RU2455302C2 - ЗАМЕЩЕННЫЕ ИЗОХИНОЛИНОВЫЕ И ИЗОХИНОЛИНОНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ - Google Patents
ЗАМЕЩЕННЫЕ ИЗОХИНОЛИНОВЫЕ И ИЗОХИНОЛИНОНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ Download PDFInfo
- Publication number
- RU2455302C2 RU2455302C2 RU2009128645/04A RU2009128645A RU2455302C2 RU 2455302 C2 RU2455302 C2 RU 2455302C2 RU 2009128645/04 A RU2009128645/04 A RU 2009128645/04A RU 2009128645 A RU2009128645 A RU 2009128645A RU 2455302 C2 RU2455302 C2 RU 2455302C2
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- alkylene
- heterocyclyl
- aryl
- compound according
- Prior art date
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- DSKCOVBHIFAJRI-UHFFFAOYSA-N CC(C)(C)OC(NC1(CC1)C(O)=O)=O Chemical compound CC(C)(C)OC(NC1(CC1)C(O)=O)=O DSKCOVBHIFAJRI-UHFFFAOYSA-N 0.000 description 1
- DYUZWMTWBYDDGQ-SFHVURJKSA-N CC(C)C[C@@H](C(N(CC1)CCC1Oc(cc1)cc(C=CN2)c1C2=O)=O)N Chemical compound CC(C)C[C@@H](C(N(CC1)CCC1Oc(cc1)cc(C=CN2)c1C2=O)=O)N DYUZWMTWBYDDGQ-SFHVURJKSA-N 0.000 description 1
- MUIBLGQNGGYERO-QGZVFWFLSA-N CCC[C@H](C(N(CC1)CCC1Oc(cc1)cc(C=CN2)c1C2=O)=O)N Chemical compound CCC[C@H](C(N(CC1)CCC1Oc(cc1)cc(C=CN2)c1C2=O)=O)N MUIBLGQNGGYERO-QGZVFWFLSA-N 0.000 description 1
- HWVDOLNNNKYNAA-NRFANRHFSA-N N[C@@H](Cc(cc1)ccc1Cl)C(N(CC1)CCC1Oc(cc1)cc(C=CN2)c1C2=O)=O Chemical compound N[C@@H](Cc(cc1)ccc1Cl)C(N(CC1)CCC1Oc(cc1)cc(C=CN2)c1C2=O)=O HWVDOLNNNKYNAA-NRFANRHFSA-N 0.000 description 1
- NNDPJBCAUOORMJ-UHFFFAOYSA-N OC(c1c2cccc1)N(CC(N(CC1)CCC1Oc(cc1)cc(C=CN3)c1C3=O)=O)C2=O Chemical compound OC(c1c2cccc1)N(CC(N(CC1)CCC1Oc(cc1)cc(C=CN3)c1C3=O)=O)C2=O NNDPJBCAUOORMJ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06026898.4 | 2006-12-27 | ||
| EP06026898 | 2006-12-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009128645A RU2009128645A (ru) | 2011-02-10 |
| RU2455302C2 true RU2455302C2 (ru) | 2012-07-10 |
Family
ID=38191090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009128645/04A RU2455302C2 (ru) | 2006-12-27 | 2007-12-19 | ЗАМЕЩЕННЫЕ ИЗОХИНОЛИНОВЫЕ И ИЗОХИНОЛИНОНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US8278294B2 (enExample) |
| EP (1) | EP2102187B1 (enExample) |
| JP (1) | JP5421783B2 (enExample) |
| KR (1) | KR101517154B1 (enExample) |
| CN (1) | CN101616909B (enExample) |
| AR (1) | AR064533A1 (enExample) |
| AU (1) | AU2007338406B2 (enExample) |
| BR (1) | BRPI0720862A2 (enExample) |
| CA (1) | CA2673916C (enExample) |
| CL (1) | CL2007003822A1 (enExample) |
| CO (1) | CO6321138A2 (enExample) |
| CR (1) | CR10812A (enExample) |
| DO (1) | DOP2009000163A (enExample) |
| EC (1) | ECSP099466A (enExample) |
| IL (1) | IL199541A (enExample) |
| MA (1) | MA31021B1 (enExample) |
| MX (1) | MX2009005825A (enExample) |
| MY (1) | MY150746A (enExample) |
| NI (1) | NI200900107A (enExample) |
| NO (1) | NO20092421L (enExample) |
| NZ (1) | NZ577981A (enExample) |
| RU (1) | RU2455302C2 (enExample) |
| TN (1) | TN2009000270A1 (enExample) |
| TW (1) | TWI435723B (enExample) |
| UY (1) | UY30840A1 (enExample) |
| WO (1) | WO2008077550A1 (enExample) |
| ZA (1) | ZA200903550B (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007008926A1 (en) | 2005-07-11 | 2007-01-18 | Aerie Pharmaceuticals, Inc. | Isoquinoline compounds |
| CA2664335C (en) | 2006-09-20 | 2014-12-02 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8455514B2 (en) | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| EP2296653B1 (en) | 2008-06-03 | 2016-01-27 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| AU2009262509B2 (en) * | 2008-06-24 | 2014-01-30 | Sanofi | Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as Rho kinase inhibitors |
| KR101607090B1 (ko) * | 2008-06-24 | 2016-03-29 | 사노피 | 6-치환된 이소퀴놀린 및 이소퀴놀리논 |
| MY157330A (en) * | 2008-06-24 | 2016-05-31 | Sanofi Aventis | Substituted isoquinolinones as rho kinase inhibitors |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| ES2553827T3 (es) | 2009-05-01 | 2015-12-14 | Aerie Pharmaceuticals, Inc. | Inhibidores de mecanismo doble para el tratamiento de enfermedad |
| IN2014CN00834A (enExample) * | 2011-07-08 | 2015-04-03 | Sanofi Sa | |
| HUE025936T2 (en) | 2011-07-08 | 2016-05-30 | Sanofi Sa | Substituted phenyl compounds |
| CA2843773C (en) * | 2011-07-08 | 2018-11-06 | Sanofi | Crystalline solvates of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochloride |
| CN103160571A (zh) * | 2011-12-09 | 2013-06-19 | 彩虹天健康科技研究(北京)有限责任公司 | 磷酸化肌球蛋白和驱动蛋白的激酶的发现 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| EP2740458B1 (en) | 2012-12-06 | 2016-08-03 | IP Gesellschaft für Management mbH | Packaging comprising forms of sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]-benzenesulfonamide |
| HUE061618T2 (hu) | 2013-03-15 | 2023-07-28 | Aerie Pharmaceuticals Inc | Vegyület szemrendellenességek kezelésére |
| EA035727B1 (ru) | 2013-10-18 | 2020-07-31 | Селджен Квонтисел Рисёрч, Инк. | Ингибиторы бромодомена |
| FR3017868A1 (fr) | 2014-02-21 | 2015-08-28 | Servier Lab | Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
| JP6385584B2 (ja) | 2014-12-24 | 2018-09-05 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖの処置のための縮合ピリミジン化合物 |
| TWI770552B (zh) | 2014-12-24 | 2022-07-11 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
| PT3237397T (pt) | 2014-12-24 | 2019-02-08 | Gilead Sciences Inc | Compostos de isoquinolina para o tratamento de hiv |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| KR102579582B1 (ko) | 2015-11-17 | 2023-09-15 | 에어리 파마슈티컬즈, 인코포레이티드 | 키나아제 억제제 및 이의 중간체의 제조 방법 |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| EP3445750A4 (en) | 2016-04-18 | 2019-11-27 | Celgene Quanticel Research, Inc. | THERAPEUTIC COMPOUNDS |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| WO2018045091A1 (en) | 2016-08-31 | 2018-03-08 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
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