RU2009119515A - Способ получения сукралозы хлорированием сахара трифосгеном (втс) - Google Patents
Способ получения сукралозы хлорированием сахара трифосгеном (втс) Download PDFInfo
- Publication number
- RU2009119515A RU2009119515A RU2009119515/04A RU2009119515A RU2009119515A RU 2009119515 A RU2009119515 A RU 2009119515A RU 2009119515/04 A RU2009119515/04 A RU 2009119515/04A RU 2009119515 A RU2009119515 A RU 2009119515A RU 2009119515 A RU2009119515 A RU 2009119515A
- Authority
- RU
- Russia
- Prior art keywords
- sucrose
- ester
- chlorinating
- btc
- dmf
- Prior art date
Links
- 239000004376 Sucralose Substances 0.000 title claims abstract 6
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 title claims abstract 6
- 235000019408 sucralose Nutrition 0.000 title claims abstract 6
- 238000005660 chlorination reaction Methods 0.000 title claims abstract 4
- 238000004519 manufacturing process Methods 0.000 title claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims abstract 15
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims abstract 12
- 238000000034 method Methods 0.000 claims abstract 12
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims abstract 8
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 claims abstract 8
- QQVDYSUDFZZPSU-UHFFFAOYSA-M chloromethylidene(dimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)=CCl QQVDYSUDFZZPSU-UHFFFAOYSA-M 0.000 claims abstract 6
- 239000003960 organic solvent Substances 0.000 claims abstract 5
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000002904 solvent Substances 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims 17
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 6
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000010792 warming Methods 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 abstract 2
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K5/00—Lactose
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K7/00—Maltose
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Seasonings (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/552,789 | 2006-10-25 | ||
| US11/552,789 US8258291B2 (en) | 2006-10-25 | 2006-10-25 | Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009119515A true RU2009119515A (ru) | 2010-11-27 |
Family
ID=39325402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009119515/04A RU2009119515A (ru) | 2006-10-25 | 2007-10-24 | Способ получения сукралозы хлорированием сахара трифосгеном (втс) |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8258291B2 (enExample) |
| EP (1) | EP2094873B1 (enExample) |
| JP (1) | JP2010508285A (enExample) |
| KR (1) | KR20090082422A (enExample) |
| CN (1) | CN101631878A (enExample) |
| AT (1) | ATE515509T1 (enExample) |
| AU (1) | AU2007308947A1 (enExample) |
| BR (1) | BRPI0718178A2 (enExample) |
| CA (1) | CA2667419A1 (enExample) |
| CY (1) | CY1112434T1 (enExample) |
| DK (1) | DK2094873T3 (enExample) |
| ES (1) | ES2366063T3 (enExample) |
| MX (1) | MX2009004355A (enExample) |
| PL (1) | PL2094873T3 (enExample) |
| PT (1) | PT2094873E (enExample) |
| RU (1) | RU2009119515A (enExample) |
| SI (1) | SI2094873T1 (enExample) |
| TW (1) | TW200833706A (enExample) |
| WO (1) | WO2008052076A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080103295A1 (en) * | 2006-10-25 | 2008-05-01 | David Losan Ho | Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst |
| US7862744B2 (en) * | 2008-07-23 | 2011-01-04 | Mamtek International Limited | Methods and systems for preparing materials for sucralose production |
| MX2013005560A (es) | 2010-11-23 | 2013-08-26 | Lexington Pharmaceuticals Lab Llc | Cloracion de baja temperatura de carbohidratos. |
| US8884004B2 (en) | 2011-09-02 | 2014-11-11 | Divi's Laboratories, Ltd. | Process for the preparation of sucralose |
| ES2574261T3 (es) | 2011-10-14 | 2016-06-16 | Lexington Pharmaceuticals Laboratories, Llc | Cloración de carbohidratos y derivados de carbohidratos |
| CN103087116A (zh) * | 2011-11-07 | 2013-05-08 | 常茂生物化学工程股份有限公司 | 三氯蔗糖的制备方法 |
| CN104774227A (zh) * | 2015-04-08 | 2015-07-15 | 常州市牛塘化工厂有限公司 | 一种蔗糖-6-乙酯的氯化方法 |
| JP6946275B2 (ja) * | 2015-05-29 | 2021-10-06 | ラクシュミ・プラサド・アラパルティＬａｋｓｈｍｉ Ｐｒａｓａｄ ＡＬＡＰＡＲＴＨＩ | スガマデクスおよびその中間体の製造方法 |
| CN105153248A (zh) * | 2015-08-28 | 2015-12-16 | 山东康宝生化科技有限公司 | 在固体光气法合成三氯蔗糖6乙酯过程中的温度控制方法 |
| CN105111250A (zh) * | 2015-08-28 | 2015-12-02 | 山东康宝生化科技有限公司 | 一种利用固体光气进行三氯蔗糖6乙酯的制备方法 |
| JP6815932B2 (ja) * | 2017-05-31 | 2021-01-20 | 株式会社トクヤマ | Ｎ−カルバメート保護カルボキシ無水物の製造方法 |
