JP2010508022A - 放射線療法および化学療法に対して癌細胞を感受性にするためのnbs1−atmのターゲティング - Google Patents

放射線療法および化学療法に対して癌細胞を感受性にするためのnbs1−atmのターゲティング Download PDF

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JP2010508022A
JP2010508022A JP2009534698A JP2009534698A JP2010508022A JP 2010508022 A JP2010508022 A JP 2010508022A JP 2009534698 A JP2009534698 A JP 2009534698A JP 2009534698 A JP2009534698 A JP 2009534698A JP 2010508022 A JP2010508022 A JP 2010508022A
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seq
polypeptide
nbs1
atm
cancer
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JP2010508022A5 (enExample
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マイケル ジェイ. カリビュー,
ボー スー,
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サザン リサーチ インスティチュート
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C07K14/43Sweetening agents, e.g. thaumatin, monellin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

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  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2009534698A 2006-10-30 2007-10-30 放射線療法および化学療法に対して癌細胞を感受性にするためのnbs1−atmのターゲティング Withdrawn JP2010508022A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86345706P 2006-10-30 2006-10-30
PCT/US2007/022886 WO2008054726A2 (en) 2006-10-30 2007-10-30 Targeting nbs1-atm interaction to sensitize cancer cells to radiotherapy and chemotherapy

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JP2010508022A true JP2010508022A (ja) 2010-03-18
JP2010508022A5 JP2010508022A5 (enExample) 2012-01-12

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JP2009534698A Withdrawn JP2010508022A (ja) 2006-10-30 2007-10-30 放射線療法および化学療法に対して癌細胞を感受性にするためのnbs1−atmのターゲティング

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US (1) US20100120679A1 (enExample)
EP (1) EP2091964A2 (enExample)
JP (1) JP2010508022A (enExample)
KR (1) KR20090102744A (enExample)
CN (1) CN101631799A (enExample)
AU (1) AU2007314366A1 (enExample)
CA (1) CA2674238A1 (enExample)
MX (1) MX2009004748A (enExample)
WO (1) WO2008054726A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014518616A (ja) * 2011-04-29 2014-08-07 オウアゴー,イェンス 癌における臨床的に関連する低酸素症を判定する方法
JP2015503538A (ja) * 2011-12-27 2015-02-02 ウニヴェルシテ ピエール エ マリー キュリー(パリ 6) 抗腫瘍アジュバント療法
JP2015521198A (ja) * 2012-05-29 2015-07-27 ザ ユニバーシティ オブ バーミンガム 付着したdna修復阻害剤及び核局在化シグナル要素を含むナノパーティクル

