AU2008213046B2 - Nitric oxide releasing steroids - Google Patents

Nitric oxide releasing steroids Download PDF

Info

Publication number
AU2008213046B2
AU2008213046B2 AU2008213046A AU2008213046A AU2008213046B2 AU 2008213046 B2 AU2008213046 B2 AU 2008213046B2 AU 2008213046 A AU2008213046 A AU 2008213046A AU 2008213046 A AU2008213046 A AU 2008213046A AU 2008213046 B2 AU2008213046 B2 AU 2008213046B2
Authority
AU
Australia
Prior art keywords
group
above defined
formula
ono
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008213046A
Other languages
English (en)
Other versions
AU2008213046A1 (en
Inventor
Francesca Benedini
Stefano Biondi
Ennio Ongini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicox SA
Original Assignee
Nicox SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox SA filed Critical Nicox SA
Publication of AU2008213046A1 publication Critical patent/AU2008213046A1/en
Application granted granted Critical
Publication of AU2008213046B2 publication Critical patent/AU2008213046B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2008213046A 2007-02-05 2008-01-28 Nitric oxide releasing steroids Ceased AU2008213046B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US89937607P 2007-02-05 2007-02-05
US60/899,376 2007-02-05
US92945607P 2007-06-28 2007-06-28
US60/929,456 2007-06-28
PCT/EP2008/050938 WO2008095806A1 (en) 2007-02-05 2008-01-28 Nitric oxide releasing steroids

Publications (2)

Publication Number Publication Date
AU2008213046A1 AU2008213046A1 (en) 2008-08-14
AU2008213046B2 true AU2008213046B2 (en) 2013-02-14

Family

ID=39232800

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008213046A Ceased AU2008213046B2 (en) 2007-02-05 2008-01-28 Nitric oxide releasing steroids

Country Status (15)

Country Link
US (4) US20100041633A1 (enExample)
EP (3) EP2118120B1 (enExample)
JP (1) JP5216782B2 (enExample)
KR (1) KR20090107525A (enExample)
CN (1) CN101652380A (enExample)
AU (1) AU2008213046B2 (enExample)
BR (1) BRPI0807078A2 (enExample)
CA (3) CA2677290A1 (enExample)
ES (1) ES2601102T3 (enExample)
IL (1) IL199815A (enExample)
MX (1) MX2009008334A (enExample)
NZ (1) NZ579067A (enExample)
RU (1) RU2442790C2 (enExample)
WO (3) WO2008095809A1 (enExample)
ZA (1) ZA200905067B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011243947A1 (en) 2010-04-23 2012-12-06 Piramal Enterprises Limited Nitric oxide releasing prodrugs of therapeutic agents
US8846723B2 (en) 2010-07-29 2014-09-30 Eastman Chemical Company Esters of O-substituted hydroxy carboxylic acids and preparations thereof
MX2014003993A (es) 2011-10-12 2014-08-08 Ascendis Pharma Ophthalmology Division As Prevencion y tratamiento de condiciones oculares.
EP2886163A1 (en) * 2011-12-20 2015-06-24 Oriflame Research and Development Ltd. Compounds with Anti-aging activities
MY186106A (en) 2012-10-11 2021-06-22 Ascendis Pharma As Diagnosis, prevention and treatment of diseases of the joint
US9844599B2 (en) 2013-01-21 2017-12-19 Apparao Satyam Nitric oxide releasing produgs of therapeutic agents
RU2545416C1 (ru) * 2014-02-18 2015-03-27 Ксения Юрьевна Еременко Способ лечения возрастной макулярной дистрофии
CN103880907A (zh) * 2014-03-11 2014-06-25 天津金耀集团有限公司 丁酸氢化可的松半水合物
CA3042428A1 (en) 2016-11-08 2018-05-17 Regeneron Pharmaceuticals, Inc. Steroids and protein-conjugates thereof
KR20250008984A (ko) 2017-05-18 2025-01-16 리제너론 파마슈티칼스 인코포레이티드 사이클로덱스트린 단백질 약물 접합체
CA3247730A1 (en) 2017-11-07 2025-10-30 Regeneron Pharmaceuticals, Inc. Hydrophilic linkers for antibody drug conjugates
MA50259A1 (fr) 2018-01-08 2021-07-29 Regeneron Pharma Stéroïdes et leurs conjugués-anticorps
WO2019217591A1 (en) 2018-05-09 2019-11-14 Regeneron Pharmaceuticals, Inc. Anti-msr1 antibodies and methods of use thereof
WO2020047496A1 (en) * 2018-08-31 2020-03-05 Aerie Pharmaceuticals, Inc. Isoquinoline-steroid conjugates and uses thereof
WO2022135332A1 (zh) * 2020-12-21 2022-06-30 映恩生物制药（苏州）有限公司 一种甾体偶联物
JP7687973B2 (ja) * 2022-01-24 2025-06-03 芳弘 二村 フィブロネクチン活性化作用を介した表皮細胞増殖作用を呈するジテルペン誘導体
CN121270639B (zh) * 2025-09-17 2026-05-19 中山大学中山眼科中心 羊毛甾醇衍生物在制备治疗视网膜变性疾病药物中的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998015568A2 (en) * 1996-10-04 1998-04-16 Nicox S.A. Nitrate esters of corticoid compounds and pharmaceutical applications thereof
WO2000061604A2 (en) * 1999-04-13 2000-10-19 Nicox S.A. Pharmaceutical compounds
WO2003064443A2 (en) * 2002-01-29 2003-08-07 Nicox S.A. New corticosteroids
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
WO2007025632A2 (en) * 2005-09-02 2007-03-08 Nicox S.A. Nitrooxy derivatives op glucocorticoids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3183252A (en) 1963-09-05 1965-05-11 Syntex Corp 16-nitratoalkyl-pregnanes
US3494941A (en) 1967-12-04 1970-02-10 American Home Prod Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones
HU164115B (enExample) 1971-05-07 1973-12-28

