JP2010514715A5 - - Google Patents
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- Publication number
- JP2010514715A5 JP2010514715A5 JP2009543371A JP2009543371A JP2010514715A5 JP 2010514715 A5 JP2010514715 A5 JP 2010514715A5 JP 2009543371 A JP2009543371 A JP 2009543371A JP 2009543371 A JP2009543371 A JP 2009543371A JP 2010514715 A5 JP2010514715 A5 JP 2010514715A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkylene
- aryl
- halogen
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06026898 | 2006-12-27 | ||
| EP06026898.4 | 2006-12-27 | ||
| PCT/EP2007/011163 WO2008077550A1 (en) | 2006-12-27 | 2007-12-19 | Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010514715A JP2010514715A (ja) | 2010-05-06 |
| JP2010514715A5 true JP2010514715A5 (enExample) | 2011-02-03 |
| JP5421783B2 JP5421783B2 (ja) | 2014-02-19 |
Family
ID=38191090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009543371A Expired - Fee Related JP5421783B2 (ja) | 2006-12-27 | 2007-12-19 | Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US8278294B2 (enExample) |
| EP (1) | EP2102187B1 (enExample) |
| JP (1) | JP5421783B2 (enExample) |
| KR (1) | KR101517154B1 (enExample) |
| CN (1) | CN101616909B (enExample) |
| AR (1) | AR064533A1 (enExample) |
| AU (1) | AU2007338406B2 (enExample) |
| BR (1) | BRPI0720862A2 (enExample) |
| CA (1) | CA2673916C (enExample) |
| CL (1) | CL2007003822A1 (enExample) |
| CO (1) | CO6321138A2 (enExample) |
| CR (1) | CR10812A (enExample) |
| DO (1) | DOP2009000163A (enExample) |
| EC (1) | ECSP099466A (enExample) |
| IL (1) | IL199541A (enExample) |
| MA (1) | MA31021B1 (enExample) |
| MX (1) | MX2009005825A (enExample) |
| MY (1) | MY150746A (enExample) |
| NI (1) | NI200900107A (enExample) |
| NO (1) | NO20092421L (enExample) |
| NZ (1) | NZ577981A (enExample) |
| RU (1) | RU2455302C2 (enExample) |
| TN (1) | TN2009000270A1 (enExample) |
| TW (1) | TWI435723B (enExample) |
| UY (1) | UY30840A1 (enExample) |
| WO (1) | WO2008077550A1 (enExample) |
| ZA (1) | ZA200903550B (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1910297B1 (en) | 2005-07-11 | 2016-05-25 | Aerie Pharmaceuticals, Inc. | Isoquinoline compounds |
| WO2008036540A2 (en) | 2006-09-20 | 2008-03-27 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8455514B2 (en) | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| CA3034994A1 (en) | 2008-06-03 | 2009-12-10 | Intermune, Inc. | Substituted aryl-2 pyridone compounds and use thereof for treating inflammatory and fibrotic disorders |
| KR101607090B1 (ko) * | 2008-06-24 | 2016-03-29 | 사노피 | 6-치환된 이소퀴놀린 및 이소퀴놀리논 |
| AU2009262509B2 (en) * | 2008-06-24 | 2014-01-30 | Sanofi | Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as Rho kinase inhibitors |
| BRPI0914696A2 (pt) * | 2008-06-24 | 2016-10-18 | Sanofi Aventis | isoquinolinas e isoquinolinonas substituídas como inibidores da rho-quinase |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| EP3053913B1 (en) | 2009-05-01 | 2018-03-07 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| EP2729463B1 (en) | 2011-07-08 | 2015-07-29 | Sanofi | Substituted phenyl compounds |
| JP6357100B2 (ja) | 2011-07-08 | 2018-07-11 | サノフイ | ６−（ピペリジン−４−イルオキシ）−２ｈ−イソキノリン−１−オン塩酸塩の結晶性溶媒和物 |
| DK2729461T3 (en) * | 2011-07-08 | 2016-04-11 | Sanofi Sa | Polymorphs of 6- (piperidin-4-yloxy) -2H-isoquinolin-1-one hydrochloride |
| CN103160571A (zh) * | 2011-12-09 | 2013-06-19 | 彩虹天健康科技研究(北京)有限责任公司 | 磷酸化肌球蛋白和驱动蛋白的激酶的发现 |
