CN101631878A - 以三光气（btc）氯化蔗糖制备三氯蔗糖的方法 - Google Patents

以三光气（btc）氯化蔗糖制备三氯蔗糖的方法 Download PDF

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Publication number
CN101631878A
CN101631878A CN200780043677A CN200780043677A CN101631878A CN 101631878 A CN101631878 A CN 101631878A CN 200780043677 A CN200780043677 A CN 200780043677A CN 200780043677 A CN200780043677 A CN 200780043677A CN 101631878 A CN101631878 A CN 101631878A
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CN
China
Prior art keywords
btc
sucrose
ester
dmf
reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200780043677A
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English (en)
Chinese (zh)
Inventor
何乐三
万正豪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mamtek International Ltd
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Mamtek International Ltd
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Filing date
Publication date
Application filed by Mamtek International Ltd filed Critical Mamtek International Ltd
Publication of CN101631878A publication Critical patent/CN101631878A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C13—SUGAR INDUSTRY
    • C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
    • C13K5/00—Lactose
    • C—CHEMISTRY; METALLURGY
    • C13—SUGAR INDUSTRY
    • C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
    • C13K7/00—Maltose

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Seasonings (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
CN200780043677A 2006-10-25 2007-10-24 以三光气（btc）氯化蔗糖制备三氯蔗糖的方法 Pending CN101631878A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/552,789 2006-10-25
US11/552,789 US8258291B2 (en) 2006-10-25 2006-10-25 Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC)

Publications (1)

Publication Number Publication Date
CN101631878A true CN101631878A (zh) 2010-01-20

Family

ID=39325402

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200780043677A Pending CN101631878A (zh) 2006-10-25 2007-10-24 以三光气（btc）氯化蔗糖制备三氯蔗糖的方法

Country Status (19)

Country Link
US (1) US8258291B2 (enExample)
EP (1) EP2094873B1 (enExample)
JP (1) JP2010508285A (enExample)
KR (1) KR20090082422A (enExample)
CN (1) CN101631878A (enExample)
AT (1) ATE515509T1 (enExample)
AU (1) AU2007308947A1 (enExample)
BR (1) BRPI0718178A2 (enExample)
CA (1) CA2667419A1 (enExample)
CY (1) CY1112434T1 (enExample)
DK (1) DK2094873T3 (enExample)
ES (1) ES2366063T3 (enExample)
MX (1) MX2009004355A (enExample)
PL (1) PL2094873T3 (enExample)
PT (1) PT2094873E (enExample)
RU (1) RU2009119515A (enExample)
SI (1) SI2094873T1 (enExample)
TW (1) TW200833706A (enExample)
WO (1) WO2008052076A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108203452A (zh) * 2018-01-24 2018-06-26 山东康宝生化科技有限公司 一种合成三氯蔗糖-6-乙酯的新方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080103295A1 (en) * 2006-10-25 2008-05-01 David Losan Ho Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst
US7862744B2 (en) * 2008-07-23 2011-01-04 Mamtek International Limited Methods and systems for preparing materials for sucralose production
MX2013005560A (es) 2010-11-23 2013-08-26 Lexington Pharmaceuticals Lab Llc Cloracion de baja temperatura de carbohidratos.
US8884004B2 (en) 2011-09-02 2014-11-11 Divi's Laboratories, Ltd. Process for the preparation of sucralose
ES2574261T3 (es) 2011-10-14 2016-06-16 Lexington Pharmaceuticals Laboratories, Llc Cloración de carbohidratos y derivados de carbohidratos
CN103087116A (zh) * 2011-11-07 2013-05-08 常茂生物化学工程股份有限公司 三氯蔗糖的制备方法
CN104774227A (zh) * 2015-04-08 2015-07-15 常州市牛塘化工厂有限公司 一种蔗糖-6-乙酯的氯化方法
JP6946275B2 (ja) * 2015-05-29 2021-10-06 ラクシュミ・プラサド・アラパルティＬａｋｓｈｍｉ Ｐｒａｓａｄ ＡＬＡＰＡＲＴＨＩ スガマデクスおよびその中間体の製造方法
CN105153248A (zh) * 2015-08-28 2015-12-16 山东康宝生化科技有限公司 在固体光气法合成三氯蔗糖6乙酯过程中的温度控制方法
CN105111250A (zh) * 2015-08-28 2015-12-02 山东康宝生化科技有限公司 一种利用固体光气进行三氯蔗糖6乙酯的制备方法
JP6815932B2 (ja) * 2017-05-31 2021-01-20 株式会社トクヤマ Ｎ−カルバメート保護カルボキシ無水物の製造方法
CN110950888B (zh) * 2019-11-11 2022-05-20 山东省科学院菏泽分院 一种Vilsmeier试剂参与的氯噁酮的制备方法

