JP2010508285A5 - - Google Patents
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- Publication number
- JP2010508285A5 JP2010508285A5 JP2009534841A JP2009534841A JP2010508285A5 JP 2010508285 A5 JP2010508285 A5 JP 2010508285A5 JP 2009534841 A JP2009534841 A JP 2009534841A JP 2009534841 A JP2009534841 A JP 2009534841A JP 2010508285 A5 JP2010508285 A5 JP 2010508285A5
- Authority
- JP
- Japan
- Prior art keywords
- ester
- sucrose
- btc
- dmf
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 16
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 14
- 238000000034 method Methods 0.000 claims 11
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 4
- QQVDYSUDFZZPSU-UHFFFAOYSA-M chloromethylidene(dimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)=CCl QQVDYSUDFZZPSU-UHFFFAOYSA-M 0.000 claims 4
- 239000003960 organic solvent Substances 0.000 claims 4
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 claims 4
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 claims 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000004376 Sucralose Substances 0.000 claims 1
- 238000005660 chlorination reaction Methods 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims 1
- 235000019408 sucralose Nutrition 0.000 claims 1
- 238000010792 warming Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/552,789 US8258291B2 (en) | 2006-10-25 | 2006-10-25 | Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC) |
| PCT/US2007/082422 WO2008052076A2 (en) | 2006-10-25 | 2007-10-24 | Process for the preparation of sucralose by the chlorination of sugar with triphosgene (btc) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010508285A JP2010508285A (ja) | 2010-03-18 |
| JP2010508285A5 true JP2010508285A5 (enExample) | 2011-01-20 |
Family
ID=39325402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009534841A Pending JP2010508285A (ja) | 2006-10-25 | 2007-10-24 | トリホスゲン（ｂｔｃ）を用いた糖の塩素化によるスクラロースの製造方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8258291B2 (enExample) |
| EP (1) | EP2094873B1 (enExample) |
| JP (1) | JP2010508285A (enExample) |
| KR (1) | KR20090082422A (enExample) |
| CN (1) | CN101631878A (enExample) |
| AT (1) | ATE515509T1 (enExample) |
| AU (1) | AU2007308947A1 (enExample) |
| BR (1) | BRPI0718178A2 (enExample) |
| CA (1) | CA2667419A1 (enExample) |
| CY (1) | CY1112434T1 (enExample) |
| DK (1) | DK2094873T3 (enExample) |
| ES (1) | ES2366063T3 (enExample) |
| MX (1) | MX2009004355A (enExample) |
| PL (1) | PL2094873T3 (enExample) |
| PT (1) | PT2094873E (enExample) |
| RU (1) | RU2009119515A (enExample) |
| SI (1) | SI2094873T1 (enExample) |
| TW (1) | TW200833706A (enExample) |
| WO (1) | WO2008052076A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080103295A1 (en) * | 2006-10-25 | 2008-05-01 | David Losan Ho | Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst |
| US7862744B2 (en) * | 2008-07-23 | 2011-01-04 | Mamtek International Limited | Methods and systems for preparing materials for sucralose production |
| EP2643338B1 (en) | 2010-11-23 | 2016-04-06 | Lexington Pharmaceuticals Laboratories, LLC | Low temperature chlorination of carbohydrates |
| US8884004B2 (en) | 2011-09-02 | 2014-11-11 | Divi's Laboratories, Ltd. | Process for the preparation of sucralose |
| MX342969B (es) | 2011-10-14 | 2016-10-20 | Lexington Pharmaceuticals Laboratories Llc | Cloracion de carbohidratos y derivados de carbohidratos. |
| CN103087116A (zh) * | 2011-11-07 | 2013-05-08 | 常茂生物化学工程股份有限公司 | 三氯蔗糖的制备方法 |
| CN104774227A (zh) * | 2015-04-08 | 2015-07-15 | 常州市牛塘化工厂有限公司 | 一种蔗糖-6-乙酯的氯化方法 |
| EP3303413A4 (en) * | 2015-05-29 | 2019-02-06 | Alaparthi, Lakshmi Prasad | PROCESS FOR THE PREPARATION OF SUGAMMADEX AND INTERMEDIATE PRODUCTS THEREOF |
| CN105111250A (zh) * | 2015-08-28 | 2015-12-02 | 山东康宝生化科技有限公司 | 一种利用固体光气进行三氯蔗糖6乙酯的制备方法 |