| CN108203452B (zh) * | 2018-01-24 | 2021-04-06 | 山东康宝生化科技有限公司 | 一种合成三氯蔗糖-6-乙酯的方法 |
| CN110950888B (zh) * | 2019-11-11 | 2022-05-20 | 山东省科学院菏泽分院 | 一种Vilsmeier试剂参与的氯噁酮的制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3072725A (en) | 1960-11-14 | 1963-01-08 | Du Pont | Preparation of dimethylformamide |
| EP0043649B1 (en) * | 1980-07-08 | 1984-09-12 | TATE & LYLE PUBLIC LIMITED COMPANY | Process for the preparation of 4, 1',6'-trichloro-4,1',6'-trideoxygalactosucrose (tgs) |
| GB8818430D0 (en) | 1988-08-03 | 1988-09-07 | Tate & Lyle Plc | Process |
| US4980463A (en) | 1989-07-18 | 1990-12-25 | Noramco, Inc. | Sucrose-6-ester chlorination |
| JP3002885B2 (ja) | 1989-11-02 | 2000-01-24 | 住友化学工業株式会社 | ジメチルホルムアミドの回収精製法 |
| JP3514495B2 (ja) * | 1992-10-02 | 2004-03-31 | エーザイ株式会社 | ハロゲン化アミノチアジアゾリル酢酸誘導体の製造法 |
| CO4410191A1 (es) | 1994-09-19 | 1997-01-09 | Lilly Co Eli | SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS |
| US5498709A (en) | 1994-10-17 | 1996-03-12 | Mcneil-Ppc, Inc. | Production of sucralose without intermediate isolation of crystalline sucralose-6-ester |
| RU2217435C2 (ru) * | 1998-05-15 | 2003-11-27 | Ростислав Георгиевич Жбанков | Способ получения 4,1'6'-трихлор-4,1',6'-тридезоксигалактосахарозы |
| ATE230738T1 (de) * | 1998-10-20 | 2003-01-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
| US6998480B2 (en) | 2002-03-08 | 2006-02-14 | Tate & Lyle Public Limited Company | Process for improving sucralose purity and yield |
| CN1176094C (zh) | 2003-05-23 | 2004-11-17 | 广东省食品工业研究所 | 一种三氯蔗糖的合成方法 |
| US20060205936A1 (en) | 2005-03-14 | 2006-09-14 | Sl Laboratories, Llc | Chlorination of Sucrose-6-esters |
| GB2442619B (en) * | 2005-05-04 | 2010-05-26 | Pharmed Medicare Pvt Ltd | Chlorination of sucrose acylates using triphosgene |
| CN101253189A (zh) | 2005-08-30 | 2008-08-27 | 法马德医疗保险私人有限公司 | 基于从反应混合物中直接萃取到有机溶剂中随后蒸除溶剂的纯化三氯半乳蔗糖的方法 |
| JP2009538293A (ja) | 2006-05-23 | 2009-11-05 | ヴイ ビー メディケア プライヴェート リミテッド | トリクロロガラクトスクロース製造のプロセスストリームからのジメチルホルムアミド及び他の溶媒の回収 |
| US20080103295A1 (en) | 2006-10-25 | 2008-05-01 | David Losan Ho | Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst |
-
2006
- 2006-10-25 US US11/552,789 patent/US8258291B2/en not_active Expired - Fee Related
-
2007
- 2007-10-19 TW TW096139365A patent/TW200833706A/zh unknown
- 2007-10-24 WO PCT/US2007/082422 patent/WO2008052076A2/en not_active Ceased
- 2007-10-24 MX MX2009004355A patent/MX2009004355A/es not_active Application Discontinuation
- 2007-10-24 BR BRPI0718178-7A2A patent/BRPI0718178A2/pt not_active Application Discontinuation
- 2007-10-24 EP EP07854397A patent/EP2094873B1/en not_active Not-in-force
- 2007-10-24 CN CN200780043677A patent/CN101631878A/zh active Pending
- 2007-10-24 ES ES07854397T patent/ES2366063T3/es active Active
- 2007-10-24 JP JP2009534841A patent/JP2010508285A/ja active Pending
- 2007-10-24 AT AT07854397T patent/ATE515509T1/de active
- 2007-10-24 DK DK07854397.2T patent/DK2094873T3/da active
- 2007-10-24 AU AU2007308947A patent/AU2007308947A1/en not_active Abandoned
- 2007-10-24 CA CA002667419A patent/CA2667419A1/en not_active Abandoned
- 2007-10-24 PT PT07854397T patent/PT2094873E/pt unknown
- 2007-10-24 SI SI200730686T patent/SI2094873T1/sl unknown
- 2007-10-24 PL PL07854397T patent/PL2094873T3/pl unknown
- 2007-10-24 RU RU2009119515/04A patent/RU2009119515A/ru not_active Application Discontinuation
- 2007-10-24 KR KR1020097010474A patent/KR20090082422A/ko not_active Withdrawn
-
2011
- 2011-08-08 CY CY20111100756T patent/CY1112434T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE515509T1 (de) | 2011-07-15 |
| WO2008052076B1 (en) | 2008-09-12 |
| AU2007308947A1 (en) | 2008-05-02 |
| SI2094873T1 (sl) | 2011-12-30 |
| US8258291B2 (en) | 2012-09-04 |
| EP2094873A4 (en) | 2009-11-25 |
| BRPI0718178A2 (pt) | 2013-12-17 |
| JP2010508285A (ja) | 2010-03-18 |
| CN101631878A (zh) | 2010-01-20 |
| KR20090082422A (ko) | 2009-07-30 |
| MX2009004355A (es) | 2009-08-25 |
| US20080103298A1 (en) | 2008-05-01 |
| CA2667419A1 (en) | 2008-05-02 |
| EP2094873B1 (en) | 2011-07-06 |
| PL2094873T3 (pl) | 2011-10-31 |
| DK2094873T3 (da) | 2011-08-15 |
| ES2366063T3 (es) | 2011-10-14 |
| TW200833706A (en) | 2008-08-16 |
| WO2008052076A3 (en) | 2008-07-17 |
| EP2094873A2 (en) | 2009-09-02 |
| CY1112434T1 (el) | 2015-12-09 |
| WO2008052076A2 (en) | 2008-05-02 |
| PT2094873E (pt) | 2011-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20120201 |