JP2010513519A5 - - Google Patents

Download PDF

Info

Publication number
JP2010513519A5
JP2010513519A5 JP2009542917A JP2009542917A JP2010513519A5 JP 2010513519 A5 JP2010513519 A5 JP 2010513519A5 JP 2009542917 A JP2009542917 A JP 2009542917A JP 2009542917 A JP2009542917 A JP 2009542917A JP 2010513519 A5 JP2010513519 A5 JP 2010513519A5
Authority
JP
Japan
Prior art keywords
ring
optionally substituted
aliphatic
aryl
heteroaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2009542917A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010513519A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/026034 external-priority patent/WO2008079277A1/en
Publication of JP2010513519A publication Critical patent/JP2010513519A/ja
Publication of JP2010513519A5 publication Critical patent/JP2010513519A5/ja
Withdrawn legal-status Critical Current

Links

JP2009542917A 2006-12-22 2007-12-19 キナーゼインヒビター活性を有するある種のピラゾリン誘導体 Withdrawn JP2010513519A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87668806P 2006-12-22 2006-12-22
PCT/US2007/026034 WO2008079277A1 (en) 2006-12-22 2007-12-19 Certain pyrazoline derivatives with kinase inhibitory activity

Publications (2)

Publication Number Publication Date
JP2010513519A JP2010513519A (ja) 2010-04-30
JP2010513519A5 true JP2010513519A5 (enExample) 2012-02-02

Family

ID=39192699

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009542917A Withdrawn JP2010513519A (ja) 2006-12-22 2007-12-19 キナーゼインヒビター活性を有するある種のピラゾリン誘導体

Country Status (4)

