JP2010514720A5 - - Google Patents

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Publication number
JP2010514720A5
JP2010514720A5 JP2009543376A JP2009543376A JP2010514720A5 JP 2010514720 A5 JP2010514720 A5 JP 2010514720A5 JP 2009543376 A JP2009543376 A JP 2009543376A JP 2009543376 A JP2009543376 A JP 2009543376A JP 2010514720 A5 JP2010514720 A5 JP 2010514720A5
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JP
Japan
Prior art keywords
alkyl
alkylene
aryl
isoquinolin
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009543376A
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English (en)
Japanese (ja)
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JP5313919B2 (ja
JP2010514720A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2007/011168 external-priority patent/WO2008077555A2/en
Publication of JP2010514720A publication Critical patent/JP2010514720A/ja
Publication of JP2010514720A5 publication Critical patent/JP2010514720A5/ja
Application granted granted Critical
Publication of JP5313919B2 publication Critical patent/JP5313919B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009543376A 2006-12-27 2007-12-19 新規な置換イソキノリン及びイソキノリノン誘導体 Expired - Fee Related JP5313919B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06026892 2006-12-27
EP06026892.7 2006-12-27
PCT/EP2007/011168 WO2008077555A2 (en) 2006-12-27 2007-12-19 Substituted isoquinolines and their use as rho-kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2010514720A JP2010514720A (ja) 2010-05-06
JP2010514720A5 true JP2010514720A5 (enExample) 2011-02-03
JP5313919B2 JP5313919B2 (ja) 2013-10-09

Family

ID=38015325

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009543376A Expired - Fee Related JP5313919B2 (ja) 2006-12-27 2007-12-19 新規な置換イソキノリン及びイソキノリノン誘導体

Country Status (30)

Country Link
US (1) US8772492B2 (enExample)
EP (1) EP2132194B1 (enExample)
JP (1) JP5313919B2 (enExample)
KR (1) KR101545533B1 (enExample)
CN (1) CN101573354B (enExample)
AR (1) AR064493A1 (enExample)
AT (1) ATE502027T1 (enExample)
AU (1) AU2007338411B2 (enExample)
BR (1) BRPI0720909A2 (enExample)
CA (1) CA2673921C (enExample)
CL (1) CL2007003819A1 (enExample)
CO (1) CO6210690A2 (enExample)
CR (1) CR10815A (enExample)
DE (1) DE602007013295D1 (enExample)
DK (1) DK2132194T3 (enExample)
EC (1) ECSP099469A (enExample)
ES (1) ES2363105T3 (enExample)
IL (1) IL199538A (enExample)
MA (1) MA31024B1 (enExample)
MX (1) MX2009005862A (enExample)
MY (1) MY148902A (enExample)
NI (1) NI200900109A (enExample)
NO (1) NO20092434L (enExample)
PT (1) PT2132194E (enExample)
RU (1) RU2009128690A (enExample)
SV (1) SV2009003316A (enExample)
TN (1) TN2009000273A1 (enExample)
TW (1) TWI448286B (enExample)
WO (1) WO2008077555A2 (enExample)
ZA (1) ZA200903554B (enExample)

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AU2007338412B2 (en) 2006-12-27 2013-03-14 Sanofi-Aventis Cycloalkylamine substituted isoquinoline and isoquinolinone derivatives
NZ577981A (en) 2006-12-27 2011-12-22 Sanofi Aventis Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase
RU2457203C2 (ru) 2006-12-27 2012-07-27 Санофи-Авентис Замещенные циклоалкиламином производные изохинолона
BRPI0720909A2 (pt) 2006-12-27 2016-11-01 Sanofi Aventis derivados de isoquinolina e isoquinolinona substituídos
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NZ711376A (en) 2013-03-15 2020-01-31 Sanofi Sa Heteroaryl compounds and uses thereof
AU2014228746B2 (en) * 2013-03-15 2018-08-30 Celgene Car Llc Heteroaryl compounds and uses thereof
HUE061618T2 (hu) 2013-03-15 2023-07-28 Aerie Pharmaceuticals Inc Vegyület szemrendellenességek kezelésére
US9321786B2 (en) 2013-03-15 2016-04-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
CN105940103B (zh) 2014-01-31 2021-06-15 株式会社Api 哌可酸4位羟化酶和利用该酶的4-羟基氨基酸的制造法
FR3017868A1 (fr) 2014-02-21 2015-08-28 Servier Lab Derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN116396991A (zh) 2015-10-02 2023-07-07 株式会社Api 羟基-l-哌可酸的制造方法
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
KR102579582B1 (ko) 2015-11-17 2023-09-15 에어리 파마슈티컬즈, 인코포레이티드 키나아제 억제제 및 이의 중간체의 제조 방법
WO2018045091A1 (en) 2016-08-31 2018-03-08 Aerie Pharmaceuticals, Inc. Ophthalmic compositions
JP2020515583A (ja) 2017-03-31 2020-05-28 アエリエ ファーマシューティカルズ インコーポレイテッド アリールシクロプロピル−アミノ−イソキノリニルアミド化合物
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