JP2010513519A5 - - Google Patents

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Publication number
JP2010513519A5
JP2010513519A5 JP2009542917A JP2009542917A JP2010513519A5 JP 2010513519 A5 JP2010513519 A5 JP 2010513519A5 JP 2009542917 A JP2009542917 A JP 2009542917A JP 2009542917 A JP2009542917 A JP 2009542917A JP 2010513519 A5 JP2010513519 A5 JP 2010513519A5
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JP
Japan
Prior art keywords
ring
optionally substituted
aliphatic
aryl
heteroaryl
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JP2009542917A
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English (en)
Japanese (ja)
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JP2010513519A (ja
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Priority claimed from PCT/US2007/026034 external-priority patent/WO2008079277A1/en
Publication of JP2010513519A publication Critical patent/JP2010513519A/ja
Publication of JP2010513519A5 publication Critical patent/JP2010513519A5/ja
Withdrawn legal-status Critical Current

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JP2009542917A 2006-12-22 2007-12-19 キナーゼインヒビター活性を有するある種のピラゾリン誘導体 Withdrawn JP2010513519A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87668806P 2006-12-22 2006-12-22
PCT/US2007/026034 WO2008079277A1 (en) 2006-12-22 2007-12-19 Certain pyrazoline derivatives with kinase inhibitory activity

Publications (2)

Publication Number Publication Date
JP2010513519A JP2010513519A (ja) 2010-04-30
JP2010513519A5 true JP2010513519A5 (enExample) 2012-02-02

Family

ID=39192699

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009542917A Withdrawn JP2010513519A (ja) 2006-12-22 2007-12-19 キナーゼインヒビター活性を有するある種のピラゾリン誘導体

Country Status (4)