Country Link
US (1) US7795249B2 (enExample)
EP (1) EP2125778A1 (enExample)
JP (1) JP2010513519A (enExample)
WO (1) WO2008079277A1 (enExample)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0625594D0 (en) * 2006-12-21 2007-01-31 Smithkline Beecham Corp Compounds
EA015952B1 (ru) 2007-05-03 2011-12-30 Пфайзер Лимитед 2-пиридинкарбоксамидные производные в качестве модуляторов натриевых каналов
EP2296653B1 (en) 2008-06-03 2016-01-27 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
UA105005C2 (uk) * 2008-06-16 2014-04-10 Юніверсіті Оф Теннессі Рісерч Фаундейшн Сполуки для лікування раку
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
JP2012503005A (ja) * 2008-09-19 2012-02-02 インスティテュート フォア ワンワールド ヘルス イミダゾール誘導体およびトリアゾール誘導体を含む、化合物、組成物ならびに方法。
CA2791738C (en) 2010-03-01 2020-06-09 Gtx, Inc. Aryl imidazolyl compounds for the treatment of cancer
SG10201502484SA (en) 2010-03-30 2015-05-28 Verseon Corp Multisubstituted aromatic compounds as inhibitors of thrombin
US8697911B2 (en) * 2010-07-07 2014-04-15 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
SG10201505997TA (en) 2010-08-05 2015-09-29 Amgen Inc Benzimidazole And Azabenzimidazole Compounds That Inhibit Anaplastic Lymphoma Kinase
AR082885A1 (es) 2010-09-03 2013-01-16 Genentech Inc Compuestos y composiciones para la inhibicion de nampt
BR112013009823A2 (pt) 2010-10-22 2016-07-05 Bayer Ip Gmbh novos compostos heterocíclicos como pesticidas
CN103619171B (zh) 2010-11-03 2015-11-25 陶氏益农公司 杀虫组合物和与其相关的方法
HU1000676D0 (en) 2010-12-17 2011-02-28 Pharmahungary 2000 Kft Inhibitors of matrix metalloproteinase, pharmaceutical compositions thereof and use of them for preventing and treating diseases where the activation of mmp is involved
GB201104153D0 (en) 2011-03-11 2011-04-27 Glaxo Group Ltd Novel compounds
JP6170043B2 (ja) * 2011-07-01 2017-07-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung ジヒドロピラゾール
CN104010505B (zh) 2011-10-26 2017-03-15 陶氏益农公司 杀虫组合物和与其相关的方法
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
EP2820017B1 (en) * 2012-03-02 2016-12-21 Genentech, Inc. Pyridinyl and pyrimidinyl sulfoxide and sulfone derivatives
CA2870090A1 (en) 2012-04-27 2013-10-31 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
US9282739B2 (en) 2012-04-27 2016-03-15 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
US9708288B2 (en) 2012-04-27 2017-07-18 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
DK2968297T3 (en) 2013-03-15 2019-01-07 Verseon Inc MULTI-SUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS
WO2014149139A2 (en) 2013-03-15 2014-09-25 Verseon, Inc. Halogenopyrazoles as inhibitors of thrombin
WO2015058024A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
MX2016004941A (es) 2013-10-17 2016-06-28 Dow Agrosciences Llc Proceso para la preparacion de compuestos plaguicidas.
KR20160072155A (ko) 2013-10-17 2016-06-22 다우 아그로사이언시즈 엘엘씨 살충성 화합물의 제조 방법
US9029554B1 (en) 2013-10-17 2015-05-12 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
BR112016007518A2 (pt) 2013-10-17 2017-08-01 Dow Agrosciences Llc processos para a preparação de compostos pesticidas
CN105636441B (zh) 2013-10-17 2018-06-15 美国陶氏益农公司 制备杀虫化合物的方法
US9085564B2 (en) 2013-10-17 2015-07-21 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
US9149040B2 (en) 2013-10-22 2015-10-06 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
JP2016534086A (ja) 2013-10-22 2016-11-04 ダウ アグロサイエンシィズ エルエルシー 相乗的有害生物防除組成物および関連する方法
KR20160077113A (ko) 2013-10-22 2016-07-01 다우 아그로사이언시즈 엘엘씨 살충 조성물 및 관련 방법
AU2014340437B2 (en) 2013-10-22 2017-09-07 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
US9801383B2 (en) 2013-10-22 2017-10-31 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
US9144241B2 (en) 2013-10-22 2015-09-29 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
US9788546B2 (en) 2013-10-22 2017-10-17 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
EP3060045A4 (en) 2013-10-22 2017-04-05 Dow AgroSciences LLC Synergistic pesticidal compositions and related methods
NZ719634A (en) 2013-10-22 2017-09-29 Dow Agrosciences Llc Pesticidal compositions and related methods
TW201519774A (zh) 2013-10-22 2015-06-01 Dow Agrosciences Llc 協同性殺蟲組成物及相關方法(六)
CN105658062A (zh) 2013-10-22 2016-06-08 美国陶氏益农公司 协同杀虫组合物和相关方法
CN105792651A (zh) 2013-10-22 2016-07-20 美国陶氏益农公司 杀虫组合物和与其相关的方法
EP3060043B1 (en) 2013-10-22 2025-11-26 Corteva Agriscience LLC Pesticidal compositions and related methods
WO2015061175A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
CN105828608A (zh) 2013-10-22 2016-08-03 美国陶氏益农公司 杀虫组合物和与其相关的方法
RU2016119359A (ru) 2013-10-22 2017-11-28 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Синергетические пестицидные композиции и связанные с ними способы
AR098102A1 (es) 2013-10-22 2016-05-04 Dow Agrosciences Llc Composiciones plaguicidas y métodos relacionados
EP2881390A1 (en) 2013-12-04 2015-06-10 Sanofi Thienomethylpiperazine derivatives as inhibitors of soluble epoxide hydrolase
RU2692485C2 (ru) 2014-04-02 2019-06-25 Интермьюн, Инк. Противофиброзные пиридиноны
US9029555B1 (en) 2014-07-31 2015-05-12 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine
CA2954631A1 (en) 2014-07-31 2016-02-04 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
CA2954747A1 (en) 2014-07-31 2016-02-04 Dow Agrosciences Lcc Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
BR112017002735A2 (pt) 2014-08-19 2017-12-19 Dow Agrosciences Llc processo para a preparação de 3-(3-cloro-1h-pirazol-1-il)piridina
KR20170058388A (ko) 2014-09-12 2017-05-26 다우 아그로사이언시즈 엘엘씨 3-(3-클로로-1h-피라졸-1-일)피리딘의 제조 방법
JP2017528486A (ja) 2014-09-17 2017-09-28 ヴァーセオン コーポレイション セリンプロテアーゼ阻害剤としてのピラゾリル置換ピリドン化合物
RU2741576C2 (ru) 2014-10-24 2021-01-27 Лэндос Байофарма, Инк. Лекарственные средства на основе лантионинсинтетаза c-подобного белка 2
ES2931460T3 (es) 2015-02-27 2022-12-29 Verseon Int Corporation Compuestos de pirazol sustituido como inhibidores de serina proteasa
CA2990564A1 (en) * 2015-06-22 2016-12-29 Sumitomo Dainippon Pharma Co., Ltd. Bicyclic heterocyclic amide derivative
CN106045982B (zh) * 2016-05-31 2018-08-07 华南农业大学 N’-5-(取代苯基)-2-呋喃甲酰基-5-丙基-1h-吡唑-3-甲酸乙酯类化合物及其制备方法和应用
CN106045908B (zh) * 2016-06-14 2018-09-28 郑州轻工业学院 一种新型化合物6,7-二溴-1,2,3,4-四氢异喹啉及其制备方法
CN107880029A (zh) * 2016-09-30 2018-04-06 南京大学 一类含吡唑骨架的吲哚类衍生物抗肿瘤化合物的设计、合成及应用
CN108017571A (zh) * 2016-10-29 2018-05-11 浙江九洲药物科技有限公司 一种取代异吲哚啉化合物的制备方法
WO2018125817A1 (en) 2016-12-29 2018-07-05 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
CN110139853B (zh) 2016-12-29 2023-06-16 美国陶氏益农公司 用于制备杀有害生物化合物的方法
EP3579872A1 (en) 2017-02-10 2019-12-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
JP7365332B2 (ja) 2017-08-07 2023-10-19 ジョイント・ストック・カンパニー “バイオキャド” Cdk8/19阻害薬としての新規ヘテロ環式化合物
CN107474006A (zh) * 2017-09-25 2017-12-15 上海馨远医药科技有限公司 一种5‑溴异二氢吲哚盐酸盐的制备方法
CA3079396A1 (en) 2017-10-18 2019-04-25 Evrys Bio, Llc Broad spectrum antiviral compositions and methods
US11197891B2 (en) 2017-11-30 2021-12-14 Landos Biopharma, Inc. Therapies with lanthionine C-like protein 2 ligands and cells prepared therewith
CA3086765A1 (en) 2017-12-28 2019-07-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
WO2020013531A1 (ko) * 2018-07-10 2020-01-16 보로노이바이오 주식회사 N-(3-(이미다조[1,2-b]피리다진-3-일에티닐)-4-메틸페닐)-5-페닐-4,5-다이하이드로-1H-피라졸-1-카복사마이드 유도체 및 이를 유효성분으로 포함하는 키나아제 관련 질환 치료용 약학적 조성물
BR112021009610A2 (pt) 2018-11-20 2021-08-10 Sironax Ltd composto, composição farmacêutica, uso de um composto ou composição, e, método de inibir necrose, ferroptose, rip1 humana ou indicações relacionadas
CN109678787A (zh) * 2018-12-31 2019-04-26 南京晓庄学院 一种新的hcv病毒ns3/4a抑制剂合成中间体及合成方法
CA3137328A1 (en) * 2019-05-09 2020-11-12 Fusheng ZHOU Bisheterocyclic carbonyl substituted dihydropyrazole compound as rip1 kinase inhibitor
AU2020407645B2 (en) 2019-12-20 2022-10-06 Nimmune Biopharma, Inc. Lanthionine C-like protein 2 ligands, cells prepared therewith, and therapies using same
US20240101552A1 (en) 2020-09-18 2024-03-28 Shanghai Pharmaceuticals Holding Co., Ltd. Carbonyl heterocyclic compound and application thereof
TW202511256A (zh) * 2023-05-25 2025-03-16 大陸商北京雙鶴潤創科技有限公司 肌成束蛋白抑制劑
WO2024246563A1 (en) * 2023-06-02 2024-12-05 Immutep S.A.S. Small molecule inhibitors of lag-3