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8118754B1 (en) 2007-11-15 2012-02-21 Flynn Edward R Magnetic needle biopsy
US9964469B2 (en) 2005-02-28 2018-05-08 Imagion Biosystems, Inc. Magnetic needle separation and optical monitoring
US8841414B1 (en) * 2006-01-27 2014-09-23 University Of Mississippi Medical Center Targeted delivery of therapeutic peptides by thermally responsive biopolymers
US8447379B2 (en) 2006-11-16 2013-05-21 Senior Scientific, LLC Detection, measurement, and imaging of cells such as cancer and other biologic substances using targeted nanoparticles and magnetic properties thereof
US10194825B2 (en) 2009-11-06 2019-02-05 Imagion Biosystems Inc. Methods and apparatuses for the localization and treatment of disease such as cancer
EP2496175A4 (en) 2009-11-06 2014-08-06 Scient Nanomedicine Inc DETECTION, MEASUREMENT, AND IMAGING OF (eg, CANCER) CELLS AND OTHER BIOLOGICAL SUBSTANCES USING TARGETED NANOPARTICLES AND THEIR MAGNETIC PROPERTIES
CN104046644A (zh) * 2013-03-14 2014-09-17 中国科学院上海生命科学研究院 人源化小鼠模型的构建方法和应用
KR101447901B1 (ko) * 2013-04-16 2014-10-16 한양대학교 산학협력단 지방세포 표적 비바이러스성 유전자 전달체
CN106029172B (zh) * 2014-02-27 2019-12-24 皇家飞利浦有限公司 用于高剂量率短距离放射治疗的医学仪器
US10213284B2 (en) 2015-06-30 2019-02-26 Tela Bio, Inc. Corner-lock stitch patterns
WO2017015421A1 (en) 2015-07-21 2017-01-26 Tela Bio, Inc. Compliance control stitching in substrate materials
US9820843B2 (en) 2016-04-26 2017-11-21 Tela Bio, Inc. Hernia repair grafts having anti-adhesion barriers
KR101875111B1 (ko) * 2016-04-29 2018-07-09 한국수력원자력 주식회사 저선량 방사선을 이용한 암화유전자 Ras-유도 악성 암화 억제
MX2019009753A (es) * 2017-02-16 2019-12-18 Firststring Res Inc Composicion y metodos para prevenir lesion por radiacion y promover la regeneracion de tejidos.
WO2018195434A1 (en) 2017-04-21 2018-10-25 Lisanti Michael P Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs)
EP3612177A4 (en) 2017-04-21 2021-01-13 Lunella Biotech, Inc. TARGETING HYPOXIC CARCINOUS STEM CELLS (SCC) USING DOXYCYCLINE: IMPLICATIONS FOR IMPROVING ANTI-ANGIOGENIC THERAPY
CA3063717C (en) 2017-05-19 2021-08-24 Lunella Biotech, Inc. Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
WO2018213764A1 (en) 2017-05-19 2018-11-22 Lunella Biotech, Inc. Companion diagnostics for mitochondrial inhibitors
BR112019026097A2 (pt) 2017-06-26 2020-07-07 Lunella Biotech, Inc. mitoketoscins: terapêuticos à base de mitocôndrias com direcionamento no metabolismo da cetona em células cancerígenas
WO2019173792A1 (en) * 2018-03-09 2019-09-12 Tela Bio, Inc. Surgical repair graft
EP4585235A3 (en) 2019-03-08 2025-08-20 Tela Bio, Inc. Textured medical textiles
US20240335575A1 (en) * 2021-10-20 2024-10-10 Aphios Corporation Method and apparatus for inactivating pathogens in units of whole blood using superparamagnetic nanoparticles coated with chemiluminescence reagents and broad-spectrum anti-viral therapeutics
CN115300449B (zh) * 2022-02-07 2023-06-27 郑州大学第一附属医院 榄香烯在制备抑制肿瘤耐药性的控释制剂中的应用
CN118126155B (zh) * 2024-02-05 2025-04-25 中山大学附属第七医院(深圳) 一种人nbs1蛋白赖氨酸388位点乳酸化抗原、抗体及其制备方法与应用

Family Cites Families (5)

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US6077880A (en) * 1997-08-08 2000-06-20 Cordis Corporation Highly radiopaque polyolefins and method for making the same
US7122343B1 (en) * 1998-04-27 2006-10-17 Wisconsin Alumni Research Foundation Methods to alter levels of a DNA repair protein
US7074902B1 (en) * 1998-04-27 2006-07-11 Warf Wisconsin Alumni Research Foundation Antibody specific for a DNA repair protein
US6530944B2 (en) * 2000-02-08 2003-03-11 Rice University Optically-active nanoparticles for use in therapeutic and diagnostic methods
US20030104427A1 (en) * 2001-06-25 2003-06-05 Petrini John H.J. Methods to modulate telomere structure and function

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014518616A (ja) * 2011-04-29 2014-08-07 オウアゴー,イェンス 癌における臨床的に関連する低酸素症を判定する方法
JP2017079750A (ja) * 2011-04-29 2017-05-18 オーフス ユニバーシティAarhus Universitet 癌における臨床的に関連する低酸素症を判定する方法
US10385399B2 (en) 2011-04-29 2019-08-20 Aarhus Universitet Method for determining clinically relevant hypoxia in cancer
JP2015503538A (ja) * 2011-12-27 2015-02-02 ウニヴェルシテ ピエール エ マリー キュリー(パリ 6) 抗腫瘍アジュバント療法
JP2015521198A (ja) * 2012-05-29 2015-07-27 ザ ユニバーシティ オブ バーミンガム 付着したdna修復阻害剤及び核局在化シグナル要素を含むナノパーティクル

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Publication number Publication date
KR20090102744A (ko) 2009-09-30
CA2674238A1 (en) 2008-05-08
EP2091964A2 (en) 2009-08-26
WO2008054726A2 (en) 2008-05-08
CN101631799A (zh) 2010-01-20
WO2008054726A3 (en) 2009-02-05
US20100120679A1 (en) 2010-05-13
MX2009004748A (es) 2009-08-25
AU2007314366A1 (en) 2008-05-08

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