Country Link
US (1) US7795249B2 (enExample)
EP (1) EP2125778A1 (enExample)
JP (1) JP2010513519A (enExample)
WO (1) WO2008079277A1 (enExample)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0625594D0 (en) * 2006-12-21 2007-01-31 Smithkline Beecham Corp Compounds
WO2008135826A2 (en) 2007-05-03 2008-11-13 Pfizer Limited 2 -pyridine carboxamide derivatives as sodium channel modulators
WO2010033626A1 (en) * 2008-09-19 2010-03-25 Institute For Oneworld Health Compounds, compositions and methods comprising imidazole and triazole derivatives
JP5627574B2 (ja) 2008-06-03 2014-11-19 インターミューン, インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
UA105005C2 (uk) * 2008-06-16 2014-04-10 Юніверсіті Оф Теннессі Рісерч Фаундейшн Сполуки для лікування раку
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
EP3064204A1 (en) 2010-03-01 2016-09-07 GTx, Inc. Compounds for treatment of cancer
EP2560966B1 (en) 2010-03-30 2021-01-06 Verseon International Corporation Multisubstituted aromatic compounds as inhibitors of thrombin
US8697911B2 (en) * 2010-07-07 2014-04-15 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
KR20130108543A (ko) 2010-08-05 2013-10-04 암젠 인코포레이션 역형성 림프종 키나제를 억제하는 벤즈이미다졸 및 아자벤즈이미다졸 화합물
AU2011295725B2 (en) 2010-09-03 2015-03-26 Forma Tm, Llc. Novel compounds and compositions for the inhibition of NAMPT
BR112013009823A2 (pt) 2010-10-22 2016-07-05 Bayer Ip Gmbh novos compostos heterocíclicos como pesticidas
CN105360131A (zh) 2010-11-03 2016-03-02 陶氏益农公司 杀虫组合物和与其相关的方法
HU1000676D0 (en) * 2010-12-17 2011-02-28 Pharmahungary 2000 Kft Inhibitors of matrix metalloproteinase, pharmaceutical compositions thereof and use of them for preventing and treating diseases where the activation of mmp is involved
GB201104153D0 (en) 2011-03-11 2011-04-27 Glaxo Group Ltd Novel compounds
AU2012279416B2 (en) * 2011-07-01 2017-04-06 Merck Patent Gmbh Dihydropyrazoles, pharmaceutical compositions thereof and their use for the treatment of fertility disorders
CA2852688C (en) 2011-10-26 2021-06-29 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
ES2620612T3 (es) * 2012-03-02 2017-06-29 Genentech, Inc. Derivados de sulfóxidos y sulfonas de piridinilo y pirimidinilo
NZ700595A (en) 2012-04-27 2016-04-29 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
US9708288B2 (en) 2012-04-27 2017-07-18 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
US9282739B2 (en) 2012-04-27 2016-03-15 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
EP2970141B1 (en) 2013-03-15 2020-02-26 Verseon Corporation Halogenopyrazoles as inhibitors of thrombin
ES2853483T3 (es) 2013-03-15 2021-09-16 Verseon Int Corporation Compuestos aromáticos multisustituidos como inhibidores de la serina proteasa
CN105636442B (zh) 2013-10-17 2018-04-27 美国陶氏益农公司 制备杀虫化合物的方法
JP2016536295A (ja) 2013-10-17 2016-11-24 ダウ アグロサイエンシィズ エルエルシー 有害生物防除性化合物の製造方法
CN105636445B (zh) 2013-10-17 2018-12-07 美国陶氏益农公司 制备杀虫化合物的方法
KR20160074540A (ko) 2013-10-17 2016-06-28 다우 아그로사이언시즈 엘엘씨 살충성 화합물의 제조 방법
MX2016004942A (es) 2013-10-17 2016-06-28 Dow Agrosciences Llc Procesos para la preparacion de compuestos plaguicidas.
CA2925952A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
CA2925873A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
WO2015061165A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Pesticidal compositions and related methods
WO2015061163A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Pesticidal compositions and related methods
CN105828612A (zh) 2013-10-22 2016-08-03 美国陶氏益农公司 协同杀虫组合物和相关方法
WO2015061146A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
KR102275655B1 (ko) 2013-10-22 2021-07-09 코르테바 애그리사이언스 엘엘씨 살충 조성물 및 관련 방법
CA2926345A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
AU2014340416B2 (en) 2013-10-22 2017-09-07 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
WO2015061148A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
AR098097A1 (es) 2013-10-22 2016-05-04 Dow Agrosciences Llc Composiciones plaguicidas sinérgicas y métodos relacionados
CA2927220A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
MX2016005310A (es) 2013-10-22 2016-08-08 Dow Agrosciences Llc Composiciones pesticidas sinergicas y metodos relacionados.