| CN105153248A (zh) * | 2015-08-28 | 2015-12-16 | 山东康宝生化科技有限公司 | 在固体光气法合成三氯蔗糖6乙酯过程中的温度控制方法 |
| JP6815932B2 (ja) * | 2017-05-31 | 2021-01-20 | 株式会社トクヤマ | Ｎ−カルバメート保護カルボキシ無水物の製造方法 |
| CN108203452B (zh) * | 2018-01-24 | 2021-04-06 | 山东康宝生化科技有限公司 | 一种合成三氯蔗糖-6-乙酯的方法 |
| CN110950888B (zh) * | 2019-11-11 | 2022-05-20 | 山东省科学院菏泽分院 | 一种Vilsmeier试剂参与的氯噁酮的制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3072725A (en) * | 1960-11-14 | 1963-01-08 | Du Pont | Preparation of dimethylformamide |
| EP0043649B1 (en) * | 1980-07-08 | 1984-09-12 | TATE & LYLE PUBLIC LIMITED COMPANY | Process for the preparation of 4, 1',6'-trichloro-4,1',6'-trideoxygalactosucrose (tgs) |
| GB8818430D0 (en) * | 1988-08-03 | 1988-09-07 | Tate & Lyle Plc | Process |
| US4980463A (en) * | 1989-07-18 | 1990-12-25 | Noramco, Inc. | Sucrose-6-ester chlorination |
| JP3002885B2 (ja) | 1989-11-02 | 2000-01-24 | 住友化学工業株式会社 | ジメチルホルムアミドの回収精製法 |
| JP3514495B2 (ja) * | 1992-10-02 | 2004-03-31 | エーザイ株式会社 | ハロゲン化アミノチアジアゾリル酢酸誘導体の製造法 |
| CO4410191A1 (es) * | 1994-09-19 | 1997-01-09 | Lilly Co Eli | SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS |
| US5498709A (en) * | 1994-10-17 | 1996-03-12 | Mcneil-Ppc, Inc. | Production of sucralose without intermediate isolation of crystalline sucralose-6-ester |
| AU1864899A (en) * | 1998-05-15 | 1999-12-06 | Tamara E. Kolosova | Method of preparation 4,1,6-trichloro-4,1,6-trideoxygalactosucrose |
| HU228576B1 (en) * | 1998-10-20 | 2013-04-29 | Lundbeck & Co As H | Method for the preparation of citalopram |
| US6998480B2 (en) * | 2002-03-08 | 2006-02-14 | Tate & Lyle Public Limited Company | Process for improving sucralose purity and yield |
| CN1176094C (zh) | 2003-05-23 | 2004-11-17 | 广东省食品工业研究所 | 一种三氯蔗糖的合成方法 |
| US20060205936A1 (en) * | 2005-03-14 | 2006-09-14 | Sl Laboratories, Llc | Chlorination of Sucrose-6-esters |
| WO2007026377A2 (en) * | 2005-05-04 | 2007-03-08 | Pharmed Medicare Private Limited | Synthesis of vilsmeier haack reagent from di (trichlo-romethyl) carbonate for chlorination reaction. |
| CN101263153A (zh) | 2005-08-30 | 2008-09-10 | 法马德医疗保险私人有限公司 | 基于疏水亲和色谱层析生产氯化蔗糖的方法 |
| US20090264640A1 (en) | 2006-05-23 | 2009-10-22 | V.B. Medicare Pvt. Ltd | Recovery of dimethylformamide and other solvents from process streams of manufacture of trichlorogalactosucrose |
| US20080103295A1 (en) | 2006-10-25 | 2008-05-01 | David Losan Ho | Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst |
-
2006
- 2006-10-25 US US11/552,789 patent/US8258291B2/en not_active Expired - Fee Related
-
2007
- 2007-10-19 TW TW096139365A patent/TW200833706A/zh unknown
- 2007-10-24 AT AT07854397T patent/ATE515509T1/de active
- 2007-10-24 JP JP2009534841A patent/JP2010508285A/ja active Pending
- 2007-10-24 PL PL07854397T patent/PL2094873T3/pl unknown
- 2007-10-24 CN CN200780043677A patent/CN101631878A/zh active Pending
- 2007-10-24 EP EP07854397A patent/EP2094873B1/en not_active Not-in-force
- 2007-10-24 SI SI200730686T patent/SI2094873T1/sl unknown
- 2007-10-24 WO PCT/US2007/082422 patent/WO2008052076A2/en not_active Ceased
- 2007-10-24 KR KR1020097010474A patent/KR20090082422A/ko not_active Withdrawn
- 2007-10-24 RU RU2009119515/04A patent/RU2009119515A/ru not_active Application Discontinuation
- 2007-10-24 DK DK07854397.2T patent/DK2094873T3/da active
- 2007-10-24 BR BRPI0718178-7A2A patent/BRPI0718178A2/pt not_active Application Discontinuation
- 2007-10-24 PT PT07854397T patent/PT2094873E/pt unknown
- 2007-10-24 ES ES07854397T patent/ES2366063T3/es active Active
- 2007-10-24 MX MX2009004355A patent/MX2009004355A/es not_active Application Discontinuation
- 2007-10-24 AU AU2007308947A patent/AU2007308947A1/en not_active Abandoned
- 2007-10-24 CA CA002667419A patent/CA2667419A1/en not_active Abandoned
-
2011
- 2011-08-08 CY CY20111100756T patent/CY1112434T1/el unknown
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