| AR092742A1 (es) * | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| EP2740458B1 (en) | 2012-12-06 | 2016-08-03 | IP Gesellschaft für Management mbH | Packaging comprising forms of sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzenesulfonamide |
| CA2905089C (en) | 2013-03-15 | 2023-06-13 | Aerie Pharmaceuticals, Inc. | Isoquinoline compounds for the treatment of ocular diseases |
| SI3290407T1 (sl) | 2013-10-18 | 2020-07-31 | Celgene Quanticel Research, Inc | Inhibitorji bromodomene |
| FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN106459042B (zh) | 2014-04-02 | 2019-06-28 | 英特穆恩公司 | 抗纤维化吡啶酮类 |
| ES2705709T3 (es) | 2014-12-24 | 2019-03-26 | Gilead Sciences Inc | Compuestos de isoquinolina para el tratamiento del VIH |
| TW202237569A (zh) | 2014-12-24 | 2022-10-01 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
| WO2016105532A1 (en) | 2014-12-24 | 2016-06-30 | Gilead Sciences, Inc. | Fused pyrimidine compounds for the treatment of hiv |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| WO2017086941A1 (en) | 2015-11-17 | 2017-05-26 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| WO2017184462A1 (en) | 2016-04-18 | 2017-10-26 | Celgene Quanticel Research, Inc. | Therapeutic compounds |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| KR102568079B1 (ko) | 2016-08-31 | 2023-08-17 | 에어리 파마슈티컬즈, 인코포레이티드 | 안과용 조성물 |
| US10865201B2 (en) * | 2016-09-12 | 2020-12-15 | Valo Health, Inc. | Bicyclic compounds useful as GPR120 modulators |
| CA3041033A1 (en) | 2016-09-12 | 2018-03-15 | Numerate, Inc. | Monocyclic compounds useful as gpr120 modulators |
| AU2018243687C1 (en) | 2017-03-31 | 2020-12-24 | Alcon Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| IL312673A (en) * | 2018-02-02 | 2024-07-01 | Genentech Inc | Salt of 1-methyl(-1H-pyrazol-4-yl)-5-(4-(trifluoromethoxy)phenyl)-1,5-dihydro-H4-imidazo[4,5c]pyridin-4-one, pharmaceutical preparations including the salt and the processes for the preparation of the salt and the composition |
| EP3849555A4 (en) | 2018-09-14 | 2022-05-04 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| CN109180586B (zh) * | 2018-10-10 | 2022-03-08 | 成都理工大学 | 作为Rho激酶抑制剂的六氢氮杂卓-4-基氧基苯甲酰胺类化合物 |
| KR102658602B1 (ko) | 2018-10-31 | 2024-04-19 | 길리애드 사이언시즈, 인코포레이티드 | Hpk1 억제 활성을 갖는 치환된 6-아자벤즈이미다졸 화합물 |
| FI3873903T3 (fi) | 2018-10-31 | 2024-03-26 | Gilead Sciences Inc | Substituoituja 6-azabentsiimidatsoliyhdisteitä HPK1-inhibiittoreina |
| WO2020237025A1 (en) | 2019-05-23 | 2020-11-26 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| US20230321114A1 (en) * | 2020-08-27 | 2023-10-12 | Woolsey Pharmaceuticals, Inc. | Methods of treating age-related cognitive decline |
| WO2023076812A1 (en) | 2021-10-30 | 2023-05-04 | Aneuryst, Inc. | Treatments for disturbed cerebral homeostasis |
| AU2022385051A1 (en) | 2021-11-11 | 2024-06-20 | Actualeyes Inc. | Cryopreservation preparation for corneal endothelial cells and method for producing said cryopreservation preparation |
| IL318082A (en) * | 2022-08-01 | 2025-02-01 | Valo Health Inc | Process for preparing 1-(2H)-ISOQUINOLINONE-type materials modified at position 6, and intermediates obtained in the process |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2485537B2 (fr) | 1977-04-13 | 1986-05-16 | Anvar | Dipyrido(4,3-b)(3,4-f)indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant |
| WO1992002476A1 (en) | 1990-07-31 | 1992-02-20 | E.I. Du Pont De Nemours And Company | Catalytic equilibration of selected halocarbons |
