JP2010514720A5 - - Google Patents

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Publication number
JP2010514720A5
JP2010514720A5 JP2009543376A JP2009543376A JP2010514720A5 JP 2010514720 A5 JP2010514720 A5 JP 2010514720A5 JP 2009543376 A JP2009543376 A JP 2009543376A JP 2009543376 A JP2009543376 A JP 2009543376A JP 2010514720 A5 JP2010514720 A5 JP 2010514720A5
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JP
Japan
Prior art keywords
alkyl
alkylene
aryl
isoquinolin
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009543376A
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English (en)
Japanese (ja)
Other versions
JP5313919B2 (ja
JP2010514720A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2007/011168 external-priority patent/WO2008077555A2/en
Publication of JP2010514720A publication Critical patent/JP2010514720A/ja
Publication of JP2010514720A5 publication Critical patent/JP2010514720A5/ja
Application granted granted Critical
Publication of JP5313919B2 publication Critical patent/JP5313919B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009543376A 2006-12-27 2007-12-19 新規な置換イソキノリン及びイソキノリノン誘導体 Expired - Fee Related JP5313919B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06026892 2006-12-27
EP06026892.7 2006-12-27
PCT/EP2007/011168 WO2008077555A2 (en) 2006-12-27 2007-12-19 Substituted isoquinolines and their use as rho-kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2010514720A JP2010514720A (ja) 2010-05-06
JP2010514720A5 true JP2010514720A5 (enExample) 2011-02-03
JP5313919B2 JP5313919B2 (ja) 2013-10-09

Family

ID=38015325

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009543376A Expired - Fee Related JP5313919B2 (ja) 2006-12-27 2007-12-19 新規な置換イソキノリン及びイソキノリノン誘導体

Country Status (30)

Country Link
US (1) US8772492B2 (enExample)
EP (1) EP2132194B1 (enExample)
JP (1) JP5313919B2 (enExample)
KR (1) KR101545533B1 (enExample)
CN (1) CN101573354B (enExample)
AR (1) AR064493A1 (enExample)
AT (1) ATE502027T1 (enExample)
AU (1) AU2007338411B2 (enExample)
BR (1) BRPI0720909A2 (enExample)
CA (1) CA2673921C (enExample)
CL (1) CL2007003819A1 (enExample)
CO (1) CO6210690A2 (enExample)
CR (1) CR10815A (enExample)
DE (1) DE602007013295D1 (enExample)
DK (1) DK2132194T3 (enExample)
EC (1) ECSP099469A (enExample)
ES (1) ES2363105T3 (enExample)
IL (1) IL199538A (enExample)
MA (1) MA31024B1 (enExample)
MX (1) MX2009005862A (enExample)
MY (1) MY148902A (enExample)
NI (1) NI200900109A (enExample)
NO (1) NO20092434L (enExample)
PT (1) PT2132194E (enExample)
RU (1) RU2009128690A (enExample)
SV (1) SV2009003316A (enExample)
TN (1) TN2009000273A1 (enExample)
TW (1) TWI448286B (enExample)
WO (1) WO2008077555A2 (enExample)
ZA (1) ZA200903554B (enExample)

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SI1912949T1 (sl) 2005-07-26 2011-12-30 Sanofi Sa Cikloheksilamin izokinolonski derivati kot inhibitorji Rho-kinaze
ES2729424T3 (es) 2006-09-20 2019-11-04 Aerie Pharmaceuticals Inc Inhibidores de Rho cinasa
JP5421783B2 (ja) 2006-12-27 2014-02-19 サノフイ Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体
PT2102164E (pt) 2006-12-27 2011-01-21 Sanofi Aventis Derivados de isoquinolina e de isoquinolinona substituída com cicloalquilamina
JP5313919B2 (ja) 2006-12-27 2013-10-09 サノフイ 新規な置換イソキノリン及びイソキノリノン誘導体
RU2457203C2 (ru) 2006-12-27 2012-07-27 Санофи-Авентис Замещенные циклоалкиламином производные изохинолона
AU2007338410B2 (en) 2006-12-27 2012-08-16 Sanofi-Aventis Cycloalkylamine substituted isoquinoline derivatives
CA2673918C (en) 2006-12-27 2015-02-17 Sanofi-Aventis Substituted isoquinoline and isoquinolinone derivatives
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EP3828172A1 (en) 2009-05-01 2021-06-02 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
KR20120100913A (ko) * 2009-10-13 2012-09-12 엠에스데 오쓰 베.베. 아세틸콜린 수용체에 관련된 질환의 치료를 위한 축합 아진 - 유도체
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US20140275160A1 (en) 2013-03-15 2014-09-18 Aerie Pharmaceuticals, Inc. Combination therapy
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CA2907243C (en) * 2013-03-15 2021-12-28 Celgene Avilomics Research, Inc. Substituted dihydropyrimidopyrimidinone compounds and pharmaceutical compositions thereof use fgfr4 inhibitor
US9321786B2 (en) 2013-03-15 2016-04-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
JP6729963B2 (ja) 2014-01-31 2020-07-29 株式会社エーピーアイ コーポレーション ピペコリン酸４位水酸化酵素およびそれを利用した４−ヒドロキシアミノ酸の製造法
FR3017868A1 (fr) 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN107532185B (zh) 2015-10-02 2023-01-06 株式会社Api 羟基-l-哌可酸的制造方法
JP6832946B2 (ja) 2015-11-17 2021-02-24 アエリエ ファーマシューティカルズ インコーポレイテッド キナーゼ阻害剤およびその中間体の調製方法
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