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998015568A2 (en) * 1996-10-04 1998-04-16 Nicox S.A. Nitrate esters of corticoid compounds and pharmaceutical applications thereof
WO2000061604A2 (en) * 1999-04-13 2000-10-19 Nicox S.A. Pharmaceutical compounds
WO2003064443A2 (en) * 2002-01-29 2003-08-07 Nicox S.A. New corticosteroids
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
WO2007025632A2 (en) * 2005-09-02 2007-03-08 Nicox S.A. Nitrooxy derivatives op glucocorticoids

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BARALDI, P. G. et al. J. Med. Chem. 2004, 47, 711-719 *
PERRETTI, M. et al. Digestive and Liver Disease 2003, 35(Suppl. 2), S41-S48 *

Also Published As

Publication number Publication date
JP5216782B2 (ja) 2013-06-19
WO2008095809A1 (en) 2008-08-14
IL199815A (en) 2015-03-31
AU2008213046A1 (en) 2008-08-14
EP2118120B1 (en) 2016-10-05
WO2008095806A1 (en) 2008-08-14
JP2010517955A (ja) 2010-05-27
CA2677441C (en) 2016-04-12
CN101652380A (zh) 2010-02-17
EP2109618A1 (en) 2009-10-21
ES2601102T3 (es) 2017-02-14
US20100041633A1 (en) 2010-02-18
EP2109617A1 (en) 2009-10-21
ZA200905067B (en) 2010-04-28
IL199815A0 (en) 2010-04-15
US20100234334A1 (en) 2010-09-16
EP2118120A1 (en) 2009-11-18
RU2442790C2 (ru) 2012-02-20
WO2008095808A1 (en) 2008-08-14
CA2677441A1 (en) 2008-08-14
US20150105547A1 (en) 2015-04-16
CA2677290A1 (en) 2008-08-14
NZ579067A (en) 2012-02-24
CA2677442A1 (en) 2008-08-14
US8933062B2 (en) 2015-01-13
MX2009008334A (es) 2009-08-12
KR20090107525A (ko) 2009-10-13
BRPI0807078A2 (pt) 2014-04-08
US20100093685A1 (en) 2010-04-15
RU2009132993A (ru) 2011-03-20

Similar Documents

Publication Publication Date Title
CA2677441C (en) Nitric oxide releasing steroids
EP0749437B1 (en) Pharmaceutical uses of steroid derivatives
KR101424046B1 (ko) 심장혈관계 장애를 위한 약물로서 안드로스탄 및 안드로스텐의 아미노 유도체
AU2008258133A1 (en) New corticosteroids
EP0900233A1 (en) Novel steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
AU2003210161A1 (en) New corticosteroids
AU2006286838B2 (en) Nitrooxy derivatives of glucocorticoids
PT2004669E (pt) Derivados aza-heterocíclicos de androstanos e androstenos como medicamentos para perturbações cardiovasculares
US10000527B2 (en) 11-substituted bile acid derivatives, process for the preparation thereof and use of these compounds as medicaments
HK1141298A (en) Nitric oxide releasing steroids
MXPA01003207A (en) Propanolamine derivatives linked with bile acid used for treating disorders of the lipid metabolism

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired