JP2010514715A5 - - Google Patents

Download PDF

Info

Publication number
JP2010514715A5
JP2010514715A5 JP2009543371A JP2009543371A JP2010514715A5 JP 2010514715 A5 JP2010514715 A5 JP 2010514715A5 JP 2009543371 A JP2009543371 A JP 2009543371A JP 2009543371 A JP2009543371 A JP 2009543371A JP 2010514715 A5 JP2010514715 A5 JP 2010514715A5
Authority
JP
Japan
Prior art keywords
alkyl
alkylene
aryl
halogen
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009543371A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010514715A (ja
JP5421783B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2007/011163 external-priority patent/WO2008077550A1/en
Publication of JP2010514715A publication Critical patent/JP2010514715A/ja
Publication of JP2010514715A5 publication Critical patent/JP2010514715A5/ja
Application granted granted Critical
Publication of JP5421783B2 publication Critical patent/JP5421783B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009543371A 2006-12-27 2007-12-19 Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体 Expired - Fee Related JP5421783B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06026898.4 2006-12-27
EP06026898 2006-12-27
PCT/EP2007/011163 WO2008077550A1 (en) 2006-12-27 2007-12-19 Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase

Publications (3)

Publication Number Publication Date
JP2010514715A JP2010514715A (ja) 2010-05-06
JP2010514715A5 true JP2010514715A5 (enExample) 2011-02-03
JP5421783B2 JP5421783B2 (ja) 2014-02-19

Family

ID=38191090

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009543371A Expired - Fee Related JP5421783B2 (ja) 2006-12-27 2007-12-19 Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体

Country Status (27)

