JP2010508022A5 - - Google Patents
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- JP2010508022A5 JP2010508022A5 JP2009534698A JP2009534698A JP2010508022A5 JP 2010508022 A5 JP2010508022 A5 JP 2010508022A5 JP 2009534698 A JP2009534698 A JP 2009534698A JP 2009534698 A JP2009534698 A JP 2009534698A JP 2010508022 A5 JP2010508022 A5 JP 2010508022A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- composition
- nbs1
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 58
- 229920001184 polypeptide Polymers 0.000 claims description 54
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 54
- 101001128138 Homo sapiens NACHT, LRR and PYD domains-containing protein 2 Proteins 0.000 claims description 25
- 101000981336 Homo sapiens Nibrin Proteins 0.000 claims description 25
- 102100031897 NACHT, LRR and PYD domains-containing protein 2 Human genes 0.000 claims description 25
- 239000000203 mixture Substances 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 20
- 150000007523 nucleic acids Chemical class 0.000 claims description 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 18
- 108020004707 nucleic acids Proteins 0.000 claims description 18
- 102000039446 nucleic acids Human genes 0.000 claims description 18
- 239000013598 vector Substances 0.000 claims description 18
- 206010028980 Neoplasm Diseases 0.000 claims description 17
- 230000003993 interaction Effects 0.000 claims description 12
- 201000011510 cancer Diseases 0.000 claims description 11
- 210000004027 cell Anatomy 0.000 claims description 7
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 210000004899 c-terminal region Anatomy 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 230000008685 targeting Effects 0.000 claims description 4
- 101710085003 Alpha-tubulin N-acetyltransferase Proteins 0.000 claims description 2
- 101710085461 Alpha-tubulin N-acetyltransferase 1 Proteins 0.000 claims description 2
- 108700031308 Antennapedia Homeodomain Proteins 0.000 claims description 2
- 101150019028 Antp gene Proteins 0.000 claims description 2
- 102100028072 Fibroblast growth factor 4 Human genes 0.000 claims description 2
- 101001060274 Homo sapiens Fibroblast growth factor 4 Proteins 0.000 claims description 2
- 108010070875 Human Immunodeficiency Virus tat Gene Products Proteins 0.000 claims description 2
- TWOFBVMVSYSAFW-UFUGHDFUSA-N N'-(3-aminopropyl)butane-1,4-diamine (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol guanidine Chemical compound NC(N)=N.NC(N)=N.NCCCCNCCCN.C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 TWOFBVMVSYSAFW-UFUGHDFUSA-N 0.000 claims description 2
- 108010088535 Pep-1 peptide Proteins 0.000 claims description 2
- 102000029797 Prion Human genes 0.000 claims description 2
- 108091000054 Prion Proteins 0.000 claims description 2
- 101710175714 Tyrosine aminotransferase Proteins 0.000 claims description 2
- 102100036976 X-ray repair cross-complementing protein 6 Human genes 0.000 claims description 2
- 101710124907 X-ray repair cross-complementing protein 6 Proteins 0.000 claims description 2
- 229940034982 antineoplastic agent Drugs 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 108010025307 buforin II Proteins 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- UKVZSPHYQJNTOU-IVBHRGSNSA-N chembl1240717 Chemical compound C([C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)[C@H](C)O)CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(O)=O)C1=CC=CC=C1 UKVZSPHYQJNTOU-IVBHRGSNSA-N 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 238000002875 fluorescence polarization Methods 0.000 claims description 2
