExample)
JP (1) JP5216782B2 (enExample)
KR (1) KR20090107525A (enExample)
CN (1) CN101652380A (enExample)
AU (1) AU2008213046B2 (enExample)
BR (1) BRPI0807078A2 (enExample)
CA (3) CA2677290A1 (enExample)
ES (1) ES2601102T3 (enExample)
IL (1) IL199815A (enExample)
MX (1) MX2009008334A (enExample)
NZ (1) NZ579067A (enExample)
RU (1) RU2442790C2 (enExample)
WO (3) WO2008095808A1 (enExample)
ZA (1) ZA200905067B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2560634A1 (en) 2010-04-23 2013-02-27 Piramal Enterprises Limited Nitric oxide releasing prodrugs of therapeutic agents
US8846723B2 (en) 2010-07-29 2014-09-30 Eastman Chemical Company Esters of O-substituted hydroxy carboxylic acids and preparations thereof
WO2013053856A1 (en) 2011-10-12 2013-04-18 Ascendis Pharma A/S Prevention and treatment of ocular conditions
MX390974B (es) * 2011-12-20 2025-03-13 Oriflame Cosmetics Ag Uso cosmético o dermatológico de naringenina para combatir efectos de envejecimiento de la piel.
US10980860B2 (en) 2012-10-11 2021-04-20 Ascendis Pharma A/S Diagnosis, prevention and treatment of diseases of the joint
US9844599B2 (en) 2013-01-21 2017-12-19 Apparao Satyam Nitric oxide releasing produgs of therapeutic agents
RU2545416C1 (ru) * 2014-02-18 2015-03-27 Ксения Юрьевна Еременко Способ лечения возрастной макулярной дистрофии
CN103880907A (zh) * 2014-03-11 2014-06-25 天津金耀集团有限公司 丁酸氢化可的松半水合物
KR102835535B1 (ko) 2016-11-08 2025-07-18 리제너론 파마슈티칼스 인코포레이티드 스테로이드 및 이의 단백질-접합체
CN110944718A (zh) 2017-05-18 2020-03-31 里珍纳龙药品有限公司 环糊精蛋白质药物偶联物
AU2018365946B2 (en) 2017-11-07 2025-08-28 Regeneron Pharmaceuticals, Inc. Hydrophilic linkers for antibody drug conjugates
MX2020006994A (es) 2018-01-08 2020-11-06 Regeneron Pharma Esteroides y conjugados de anticuerpos de los mismos.
CN118955710A (zh) 2018-05-09 2024-11-15 里珍纳龙药品有限公司 抗msr1抗体及其使用方法
MX2021002380A (es) * 2018-08-31 2021-07-15 Aerie Pharmaceuticals Inc Conjugados de isoquinolina-esteroide y usos de los mismos.
WO2022135332A1 (zh) * 2020-12-21 2022-06-30 映恩生物制药（苏州）有限公司 一种甾体偶联物
JP7687973B2 (ja) * 2022-01-24 2025-06-03 芳弘 二村 フィブロネクチン活性化作用を介した表皮細胞増殖作用を呈するジテルペン誘導体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3183252A (en) 1963-09-05 1965-05-11 Syntex Corp 16-nitratoalkyl-pregnanes
US3494941A (en) 1967-12-04 1970-02-10 American Home Prod Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones
HU164115B (enExample) 1971-05-07 1973-12-28
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
IT1311922B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
ITMI20020148A1 (it) * 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
SG158916A1 (en) 2005-09-02 2010-02-26 Nicox Sa Nitrooxy derivatives op glucocorticoids

Also Published As

Publication number Publication date
CN101652380A (zh) 2010-02-17
EP2118120B1 (en) 2016-10-05
IL199815A0 (en) 2010-04-15
WO2008095809A1 (en) 2008-08-14
US20150105547A1 (en) 2015-04-16
NZ579067A (en) 2012-02-24
AU2008213046B2 (en) 2013-02-14
RU2009132993A (ru) 2011-03-20
WO2008095806A1 (en) 2008-08-14
RU2442790C2 (ru) 2012-02-20
WO2008095808A1 (en) 2008-08-14
US20100093685A1 (en) 2010-04-15
MX2009008334A (es) 2009-08-12
EP2109617A1 (en) 2009-10-21
KR20090107525A (ko) 2009-10-13
ES2601102T3 (es) 2017-02-14
US8933062B2 (en) 2015-01-13
CA2677441C (en) 2016-04-12
US20100234334A1 (en) 2010-09-16
CA2677441A1 (en) 2008-08-14
CA2677290A1 (en) 2008-08-14
IL199815A (en) 2015-03-31
CA2677442A1 (en) 2008-08-14
JP5216782B2 (ja) 2013-06-19
AU2008213046A1 (en) 2008-08-14
BRPI0807078A2 (pt) 2014-04-08
JP2010517955A (ja) 2010-05-27
EP2109618A1 (en) 2009-10-21
EP2118120A1 (en) 2009-11-18
US20100041633A1 (en) 2010-02-18

Similar Documents

Publication Publication Date Title
ZA200905067B (en) Nitric oxide releasing steroids
EP2326382A4 (en) NITRIC OXIDE PRODUCTION SYSTEMS
EP2501427A4 (en) NITROGEN OXIDE OUTPUT SYSTEM
EP2376136A4 (en) DRY DIAZENIUM DIOLATION PROCESS FOR THE PRODUCTION OF NITROGEN OXIDE FILTERING MEDICAL PRODUCTS
ZA201004620B (en) Integrated bio-digestion facility
EP2366450A4 (en) MICRO CHANNEL DEVICE
TWI366982B (en) Balun device
PL2340543T3 (pl) Dyspersja tlenku metalu
EP2407476A4 (en) STEROID COMPOUND
SG10201406420XA (en) Antiproliferative agent
GB2472648B (en) Composition and pyrotechnic device
EP2517911A4 (en) SUN VISORS DEVICE
GB0908174D0 (en) Steroid containing composition and uses thereof
GB0705792D0 (en) Magnesium oxide cement
TWI351159B (en) Motor and guiding structure thereof
GB2447489B (en) Retaining device
ZA201105633B (en) Micro-relief structures
GB0922510D0 (en) Compound and use
TWI348349B (en) Latching and releasing mechanism
EP2114558A4 (en) MIXER-DISTRIBUTOR OF OXYGEN AND HYDROGEN
GB0701321D0 (en) Agent
TWI370824B (en) The phpit and fabrication thereof
GB2467309B (en) Spacecraft decontamination
GB2502459B (en) Composition and pyrotechnic device
IL211981A0 (en) Effective nitric oxide generating preparations