Country Link
US (2) US8278294B2 (enExample)
EP (1) EP2102187B1 (enExample)
JP (1) JP5421783B2 (enExample)
KR (1) KR101517154B1 (enExample)
CN (1) CN101616909B (enExample)
AR (1) AR064533A1 (enExample)
AU (1) AU2007338406B2 (enExample)
BR (1) BRPI0720862A2 (enExample)
CA (1) CA2673916C (enExample)
CL (1) CL2007003822A1 (enExample)
CO (1) CO6321138A2 (enExample)
CR (1) CR10812A (enExample)
DO (1) DOP2009000163A (enExample)
EC (1) ECSP099466A (enExample)
IL (1) IL199541A (enExample)
MA (1) MA31021B1 (enExample)
MX (1) MX2009005825A (enExample)
MY (1) MY150746A (enExample)
NI (1) NI200900107A (enExample)
NO (1) NO20092421L (enExample)
NZ (1) NZ577981A (enExample)
RU (1) RU2455302C2 (enExample)
TN (1) TN2009000270A1 (enExample)
TW (1) TWI435723B (enExample)
UY (1) UY30840A1 (enExample)
WO (1) WO2008077550A1 (enExample)
ZA (1) ZA200903550B (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2580108T3 (es) 2005-07-11 2016-08-19 Aerie Pharmaceuticals, Inc Compuestos de isoquinolina
ES2729424T3 (es) 2006-09-20 2019-11-04 Aerie Pharmaceuticals Inc Inhibidores de Rho cinasa
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
JP5627574B2 (ja) 2008-06-03 2014-11-19 インターミューン， インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
JP5715561B2 (ja) * 2008-06-24 2015-05-07 サノフイ 二及び多環式置換イソキノリン及びイソキノリノン誘導体
JP5713893B2 (ja) * 2008-06-24 2015-05-07 サノフイ Ｒｈｏ−キナーゼ阻害剤としての置換イソキノリン類及びイソキノリノン類
JP5714485B2 (ja) * 2008-06-24 2015-05-07 サノフイ ６−置換イソキノリン類及びイソキノリノン類
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
EP3828172A1 (en) 2009-05-01 2021-06-02 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
SI2729460T1 (sl) * 2011-07-08 2016-05-31 Sanofi Kristalinični solvati 6-(piperidin-4-iloksi)-2H-izokinolin-1-on hidroklorida
AU2012283277B2 (en) * 2011-07-08 2016-07-21 Sanofi Polymorphs of 6-(piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride
AU2012283335B2 (en) 2011-07-08 2016-09-01 Sanofi Substituted phenyl compounds
CN103160571A (zh) * 2011-12-09 2013-06-19 彩虹天健康科技研究(北京)有限责任公司 磷酸化肌球蛋白和驱动蛋白的激酶的发现
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
EP3141235A1 (en) 2012-12-06 2017-03-15 IP Gesellschaft für Management mbH N-(6-((2r,3s)-3,4-dihydroxybutan-2-yloxy)-2-(4-fluorobenzylthio)pyrimidin-4-yl)-3-methylazetidine-l -sulfonamide
US20140275160A1 (en) 2013-03-15 2014-09-18 Aerie Pharmaceuticals, Inc. Combination therapy
DK3290407T3 (da) 2013-10-18 2020-03-23 Celgene Quanticel Res Inc Bromodomæneinhibitorer
FR3017868A1 (fr) 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US10233195B2 (en) * 2014-04-02 2019-03-19 Intermune, Inc. Anti-fibrotic pyridinones
ES2735087T3 (es) 2014-12-24 2019-12-16 Gilead Sciences Inc Compuestos de pirimidina fusionados para el tratamiento de VIH
EP3237397B1 (en) 2014-12-24 2018-11-21 Gilead Sciences, Inc. Isoquinoline compounds for the treatment of hiv
TW202237569A (zh) 2014-12-24 2022-10-01 美商基利科學股份有限公司 喹唑啉化合物
AR104259A1 (es) 2015-04-15 2017-07-05 Celgene Quanticel Res Inc Inhibidores de bromodominio
JP6832946B2 (ja) 2015-11-17 2021-02-24 アエリエ ファーマシューティカルズ インコーポレイテッド キナーゼ阻害剤およびその中間体の調製方法
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
WO2017184462A1 (en) 2016-04-18 2017-10-26 Celgene Quanticel Research, Inc. Therapeutic compounds
US10150754B2 (en) 2016-04-19 2018-12-11 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
CN109640966A (zh) 2016-08-31 2019-04-16 爱瑞制药公司 眼用组合物
KR102537985B1 (ko) 2016-09-12 2023-05-30 인테그랄 헬스 인코퍼레이티드 Gpr120 조정제로서 유용한 단환형 화합물
EP3509588B1 (en) * 2016-09-12 2023-06-07 Integral Health,Inc. Bicyclic compounds useful as gpr120 modulators
WO2018183911A1 (en) 2017-03-31 2018-10-04 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
ES2949662T3 (es) * 2018-02-02 2023-10-02 Genentech Inc Compuesto farmacéutico, sales del mismo, formulaciones del mismo y métodos de fabricación y uso del mismo
US11427563B2 (en) 2018-09-14 2022-08-30 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
CN109180586B (zh) * 2018-10-10 2022-03-08 成都理工大学 作为Rho激酶抑制剂的六氢氮杂卓-4-基氧基苯甲酰胺类化合物
PE20211655A1 (es) 2018-10-31 2021-08-24 Gilead Sciences Inc Compuestos de 6-azabencimidazol sustituidos como inhibidores de hpk1
WO2020092528A1 (en) 2018-10-31 2020-05-07 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
TWI826690B (zh) 2019-05-23 2023-12-21 美商基利科學股份有限公司 經取代之烯吲哚酮化物及其用途
CA3188722A1 (en) * 2020-08-27 2022-03-03 Thomas Macallister Methods of treating age-related cognitive decline
EP4422626A1 (en) 2021-10-30 2024-09-04 Aneuryst, Inc Treatments for disturbed cerebral homeostasis
US20250000083A1 (en) 2021-11-11 2025-01-02 The Doshisha Cryopreservation preparation for corneal endothelial cells and method for producing said cryopreservation preparation
EP4402129A1 (en) * 2022-08-01 2024-07-24 Valo Health, Inc. <smallcaps/>? ? ?h? ? ? ? ?process for preparing 6-substituted-1-(2)-isoquinolinones and intermediate compound