- -1 pVEC Proteins 0.000 claims description 2
- 108010043655 penetratin Proteins 0.000 claims description 2
- MCYTYTUNNNZWOK-LCLOTLQISA-N penetratin Chemical compound C([C@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CC=CC=C1 MCYTYTUNNNZWOK-LCLOTLQISA-N 0.000 claims description 2
- 229920000724 poly(L-arginine) polymer Polymers 0.000 claims description 2
- 108010011110 polyarginine Proteins 0.000 claims description 2
- 239000013641 positive control Substances 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 230000005855 radiation Effects 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 230000035945 sensitivity Effects 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- PBKWZFANFUTEPS-CWUSWOHSSA-N transportan Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)CC)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CC=C(O)C=C1 PBKWZFANFUTEPS-CWUSWOHSSA-N 0.000 claims description 2
- 108010062760 transportan Proteins 0.000 claims description 2
- 241000701161 unidentified adenovirus Species 0.000 claims description 2
- 239000013603 viral vector Substances 0.000 claims description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86345706P | 2006-10-30 | 2006-10-30 | |
| PCT/US2007/022886 WO2008054726A2 (en) | 2006-10-30 | 2007-10-30 | Targeting nbs1-atm interaction to sensitize cancer cells to radiotherapy and chemotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010508022A JP2010508022A (ja) | 2010-03-18 |
| JP2010508022A5 true JP2010508022A5 (enExample) | 2012-01-12 |
Family
ID=39344878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009534698A Withdrawn JP2010508022A (ja) | 2006-10-30 | 2007-10-30 | 放射線療法および化学療法に対して癌細胞を感受性にするためのｎｂｓ１−ａｔｍのターゲティング |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20100120679A1 (enExample) |
| EP (1) | EP2091964A2 (enExample) |
| JP (1) | JP2010508022A (enExample) |
| KR (1) | KR20090102744A (enExample) |
| CN (1) | CN101631799A (enExample) |
| AU (1) | AU2007314366A1 (enExample) |
| CA (1) | CA2674238A1 (enExample) |
| MX (1) | MX2009004748A (enExample) |
| WO (1) | WO2008054726A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8118754B1 (en) | 2007-11-15 | 2012-02-21 | Flynn Edward R | Magnetic needle biopsy |
| US9964469B2 (en) | 2005-02-28 | 2018-05-08 | Imagion Biosystems, Inc. | Magnetic needle separation and optical monitoring |
| US8841414B1 (en) * | 2006-01-27 | 2014-09-23 | University Of Mississippi Medical Center | Targeted delivery of therapeutic peptides by thermally responsive biopolymers |
| WO2011057146A1 (en) | 2009-11-06 | 2011-05-12 | Scientific Nanomedicine, Inc. | Detection, measurement, and imaging of cells such as cancer and other biologic substances using targeted nanoparticles and magnetic properties thereof |
| US8447379B2 (en) | 2006-11-16 | 2013-05-21 | Senior Scientific, LLC | Detection, measurement, and imaging of cells such as cancer and other biologic substances using targeted nanoparticles and magnetic properties thereof |
| US10194825B2 (en) | 2009-11-06 | 2019-02-05 | Imagion Biosystems Inc. | Methods and apparatuses for the localization and treatment of disease such as cancer |
| RU2013153096A (ru) * | 2011-04-29 | 2015-06-10 | Орхус Университет | Способ определения клинически значимой гипоксии при раке |
| EP2797617B1 (en) * | 2011-12-27 | 2020-01-22 | Sorbonne Université | Anti-tumor adjuvant therapy |
| GB201209517D0 (en) * | 2012-05-29 | 2012-07-11 | Univ Birmingham | Nanoparticles |
| CN104046644A (zh) * | 2013-03-14 | 2014-09-17 | 中国科学院上海生命科学研究院 | 人源化小鼠模型的构建方法和应用 |
| KR101447901B1 (ko) * | 2013-04-16 | 2014-10-16 | 한양대학교 산학협력단 | 지방세포 표적 비바이러스성 유전자 전달체 |
