JP2009525055A5 - - Google Patents
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- JP2009525055A5 JP2009525055A5 JP2008553510A JP2008553510A JP2009525055A5 JP 2009525055 A5 JP2009525055 A5 JP 2009525055A5 JP 2008553510 A JP2008553510 A JP 2008553510A JP 2008553510 A JP2008553510 A JP 2008553510A JP 2009525055 A5 JP2009525055 A5 JP 2009525055A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- conservative amino
- acid substitutions
- csggkvldc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 273
- 238000006467 substitution reaction Methods 0.000 claims 261
- 206010028980 Neoplasm Diseases 0.000 claims 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims 24
- 201000011510 cancer Diseases 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 14
- 150000001413 amino acids Chemical class 0.000 claims 10
- 210000001365 lymphatic vessel Anatomy 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 210000001519 tissue Anatomy 0.000 claims 7
- 206010060862 Prostate cancer Diseases 0.000 claims 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 5
- 230000003211 malignant effect Effects 0.000 claims 4
- 210000002307 prostate Anatomy 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 239000002254 cytotoxic agent Substances 0.000 claims 3
- 229940127089 cytotoxic agent Drugs 0.000 claims 3
- 231100000599 cytotoxic agent Toxicity 0.000 claims 3
- 230000008685 targeting Effects 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 230000035168 lymphangiogenesis Effects 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 101710085003 Alpha-tubulin N-acetyltransferase Proteins 0.000 claims 1
- 101710085461 Alpha-tubulin N-acetyltransferase 1 Proteins 0.000 claims 1
- 101800002011 Amphipathic peptide Proteins 0.000 claims 1
- 108700031308 Antennapedia Homeodomain Proteins 0.000 claims 1
- 101150019028 Antp gene Proteins 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 102100028072 Fibroblast growth factor 4 Human genes 0.000 claims 1
- 101001060274 Homo sapiens Fibroblast growth factor 4 Proteins 0.000 claims 1
- 108010070875 Human Immunodeficiency Virus tat Gene Products Proteins 0.000 claims 1
- TWOFBVMVSYSAFW-UFUGHDFUSA-N N'-(3-aminopropyl)butane-1,4-diamine (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol guanidine Chemical compound NC(N)=N.NC(N)=N.NCCCCNCCCN.C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 TWOFBVMVSYSAFW-UFUGHDFUSA-N 0.000 claims 1
- 108010088535 Pep-1 peptide Proteins 0.000 claims 1
- 102000029797 Prion Human genes 0.000 claims 1
- 108091000054 Prion Proteins 0.000 claims 1
- 101710175714 Tyrosine aminotransferase Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 102100036976 X-ray repair cross-complementing protein 6 Human genes 0.000 claims 1
- 101710124907 X-ray repair cross-complementing protein 6 Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 108010025307 buforin II Proteins 0.000 claims 1
- UKVZSPHYQJNTOU-IVBHRGSNSA-N chembl1240717 Chemical compound C([C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)[C@H](C)O)CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(O)=O)C1=CC=CC=C1 UKVZSPHYQJNTOU-IVBHRGSNSA-N 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000003511 endothelial effect Effects 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 230000001926 lymphatic effect Effects 0.000 claims 1
- 210000005073 lymphatic endothelial cell Anatomy 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- -1 pVEC Proteins 0.000 claims 1
- 108010043655 penetratin Proteins 0.000 claims 1
- MCYTYTUNNNZWOK-LCLOTLQISA-N penetratin Chemical compound C([C@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CC=CC=C1 MCYTYTUNNNZWOK-LCLOTLQISA-N 0.000 claims 1
- 230000000861 pro-apoptotic effect Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- PBKWZFANFUTEPS-CWUSWOHSSA-N transportan Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)CC)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CC=C(O)C=C1 PBKWZFANFUTEPS-CWUSWOHSSA-N 0.000 claims 1
- 108010062760 transportan Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76417506P | 2006-02-01 | 2006-02-01 | |
