JP2010513506A5 - - Google Patents
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- JP2010513506A5 JP2010513506A5 JP2009542880A JP2009542880A JP2010513506A5 JP 2010513506 A5 JP2010513506 A5 JP 2010513506A5 JP 2009542880 A JP2009542880 A JP 2009542880A JP 2009542880 A JP2009542880 A JP 2009542880A JP 2010513506 A5 JP2010513506 A5 JP 2010513506A5
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- Prior art keywords
- composition
- polypeptide
- amino acid
- acid sequence
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- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 238000000746 purification Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims 32
- 229920001184 polypeptide Polymers 0.000 claims 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims 29
- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 125000003275 alpha amino acid group Chemical group 0.000 claims 24
- 150000001413 amino acids Chemical class 0.000 claims 18
- 239000005557 antagonist Substances 0.000 claims 9
- 108020001507 fusion proteins Proteins 0.000 claims 7
- 102000037865 fusion proteins Human genes 0.000 claims 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 210000003743 erythrocyte Anatomy 0.000 claims 5
- 102000005606 Activins Human genes 0.000 claims 4
- 108010059616 Activins Proteins 0.000 claims 4
- 239000000488 activin Substances 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 102000007562 Serum Albumin Human genes 0.000 claims 2
- 108010071390 Serum Albumin Proteins 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 230000009918 complex formation Effects 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 230000004068 intracellular signaling Effects 0.000 claims 2
- 125000003473 lipid group Chemical group 0.000 claims 2
- 230000004807 localization Effects 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 102000001554 Hemoglobins Human genes 0.000 claims 1
- 108010054147 Hemoglobins Proteins 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 108020001756 ligand binding domains Proteins 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 210000002027 skeletal muscle Anatomy 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 description 3
- 229920002684 Sepharose Polymers 0.000 description 2
- 238000001542 size-exclusion chromatography Methods 0.000 description 2
- 238000005277 cation exchange chromatography Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 238000011100 viral filtration Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87568206P | 2006-12-18 | 2006-12-18 | |
| US60/875,682 | 2006-12-18 | ||
| PCT/US2007/025868 WO2008076437A2 (en) | 2006-12-18 | 2007-12-18 | Activin-actrii antagonists and uses for increasing red blood cell levels |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013055102A Division JP5865281B2 (ja) | 2006-12-18 | 2013-03-18 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010513506A JP2010513506A (ja) | 2010-04-30 |
| JP2010513506A5 true JP2010513506A5 (cg-RX-API-DMAC7.html) | 2012-02-09 |
| JP5415279B2 JP5415279B2 (ja) | 2014-02-12 |
Family
ID=39183159
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009542880A Active JP5415279B2 (ja) | 2006-12-18 | 2007-12-18 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
| JP2013055102A Active JP5865281B2 (ja) | 2006-12-18 | 2013-03-18 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
| JP2013243668A Pending JP2014040483A (ja) | 2006-12-18 | 2013-11-26 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
| JP2015211115A Pending JP2016020391A (ja) | 2006-12-18 | 2015-10-27 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
| JP2017018409A Pending JP2017075187A (ja) | 2006-12-18 | 2017-02-03 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
| JP2017119494A Withdrawn JP2017155064A (ja) | 2006-12-18 | 2017-06-19 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
| JP2019044553A Withdrawn JP2019089850A (ja) | 2006-12-18 | 2019-03-12 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
| JP2021032007A Pending JP2021080290A (ja) | 2006-12-18 | 2021-03-01 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013055102A Active JP5865281B2 (ja) | 2006-12-18 | 2013-03-18 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
| JP2013243668A Pending JP2014040483A (ja) | 2006-12-18 | 2013-11-26 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
| JP2015211115A Pending JP2016020391A (ja) | 2006-12-18 | 2015-10-27 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
| JP2017018409A Pending JP2017075187A (ja) | 2006-12-18 | 2017-02-03 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
| JP2017119494A Withdrawn JP2017155064A (ja) | 2006-12-18 | 2017-06-19 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
| JP2019044553A Withdrawn JP2019089850A (ja) | 2006-12-18 | 2019-03-12 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
| JP2021032007A Pending JP2021080290A (ja) | 2006-12-18 | 2021-03-01 | アクチビン−ＡｃｔＲＩＩアンタゴニストおよび赤血球レベルを増加させるためのその使用 |
Country Status (30)
Families Citing this family (93)
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