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2485537B2 (fr) 1977-04-13 1986-05-16 Anvar Dipyrido(4,3-b)(3,4-f)indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant
WO1992002476A1 (en) 1990-07-31 1992-02-20 E.I. Du Pont De Nemours And Company Catalytic equilibration of selected halocarbons
US5480883A (en) 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
GB9516709D0 (en) 1995-08-15 1995-10-18 Zeneca Ltd Medicament
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
NZ334613A (en) 1996-08-12 2002-02-01 Welfide Corp Pharmaceutical agents comprising Rho kinase inhibitor
JPH1087629A (ja) 1996-09-18 1998-04-07 Fujisawa Pharmaceut Co Ltd 新規イソキノリン誘導体、およびその医薬用途
US6362191B1 (en) 1997-08-29 2002-03-26 Zeneca Ltd. Aminometyl oxooxazolidinyl benzene derivatives
TW575567B (en) * 1998-10-23 2004-02-11 Akzo Nobel Nv Serine protease inhibitor
GB9912701D0 (en) 1999-06-01 1999-08-04 Smithkline Beecham Plc Novel compounds
US6541456B1 (en) 1999-12-01 2003-04-01 Isis Pharmaceuticals, Inc. Antimicrobial 2-deoxystreptamine compounds
CA2398388A1 (en) 2000-01-20 2001-07-26 Koji Kato Novel piperidine compound and pharmaceutical thereof
US7217722B2 (en) 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
WO2001064238A2 (en) 2000-02-29 2001-09-07 Curis, Inc. Methods and compositions for regulating adipocytes
GB0004887D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
AR033517A1 (es) 2000-04-08 2003-12-26 Astrazeneca Ab Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
GB0013060D0 (en) 2000-05-31 2000-07-19 Astrazeneca Ab Chemical compounds
WO2002034712A1 (en) 2000-10-27 2002-05-02 Takeda Chemical Industries, Ltd. Process for preparing substituted aromatic compounds and intermediates therefor
JP2004520347A (ja) 2001-01-15 2004-07-08 グラクソ　グループ　リミテッド Ｌｄｌ−受容体発現のインデューサーとしてのアリールピペリジンおよびピペラジン誘導体
SE0101038D0 (sv) 2001-03-23 2001-03-23 Astrazeneca Ab Novel compounds
AU2002256418A1 (en) 2001-04-27 2002-11-11 Vertex Pharmaceuticals Incorporated Inhibitors of bace
US7199147B2 (en) 2001-06-12 2007-04-03 Dainippon Sumitomo Pharma Co., Ltd. Rho kinase inhibitors
GB0117899D0 (en) 2001-07-23 2001-09-12 Astrazeneca Ab Chemical compounds
WO2003024450A1 (en) 2001-09-20 2003-03-27 Eisai Co., Ltd. Methods for treating prion diseases
SE0104340D0 (sv) 2001-12-20 2001-12-20 Astrazeneca Ab New compounds
JPWO2004009555A1 (ja) * 2002-07-22 2005-11-17 旭化成ファーマ株式会社 ５−置換イソキノリン誘導体
EP1550660A1 (en) 2002-09-12 2005-07-06 Kirin Beer Kabushiki Kaisha Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same
RU2327689C2 (ru) * 2003-03-03 2008-06-27 Ф.Хоффманн-Ля Рош Аг 2,5- замещенные тетрагидроизохинолины и фармацевтическая композиция для модуляции 5-нт6
US20050014783A1 (en) 2003-05-29 2005-01-20 Schering Aktiengesellschaft Use of Rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy
EP1638939A2 (en) 2003-06-24 2006-03-29 Neurosearch A/S Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US7691879B2 (en) 2003-09-23 2010-04-06 Merck Sharp & Dohme Corp. Isoquinoline potassium channel inhibitors
JP4718467B2 (ja) 2003-09-23 2011-07-06 メルク・シャープ・エンド・ドーム・コーポレイション イソキノリノンカリウムチャネル阻害剤
US20050067037A1 (en) 2003-09-30 2005-03-31 Conocophillips Company Collapse resistant composite riser
EP1671962A1 (en) 2003-10-10 2006-06-21 Ono Pharmaceutical Co., Ltd. Novel fused heterocyclic compound and use thereof
WO2005054202A1 (en) 2003-11-25 2005-06-16 Eli Lilly And Company 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (proteinkinase b)
JP2005232175A (ja) * 2004-01-21 2005-09-02 Asahi Kasei Pharma Kk ５−置換イソキノリン医薬
WO2005074535A2 (en) 2004-01-30 2005-08-18 Eisai Co., Ltd. Cholinesterase inhibitors for spinal cord disorders
WO2005087226A1 (en) 2004-03-05 2005-09-22 Eisai Co., Ltd. Cadasil treatment with cholinesterase inhibitors
SE0400850D0 (sv) 2004-03-30 2004-03-31 Astrazeneca Ab Novel Compounds
US7517991B2 (en) 2004-10-12 2009-04-14 Bristol-Myers Squibb Company N-sulfonylpiperidine cannabinoid receptor 1 antagonists
EP1899322B1 (en) * 2005-06-28 2009-09-02 Sanofi-Aventis Isoquinoline derivatives as inhibitors of rho-kinase
PT1910333E (pt) * 2005-07-26 2013-08-01 Sanofi Sa Derivados de isoquinolona substituída com piperidinilo como inibidores da rho-cinase
SI1912949T1 (sl) 2005-07-26 2011-12-30 Sanofi Sa Cikloheksilamin izokinolonski derivati kot inhibitorji Rho-kinaze
TW200745101A (en) 2005-09-30 2007-12-16 Organon Nv 9-Azabicyclo[3.3.1]nonane derivatives
TW200738682A (en) * 2005-12-08 2007-10-16 Organon Nv Isoquinoline derivatives
US7618985B2 (en) * 2005-12-08 2009-11-17 N.V. Organon Isoquinoline derivatives
US7893088B2 (en) 2006-08-18 2011-02-22 N.V. Organon 6-substituted isoquinoline derivatives
PT2102164E (pt) 2006-12-27 2011-01-21 Sanofi Aventis Derivados de isoquinolina e de isoquinolinona substituída com cicloalquilamina
JP5313919B2 (ja) 2006-12-27 2013-10-09 サノフイ 新規な置換イソキノリン及びイソキノリノン誘導体