| US5480883A (en) | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
| ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| AU738620B2 (en) | 1996-08-12 | 2001-09-20 | Mitsubishi Pharma Corporation | Pharmaceutical agent containing Rho kinase inhibitor |
| JPH1087629A (ja) | 1996-09-18 | 1998-04-07 | Fujisawa Pharmaceut Co Ltd | 新規イソキノリン誘導体、およびその医薬用途 |
| AU8872198A (en) | 1997-08-29 | 1999-03-22 | Zeneca Limited | Aminometyl oxooxazolidinyl benzene derivatives |
| TW575567B (en) * | 1998-10-23 | 2004-02-11 | Akzo Nobel Nv | Serine protease inhibitor |
| GB9912701D0 (en) | 1999-06-01 | 1999-08-04 | Smithkline Beecham Plc | Novel compounds |
| US6541456B1 (en) | 1999-12-01 | 2003-04-01 | Isis Pharmaceuticals, Inc. | Antimicrobial 2-deoxystreptamine compounds |
| US6784192B2 (en) | 2000-01-20 | 2004-08-31 | Eisai Co., Ltd. | Piperidine compound and pharmaceutical composition thereof |
| US7217722B2 (en) * | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
| WO2001064238A2 (en) | 2000-02-29 | 2001-09-07 | Curis, Inc. | Methods and compositions for regulating adipocytes |
| GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| AR033517A1 (es) | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
| GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
| AU2001296008A1 (en) | 2000-10-27 | 2002-05-06 | Takeda Chemical Industries Ltd. | Process for preparing substituted aromatic compounds and intermediates therefor |
| JP2004520347A (ja) | 2001-01-15 | 2004-07-08 | グラクソ グループ リミテッド | Ｌｄｌ−受容体発現のインデューサーとしてのアリールピペリジンおよびピペラジン誘導体 |
| SE0101038D0 (sv) | 2001-03-23 | 2001-03-23 | Astrazeneca Ab | Novel compounds |
| EP1389194A2 (en) | 2001-04-27 | 2004-02-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
| JPWO2002100833A1 (ja) * | 2001-06-12 | 2004-09-24 | 住友製薬株式会社 | Ｒｈｏキナーゼ阻害剤 |
| GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
| WO2003024450A1 (en) | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methods for treating prion diseases |
| SE0104340D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
| JPWO2004009555A1 (ja) * | 2002-07-22 | 2005-11-17 | 旭化成ファーマ株式会社 | ５−置換イソキノリン誘導体 |
| US7615564B2 (en) | 2002-09-12 | 2009-11-10 | Kirin Beer Kabushiki Kaisha | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same |
| MXPA05009359A (es) * | 2003-03-03 | 2005-11-04 | Hoffmann La Roche | Tetrahidroisoquinolinas 2,5- y 2,6 substituidas para uso como moduladores 5-ht6. |
| US20050014783A1 (en) | 2003-05-29 | 2005-01-20 | Schering Aktiengesellschaft | Use of Rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy |
| EP1638939A2 (en) | 2003-06-24 | 2006-03-29 | Neurosearch A/S | Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| CN1856475A (zh) | 2003-09-23 | 2006-11-01 | 默克公司 | 异喹啉钾通道抑制剂 |
| WO2005030791A2 (en) | 2003-09-23 | 2005-04-07 | Merck & Co., Inc. | Isoquinolinone potassium channel inhibitors |
| US20050067037A1 (en) | 2003-09-30 | 2005-03-31 | Conocophillips Company | Collapse resistant composite riser |
| EP1671962A1 (en) | 2003-10-10 | 2006-06-21 | Ono Pharmaceutical Co., Ltd. | Novel fused heterocyclic compound and use thereof |
| EP1689719A1 (en) | 2003-11-25 | 2006-08-16 | Eli Lilly And Company | 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (proteinkinase b) |
| JP2005232175A (ja) * | 2004-01-21 | 2005-09-02 | Asahi Kasei Pharma Kk | ５−置換イソキノリン医薬 |
| WO2005074535A2 (en) | 2004-01-30 | 2005-08-18 | Eisai Co., Ltd. | Cholinesterase inhibitors for spinal cord disorders |