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US3072725A (en) 1960-11-14 1963-01-08 Du Pont Preparation of dimethylformamide
EP0043649B1 (en) * 1980-07-08 1984-09-12 TATE & LYLE PUBLIC LIMITED COMPANY Process for the preparation of 4, 1',6'-trichloro-4,1',6'-trideoxygalactosucrose (tgs)
GB8818430D0 (en) 1988-08-03 1988-09-07 Tate & Lyle Plc Process
US4980463A (en) 1989-07-18 1990-12-25 Noramco, Inc. Sucrose-6-ester chlorination
JP3002885B2 (ja) 1989-11-02 2000-01-24 住友化学工業株式会社 ジメチルホルムアミドの回収精製法
JP3514495B2 (ja) * 1992-10-02 2004-03-31 エーザイ株式会社 ハロゲン化アミノチアジアゾリル酢酸誘導体の製造法
CO4410191A1 (es) 1994-09-19 1997-01-09 Lilly Co Eli SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS
US5498709A (en) 1994-10-17 1996-03-12 Mcneil-Ppc, Inc. Production of sucralose without intermediate isolation of crystalline sucralose-6-ester
RU2217435C2 (ru) * 1998-05-15 2003-11-27 Ростислав Георгиевич Жбанков Способ получения 4,1'6'-трихлор-4,1',6'-тридезоксигалактосахарозы
ATE230738T1 (de) * 1998-10-20 2003-01-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
US6998480B2 (en) 2002-03-08 2006-02-14 Tate & Lyle Public Limited Company Process for improving sucralose purity and yield
CN1176094C (zh) 2003-05-23 2004-11-17 广东省食品工业研究所 一种三氯蔗糖的合成方法
US20060205936A1 (en) 2005-03-14 2006-09-14 Sl Laboratories, Llc Chlorination of Sucrose-6-esters
GB2442619B (en) * 2005-05-04 2010-05-26 Pharmed Medicare Pvt Ltd Chlorination of sucrose acylates using triphosgene
CN101253189A (zh) 2005-08-30 2008-08-27 法马德医疗保险私人有限公司 基于从反应混合物中直接萃取到有机溶剂中随后蒸除溶剂的纯化三氯半乳蔗糖的方法
JP2009538293A (ja) 2006-05-23 2009-11-05 ヴイ ビー メディケア プライヴェート リミテッド トリクロロガラクトスクロース製造のプロセスストリームからのジメチルホルムアミド及び他の溶媒の回収
US20080103295A1 (en) 2006-10-25 2008-05-01 David Losan Ho Process for the preparation of sucrose-6-ester by esterification in the presence of solid superacid catalyst

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108203452A (zh) * 2018-01-24 2018-06-26 山东康宝生化科技有限公司 一种合成三氯蔗糖-6-乙酯的新方法

Also Published As

Publication number Publication date
ATE515509T1 (de) 2011-07-15
WO2008052076B1 (en) 2008-09-12
AU2007308947A1 (en) 2008-05-02
SI2094873T1 (sl) 2011-12-30
US8258291B2 (en) 2012-09-04
EP2094873A4 (en) 2009-11-25
BRPI0718178A2 (pt) 2013-12-17
JP2010508285A (ja) 2010-03-18
KR20090082422A (ko) 2009-07-30
MX2009004355A (es) 2009-08-25
US20080103298A1 (en) 2008-05-01
CA2667419A1 (en) 2008-05-02
EP2094873B1 (en) 2011-07-06
PL2094873T3 (pl) 2011-10-31
DK2094873T3 (da) 2011-08-15
ES2366063T3 (es) 2011-10-14
TW200833706A (en) 2008-08-16
WO2008052076A3 (en) 2008-07-17
EP2094873A2 (en) 2009-09-02
CY1112434T1 (el) 2015-12-09
WO2008052076A2 (en) 2008-05-02
PT2094873E (pt) 2011-08-24
RU2009119515A (ru) 2010-11-27

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