NZ719776A (en) 2013-10-22 2017-06-30 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
KR102286233B1 (ko) 2013-10-22 2021-08-06 코르테바 애그리사이언스 엘엘씨 살충 조성물 및 관련 방법
US9549560B2 (en) 2013-10-22 2017-01-24 Dow Agrosciences Llc Pesticidal compositions and related methods
JP2016534076A (ja) 2013-10-22 2016-11-04 ダウ アグロサイエンシィズ エルエルシー 相乗的有害生物防除組成物および関連する方法
AR098091A1 (es) 2013-10-22 2016-05-04 Dow Agrosciences Llc Composiciones pesticidas sinérgicas y métodos relacionados
CA2926433A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Pesticidal compositions and related methods
EP2881390A1 (en) 2013-12-04 2015-06-10 Sanofi Thienomethylpiperazine derivatives as inhibitors of soluble epoxide hydrolase
CN106459042B (zh) 2014-04-02 2019-06-28 英特穆恩公司 抗纤维化吡啶酮类
JP2017523163A (ja) 2014-07-31 2017-08-17 ダウ アグロサイエンシィズ エルエルシー 3−(3−クロロ−1h−ピラゾール−1−イル)ピリジンの製造方法
AR098108A1 (es) 2014-07-31 2016-05-04 Dow Agrosciences Llc Proceso para la preparación de 3-(3-cloro-1h-pirazol-1-il)piridina
EP3186229A4 (en) 2014-07-31 2018-01-10 Dow AgroSciences LLC Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
CN107074774A (zh) 2014-08-19 2017-08-18 美国陶氏益农公司 制备3‑(3‑氯‑1h‑吡唑‑1‑基)吡啶的方法
WO2016039781A1 (en) 2014-09-12 2016-03-17 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
BR112017004704A2 (pt) 2014-09-17 2018-01-23 Verseon Corp composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio em um indivíduo
US9556146B2 (en) 2014-10-24 2017-01-31 Biotherapeutics, Inc. Lanthionine synthetase C-like 2-based therapeutics
US10532995B2 (en) 2015-02-27 2020-01-14 Verseon Corporation Substituted pyrazole compounds as serine protease inhibitors
JPWO2016208592A1 (ja) * 2015-06-22 2018-04-05 大日本住友製薬株式会社 二環性複素環アミド誘導体
CN106045982B (zh) * 2016-05-31 2018-08-07 华南农业大学 N’-5-(取代苯基)-2-呋喃甲酰基-5-丙基-1h-吡唑-3-甲酸乙酯类化合物及其制备方法和应用
CN106045908B (zh) * 2016-06-14 2018-09-28 郑州轻工业学院 一种新型化合物6,7-二溴-1,2,3,4-四氢异喹啉及其制备方法
CN107880029A (zh) * 2016-09-30 2018-04-06 南京大学 一类含吡唑骨架的吲哚类衍生物抗肿瘤化合物的设计、合成及应用
CN108017571A (zh) * 2016-10-29 2018-05-11 浙江九洲药物科技有限公司 一种取代异吲哚啉化合物的制备方法
CN110139853B (zh) 2016-12-29 2023-06-16 美国陶氏益农公司 用于制备杀有害生物化合物的方法
CN110325036B (zh) 2016-12-29 2021-10-26 美国陶氏益农公司 用于制备杀虫化合物的方法
EP3579872A1 (en) 2017-02-10 2019-12-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
KR102700664B1 (ko) 2017-08-07 2024-08-29 조인트 스탁 컴퍼니 “바이오케드” Cdk8/19 저해제로서 새로운 헤테로사이클릭 화합물
CN107474006A (zh) * 2017-09-25 2017-12-15 上海馨远医药科技有限公司 一种5‑溴异二氢吲哚盐酸盐的制备方法
CA3079396A1 (en) 2017-10-18 2019-04-25 Evrys Bio, Llc Broad spectrum antiviral compositions and methods
CN111511904A (zh) 2017-11-30 2020-08-07 朗多生物制药股份有限公司 使用羊毛硫氨酸c样蛋白2配体和用其制备的细胞的疗法
EP3732285A1 (en) 2017-12-28 2020-11-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
WO2020013531A1 (ko) * 2018-07-10 2020-01-16 보로노이바이오 주식회사 N-(3-(이미다조[1,2-b]피리다진-3-일에티닐)-4-메틸페닐)-5-페닐-4,5-다이하이드로-1H-피라졸-1-카복사마이드 유도체 및 이를 유효성분으로 포함하는 키나아제 관련 질환 치료용 약학적 조성물
CN113302183A (zh) * 2018-11-20 2021-08-24 圣瑞诺有限公司 环脲
CN109678787A (zh) * 2018-12-31 2019-04-26 南京晓庄学院 一种新的hcv病毒ns3/4a抑制剂合成中间体及合成方法
CN113767092B (zh) * 2019-05-09 2024-07-16 劲方医药科技(上海)有限公司 双杂环羰基取代的二氢吡唑类化合物,其制法与医药上的用途
WO2021127472A1 (en) 2019-12-20 2021-06-24 Landos Biopharma, Inc. Lanthionine c-like protein 2 ligands, cells prepared therewith, and therapies using same
CN114195780A (zh) 2020-09-18 2022-03-18 上海医药集团股份有限公司 一种羰基杂环类化合物及其应用
TW202511256A (zh) * 2023-05-25 2025-03-16 大陸商北京雙鶴潤創科技有限公司 肌成束蛋白抑制劑
WO2024246563A1 (en) * 2023-06-02 2024-12-05 Immutep S.A.S. Small molecule inhibitors of lag-3

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05112555A (ja) 1991-10-18 1993-05-07 Nippon Bayeragrochem Kk 選択的殺虫性ピラゾリン類
JPH05112556A (ja) 1991-10-18 1993-05-07 Nippon Bayeragrochem Kk 殺虫性ピラゾリン類
WO2001032173A1 (en) 1999-10-29 2001-05-10 Yamanouchi Pharmaceutical Co., Ltd. Kainic acid neurocytotoxicity inhibitors
WO2003079973A2 (en) * 2002-03-08 2003-10-02 Merck & Co., Inc. Mitotic kinesin inhibitors
CA2571824A1 (en) 2004-07-01 2006-01-19 Merck & Co., Inc. Mitotic kinesin inhibitors
WO2006007496A2 (en) 2004-07-01 2006-01-19 Merck & Co., Inc. Mitotic kinesin inhibitors

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