| WO2005087226A1 (en) | 2004-03-05 | 2005-09-22 | Eisai Co., Ltd. | Cadasil treatment with cholinesterase inhibitors |
| SE0400850D0 (sv) | 2004-03-30 | 2004-03-31 | Astrazeneca Ab | Novel Compounds |
| US7517991B2 (en) | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
| EP1899322B1 (en) * | 2005-06-28 | 2009-09-02 | Sanofi-Aventis | Isoquinoline derivatives as inhibitors of rho-kinase |
| RU2440988C2 (ru) | 2005-07-26 | 2012-01-27 | Санофи-Авентис | ПРОИЗВОДНЫЕ ЦИКЛОГЕКСИЛАМИНИЗОХИНОЛОНА В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ |
| WO2007012421A1 (en) * | 2005-07-26 | 2007-02-01 | Sanofi-Aventis | Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors |
| TW200745101A (en) | 2005-09-30 | 2007-12-16 | Organon Nv | 9-Azabicyclo[3.3.1]nonane derivatives |
| TW200738682A (en) * | 2005-12-08 | 2007-10-16 | Organon Nv | Isoquinoline derivatives |
| US7618985B2 (en) * | 2005-12-08 | 2009-11-17 | N.V. Organon | Isoquinoline derivatives |
| US7893088B2 (en) | 2006-08-18 | 2011-02-22 | N.V. Organon | 6-substituted isoquinoline derivatives |
| MX2009005862A (es) | 2006-12-27 | 2009-06-17 | Sanofi Aventis | Nuevos derivados de isoquinolina e isoquinolinona sustituidos. |
| RS51655B (sr) | 2006-12-27 | 2011-10-31 | Sanofi-Aventis | Derivati izohinolina i izohinolinona supstituisani cikloalkilaminom |
-
2007
- 2007-12-19 CN CN2007800485477A patent/CN101616909B/zh not_active Expired - Fee Related
- 2007-12-19 MX MX2009005825A patent/MX2009005825A/es active IP Right Grant
- 2007-12-19 WO PCT/EP2007/011163 patent/WO2008077550A1/en not_active Ceased
- 2007-12-19 BR BRPI0720862-6A patent/BRPI0720862A2/pt not_active IP Right Cessation
- 2007-12-19 MY MYPI20092506 patent/MY150746A/en unknown
- 2007-12-19 JP JP2009543371A patent/JP5421783B2/ja not_active Expired - Fee Related
- 2007-12-19 NZ NZ577981A patent/NZ577981A/en not_active IP Right Cessation
- 2007-12-19 RU RU2009128645/04A patent/RU2455302C2/ru not_active IP Right Cessation
- 2007-12-19 CA CA2673916A patent/CA2673916C/en not_active Expired - Fee Related
- 2007-12-19 EP EP07856886.2A patent/EP2102187B1/en active Active
- 2007-12-19 AU AU2007338406A patent/AU2007338406B2/en not_active Ceased
- 2007-12-19 KR KR1020097013514A patent/KR101517154B1/ko not_active Expired - Fee Related
- 2007-12-25 TW TW096149805A patent/TWI435723B/zh not_active IP Right Cessation
- 2007-12-26 AR ARP070105900A patent/AR064533A1/es unknown
- 2007-12-26 UY UY30840A patent/UY30840A1/es unknown
- 2007-12-26 CL CL2007003822A patent/CL2007003822A1/es unknown
-
2009
- 2009-05-20 CR CR10812A patent/CR10812A/es not_active Application Discontinuation
- 2009-05-22 ZA ZA200903550A patent/ZA200903550B/xx unknown
- 2009-06-01 NI NI200900107A patent/NI200900107A/es unknown
- 2009-06-16 CO CO09062104A patent/CO6321138A2/es active IP Right Grant
- 2009-06-18 US US12/487,403 patent/US8278294B2/en not_active Expired - Fee Related
- 2009-06-24 MA MA32035A patent/MA31021B1/fr unknown
- 2009-06-24 IL IL199541A patent/IL199541A/en active IP Right Grant
- 2009-06-25 NO NO20092421A patent/NO20092421L/no not_active Application Discontinuation
- 2009-06-25 TN TNP2009000270A patent/TN2009000270A1/fr unknown
- 2009-06-26 EC EC2009009466A patent/ECSP099466A/es unknown
- 2009-06-26 DO DO2009000163A patent/DOP2009000163A/es unknown
-
2012
- 2012-08-15 US US13/586,468 patent/US8461144B2/en not_active Expired - Fee Related
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