| PCT/US2007/061480 WO2007090194A2 (en) | 2006-02-01 | 2007-02-01 | Lymphatic zip codes in tumors and pre-malignant lesions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009525055A JP2009525055A (ja) | 2009-07-09 |
| JP2009525055A5 true JP2009525055A5 (enExample) | 2010-03-25 |
Family
ID=38328164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008553510A Pending JP2009525055A (ja) | 2006-02-01 | 2007-02-01 | 腫瘍および前癌性病変におけるリンパ管のジップコード |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US7919466B2 (enExample) |
| EP (1) | EP1996607A4 (enExample) |
| JP (1) | JP2009525055A (enExample) |
| CA (1) | CA2638807A1 (enExample) |
| WO (1) | WO2007090194A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7919466B2 (en) | 2006-02-01 | 2011-04-05 | The Regents Of The University Of California | Lymphatic zip codes in tumors and pre-malignant lesions |
| FI121959B (fi) | 2008-05-09 | 2011-06-30 | Pirjo Laakkonen | Aivokasvaimiin hakeutuva peptidi |
| WO2010014895A2 (en) * | 2008-07-31 | 2010-02-04 | Enzon Pharmaceuticals, Inc. | Nanoparticle compositions for nucleic acids delivery system |
| US20110223257A1 (en) * | 2008-11-17 | 2011-09-15 | Enzon Pharmaceuticals, Inc. | Releasable fusogenic lipids for nucleic acids delivery systems |
| JP2012509272A (ja) * | 2008-11-17 | 2012-04-19 | エンゾン ファーマシューティカルズ，インコーポレーテッド | 核酸送達系のための放出性カチオン脂質 |
| CN102869384B (zh) | 2009-06-22 | 2016-01-13 | 伯纳姆医学研究所 | 使用带有c-端元件的肽和蛋白质的方法和组合物 |
| WO2011039646A2 (en) | 2009-09-30 | 2011-04-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Papilloma virus -like particles for targeted gene delivery |
| US20110262347A1 (en) | 2010-04-08 | 2011-10-27 | The Salk Institute For Biological Studies | Methods and compositions for enhanced delivery of compounds |
| WO2012118778A1 (en) | 2011-02-28 | 2012-09-07 | Sanford-Burnham Medical Research Institute | Truncated car peptides and methods and compositions using truncated car peptides |
| EP2715291A4 (en) | 2011-05-31 | 2015-10-21 | Airware Inc | NON-DISPERSIVE GAS SENSORS WITH ABSORPTION INFRARED ABSORPTION (NDIR) |
| WO2016172515A1 (en) | 2015-04-23 | 2016-10-27 | Sanford Burnham Prebys Medical Discovery Institute | Targeted delivery system and methods of use therefor |
| GB201710097D0 (en) * | 2017-06-23 | 2017-08-09 | Univ Ulster | A sensitizer - peptide conjugate |
| WO2023064887A1 (en) | 2021-10-15 | 2023-04-20 | The Board Of Trustees Of The University Of Illinois | Mechanochemical dynamic therapy for focal cancer treatment |
| EP4626905A1 (en) * | 2022-12-01 | 2025-10-08 | Hairvel Oü | Novel peptide conjugates |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4786793B2 (ja) | 1998-03-30 | 2011-10-05 | ノースウエスト バイオセラピューティクス，インコーポレイティド | 腫瘍形成におけるｃｘｃｒ−４遺伝子の役割に基く治療的および診断的応用 |
| US6436703B1 (en) * | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| US20110131679A2 (en) * | 2000-04-19 | 2011-06-02 | Thomas La Rosa | Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement |
| US20050123910A1 (en) * | 2001-04-24 | 2005-06-09 | Cookson William Osmond C.M. | Enzyme and snp marker for disease |
| JP2005514348A (ja) * | 2001-11-08 | 2005-05-19 | ザ バーナム インスティチュート | 腫瘍リンパ性脈管構造を目指すペプチドおよびその使用方法 |
| US7723474B2 (en) * | 2003-10-21 | 2010-05-25 | The Regents Of The University Of California | Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies |
| US7919466B2 (en) | 2006-02-01 | 2011-04-05 | The Regents Of The University Of California | Lymphatic zip codes in tumors and pre-malignant lesions |
-
2007
- 2007-02-01 US US11/670,318 patent/US7919466B2/en not_active Expired - Fee Related
- 2007-02-01 CA CA002638807A patent/CA2638807A1/en not_active Abandoned
- 2007-02-01 JP JP2008553510A patent/JP2009525055A/ja active Pending
- 2007-02-01 WO PCT/US2007/061480 patent/WO2007090194A2/en not_active Ceased
- 2007-02-01 EP EP07762715A patent/EP1996607A4/en not_active Withdrawn
-
2011
- 2011-02-10 US US13/024,445 patent/US8536132B2/en not_active Expired - Fee Related
-
2013
- 2013-09-13 US US14/026,377 patent/US8951971B2/en not_active Expired - Fee Related
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