CN101616909B - 作为Rho-激酶抑制剂的被取代的异喹啉和异喹啉酮衍生物 - Google Patents

作为Rho-激酶抑制剂的被取代的异喹啉和异喹啉酮衍生物 Download PDF

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CN101616909B
CN101616909B CN2007800485477A CN200780048547A CN101616909B CN 101616909 B CN101616909 B CN 101616909B CN 2007800485477 A CN2007800485477 A CN 2007800485477A CN 200780048547 A CN200780048547 A CN 200780048547A CN 101616909 B CN101616909 B CN 101616909B
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alkyl
alkylene
halogen
heterocyclyl
aryl
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CN101616909A (zh
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O·普来登伯格
A·霍夫迈斯特
J·布伦德尔
M·勒恩
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Sanofi SRL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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CN2007800485477A 2006-12-27 2007-12-19 作为Rho-激酶抑制剂的被取代的异喹啉和异喹啉酮衍生物 Expired - Fee Related CN101616909B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06026898.4 2006-12-27
EP06026898 2006-12-27
PCT/EP2007/011163 WO2008077550A1 (en) 2006-12-27 2007-12-19 Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase

Publications (2)

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CN101616909A CN101616909A (zh) 2009-12-30
CN101616909B true CN101616909B (zh) 2013-09-11

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US (2) US8278294B2 (enExample)
EP (1) EP2102187B1 (enExample)
JP (1) JP5421783B2 (enExample)
KR (1) KR101517154B1 (enExample)
CN (1) CN101616909B (enExample)
AR (1) AR064533A1 (enExample)
AU (1) AU2007338406B2 (enExample)
BR (1) BRPI0720862A2 (enExample)
CA (1) CA2673916C (enExample)
CL (1) CL2007003822A1 (enExample)
CO (1) CO6321138A2 (enExample)
CR (1) CR10812A (enExample)
DO (1) DOP2009000163A (enExample)
EC (1) ECSP099466A (enExample)
IL (1) IL199541A (enExample)
MA (1) MA31021B1 (enExample)
MX (1) MX2009005825A (enExample)
MY (1) MY150746A (enExample)
NI (1) NI200900107A (enExample)
NO (1) NO20092421L (enExample)
NZ (1) NZ577981A (enExample)
RU (1) RU2455302C2 (enExample)
TN (1) TN2009000270A1 (enExample)
TW (1) TWI435723B (enExample)
UY (1) UY30840A1 (enExample)
WO (1) WO2008077550A1 (enExample)
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