JP5421783B2 - Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体 - Google Patents

Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体 Download PDF

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JP5421783B2
JP5421783B2 JP2009543371A JP2009543371A JP5421783B2 JP 5421783 B2 JP5421783 B2 JP 5421783B2 JP 2009543371 A JP2009543371 A JP 2009543371A JP 2009543371 A JP2009543371 A JP 2009543371A JP 5421783 B2 JP5421783 B2 JP 5421783B2
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alkyl
alkylene
aryl
isoquinolin
yloxy
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JP2010514715A (ja
JP2010514715A5 (enExample
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オリヴァー・プレッテンブルク
アルミン・ホーフマイスター
ヨーアヒム・ブレンデル
マティーアス・レーン
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Endocrinology (AREA)
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JP2009543371A 2006-12-27 2007-12-19 Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体 Expired - Fee Related JP5421783B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06026898.4 2006-12-27
EP06026898 2006-12-27
PCT/EP2007/011163 WO2008077550A1 (en) 2006-12-27 2007-12-19 Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase

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JP2010514715A JP2010514715A (ja) 2010-05-06
JP2010514715A5 JP2010514715A5 (enExample) 2011-02-03
JP5421783B2 true JP5421783B2 (ja) 2014-02-19

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JP2009543371A Expired - Fee Related JP5421783B2 (ja) 2006-12-27 2007-12-19 Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体

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US (2) US8278294B2 (enExample)
EP (1) EP2102187B1 (enExample)
JP (1) JP5421783B2 (enExample)
KR (1) KR101517154B1 (enExample)
CN (1) CN101616909B (enExample)
AR (1) AR064533A1 (enExample)
AU (1) AU2007338406B2 (enExample)
BR (1) BRPI0720862A2 (enExample)
CA (1) CA2673916C (enExample)
CL (1) CL2007003822A1 (enExample)
CO (1) CO6321138A2 (enExample)
CR (1) CR10812A (enExample)
DO (1) DOP2009000163A (enExample)
EC (1) ECSP099466A (enExample)
IL (1) IL199541A (enExample)
MA (1) MA31021B1 (enExample)
MX (1) MX2009005825A (enExample)
MY (1) MY150746A (enExample)
NI (1) NI200900107A (enExample)
NO (1) NO20092421L (enExample)
NZ (1) NZ577981A (enExample)
RU (1) RU2455302C2 (enExample)
TN (1) TN2009000270A1 (enExample)
TW (1) TWI435723B (enExample)
UY (1) UY30840A1 (enExample)
WO (1) WO2008077550A1 (enExample)
ZA (1) ZA200903550B (enExample)

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