| CN106029172B (zh) * | 2014-02-27 | 2019-12-24 | 皇家飞利浦有限公司 | 用于高剂量率短距离放射治疗的医学仪器 |
| EP3317448B1 (en) | 2015-06-30 | 2021-09-08 | Tela Bio, Inc. | Corner-lock stitch patterns |
| EP3324882B1 (en) | 2015-07-21 | 2023-10-25 | Tela Bio, Inc. | Compliance control stitching in substrate materials |
| US9820843B2 (en) | 2016-04-26 | 2017-11-21 | Tela Bio, Inc. | Hernia repair grafts having anti-adhesion barriers |
| KR101875111B1 (ko) * | 2016-04-29 | 2018-07-09 | 한국수력원자력 주식회사 | 저선량 방사선을 이용한 암화유전자 Ras-유도 악성 암화 억제 |
| EP3582754B1 (en) * | 2017-02-16 | 2024-01-10 | Xequel Bio, Inc. | Composition and methods for preventing radiation injury and promoting tissue regeneration |
| EP3612187B1 (en) | 2017-04-21 | 2022-04-13 | Lunella Biotech, Inc. | Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs) |
| US11229657B2 (en) | 2017-04-21 | 2022-01-25 | Lunella Biotech, Inc. | Targeting hypoxic cancer stem cells (CSCs) with doxycycline: implications for improving anti-angiogenic therapy |
| CA3063450A1 (en) | 2017-05-19 | 2018-11-22 | Lunella Biotech, Inc. | Companion diagnostics for mitochondrial inhibitors |
| CU20190092A7 (es) | 2017-05-19 | 2020-10-20 | Lunella Biotech Inc | Antimitoscinas: inhibidores específicos de la biogénesis mitocondrial para erradicar células madre cancerosas |
| MX2019014806A (es) | 2017-06-26 | 2020-02-10 | Lunella Biotech Inc | Mitocetoscinas: agentes terapeuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en celulas cancerosas. |
| US11590262B2 (en) | 2018-03-09 | 2023-02-28 | Tela Bio, Inc. | Surgical repair graft |
| US11446130B2 (en) | 2019-03-08 | 2022-09-20 | Tela Bio, Inc. | Textured medical textiles |
| US20240335575A1 (en) * | 2021-10-20 | 2024-10-10 | Aphios Corporation | Method and apparatus for inactivating pathogens in units of whole blood using superparamagnetic nanoparticles coated with chemiluminescence reagents and broad-spectrum anti-viral therapeutics |
| CN115300449B (zh) * | 2022-02-07 | 2023-06-27 | 郑州大学第一附属医院 | 榄香烯在制备抑制肿瘤耐药性的控释制剂中的应用 |
| CN118126155B (zh) * | 2024-02-05 | 2025-04-25 | 中山大学附属第七医院(深圳) | 一种人nbs1蛋白赖氨酸388位点乳酸化抗原、抗体及其制备方法与应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077880A (en) * | 1997-08-08 | 2000-06-20 | Cordis Corporation | Highly radiopaque polyolefins and method for making the same |
| US7122343B1 (en) * | 1998-04-27 | 2006-10-17 | Wisconsin Alumni Research Foundation | Methods to alter levels of a DNA repair protein |
| US7074902B1 (en) * | 1998-04-27 | 2006-07-11 | Warf Wisconsin Alumni Research Foundation | Antibody specific for a DNA repair protein |
| US6530944B2 (en) * | 2000-02-08 | 2003-03-11 | Rice University | Optically-active nanoparticles for use in therapeutic and diagnostic methods |
| US20030104427A1 (en) * | 2001-06-25 | 2003-06-05 | Petrini John H.J. | Methods to modulate telomere structure and function |
-
2007
- 2007-10-30 WO PCT/US2007/022886 patent/WO2008054726A2/en not_active Ceased
- 2007-10-30 AU AU2007314366A patent/AU2007314366A1/en not_active Abandoned
- 2007-10-30 KR KR1020097011353A patent/KR20090102744A/ko not_active Withdrawn
- 2007-10-30 MX MX2009004748A patent/MX2009004748A/es not_active Application Discontinuation
- 2007-10-30 EP EP07867306A patent/EP2091964A2/en not_active Withdrawn
- 2007-10-30 US US12/447,717 patent/US20100120679A1/en not_active Abandoned
- 2007-10-30 CA CA002674238A patent/CA2674238A1/en not_active Abandoned
- 2007-10-30 CN CN200780048001A patent/CN101631799A/zh active Pending
- 2007-10-30 JP JP2009534698A patent/JP2010508022A/ja not_active Withdrawn
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