CN101573354B - 取代的异喹啉类及其作为Rho-激酶抑制剂的用途 - Google Patents

取代的异喹啉类及其作为Rho-激酶抑制剂的用途 Download PDF

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Publication number
CN101573354B
CN101573354B CN200780048335.9A CN200780048335A CN101573354B CN 101573354 B CN101573354 B CN 101573354B CN 200780048335 A CN200780048335 A CN 200780048335A CN 101573354 B CN101573354 B CN 101573354B
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alkyl
isoquinolin
alkylene
yloxy
carboxylic acid
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CN101573354A (zh
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O·普来登伯格
K·洛伦茨
J·格利策
M·勒恩
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Sanofi SRL
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Sanofi Aventis SpA
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    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
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    • A61K31/47—Quinolines; Isoquinolines
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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CN200780048335.9A 2006-12-27 2007-12-19 取代的异喹啉类及其作为Rho-激酶抑制剂的用途 Expired - Fee Related CN101573354B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06026892 2006-12-27
EP06026892.7 2006-12-27
PCT/EP2007/011168 WO2008077555A2 (en) 2006-12-27 2007-12-19 Substituted isoquinolines and their use as rho-kinase inhibitors

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CN101573354A CN101573354A (zh) 2009-11-04
CN101573354B true CN101573354B (zh) 2014-02-12

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US (1) US8772492B2 (enExample)
EP (1) EP2132194B1 (enExample)
JP (1) JP5313919B2 (enExample)
KR (1) KR101545533B1 (enExample)
CN (1) CN101573354B (enExample)
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