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05112555A (ja) 1991-10-18 1993-05-07 Nippon Bayeragrochem Kk 選択的殺虫性ピラゾリン類
JPH05112556A (ja) 1991-10-18 1993-05-07 Nippon Bayeragrochem Kk 殺虫性ピラゾリン類
AU7961300A (en) 1999-10-29 2001-05-14 Yamanouchi Pharmaceutical Co., Ltd. Kainic acid neurocytotoxicity inhibitors
EP1492487B1 (en) * 2002-03-08 2009-11-11 Merck & Co., Inc. Mitotic kinesin inhibitors
JP2008505089A (ja) 2004-07-01 2008-02-21 メルク エンド カムパニー インコーポレーテッド 有糸分裂キネシン阻害剤
CA2571824A1 (en) 2004-07-01 2006-01-19 Merck & Co., Inc. Mitotic kinesin inhibitors

Similar Documents

Publication Publication Date Title
CN111315737B (zh) 经砜吡啶烷基酰胺取代的杂芳基化合物
AU2008286349B2 (en) Azabiphenylaminobenzoic acid derivatives as DHODH inhibitors
JP2022545359A5 (enExample)
JP2023512213A5 (enExample)
RU2016141647A (ru) ИНГИБИТОРЫ TrkA КИНАЗЫ, ОСНОВАННЫЕ НА НИХ КОМПОЗИЦИИ И СПОСОБЫ
JP2019517487A5 (enExample)
JP2022506687A (ja) ピリダジノン化合物およびその使用
JP2020521730A5 (enExample)
JP2017512786A5 (enExample)
RU2009120389A (ru) Гетероциклические соединения в качестве противовоспалительных агентов
JP2021524487A5 (enExample)
WO2023232069A1 (zh) 一种氮杂喹啉酮类衍生物、其制备方法及用途
JP2013545808A5 (enExample)
JP2016517417A5 (enExample)
JP2020533352A5 (enExample)
JP2008509187A5 (enExample)
JP2005505618A5 (enExample)
JP2021501151A5 (enExample)
JP2007501831A5 (enExample)
JP2023539362A (ja) ヒストン脱アセチル化酵素6阻害剤としての新規な構造の化合物およびこれを含む薬剤学的組成物
JP2021500332A5 (enExample)
RU2009119181A (ru) Гетероциклические соединения и их применение в качестве ингибиторов гликогенсинтаза-киназы-3
JP2019524895A (ja) 縮合複素環誘導体、その調製方法、及びその医学的使用
JPS58189179A (ja) イミダゾピリジン誘導体
JP2003513066A5 (enExample)