Similar Documents

Publication Publication Date Title
JP2010514717A5 (enExample)
JP2010514718A5 (enExample)
JP2010514719A5 (enExample)
JP2010514716A5 (enExample)
JP2010514721A5 (enExample)
JP2010514720A5 (enExample)
CN104193725B (zh) 有机化合物
TW199095B (enExample)
JP5097701B2 (ja) Ｒｈｏ−キナーゼの阻害剤としてのイソキノリン誘導体
AU713676B2 (en) Integrin receptor antagonists
ES2852351T3 (es) Pirrolamidas como inhibidores de la integrina alfa V
RU2125047C1 (ru) N-производные хинолина или их аддитивные соли с неорганическими и органическими кислотами или с неорганическими и органическими основаниями, способы их получения и фармацевтическая композиция на их основе
JP2008543956A5 (enExample)
RS55764B1 (sr) Inhibitori histonskih demetilaza
CA2257950A1 (en) Fibrinogen receptor antagonist prodrugs
JP2009508949A5 (enExample)
CA2258093A1 (en) Fibrinogen receptor antagonists
JP2008526692A5 (enExample)
WO1999016747A1 (en) Sulfonyl derivatives
UY28961A1 (es) Derivados de ácido carboxílico de bencimidazolona antecedentes de la invención
AU2003269775B2 (en) Novel compounds
JP2016508135A5 (enExample)
AU2017251555A1 (en) Pyridone derivative comprising heteroatomic ring butane substituent, for treating fibrosis and inflammatory diseases
RU2010154089A (ru) Макроциклические производные мочевины и сульфамида в качестве ингибиторов tafia
WO2021236885A1 (en) Piperidine-2,6-diones as small molecule degraders of helios and methods of use